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| 1 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 2 | Postmarketing safety evaluation: depside salt injection made from Danshen(Radix Salviae Miltiorrhizae)显示文摘OBJECTIVE: To systematically examine the postmarketing safety of depside salt injection made from Danshen(Radix Salviae Miltiorrhizae),identifythe potential risk factors, and ensure its clinical safety.METHODS: We examined a comprehensive series of studies on the production process, quality standards, pharmacology, population pharmacokinetics, and safety evaluation of depside salt injection made from Danshen(Radix Salviae Miltiorrhizae). Data from Ⅰ-Ⅳ clinical drug trials, hospital information systems(HIS), and spontaneous reporting systems(SRS) were also analyzed.RESULTS: The effective components of salvianolic acid salt content reached almost 100%, and the magnesium lithospermate B content reached morethan 80%. The median lethal dose(LD50) calculated by the Bliss method was 1.49 g/kg, with 95%confidence intervals of 1.29-1.72 g/kg. Long-term tests on Beagle dogs indicated that doses of less than 80 mg/kg were safe and doses of 320 mg/kg were toxic. Adverse drug reactions(ADRs) included digestive disorders; drug-induced erythrocyte deformation in lung, liver, spleen, kidney, bone marrow, intestinal mucosa, lymph nodes, and other tissues; megakaryocytes in lung, liver, and spleen resulting from mild hemolysis; and mild hyperplasia in bone marrow hematopoietic tissue. Other studies indicated no irritative effect of the injection on local tissues and blood vessels, and no allergic reactions, erythrocyte coagulation, or hemolysis. SRS data showed that the most common ADRs were headache, head distention, dizziness, facial flushing, skin itching, thrombocytopenia, and the reversibility of elevated Aspartate transaminase. HIS data indicated no damage to renal function from using depside salt injection made from Danshen(Radix Salviae Miltiorrhizae) at a dosage higher than the recommended dose.CONCLUSION: This study analyzes the clinical characteristics of ADRs from depside salt injection made from Danshen(Radix Salviae Miltiorrhizae),and discusses the factors influencing such reactions. It provides scientific reference and recommendations for clinically safe medication of the Danshen injection. | Yanpeng Chang Wen Zhang Yanming Xie Xiangyang Xu Rendi Sun Zheng Wang Ruihua Yan | 2014 | Journal of Traditional Chinese Medicine2014，34，6： | 8 |
| 3 | Relation of Isotope Geochemical Steep Zones with Geophysical Fields and Tectonics in the Junction Area of the Cathaysian,Yangtze and Indochina Plates显示文摘Through lead isotope geochemical mapping in the Yunnan-Guizhou area geochemical steep zones (GSZ) have been established, which clearly reveal the junction relationship of the Cathaysian, Yangtze and Indo-China plates. GSZ are closey related to gravity Mono gradient zones and lithospheric thickness. The GSZ between the Yangtze and Cathaysian plates is consistent with the Shizong-Mile tectonic belt, where island arc basalts are well developed. The Yangtze-Indo-China GSZ is parallel to the Jingdong-Mojiang volcanic belt in rift-island arc environments. The evidence of geology, geophysics and geochemistry all indicates that Cathaysia was subducted towards the Yangtze plate and that the Yangtze plate was underthrust beneath the Indo-China, which took place from the Early Carboniferous to the Early Triassic. | ZHU Bingquan Dong Yunpeng CHANG Xiangyang ZHANG Zhengwei | 2000 | Acta Geologica Sinica(English Edition)2000，74，2： | 5 |
| 4 | Protective effect of estrogen against intervertebral disc degeneration is attenuated by miR-221 through targeting estrogen receptor α显示文摘因为终板有,软骨的终板(CEP ) 的机能障碍是 intervertebral 圆盘退化(国际直拨长途电话) 的一个重要 etiologic 方面营养并且在维持合适的圆盘健康的 biomechanical 功能。在这研究,我们在这些效果在堕落人的 CEP 房间和 miR-221 的参与上调查了雌激素的规章的效果。正常、堕落的人的 CEP 纸巾分别地与自发的脊柱侧凸和国际直拨长途电话从病人被收集。CEP 房间从这些纸巾被孤立。聚合酶链反应(PCR ) 和西方的污点分析被执行分别地检测特定的基因和蛋白质的表示。Apoptosis 和房间周期被流动 cytometry 分析。结果证明 aggrecan,骨胶原 II, TGF- 和雌激素受体的层次(嗯) 当 MMP-3, adamts-5, IL-1, TNF- , IL-6,和 miR-221 的层次被增加时,在堕落 CEP 纸巾被减少。有 17beta-estradiol (E2 ) 的堕落 CEP 房间的治疗增加了 aggrecan 和骨胶原的表情 TGF- 的 II,以及分泌物,而是减少的 IL-6 分泌物。而且, E2 禁止了 apoptosis,在 G0/G1 阶段的恢复房间周期前进,并且改进了房间生存能力。这些数据显示雌激素对 CEP 房间的退化有保护的效果。而且,嗯被证实是由酶试金的 miR-221 的一个目标。合成 miR-221 模仿或击倒嗯稀释了 E2 的保护的效果,但是 miR-221 禁止者支持了 E2 的保护的效果。这些结果建议 miR-221 可以通过指向在堕落 CEP 房间损害雌激素的保护的效果嗯。这研究揭示位于 CEP 房间的退化下面的重要机制。 | Bin Sheng Youchao Yuan Xiangyang Liu Yi Zhang Hongzhe Liu Xiongjie Shen Bin Liu Lei Chang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，4： | 5 |
| 5 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 6 | Hybrid total arch repair without deep hypothermic circulatory arrest for acute type A aortic dissection (R1)显示文摘 | Qian Chang Chuan Tian Yizhen Wei Xiangyang Qian Xiaogang Sun Cuntao Yu | 2012 | The Journal of Thoracic and Cardiovascular Surgery2012，，： | 1 |
| 7 | Low-temperature mineralization domain associated with the parallel positions between geochemical steep zones and geophysical gradient zones显示文摘THE parallel strike of geochemical steep zones and geophysical gradient zones represent geochemicalboundaries with tectonic hiding and almost no magmatism, but there existed great variation of lithosphereor crustal thickness. Tectonically, these areas were located in the foreland basins of craton margin. Thesegeochemical boundaries were usually associated with the low-temperature mineralization and petroleumgeneration. The Nd, Sr and Pb isotopic evidence indicated that there still existed strong crustal-mantle interaction through fluid activation along deep-seated faults at the craton margin. Fig. 1 is the 207Pb/204 Pb-208Pb/204 Pb diagram, which shows the evident crust-mantle mixing for crude oil, chloroform bitumen-A, | ZHU Bingquan, DONG Yunpeng, CHANG Xiangyang and ZHANG Zhengwei Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China | 1999 | Chinese Science Bulletin1999，44，S2： | 1 |
| 8 | A highly sensitive and rapid organophosphate biosensor based on enhancement of CdS–decorated graphene nanocomposite显示文摘 | Kun Wang Qian Liu Lina Dai Jiajia Yan Chang Ju Baijing Qiu Xiangyang Wu | 2011 | Analytica Chimica Acta2011，，1： | 1 |
| 9 | Electrochemical performance of LiFePO 4 nanorods obtained from hydrothermal process显示文摘 | Xiaojun Huang Shengjie Yan Huiying Zhao Lei Zhang Rui Guo Chengkang Chang Xiangyang Kong Haibo Han | 2010 | Materials Characterization2010，，7： | 1 |
| 10 | Lead isotopic exploration intersecting mineralization zones for the depth forecast of concealed deposits显示文摘 | Xiangyang Chang Bingquan Zhu Ri Zou | 2000 | Science in China Series D: Earth Sciences2000，，3： | 1 |
| 11 | Discovery of the copper deposits with features of the Keweenawan type in the border area of Yunnan and Guizhou provinces显示文摘 | Bingquan Zhu Yaoguo Hu Zhengwei Zhang Xiangyang Chang | 2003 | Science in China Series D: Earth Sciences2003，，1： | 1 |
| 12 | Electrochemical performance of LiFePO 4 nanorods obtained from hydrothermal process显示文摘 | Xiaojun Huang Shengjie Yan Huiying Zhao Lei Zhang Rui Guo Chengkang Chang Xiangyang Kong Haibo Han | 2010 | Materials Characterization2010，，7： | 1 |
| 13 | Distribution of natural and anthropogenie thallium in highly weathered soils 显示文摘 | Chunxia Yang Yongheng Chen Ping' an Peng Chao Li Xiangyang Chang Changsheng Xie | 2005 | The Science of Total Environment2005，341，： | 1 |
| 14 | Trace element transformations and partitioning during the roasting of pyrite ores in the sulfuric acid industry显示文摘 | Chunxia Yang Yongheng Chen Ping’an Peng Chao Li Xiangyang Chang Yingjuan Wu | 2009 | Journal of Hazardous Materials2009，，1： | 1 |
| 15 | Fucoidan ex- tract derived from Undaria pinnatifida inhibits angiogenesis by human umbilical vein endothelial cells显示文摘 | Fang Liu Jia Wang Alan K Chang Bing Liu Lili Yang Qiaomei Li Peisheng Wang Xiangyang Zou | 2012 | Phytomedicine 20122012，，： | 1 |
| 16 | Novel objects 3-D dense packing through robotic pushing显示文摘Robotic picking and placing systems can increase the flexibility of packing objects in a box and are attractive in many fields.However,owing to inevitable uncertainties in both the picking and placing stages,the objects cannot be placed at desired positions accurately and hence cannot be packed densely.This paper presents an additional pushing action that maximizes the packing density;i.e.,after being released from the robot end,the object is moved by robotic pushing actions to arrange the packing densely.The robotic pushing strategy is determined through a deep reinforcement learning algorithm.The idea is to compress the objects toward a corner to improve the volume utilization rate by minimizing the result of a heuristic score.The learning process is implemented in simulation and the trained network is transferred to a robot system directly.Simulations and experiments are presented for the packing of regular and irregular objects to verify the proposed method. | WU JianHua ZHANG HaoDong CHANG YaFei XIONG ZhenHua ZHU XiangYang | 2022 | Science China(Technological Sciences)2022，65，12： | 0 |
| 17 | Effects of dynamic segmentation of nutrient supply on growth performance and intestinal development of broilers显示文摘This experiment was to investigate the effects of dynamic segmentation of interval nutrient supply phase feeding on the growth performance, carcass characteristics, immune organs indexes and intestinal morphology of broilers. A total of 320 one-day-old broilers were randomly assigned into 4 feeding treatments, which included 4 interval nutrient supply phases as follows. Treatment A: a nutrient supply standard was used for every 14 d. Treatment B: a nutrient supply standard was used for every 7 d. Treatment C: a nutrient supply standard was used for every 3.5 d except that one nutrient supply standard was used for d 1 to 7. Treatment D: a nutrient supply standard was used for every 3.5 d including d 1 to 7. Each treatment was represented by 8 replicates with 10 broilers per replicate. The trial lasted for 42 days. Throughout the 42 d trial period, treatment A showed significantly higher average daily gain than treatments B and C(P < 0.05). The feed:gain ratio of treatment A was significantly lower than those of treatments C and D(P < 0.05). On d 28 and 42, body weight of broilers in treatment A was much higher than those of treatments B and C(P < 0.05). The slaughter rate of treatment A was significantly higher than that of treatment B(P < 0.05). Eviscerated percentage of treatment A was significantly higher than those of treatment B and D(P < 0.05). There were no significant differences among 4 treatments in immune organs indexes(P > 0.05). The crypt depth of duodenum was significantly greater in treatments A and B than in treatment C on day 42(P < 0.05).Meanwhile, the ratio of villus height to crypt depth(V:C ratio) of treatment D was significantly higher than that of treatment A(P < 0.05). No significant differences were found between treatments C and D in growth performance, carcass performance, immune organs indexes and intestinal structure(P> 0.05). In conclusion, this study revealed that the growth and carcass performance of broilers is the best for 14 days segmentation phase feeding, and 3.5 days segmentation interval phase feeding can promote small intestinal development of broilers. Dynamic segmentation of dietary supply fails to affect the immune function of broilers. | Xiangyang Huang Huiyi Cai Guohua Liu Haijie Yan Wenhuan Chang Shu Zhang | 2016 | Animal Nutrition2016，，4： | 0 |
| 18 | Isotopic dating of the Chengjiang Fauna-bearing horizon in Central Yunnan Province, China显示文摘Twenty black shale samples, which are free from the influence of weathering, were collected from the Chengjiang Fauna-bearing horizon, central Yunnan Province, yielding a Pb-Pb isochron age of 534±60 Ma. Although this age is younger than both the Rb-Sr isochron age and 40Ar-39Ar age, it should represent the lower isotopic age limit of the Chengjiang Fauna. | CHANG Xiangyang CHEN Liangzhong HU Shixue WANG Jianghai ZHU Bingquan | 2007 | Chinese Journal Of Geochemistry2007，26，4： | 0 |
| 19 | Reflection on the Sharp Contrast between Europe and Asia on Postwar Reconciliation显示文摘The year 2015 marks the 70thAnniversary of Victory of World Anti-Fascist War and Chinese People’s Resistance against Japanese Aggression.The occasion reminds people to draw lessons from WWII,and the sharp contrast between Europe and Asia on postwar reconciliation calls for deep reflection.People must keep a vigilant watch on the right-wing tendency of Japan.Much still needs to be done to maintain peace in the world. | Chen Xiangyang Shu Chang | 2015 | International Understanding2015，，3： | 0 |
| 20 | Identifications of products of geographical origin based on geochemical zoning显示文摘The protection system of products of geographical origin has become one hot subject with which various countries throughout the world are concerned. Results of element-Pb isotope geochemical mapping indicate that there emerge a number of famous-brand high-quality product groups of geographical origin in China. The environment of production of China’s famous-brand white spirits of geographical origin at the Sichuan-Guizhou border is still a mystery to be solved. China has two main communities of white spirits of geographical origin, i.e., the most famous are Moutai and Wuliangye spirits. By element-Pb isotope geochemical tracing, we can establish the natural background geological, geographical and geochemical scientific data mark ers in close relation with source areas. Research on the product of geographical origin, named Kaempferia galangal L. in the Shuangjiao district, Yangchun, Guangdong Province, showed that the trace elements have an excellent heritance between Kaempferia galangal L. and soil in this area, and the trace elements are highly effective for tracing the origin. | CHANG Xiangyang FU Shanming LIU Hui CHEN Nan ZHAO Xiaofeng ZHU Bingquan TU Xianglin | 2011 | Chinese Journal Of Geochemistry2011，30，1： | 0 |
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