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| 1 | Achalasia: A review of clinical diagnosis, epidemiology,treatment and outcomes显示文摘Achalasia is a neurodegenerative motility disorder of the oesophagus resulting in deranged oesophageal peristalsis and loss of lower oesophageal sphincter function.Historically,annual achalasia incidence rates were believed to be low,approximately 0.5-1.2 per 100000.More recent reports suggest that annual incidence rates have risen to 1.6 per 100000 in some populations.The aetiology of achalasia is still unclear but is likely to be multi-factorial.Suggested causes include environmental or viral exposures resulting in inflammation of the oesophageal myenteric plexus,which elicits an autoimmune response.Risk of achalasia may be elevated in a sub-group of genetically susceptible people.Improvement in the diagnosis of achalasia,through the introduction of high resolution manometry with pressure topography plotting,has resulted in the development of a novel classification system for achalasia.This classification system can evaluate patient prognosis and predict responsiveness to treatment.There is currently much debate over whether pneumatic dilatation is a superior method compared to the Heller’s myotomy procedure in the treatment of achalasia.A recent com-parative study found equal efficacy,suggesting that patient preference and local expertise should guide the choice.Although achalasia is a relatively rare condition,it carries a risk of complications,including aspiration pneumonia and oesophageal cancer.The risk of both squamous cell carcinoma and adenocarcinoma of the oesophagus is believed to be significantly increased in patients with achalasia,however the absolute excess risk is small.Therefore,it is currently unknown whether a surveillance programme in achalasia patients would be effective or cost-effective. | Orla M O'Neill Brian T Johnston Helen G Coleman | 2013 | World Journal of Gastroenterology2013，19，35： | 26 |
| 2 | Risk factors for Barrett’s oesophagus and oesophageal adenocarcinoma:Results from the FINBAR study显示文摘AIM:To investigate risk factors associated with Barrett's oesophagus and oesophageal adenocarcinoma.METHODS:This all-Ireland population-based case-control study recruited 224 Barrett's oesophagus patients,227 oesophageal adenocarcinoma patients and 260 controls.All participants underwent a structured interview with information obtained about potential lifestyle and environmental risk factors.RESULTS:Gastro-oesophageal reflux was associated with Barrett's [OR 12.0(95% CI 7.64-18.7)] and oesophageal adenocarcinoma [OR 3.48(95% CI 2.25-5.41)].Oesophageal adenocarcinoma patients were more likely than controls to be ex-or current smokers [OR 1.72(95% CI 1.06-2.81)and OR 4.84(95% CI 2.72-8.61)respectively] and to have a high body mass index [OR 2.69(95% CI 1.62-4.46)].No significant associations were observed between these risk factors and Barrett's oesophagus.Fruit but not vegetables were negatively associated with oesophageal adenocarcinoma [OR 0.50(95% CI 0.30-0.86)].CONCLUSION:A high body mass index,a diet low in fruit and cigarette smoking may be involved in the progression from Barrett's oesophagus to oesophageal adenocarcinoma. | Lesley A Anderson RG Peter Watson Seamus J Murphy Brian T Johnston Harry Comber Jim Mc Guigan John V Reynolds Liam J Murray | 2007 | World Journal of Gastroenterology2007，13，10： | 5 |
| 3 | Secretion of Angiogenic and Antiapoptotic Factors by Human Adipose Stromal Cells显示文摘 | Jalees Rehman Dmitry Traktuev Jingling Li Stephanie Merfeld-Clauss Constance J. Temm-Grove Jason E. Bovenkerk Carrie L. Pell Brian H. Johnstone Robert V. Considine Keith L. March | 2004 | Circulation: Journal of the American Heart Association2004，，10： | 4 |
| 4 | Have patients with esophagitis got an increased risk of adenocarcinoma? Results from a population-based study显示文摘AIM: To examine an increased risk of esophageal adenocarcinoma is restricted to patients who develop Barrett's esophagus or whether esophagitis per se is a risk factor for adenocarcinoma.METHODS: A population-based cohort of patients with histological evidence of esophagitis without Barrett's esophagus was constructed using electronic pathology reports relating to all esophageal biopsies in Northern Ireland between 1993 and 1996. Person-years of followup and incident cases of esophageal cancer were calculated by linking the cohort to death files and the Northern Ireland Cancer Registry records. Standardized incidence ratios (SIR) were calculated for esophageal cancers (adenocarcinoma, squamous cell carcinoma (SCC), and histologically unspecified cancers).RESULTS: A total of 2 013 patients in the cohort provided 13 559 patient-years of follow-up (mean follow-up 6.7 years). None of the patients developed adenocarcinoma. Three patients developed SCC, and six developed histologically unspecified cancers. The SIR for all esophageal cancers and for SCC were 2.73 (95%CI 1.25-5.19) and 2.93 (95%CI 0.61-8.59), respectively. In a sensitivity analysis in which all unspecified esophageal cancers were treated as adenocarcinomas, the SIR for adenocarcinoma was 2.64 (0.97-5.75).CONCLUSION: The risk of adenocarcinoma is not elevated in patients with histological evidence of esophagitis without Barrett's esophagus; however, these patients may have a moderately increased risk of SCC.Further studies are required to confirm these findings,which suggest that Barrett's esophagus, not esophagitis,is the key precursor lesion in the development of adenocarcinoma. | Seamus J Murphy Lesley A Anderson Brian T Johnston Deirdre A Fitzpatrick Peter RG Watson Pauline Monaghan Liam J Murray | 2005 | World Journal of Gastroenterology2005，11，46： | 4 |
| 5 | Tobacco Smoking Increases the Risk of High-Grade Dysplasia and Cancer Among Patients With Barrett’s Esophagus显示文摘 | Helen G. Coleman Shivaram Bhat Brian T. Johnston Damian McManus Anna T. Gavin Liam J. Murray | 2012 | Gastroenterology2012，，2： | 2 |
| 6 | Theorizing Language Teacher Identity: Three Perspectives and Beyond显示文摘 | Manka Varghese Brian Morgan Bill Johnston Kimberly A. Johnson | 2005 | Journal of Language Identity & Education2005，，1： | 2 |
| 7 | Detection of hydrocarbon fuel spills using a distributed fibre optic sensor显示文摘 | Alistair MacLean Chris Moran Walter Johnstone Brian Culshaw Dan Marsh Paul Parker | 2003 | Physical2003，，1： | 2 |
| 8 | Secretion of Angiogenic and Antiapoptotic Factors by Human Adipose Stromal Cells显示文摘 | Jalees Rehman Dmitry Traktuev Jingling Li Stephanie Merfeld-Clauss Constance J. Temm-Grove Jason E. Bovenkerk Carrie L. Pell Brian H. Johnstone Robert V. Considine Keith L. March | 2004 | Circulation: Journal of the American Heart Association2004，，10： | 2 |
| 9 | Enhanced reactivity of peripheral blood immune cells to HSV-1 in primary achalasia显示文摘 | Kar W. Lau Conal McCaughey Peter V. Coyle Liam J. Murray Brian T. Johnston | 2010 | Scandinavian Journal of Gastroenterology (-)2010，，7： | 1 |
| 10 | In vitro chondrogenesis of bone marrow derived mesencymal progenitor cells显示文摘 | Brian Johnstone Thomas Hering Arnold Caplan | 1998 | Experiment Cell Research1998，238，1： | 1 |
| 11 | Pu-erh tea aqueous extracts lower atherosclerotic risk factors in a rat hyperlipidemia model显示文摘 | Yan Hou Wanfang Shao Rong Xiao Kunlong Xu Zhizhong Ma Brian H. Johnstone Yansheng Du | 2009 | Experimental Gerontology2009，，6： | 1 |
| 12 | Ineffective Esophageal Motility (IEM) (The Primary Finding in Patients with Nonspecific Esophageal Motility Disorder)显示文摘 | Louis P. Leite Brian T. Johnston Jeffrey Barrett June A. Castell Donald O. Castell | 1997 | Digestive Diseases and Sciences1997，，9： | 1 |
| 13 | Adipose stromal cells and platelet-rich plasma therapies synergistically increase revascularization during wound healing显示文摘 | Blanton Matthew W Hadad Ivan Johnstone Brian H | | 0，，02： | 1 |
| 14 | Boopsie and librarians: connecting mobile learners and the library显示文摘 | Brian T Johnstone | 2011 | Library HiTech News2011，，4： | 1 |
| 15 | Differential effects of ouabain and ethacrynic acid on the labyrinthine potentials显示文摘 | Peter M. Sellick Brian M. Johnstone | 1974 | Pflügers Archiv European Journal of Physiology1974，，4： | 1 |
| 16 | Prevalence of and Risk Factors for Hepatic Steatosis and Nonalcoholic Fatty Liver Disease in People With Type 2 Diabetes: the Edinburgh Type 2 Diabetes Study显示文摘 | Williamson Rachel M Price Jackie F Glancy Stephen Perry Elisa Nee Lisa D Hayes Peter C Frier Brian M Van Look Liesbeth A F Johnston Geoffrey I Reynolds Rebecca M Strachan Mark W J | 2011 | Diabetes Care2011，，5： | 1 |
| 17 | Ineffective Esophageal Motility (IEM) (The Primary Finding in Patients with Nonspecific Esophageal Motility Disorder)显示文摘 | Louis P. Leite Brian T. Johnston Jeffrey Barrett June A. Castell Donald O. Castell | 1997 | Digestive Diseases and Sciences1997，，9： | 1 |
| 18 | The Association Between Alcohol and Reflux Esophagitis, Barrett’s Esophagus, and Esophageal Adenocarcinoma显示文摘 | Lesley A. Anderson Marie M. Cantwell R.G. Peter Watson Brian T. Johnston Seamus J. Murphy Heather R. Ferguson Jim McGuigan Harry Comber John V. Reynolds Liam J. Murray | 2009 | Gastroenterology2009，，3： | 1 |
| 19 | Robust Functional Vascular Network Formation In Vivo by Cooperation of Adipose Progenitor and Endothelial Cells显示文摘 | Dmitry O. Traktuev Daniel N. Prater Stephanie Merfeld-Clauss Aravind Raj Sanjeevaiah M Reza Saadatzadeh Michael Murphy Brian H. Johnstone David A. Ingram Keith L. March | 2009 | Circulation Research2009，，12： | 1 |
| 20 | Developing an Approach for Data Management Education: A Re- port from the Data Information Literacy Project显示文摘 | Jake Carlson Lisa Johnston Brian Westra Mason Nichols | 2013 | The International Journal of Digital Curation2013，8，1： | 1 |
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