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| 1 | A seven-gene-deleted African swine fever virus is safe and effective as a live attenuated vaccine in pigs显示文摘African swine fever(ASF)is a devastating infectious disease in swine that is severely threatening the global pig industry.An efficacious vaccine is urgently required.Here,we used the Chinese ASFV HLJ/18 as a backbone and generated a series of genedeleted viruses.The virulence,immunogenicity,safety,and protective efficacy evaluation in specific-pathogen-free pigs,commercial pigs,and pregnant sows indicated that one virus,namely HLJ/18-7GD,which has seven genes deleted,is fully attenuated in pigs,cannot convert to the virulent strain,and provides complete protection of pigs against lethal ASFV challenge.Our study shows that HLJ/-18-7GD is a safe and effective vaccine against ASFV,and as such is expected to play an important role in controlling the spread of ASFV. | Weiye Chen Dongming Zhao Xijun He Renqiang Liu Zilong Wang Xianfeng Zhang Fang Li Dan Shan Hefeng Chen Jiwen Zhang Lulu Wang Zhiyuan Wen Xijun Wang Yuntao Guan Jinxiong Liu Zhigao Bu | 2020 | Science China(Life Sciences)2020，63，5： | 72 |
| 2 | Safflor yellow A protects neonatal rat cardiomyocytes against anoxia/reoxygenation injury in vitro显示文摘 | Jia-lin DUAN Jing-wen WANG Yue GUAN Ying YIN Guo WEI Jia CUI Dan ZHOU Yan-rong ZHU Wei QUAN Miao-miao XI Ai-dong WEN | 2013 | Acta Pharmacologica Sinica2013，34，4： | 27 |
| 3 | Decreased expression of human aquaporin-5 correlated with mucus overproduction in airways of chronic obstructive pulmonary disease显示文摘目的:调查在 aquaporin-5 ( AQP5 )之间的关系在有长期的妨碍的肺的疾病( COPD )和与肺的功能 change.Methods 的关联的中国病人的航线的表示和粘液生产过剩:支气管的纸巾从纤维被获得到 July2004.Twenty 的从4月的韦斯特中国医院里的眼的 bronchoscopy 和支气管的活体检视--五病人们作为 COPD 病人,和另外一个被诊断 20 作为控制病人被诊断。 AQP5 ,粘蛋白 5AC ( MUC5AC ),和在支气管的纸巾的粘蛋白的表情被半检测量的 RT-PCR 在 situ 杂交,和组织化学的免疫和染色的alcianblue周期的 acid-Schiff (AB舞步), respectively.Results :与控制组相比, AQP5 的稀释表情从病人 withCOPD 在整个支气管的纸巾被检测( P < 0.01 ),但是没有差别在肺纸巾存在( P > 0.05 )。同时,增加了 MUC5AC 染色,在 submucosal 腺的粘液被注意(P < 0.01,分别地) 。吸烟稀释了 AQP5 的表情并且增加了在 COPDgroups 在 submucosal 腺染色 MUC5AC 和粘液( P < 0.01 ),当有时,没有重要差别在控制组观察了( P > 0.05 ) AQP5 mRNA 的 .Thedecreased 表示在 1 s ( FEV1 )与强迫的吐气的体积被相关 /forcedvital 能力( FVC )( r=0.60 , P < 0.01 ),FEV1%预言了值( r=0.60 , P < 0.01 ),重要能力( V50 )%预言了的最大的吐气的流动in50%值( r=0.55 , P < 0.01 ),并且在25%重要能力( V25 )的最大的吐气的流动%预言了值( r=0,45 , P < 0.01 )。减少的表达式否定地与上皮航线的 MUC5AC mRNA 被相关(r=-0.45, P < 0.01 ) 并且 submucosalglands 的 AB-PAS-stained 区域(r=-0.61, P < 0.01 ) 。起来 MUC5AC mRNA 的规定相关与断然 submucosal 腺的 AB-PAS-stainedarea 并且与 FEV1/FVC 否定地相关( r=-0.53 ; P < 0.01 ),FEV1%预言了值( r=-0.53 ; P < 0.01 ),V50%预言了值( r=-0.48 ; P < 0.01 ),并且V25%预言了值( r=-0.43 ; P < 0.01 ) .Conclusion : AQP5 的稀释基因表达式在中国 COPD 病人的航线存在,它由粘液分泌过盛是复杂的。AQP5mRNA 的减少的表达式可能与气流阻塞的严厉有关。 | Ke WANG Yu-lin FENG Fu-qiang WEN Xue-rong CHEN Xue-mei OU Dan XU Jie YANG Zhi-ping DENG | 2007 | Acta Pharmacologica Sinica2007，28，8： | 24 |
| 4 | Role of plasma C-reactive protein and white blood cell count in predicting in-hospital clinical events of acute type A aortic dissection显示文摘最近的研究报导了的背景一些那发炎与然而, .There 是的尖锐大动脉的解剖(广告)的预后被联系关于C反应的蛋白质( CRP )和白血房间(白血球)在预言在里面医院铺平的血浆的角色的没有全身的调查尖锐类型 AAD.Methods 的临床的事件高敏感的 CRP 和白血球计数的层次全身地与尖锐类型 A 在 36 个病人在承认以后被决定血浆 CRP 的 AD.The 变化并且在 diffe | WEN Dan WU Hai-ying JIANG Xiong-jing ZHANG Hui-min ZHOU Xian-liang LI Jian-jun HUI Ru-tai | 2011 | Chinese Medical Journal2011，，17： | 21 |
| 5 | Antioxidant properties of magnesium lithospermate B contribute to the cardioprotection against myocardial ischemia/reperfusion injury in vivo and in vitro显示文摘OBJECTIVE: To determine the cardioprotective effect of magnesium lithospermate B (MLB) on myocardial ischemia/reperfusion (MI/R) injury and to investigate the antioxidant potential in vivo and in vitro. METHODS: MI/R injury was induced by the occlusion of left anterior descending coronary artery for 30 min followed by reperfusion for 3 h in rats. After reperfusion, hearts were harvested to assess infarct size, histopathological damages, the levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH) and malondialdehyde (MDA). Blood samples were col- lected to determine serum levels of creatine kinase-MB (CK-MB), cardiac troponin (cTnI) and lactate dehydrogenase (LDH). Furthermore, simulatedischemia/reperfusion (SI/R) injury in vitro was established by oxygen and glucose deprivation (OGD) for 2 h followed by 24-hour recovery period in cardiomyocytes. The activity of LDH in the cultured supernatant and the levels of intracellular reactive oxygen species (ROS), SOD and MDA in cardiomyocytes were also measured. Finally, cardiomyocytes apoptosis was determined with flow cytometry. RESULTS: MLB significantly limited infarct size, ameliorated histopathological damages and prevented leakage of CK-MB, cTnI and LDH. Additionally, SOD, CAT, GPx and GSH activities were notably increased by MLB, along with the MDA content decreased as compared with the model group in rats. In vitro study, MLB also decreased LDH activity in the cultured supernatant, increased SOD activity in cardiomyocytes, reduced intracellular ROS and MDA levels, and significantly suppressed cardiomyocytes apoptosis. CONCLUSION: MLB possessed remarkably cardioprotective effects on MI/R injury in vivo and in vitro. The protection of MLB may contribute to its antioxidant properties. | Wei Quan Ying Yin Miaomiao Xi Dan Zhou Yanrong Zhu Yue Guan Chao Guo Yanhua Wang Jialin Duan Aidong Wen | 2013 | Journal of Traditional Chinese Medicine2013，33，1： | 21 |
| 6 | Comparison of Undernutrition Prevalence of Children under 5 Years in China between 2002 and 2013显示文摘Objective To describe the undernutrition status of children under 5-year in China, and study the trend between 2002 and 2013. Methods The study was based on two national surveys. Undernutrition was determined against WHO's 2006 growth standards. The prevalence in 2013 and 2002 was weighted by China sixth National Population Census(2010). The relationship between undernutrition and gender/age groups/different areas use weighted logistic regression. Results The results indicated the overall prevalence of stunting, underweight, and wasting of Chinese children under 5-year was 8.1%, 2.4%, and 1.9% in 2013, respectively. The prevalence of stunting was higher for children aged 12-47 month, while underweight was higher for children aged 48-59 month. The prevalence of undernutrition was higher in rural areas than in urban areas, especially in poor rural areas. There was a decline of stunting, underweight, and wasting between 2002 and 2013 among the children, with greater reduction in rural areas than in urban areas. Conclusion The prevalence of undernutrition of children under 5-year remains high in rural areas especially in poor rural areas in China. It is urgent to take action to control undernutrition in the vulnerable areas and subgroups. | YU Dong Mei ZHAO Li Yun YANG Zhen Yu CHANG Su Ying YU Wen Tao FANG Hong Yun WANG Xun YU Dan GUO Qi Ya XU Xiao Li FANG Yue Hui ZHAO Wen Hua YANG Xiao Guang DING Gang Qiang LIANG Xiao Feng | 2016 | Biomedical and Environmental Sciences2016，29，3： | 18 |
| 7 | Enhancing photocatalytic performance by constructing ultrafine TiO2 nanorods/g-C3N4 nanosheets heterojunction for water treatment显示文摘Photocatalysis is considered to be a clean, green and efficient method to purify water. In this report, we first developed a highly efficient ultrafine TiO_2 nanorods/g-C3 N4 nanosheets(TiO_2 NR/CN NS) composites via a simple hydrothermal method. Tiny TiO_2 nanorods(diameter:~1.5 nm and length:~8.3 nm) were first loaded in situ on the CN NS by adding graphitic carbon nitride(g-C3 N4) to the reaction solution.The TiO_2 NR/CN NS composites present high charge separation efficiency and broader light absorbance than P25 TiO_2. Furthermore, we illustrate that the Ti0_2 NR/CN NS catalyst possesses high performance for the photocatalytic degradation of the common and stubborn pollutants in water, such as the rhodamine B(RhB) dye and phenol. Under visible light(λ> 420 nm) irradiation, the apparent rate of the TiO_2 NR/CN NR is 172 and 41 times higher than that of the P25 TiO_2 and TiO_2 NR, respectively.Additionally, we speculated that the heterojunction formed between TiO_2 NR and CN NS, which is the basis for the experiments we have designed and the corresponding results. We demonstrated that reactive oxidative species such as superoxide anion radical and holes play critical roles in the degradation,and the hydroxyl radical contributes nothing to the degradation. | Shiliang Luan Dan Qu Li An Wenshuai Jiang xiang Gao Shixin Hua Xiang Miao Yuanjing Wen Zaicheng Sun | 2018 | Science Bulletin2018，63，11： | 16 |
| 8 | In vitro chondrogenesis of the goat bone marrow mesenchymal stem cells directed by chondrocytes in monolayer and 3-dimetional indirect co-culture system显示文摘背景软骨损害为内在的新生有一个很差的能力。为使用的软骨修理的基于房间的治疗策略区分了骨头髓间充质的干细胞(BMSC ) 然而,是软骨的修理的一条有希望的途径。这研究被瞄准在 Transwell 合作文化系统和 poly-laetide-co-glycolide (PLGA ) scaffolds.Methods 探索山羊 BMSC 的 chondrogenic 潜力 BMSC 从山羊被孤立肠骨的冠当 chondrocytes 从山羊的家被获得时上次肋骨的软骨。在 Transwell 合作文化系统,与 chondrocytes co 有教养的 BMSC 作为组 A 被设计,而山羊与 chondrogenic 媒介导致的 BMSC 是组 B。组 A 和 B 是试验性的组,当仅仅包含了 BMSC 的组 C 是控制组时。在 PLGA 脚手架合作文化系统, BMSC 被播种进 PLGA 脚手架,它在 24 井板中被推迟,并且控制组被 chondrocytes 的存在或缺席在 24 井板的底部建立。染色的 Toluidine 蓝色,染色的 Alcian 蓝色,骨胶原 immunofluoresence ,骨胶原免疫化学的染色,骨胶原,骨胶原, COL2a Q-PCR 和 osteopontin Q-PCR 被用来检验 chondrogenic 条件以及 chondrogenic 和从山羊骨头髓的aspirates 孤立的 osteogenic genes.Results 房间的表情很快增殖了并且在经过 4 获得了干细胞的特征。然而, chondrocytes 的区别不在经过 3 是明显的。从染色的 Toluidine 蓝色的结果,骨胶原 immunofluoresence 和 PCR 在 Transwell 合作文化系统和 PLGA 脚手架显示出 BMSC 的转变到 chondrocytes。尽管软骨基因表达式在 chondrogenesis 组和合作文化系统被升级, osteopontin 基因表达式,代表 osteogenic 水平,也是 Transwell 合作文化系统和 PLGA 脚手架合作文化系统能支持的 up-regulated.Conclusions 山羊的 BMSC 的 chondrogenic 区别,当在 Transwell 合作文化系统的起来调整的 osteopontin 基因表示暗示 BMSC 的 osteogenic 潜力时。 | LI Jian-wei GUO Xiao-lei HE Chun-la TUO Yong-hua WANG Zhao WEN Jun JIN Dan | 2011 | Chinese Medical Journal2011，，19： | 13 |
| 9 | Chemoresistance of CD133+ cancer stem cells in laryngeal carcinoma显示文摘背景增长证据建议肿瘤是组织学地异构的并且被肿瘤房间的一张小人口维持称为的癌症干细胞。CD133 在喉的癌作为癌症干细胞的一个候选人标记被识别了。这研究试图分析 CD133+ 癌症茎 cells.Methods 的 chemoresistance 到不同化学疗法的代理人的 Hep-2 细胞的反应被调查, CD133 的表示被学习。激活荧光的房间排序分析在殖民地形成试金被用来识别 CD133 ,并且房间的CD133+子集被分开并且分析,房间侵略试金,化疗抵抗研究,并且关于 Hep-2 房间的1%-2%为药抵抗基因 ABCG2.Results 的表示分析了是CD133+房间,并且CD133+比例被chemotherapy.CD133+癌症干细胞充实为 clonogenicity 和侵略展出了更高的潜力,并且对化疗更抵抗。这个电阻与这研究建议了的 ABCG2.Conclusions 的更高的表示被相关 CD133+ 癌症干细胞对化疗更抵抗。ABCG2 的表示能为这部分负责。指向 CD133+ 癌症干细胞的这张小人口能是策略为喉的癌开发更有效的治疗。 | YANG Jing-pu LIU Yan ZHONG Wei YU Dan WEN Lian-ji JIN Chun-shun | 2011 | Chinese Medical Journal2011，，7： | 12 |
| 10 | Emodin alleviates cardiac fibrosis by suppressing activation of cardiac fibroblasts via upregulating metastasis associated protein 3显示文摘Excess activation of cardiac fibroblasts inevitably induces cardiac fibrosis. Emodin has been used as a natural medicine against several chronic diseases. The objective of this study is to determine the effects of emodin on cardiac fibrosis and the underlying molecular mechanisms. Intragastric administration of emodin markedly decreased left ventricular wall thickness in a mouse model of pathological cardiac hypertrophy with excess fibrosis induced by transaortic constriction(TAC) and suppressed activation of cardiac fibroblasts induced by angiotensin II(AngII). Emodin upregulated expression of metastasis associated protein 3(MTA3) and restored the MTA3 expression in the setting of cardiac fibrosis. Moreover, overexpression of MTA3 promoted cardiac fibrosis;in contrast, silence of MTA3 abrogated the inhibitory effect of emodin on fibroblast activation. Our findings unraveled the potential of emodin to alleviate cardiac fibrosis via upregulating MTA3 and highlight the regulatory role of MTA3 in the development of cardiac fibrosis. | Dan Xiao Yue Zhang Rui Wang Yujie Fu Tong Zhou Hongtao Diao Zhixia Wang Yuan Lin Zhange Li Lin Wen Xujuan Kang Philipp Kopylov Dmitri Shchekochikhin Yong Zhang Baofeng Yang | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 11 |
| 11 | Re-identifying Grateloupia yangjiangensis(Rhodophyta, Halymeniaceae) based on morphological observations, life history and rbcL sequence analyses显示文摘On the basis of morphological observations, life history and molecular phylogeny, Grateloupia yangjiangensis, which is similar to G. filicina, G. orientalis, G. catenata, and G. ramosissima in appearance, was re-examined. The results are as follows:(1) the auxiliary-cell ampullae of G. yangjiangensis were of Grateloupia type, thalli was fleshy and gelatinous in texture, and the erect axes were compressed; the cortex was 0.25–0.30 mm thick, consisting of five to seven outer layers, and there were five inner layers of triangular or stellate cells;(2) there was no filamentous stage in the development of the carpospores;(3) the ribulose-1,5-bisphosphate carboxylase/oxygenase gene(rbcL) sequence of four G. yangjiangensis examined showed that there was no intergeneric divergence among them, and for the phylogenetic tree, four sequences of G. yangjiangensis formed a single monophyletic subclade within the large Grateloupia clade of Halymeniaceae. In conclusion, G. yangjiangensis was a single species within the genus Grateloupia. This research provided criterion for identification and cultivation of G. yangjiangensis. | WANG Hongwei GUO Shaoru ZHANG Xiaoming ZHAO Dan ZHANG Wen LUAN Rixiao | 2014 | Acta Oceanologica Sinica2014，33，4： | 10 |
| 12 | Impact of Smoking on Anal Abscess and Anal Fistula Diseases显示文摘 | Li-Hua Zheng Ao-Zhe Zhang Yu-Ying Shi Xin Li Lan-Si Jia Cong-Cong Zhi Qiu-Xiang Yu Wen Zhang Yan-Jun Liu Luan Wang Dan Xiao Chen Wang | 2018 | Chinese Medical Journal2018，，9： | 10 |
| 13 | Chinese herbal medicine reduces mortality in patients with severe and critical coronavirus disease 2019: a retrospective cohort study显示文摘This study aimed to evaluate the efficacy of Chinese herbal medicine(CHM)in patients with severe/critical coronavirus disease 2019(COVID-19).In this retrospective study,data were collected from 662 patients with severe/critical COVID-19 who were admitted to a designated hospital to treat patients with severe COVID-19 in Wuhan before March 20,2020.All patients were divided into an exposed group(CHM users)and a control group(non-users).After propensity score matching in a 1:1 ratio,156 CHM users were matched by propensity score to 156 non-users.No significant differences in seven baseline clinical variables were found between the two groups of patients.All-cause mortality was reported in 13 CHM users who died and 36 non-users who died.After multivariate adjustment,the mortality risk of CHM users was reduced by 82.2%(odds ratio 0.178,95%CI 0.076–0.418;P<0.001)compared with the non-users.Secondly,age(odds ratio 1.053,95%CI 1.023–1.084;P<0.001)and the proportion of severe/critical patients(odds ratio 0.063,95%CI 0.028–0.143;P<0.001)were the risk factors of mortality.These results show that the use of CHM may reduce the mortality of patients with severe/critical COVID-19. | Guohua Chen Wen Su Jiayao Yang Dan Luo Ping Xia Wen Jia Xiuyang Li Chuan Wang Suping Lang Qingbin Meng Ying Zhang Yuhe Ke An Fan Shuo Yang Yujiao Zheng Xuepeng Fan Jie Qiao Fengmei Lian Li Wei Xiaolin Tong | 2020 | Frontiers of Medicine2020，14，6： | 10 |
| 14 | Effect of Integrated Chinese and Western Medicine Therapy on Severe Hand, Foot and Mouth Disease: A Prospective, Randomized, Controlled Trial显示文摘Objective: To evaluate the efficacy and safety of Chinese medicine(CM) plus Western medicine(WM) in the treatment of pediatric patients with severe hand, foot and mouth disease(HFMD) by conducting a prospective, controlled, and randomized trial. Methods: A total of 451 pediatric patients with severe HFMD were randomly assigned to receive WM therapy alone(224 cases, WM therapy group) or CM [Reduning Injection(热毒宁注射液) or Xiyanping Injection(喜炎平注射液)] plus WM therapy(227 cases, CM plus WM therapy group) for 7–10 days, according to a web-based randomization system. The primary outcome was fever clearance time, which was presented as temperature decreased half-life time. The secondary outcomes included the rate of rash/herpes disappearance within 120 h, as well as the rate for cough, runny nose, lethargy and weakness, agitation or irritability, and vomiting clearance within 120 h. The drug-related adverse events were also recorded. Results: The temperature decreased half-life time was 40.4 h in the WM therapy group, significantly longer than 27.2 h in the CM plus WM therapy group(P<0.01). Moreover, the rate for rash/herpes disappearance within 120 h was 43.6%(99/227) in the CM plus WM therapy group, significantly higher than 29.5%(66/224) in the WM therapy group(P<0.01). In addition, the rate for cough, lethargy and weakness, agitation or irritability disappearance within 120 h was 32.6%(74/227) in the CM plus WM therapy group, significantly higher than 19.2%(43/224) in the WM therapy group(P<0.01). No drug-related adverse events were observed during the course of the study. Conclusions: The combined CM and WM therapy achieved a better therapeutic efficacy in treating severe HFMD than the WM therapy alone. Reduning or Xiyanping Injections may become an important complementary therapy to WM for relieving the symptoms of severe HFMD. | LI Xiu-hui LI Shuang-jie XU Yi WEI Dan SHI Qing-sheng ZHU Qing-xiong YANG Tong DING Jian-bo TIAN Yi-mei HUANG Ji-han WANG Kun WEN Tao ZHANG Xi | 2017 | Chinese Journal of Integrative Medicine2017，23，12： | 10 |
| 15 | Effects of single nucleotide polymorphisms 869 T/C and 915 G/C in the exon 1 locus of transforming growth factor-β1 gene on chronic obstructive pulmonary disease susceptibility in Chinese显示文摘背景为长期的妨碍的肺的疾病(COPD ) 的主要风险因素是香烟吸烟。然而,仅仅长期的重吸烟者的 10%-20% 开发系统的 COPD。我们假设了基因多型性的继承能影响 COPD 的发展,它被在 exon 学习二单个核苷酸多型性( SNP )调查 1 转变生长 factor-1 ( TGF-1 ) gene.Methods 我们作为控制组,作为研究组和 148 个健康的人与 COPD 注册了 219 个病人所有谁是中国汉人。 TGF-1 基因, 869T/C 和 915G/C 的多型性,用扩大的方法被分析在有 COPD 的病人的 TGF-1 基因 869T/C 多型性的出现是的倔强的变化系统聚合酶链反应( ARMS-PCR ) .Results 与控制组显著地不同( P < 0.05 ),在哪个这疾病的相对风险在情况中增加了有 C 等位基因(或:1.131, 95% Cl:1.101-1.539 ) 。与控制题目相比没有在 COPD 病人的 TGF-1 915G/C 基因的增加的频率(P > 0.05 ) 在 TGF-1 基因的多型性 869T/C 有的 .Conclusions 有在 COPD 病人和 C 等位基因的疾病出现的一个重要协会可能是一个风险因素。TGF1 上的 869T/C 的同型结合的野类型的 CC 能是在 COPD 的一个预先安排的因素,带 C 等位基因的那些可能特别地有危险性到开发 COPD。 | LIU Dai-shun LI Xiao-ou YING Bin-wu CHEN Lei WANG Tao XU Dan WEN Fu-qiang | 2010 | Chinese Medical Journal2010，，4： | 9 |
| 16 | YEATS2 是一个选择 histone crotonylation 读者显示文摘 | Dan Zhao Haipeng Guan Shuai Zhao Wenyi Mi Hong Wen Yuanyuan Li Yingming Zhao C David Allis Xiaobing Shi Haitao Li | 2016 | Cell Research2016，26，5： | 9 |
| 17 | Mucus hypersecretion in the airway显示文摘 | WANG Ke WEN Fu-qiang XU Dan | 2008 | Chinese Medical Journal2008，，7： | 8 |
| 18 | Observational evidences for the speed of the gravity based on the Earth tide显示文摘We have found that the current practical Newtonian formula for the gravity tide of the Earth implies a hypothesis that gravity travels at the speed of light; furthermore, we have derived and solved the propagation equation of gravity using the observation data of Earth tides from Shiquanhe and Wushi, after correction of phase lag due to the anelasticity of the Earth, and found that the speeds of gravity are from 0.93 to 1.05 times the speed of light with a relative error of about 5%. This provides first set of strong evidences to show that the speed of gravity is the same as the speed of light. | TANG KeYun HUA ChangCai WEN Wu CHI ShunLiang YOU QingYu YU Dan | 2013 | Chinese Science Bulletin2013，58，4： | 8 |
| 19 | Survival of people living with HIV after treatment with Traditional Chinese Medicine in Henan province of China: a retrospective cohortstudy显示文摘OBJECTIVE: To provide survival estimates of people living with human immunodeficiency virus(PLHIV) after treatment with Traditional Chinese Medicine(TCM) in rural China, to identify the prognostic factors at enrollment, and to explore the effectiveness of TCM intreating PLHIV.METHODS: PLHIV who enrolled in national TCM HIV treatment trial program in October 2004 were analyzed in this study and followed up to October 2010. Survival time was estimated by the Kaplan-Meier curve and hazard ratios, and identifying prognostic factors were computed through Cox proportional hazard models.RESULTS:A total of 1666 PLHIV were included with 102 591 person-months of follow-up. Overall, 312(18.7%) patients died. The total mortality rate over the study period was 3.6 per 100 person-years,which was lower than the worldwide rate. The cumulative survival rate was 95.9% at 1 year[95% confidence interval(CI)(94.8-96.8)] and 80.4% at 6years [95% CI(78.4-82.3)]. Elevated death risks emerged among males, older individuals, and thosewithlowerCD4+T-cellcounts.CONCLUSION: TCM could increase survival and lengthen the life span of PLHIV in Henan province of China, as shown by our retrospective cohort study. Factors such as sex, age, education, and CD4+ T-cell counts correlated to survival. However,retrospective cohorts bias the data, so more prospective studies should be performed to confirm our primary results. | Yantao Jin Zhibin Liu Xiumin Chen Xin Wang Dan Wang Ziqiang Jiang Ying Liu Jian Wang Wen Zou Huijun Guo Liran Xu | 2014 | Journal of Traditional Chinese Medicine2014，34，4： | 8 |
| 20 | Increased expression of human calcium-activated chloride channel 1 is correlated with mucus overproduction in the airways of Chinese patients with chronic obstructive pulmonary disease显示文摘背景长期的妨碍的肺的疾病(COPD ) 与在航线的粘液生产过剩通常是复杂的。最近人的激活钙的氯化物隧道的增加的表示(CaCC1 ) 1 被发现在气喘的航线在粘液生产过剩起一个重要作用。在支气管的纸巾与 COPD, CaCC1 的表情, MUC5AC 和粘液在中国病人的航线调查 CaCC1 和粘液生产过剩的关系是 examined.Methods 支气管的纸巾在 2004 从 4 月在韦斯特中国医院里从 fiberoptic bronchoscopy 和支气管的活体检视被获得到 7 月。25 个病人与 COPD 生产过剩作为病人被诊断,并且另外的 20 是控制题目。在支气管的纸巾的 CaCC1 , MUC5AC 和粘蛋白的表情被反向的transcriptase聚合酶链反应( RT-PCR )检测,在有 digoxigenin 的 situ 杂交(挖) -Iabeled RNA 探查, immunohistochemical 和 alcian 染色的蓝色周期的酸 Schiff (AB舞步), respectively.Results 与控制组相比, CaCC1 的更强壮的表情进一步与 COPD ( P0.01 )从病人在整个支气管的纸巾被检测。而且, CaCC1 mRNA 的更强壮的表情与气流阻塞的严厉有关。从 COPD 的样品显示出在控制题目(P0.01 ) 的比那些的为 MUC5AC 的更强壮的染色,染色的 AB 舞步在 COPD 病人在控制题目(P0.01 ) 与那作比较的 submucosal 腺揭示了更多的粘蛋白。 CaCC1 mRNA 的表达式层次否定地分别地与病人一起被相关在/强迫了的一秒( FEV1 )强迫了吐气的体积重要能力( FVC )数据,FEV1%预言了数据,V50%预言了数据,V25%预言了数据( r=0.43 , r=0.43 , r=0.35 , r=0.36 , P0.01 , P0.01 , P0.05 , P0.05 )。当 CaCC1 mRNA 的表示层次很好与 MUC5AC 的表示层次被相关时,航线上皮和 PAS-AB 的 mRNA 染色了 submucosal 腺的区域(r=0.39, r=0.46, P0.05, P0.01 ) 。MUC5AC mRNA 的表示层次否定地与病人的 FEV1/FVC 数据(P=0.01 ) 被相关, FEV1%pred 数据(P=0.01 ) , V50% 预言了数据, V25% 预言了数据(r=0.53, r=0.53, r=0.48, r=0.43, P0.01, P0.01, P0.01, P0.01 ) 。当 MUC5AC mRNA 的表示层次很好被相关与时断然, PAS-AB 染色了 submucosal 腺(P0.05 ) 的区域,并且关联系数是这些结果建议的 0.43 .Conclusion CaCC1 的更强壮的基因表示存在,与在有 COPD 的中国病人的航线的粘液生产过剩复杂。 | WANG Ke FENG Yu-ling WEN Fu-qiang CHEN Xue-rong OU Xue-mei XU Dan YANG Jie DENG Zhi-pin | 2007 | Chinese Medical Journal2007，，12： | 8 |
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