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| 1 | 5-methylcytosine promotes mRNA export--NSUN2 as the methyltransferase and ALYREF as an m5C reader显示文摘 | Yang, Xin Yang, Ying Sun, Bao-Fa Chen, Yu-Sheng Xu, Jia-Wei Lai, Wei-Yi Li, Ang Wang, Xing Bhattarai, Devi Prasad Xiao, Wen Sun, Hui-Ying Zhu, Qin Ma, Hai-Li Adhikari, Samir Sun, Min Hao, Ya-Juan Zhang, Bing Huang, Chun-Min Huang, Niu Jiang, Gui-Bin Zhao, Yong-Liang Wang, Hai-Lin Sun, Ying-Pu Yang, Yun-Gui | 2017 | Cell Research2017，27，5： | 62 |
| 2 | TLR4 is essential for dendritic cell activation and anti-tumor T-cell response enhancement by DAMPs released from chemically stressed cancer cells显示文摘免疫疗法和化疗的联合为癌症的某些类型的治疗被认为是一条有希望的途径。然而,内在的机制需要充分被调查为癌症 chemoimmunotherapy 指导更有效的协议的设计。联系危险的分子的模式(阻尼) 能激活有免疫力的房间,是众所周知的,包括树枝状的房间(DC ) ,经由像使用费的受体(TLR ) ;然而,在有免疫力的反应的激活免除化学对待药的肿瘤房间的阻尼的角色需要进一步被阐明。这里,我们发现那 colorectal 与 oxaliplatin (OXA ) 对待的癌症(CRC ) 房间或 5 氟尿嘧啶(5-Fu ) 释放了高活动性的组盒子 1 的高水平(HMGB1 ) 和热吃惊蛋白质 70 (HSP70 ) 。在 OXA/5-Fu 治疗以后,也展出的 CRC 病人的 sera 增加了 HMGB1 和 HSP70 的层次,哪个是著名阻尼。与 OXA/5-Fu 对待的垂死的 CRC 房间的上层清液支持了老鼠和人的 DC 成熟,与 HLA 医生, CD80 和 CD86 表示和 IL-1β 的改进的 upregulation;, TNF-α, MIP-1α, MIP-1β, RANTES 和 IP-10 生产。由 DC 组成的疫苗与导致的化学上强调的 CRC 房间的上层清液搏动了更重要的 IFN-γ在 vitro 并且在 vivo 生产 Th1 反应。然而,化学上强调的 CRC 房间的上层清液没能在 TLR4 缺乏的 DC 导致 phenotypic 成熟和 cytokine 生产,显示在导致阻尼的 DC 成熟和激活的 TLR4 的一个必要角色。而且,有化学上强调的 CRC 房间的上层清液的 pulsing 高效地没导致 IFN-γ在 TLR4 缺乏的 DC 生产 Th1 反应。一起,这些结果证明免除化学上强调的癌症房间的阻尼能经由 TLR4 激活 DC 并且提高反肿瘤 T 房间有免疫力的回答的正式就职,描出一条临床上相关的免疫助手小径由阻尼被触发。 | Hongliang Fang Bing Ang Xinyun Xu Xiaohui Huang Yanfeng Wu Yanping Sun Wenying Wang Nan Li Xuetao Cao Tao Wan | 2014 | Cellular & Molecular Immunology2014，11，2： | 11 |
| 3 | ASAF: altered spontaneous activity fingerprinting in Alzheimer’s disease based on multisite fMRI显示文摘Several monocentric studies have noted alterations in spontaneous brain activity in Alzheimer's disease (AD), although there is no consensus on the altered amplitude of low-frequency fluctuations in AD patients. The main aim of the present study was to identify a reliable and reproducible abnormal brain activity pattern in AD. The amplitude of local brain activity (AM), which can provide fast mapping of spontaneous brain activity across the whole brain, was evaluated based on multisite rs-fMRI data for 688 subjects (215 normal controls (NCs), 221 amnestic mild cognitive impairment (aMCI) 252 AD). Two-sample t-tests were used to detect group differences between AD patients and NCs from the same site. Differences in the AM maps were statistically analyzed via the Stouffer's meta-analysis. Consistent regions of lower spontaneous brain activity in the default mode network and increased activity in the bilateral hippocampus/parahippocampus, thalamus, caudate nucleus, orbital part of the middle frontal gyrus and left fusiform were observed in the AD patients compared with those in NCs. Significant correlations (P? | Jiachen Li Dan Jin Ang Li Bing Liu Chengyuan Song Pan Wang Dawei Wang Kaibin Xu Hongwei Yang Hongxiang Yao Bo Zhou Alexandre Bejanin Gael Chetelat Tong Han Jie Lu Qing Wang Chunshui Yu Xinqing Zhang Yuying Zhou Xi Zhang Tianzi Jiang Yong Liu Ying Han | 2019 | Science Bulletin2019，64，14： | 3 |
| 4 | A Pattern-Based Method for the Identification of MicroRNA Binding Sites and Their Corresponding Heteroduplexes显示文摘 | Kevin C. Miranda Tien Huynh Yvonne Tay Yen-Sin Ang Wai-Leong Tam Andrew M. Thomson Bing Lim Isidore Rigoutsos | 2006 | Cell2006，，6： | 3 |
| 5 | EgFp gene transfection into the synovial joint tissues of rats withrheumatoid arthritis by ultrasound?mediated microbubble destruction显示文摘 | Xiang?Xiang Jing Jie Liu Bing?Ang Yang Shao?Qing Fu Tang?Na Wu Dong?Lin Wang | 2014 | Experimental and Therapeutic Medicine2014，，5： | 1 |
| 6 | Sall4 Regulates Distinct Transcription Circuitries in Different Blastocyst-Derived Stem Cell Lineages显示文摘 | Chin Yan Lim Wai-Leong Tam Jinqiu Zhang Haw Siang Ang Hui Jia Leonard Lipovich Huck-Hui Ng Chia-Lin Wei Wing Kin Sung Paul Robson Henry Yang Bing Lim | 2008 | Cell Stem Cell2008，，5： | 1 |
| 7 | Relation between gravitational mass and baryonic mass for non-rotating and rapidly rotating neutron stars显示文摘With a selected sample of neutron star(NS)equations of state(EOSs)that are consistent with the current observations and have a range of maximum masses,we investigate the relations between NS gravitational mass Mg and baryonic mass and the relations between the maximum NS mass supported through uniform rotation(Mmax)and that of nonrotating NSs(Mtov).We find that for an EOS-independent quadratic,universal transformation formula(Mb=Mg+A×M^2/g),the best-fit A value is 0.080 for non-rotating NSs,0.064 for maximally rotating NSs,and 0.073 when NSs with arbitrary rotation are considered.The residual error of the transformation is?0.1M⊙ for non-spin or maximum-spin,but is as large as?0.2M⊙ for all spins.For different EOSs,we find that the parameter A for non-rotating NSs is proportional to R^-1/1.4(where R1.4 is NS radius for 1.4M⊙ in units of km).For a particular EOS,if one adopts the best-fit parameters for different spin periods,the residual error of the transformation is smaller,which is of the order of O.O1M⊙ for the quadratic form and less than O.O1M⊙ for the cubic form(Mb=Mg+A1×M^2/g+A2×M^3/g).We also find a very tight and general correlation between the normalized mass gain due to spin △m≡(Mmax-MTOV)MTOV and the spin period normalized to the Keplerian period P,i.e.,log10 △m=(-2.74±0.05)log10 P+log10(0.20±0.01),which is independent of EOS models.These empirical relations are helpful to study NS-NS mergers with a long-lived NS merger product using multi-messenger data.The application of our results to GW170817 is discussed. | He Gao Shun-Ke Ai Zhou-Jian Cao Bing Zhang Zhen-Yu Zhu Ang Li Nai-Bo Zhang Andreas Bauswein | 2020 | Frontiers of physics2020，15，2： | 0 |
| 8 | AN IMPROVED MODEL FOR COMPUTING SOLUTION DYNAMICS OF NATURAL PRODUCTS WITH ^(13)C NUCLEAR MAGNETIC RELAXATION显示文摘The fully anisotropic molecular overall tumbling model withmethyl conformation jumps internal rotation among three equivalent sites isproposed,the overall tumbling rotation rates and the methyl internalrotation rates of ponicidin are computed with this model from Crelaxation parameters. | Yan Wu YANG Ang JI Bing Lin HE Institute of Polymer Chemistry,Nankai University,Tianjin 300071Xin YAN Xiao Long XU De Hun WANG Bao Gong QIAN Wuhan Institute of Physics,The Chinese Academy of Sciences,Wuhan 430071 | 1993 | Chinese Chemical Letters1993，4，10： | 0 |
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