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| 1 | Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression显示文摘Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression.Using AD mouse models,we discovered that,during AD progression,the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine,which stimulates the differentiation and proliferation of pro-inflammatory T helper 1(Thl)cells.The brain-infiltrated peripheral Th1 immune cells are associated with the Ml microglia aaivation,contributing to AD-associated neuroinflammation.Importantly,the elevation of phenylalanine and isoleucine concentrations and the increase of Th1 cell frequency in the blood were also observed in two small independent cohorts of patients with mild cognitive impairment(MCI)due to AD.Furthermore,GV-971,a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China,suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation,harnesses neuroinflammation and reverses the cognition impairment.Together,our findings highlight the role of gut dysbiosis-promoted neuroinflammation in AD progression and suggest a novel strategy for AD therapy by remodelling the gut microbiota. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2019 | Cell Research2019，29，10： | 192 |
| 2 | Salusins protect myocardium against ischemic injury by alleviating endoplasmic reticulum stress显示文摘Salusins are regulatory peptides that affect cardiovascular function. We previously reported that salusin-α and -β protected cultured cardiomyocytes from serum deprivation-induced cell death through upregulating glucose-regulated protein 78 (GRP78), an endoplasmic reticulum (ER) resident protein whose overexpression acts as a marker and suppressor of ER stress. The present study examined whether salusin-α and -β inhibit ER stress in ischemic myocardium. In a rat model of myocardial infarction created by ligating the left anterior descending coronary artery (LAD), salusin-α or -β was intravenously injected at 5 or 15 nmol kg 1 15 min prior to 2 h of LAD occlusion. The high dose of salusin-α and -β significantly improved heart function and hemodynamics in LAD-occluded rats, but had no effects in sham-operated rats. The arrhythmias caused by LAD occlusion were markedly attenuated by salusin-α and -β. The apoptotic rate in ischemic myocardium was reduced from 31.5%±3.7% to 19.8%±2.2% and 12.3%±2.2%, and the infarct size was reduced from 53.4%±4.0% of the risk area to 26.5%±9.7% and 23.7%±8.9% by 15 nmol kg 1 salusin-α and -β, respectively. Furthermore, salusin-α and -β prevented the activation of GRP78 and ER stress-specific apoptotic effectors caspase-12 and CHOP (C/EBP homologous protein), and attenuated the reduction of an ER stress-associated antiapoptotic protein Bcl-2 in ischemic cardiac tissue. The salusins also inhibited the ER stress induced by tunicamycin in cultured rat H9c2 cardiomyocytes. These results indicate that salusins protect myocardium against ischemic injury by inhibiting ER stress and ER stress-associated apoptosis. | WANG JianFei WANG Yin SHAN ShiFu HU TianTian CHEN HuYan TIAN Jing REN AnJing ZHOU Xu YUAN WenJun LIN Li | 2012 | Science China(Life Sciences)2012，55，4： | 11 |
| 3 | OsSPL18 controls grain weight and grain number in rice显示文摘Grain weight and grain number are two important traits directly determining grain yield in rice. To date,a lot of genes related to grain weight and grain number have been identified; however, the regulatory mechanism underlying these genes remains largely unknown. In this study, we studied the biological function of OsSPL18 during grain and panicle development in rice. Knockout (KO) mutants of OsSPL18exhibited reduced grain width and thickness, panicle length and grain number, but increased tiller number. Cytological analysis showed that OsSPL18 regulates the development of spikelet hulls by affecting cell proliferation. qRT-PCR and GUS staining analyses showed that OsSPL18 was highly expressed in developing young panicles and young spikelet hulls, in agreement with its function in regulating grain and panicle development. Transcriptional activation experiments indicated that OsSPL18is a functional transcription factor with activation domains in both the N-terminus and C-terminus, and both activation domains are indispensable for its biological functions. Quantitative expression analysis showed that DEP1, a major grain number regulator, was significantly down-regulated in OsSPL18 KO lines.Both yeast one-hybrid and dual-luciferase (LUC) assays showed that OsSPL18 could bind to the DEP1promoter, suggesting that OsSPL18 regulates panicle development by positively regulating the expression of DEP1. Sequence analysis showed that OsSPL18 contains the OsmiR156k complementary sequence in the third exon; 5?RLM-RACE experiments indicated that OsSPL18 could be cleaved by OsmiR156k. Taken together, our results uncovered a new OsmiR156k-OsSPL18-DEP1 pathway regulating grain number in rice. | Hua Yuan Peng Qin Li Hu Shijie Zhan Shifu Wang Peng Gao Jing Li Mengya Jin Zhengyan Xu Qiang Gao Anping Du Bin Tu Weilan Chen Bingtian Ma Yuping Wang Shigui Li | 2019 | Journal of Genetics and Genomics2019，46，1： | 8 |
| 4 | Visible-light photocatalytic activity and mechanism of novel AgBr/BiOBr prepared by deposition-precipitation显示文摘A new composite photocatalyst AgBr/BiOBr was prepared by loading AgBr on a BiOBr substrate via deposition-precipitation and characterized by X-ray diffraction,scanning electron microscopy,high-resolution transmission electron microscopy and UV-vis diffuse reflectance spectroscopy.The as-prepared AgBr/BiOBr comprised face-centered cubic AgBr and tetragonal BiOBr particles.The average crystalline sizes of AgBr in the AgBr/BiOBr composites were less than 28.5 nm.The absorption edges of AgBr/BiOBr in visible-light region had a red shift with increasing AgBr content.Photocatalytic degradation of methyl orange results show that the AgBr/BiOBr composites could degrade methyl orange efficiently under visible-light irradiation (λ>420 nm).The optimal molar percentage of AgBr was 50 mol% with corresponding maximum k app of 0.00619 min -1.Active ·O 2- played a major role for methyl orange degradation while h + and ·OH had little effect on the photocatalytic process.The enhancement of photocatalytic activity of AgBr/BiOBr is mainly ascribed to the heterojunction effect between AgBr and BiOBr. | LIN HaiLi CAO Jing LUO BangDe XU BenYan CHEN ShiFu | 2012 | Chinese Science Bulletin2012，57，22： | 8 |
| 5 | Ethylene glycol-assisted synthesis, photoelectrochemical and photocatalytic properties of BiOI microflowers显示文摘Hierarchical bismuth oxyiodide(BiOI) microflower photocatalysts were synthesized by hydrolysis at room temperature. The concentration of ethylene glycol modulated the resulting BiOI morphology. The morphology, elemental composition, crystal phase structure, and absorption properties of the BiOI samples were characterized. Under visible light irradiation(k [ 400 nm), BiOI(S10) with a microflower morphology exhibited the highest photocatalytic activity in the degradation of methyl orange. The corresponding apparent pseudo-first-order rate constant was 0.826 h-1. The trend in photocatalytic activities of the prepared BiOI samples coincided with the trend in their photocurrents. A strategy for preparing hierarchical BiOI microflowers with good visible lightinduced photocatalytic activity is provided. | Haili Lin Chunchun Zhou Jing Cao Shifu Chen | 2014 | Chinese Science Bulletin2014，59，27： | 7 |
| 6 | A Novel CdS/g-C3N4 Composite Photocatalyst: Preparation, Characterization and Photocatalytic Performance with Different Reaction Solvents under Visible Light Irradiation显示文摘 | Xiangju Ye Xia Dai Sugang Meng Xianliang Fu Shifu Chen | 2017 | Chinese Journal of Chemistry2017，35，2： | 6 |
| 7 | Surface Na2CO3 etching induced activity enhancement of 2D BiOI photocatalyst working under visible light显示文摘The visible light photocatalytic activity of two-dimensional(2D) BiOI microplates was intensively enhanced through simply dipping in Na_2CO_3 solutions at room temperature. The X-ray powder diffraction(XRD) and scanning electron microscopy(SEM) investigations suggest that little amount of(BiO)_2CO_3phase was formed on the surface of 2D BiOI via the in situ chemical conversion. The concentration of Na_2CO_3 solutions affected the structure, morphology, light absorption and surface element component of 2D BiOI. The surface loaded(BiO)_2CO_3mainly trapped the photoinduced electrons of BiOI, improved the separation efficiency of photocharges and finally raised the photocatalytic activity of BiOI under visible light(k > 420 nm). Furthermore, the product of the as-prepared(BiO)_2CO_3/BiOI displayed excellent stability in the repeated experiment. This study provides a facile way to improve the photocatalytic activity of BiOX(X = Cl, Br, I) by means of surface treatment with Na_2CO_3 solutions. | Lei Liang Jing Cao Haili Lin Shifu Chen | 2017 | Science Bulletin2017，62，8： | 4 |
| 8 | Parallel computing study for the large-scale generalized eigenvalue problems in modal analysis显示文摘In this paper we study the algorithms and their parallel implementation for solving large-scale generalized eigenvalue problems in modal analysis.Three predominant subspace algorithms,i.e.,Krylov-Schur method,implicitly restarted Arnoldi method and Jacobi-Davidson method,are modified with some complementary techniques to make them suitable for modal analysis.Detailed descriptions of the three algorithms are given.Based on these algorithms,a parallel solution procedure is established via the PANDA framework and its associated eigensolvers.Using the solution procedure on a machine equipped with up to 4800processors,the parallel performance of the three predominant methods is evaluated via numerical experiments with typical engineering structures,where the maximum testing scale attains twenty million degrees of freedom.The speedup curves for different cases are obtained and compared.The results show that the three methods are good for modal analysis in the scale of ten million degrees of freedom with a favorable parallel scalability. | FAN XuanHua CHEN Pu WU RuiAn XIAO ShiFu | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，3： | 4 |
| 9 | Bifurcation and buckling analysis of a unilaterally confined self-rotating cantilever beam显示文摘包括受到单方的锁或开的限制的一根自我旋转的伸臂横梁的一个简单 non-holonomic 系统的一个非线性的动态模型被采用一般哈密尔顿的变化原则建立。临界数值,小平衡在失去它的稳定性或单方的限制被激活或僵绳节点分叉发生,并且 equilibria 被近似分析、数字的方法调查。结果显示弄弯的 equilibria 和横梁的分叉模式是不同的取决于单方的限制的清理的距离是否等于零并且单方的限制是否被锁。单向性的猛咬彻底地现象(即大祸现象) 被注定发生在系统不管限制是否是锁能。僵绳节点分叉能仅仅在单方的限制是能的锁,它的清理是非零的条件上发生。二个方法获得的结果是一致的。 | Shifu Xiao Bin Chen Min Yang | 2006 | Acta Mechanica Sinica2006，22，2： | 4 |
| 10 | PHOTOCATAL YTIC DEGRADATION OF ORGANOPHOS-PHOROUSPESTICIDESUSING Ti O2 THIN FIL M显示文摘PHOTOCATALYTICDEGRADATIONOFORGANOPHOS┐PHOROUSPESTICIDESUSINGTiO2THINFILMChenShifu,ZhaoMengyue,TaoYaowu(DepartmentofChemicalEn... | Chen Shifu ZhaoMe | 1996 | 催化学报1996，17，5： | 3 |
| 11 | Photocatalytic Reduction of Nitro Compounds Using TiO2 Photocatalyst by UV and Vis Dye-sensitized Systems显示文摘Nitro 芳香的混合物能 photocatalytically 被简化为在 UV/TiO2/holes scavenger 和 Vis/TiO2/dye-sensitized 系统把 TiO2 用作光催化剂的相应胺芳香的混合物。在 UV/TiO2/holes scavenger 系统,象甲醇那样的反应底层白酒能被用作洞 scavengers,并且在 Vis/TiO2/dye-sensitized 系统,底层白酒能与高选择被氧化到相应的醛。当甲醇被用作洞 scavengers,照明时间是 6 h 时, 87.2%p 硝基甲苯能 photocatalytically 被简化为 p-toluidine。在 Vis/TiO2/dye-sensitized 系统,为硝基苯的 photocatalytic 减小的芳香的白酒的效果比另外的白酒的好。同时,芳香的白酒能容易被氧化,并且相应的醛的生产效率比另外的白酒的那些高。可能的反应机制也被建议。 | Chen, Shifu Zhang, Huaye Yu, Xiaoling Liu, Wei | 2011 | Chinese Journal of Chemistry2011，29，3： | 2 |
| 12 | A new phosphidation route for the synthesis of NiPx and their cocatalytic performances for photocatalytic hydrogen evolution over g-C3N4显示文摘Ni-based phosphides(NiPx)composed of earth-abundant elements are promising cocatalysts to replace noble metals for photocatalytic H2 evolution reaction(HER).A safe,energy-saving,and compositioncontrollable synthesis of NiPx is still highly desired.A facile and mild solvothermal process was developed for the first time for selective synthesis of a series of NiPx,including Ni,Ni12P5,Ni2P/Ni12P5,Ni/Ni2P and Ni2P,through controlling the dosage of NaBH4 and NaH2PO2.The phosphidation process was mainly composed of(1)a sequential reduction of Ni2+to Nj0 and(H2PO2)-to P(around the formed Ni0)triggered by NaBH4,and(2)a final phosphidation between Nj0 and the in situ generated P atoms.The photocatalytic HER performance of g-C3N4 can be substantially improved with the decoration of NiPx(3 wt%)as the separation of photoinduced charge carriers can be promoted and some active sites with low over-potential for HER can be introduced.The cocatalytic efficiency of NiPx is mainly determined by P content.Ni2P with a high ratio of P consequently exhibits the highest HER performance(215.1 umol g-1 h-1),which is almost six times higher than that of the pristine g-C3N4(35.6 umol g-1 h-1).Thus,as for the cocatalyst based on Ni phosphides,Ni2P is the preferable crystal phase and more efforts should be devoted to Ni2P to further optimize its structure,texture,and morphology in future works. | Ziqun Wang Longfeng Li Mingzhu Liu Tifang Miao Xiangju Ye Sugang Meng Shifu Chen Xianliang Fu | 2020 | Journal of Energy Chemistry2020，29，9： | 2 |
| 13 | Synthesis of AgGa1-xInxSe2 Polycrystalline Materials显示文摘AgGa1-xInxSe2 polycrystals were synthesized by the method of mechanical oscillation and temperature oscillation. X-ray diffraction spectra of polycrystal powder are conformable with the JCPDS cards. Lattice constants a and c calculated from the XRD were found to obey Vegard's law. The melting point of AgGa0.8In0.2Se2 obtained by means of differential scanning calorimetry (DSC) is 796.53 ℃. The DSC curve also show that there are no other transformation points below the melting point. The results indicate that polycrystalline materials synthesized by the method mentioned above are high-quality and can be used to grow single crystals by the vertical Bridgman technology. | Liu Juan Zhao Beijun Zhu Shifu Huang Yi Zhang Jianjun Zhu Weilin Xu Chengfu Chen Baojun Li Ming He Zhiyu | 2006 | Journal of Rare Earths2006，24，z1： | 2 |
| 14 | Synthesis of high-quality CdSiP 2 polycrystalline materials directly from the constituent elements显示文摘 | Long Fan Shifu Zhu Beijun Zhao Baojun Chen Zhiyu He Hui Yang Guangyao Liu | 2011 | Journal of Crystal Growth2011，，： | 2 |
| 15 | Studies on preparation, characterization and activity evaluation of heterostructure In2 O3/In (OH) 3 photocatalyst 显示文摘 | CHEN Shifu YU Xiaoling ZHANG Huaye | 2010 | Jour- nal of Hazardous Materials2010，180，1： | 1 |
| 16 | Hexam- ethylenetertramine directed synthesis and properties of a new family of α-nickel hydroxide organic-inorganic hybrid materials with high chemic stability 显示文摘 | LIU Bianhua YU Shuhong CHEN Shifu | 2006 | The Journal of Physical Chemistry Part B2006，110，： | 1 |
| 17 | Preparation,characterization and activity evaluation of p-n junction photocatalyst p-ZnO/n-TiO2显示文摘 | Chen Shifu Zhao Wei Liu Wei | | 0，，05： | 1 |
| 18 | Novel Bi 2 S 3 -sensitized BiOCl with highly visible light photocatalytic activity for the removal of rhodamine B显示文摘 | Jing Cao Benyan Xu Haili Lin Bangde Luo Shifu Chen | 2012 | Catalysis Communications2012，，： | 1 |
| 19 | Studies on polypyrrole modified nafion membrane for vanadium redox flow battery显示文摘 | Jie Zeng Chunping Jiang Yaohui Wang Jinwei Chen Shifu Zhu Beijun Zhao Ruilin Wang | 2007 | Electrochemistry Communications2007，，3： | 1 |
| 20 | Chemical etching preparation of BiOI/BiOBr heterostructures with enhanced photocatalytic properties for organic dye removal显示文摘 | Jing Cao Benyan Xu Haili Lin Bangde Luo Shifu Chen | 2012 | Chemical Engineering Journal2012，，： | 1 |
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