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| 1 | Efficacy and Economic Evaluation of Nonbiological Artificial Liver Therapy in Acute-on-chronic Hepatitis B Liver Failure显示文摘Background and Aims:Nonbiological artificial liver(NBAL)is frequently used as a first-line treatment for hepatitis B virus-associated acute-on-chronic liver failure(HBV-ACLF).This study aimed to compare the therapeutic efficacy and cost-effectiveness ratio(CER)of comprehensive medical treatment,plasma exchange(PE),and double plasma molecular adsorption system(DPMAS)plus half-dose PE(DPMAS+PE)in patients with HBV-ACLF.Methods:A total of 186 patients with HBV-ACLF randomly received comprehensive medical treatment,PE,or DPMAS+PE and were prospectively evaluated.Patients were divided into four subgroups based on the pretreatment prothrombin activity(PTA):Group I(PTA>40%),group II(PTA 30–40%),group III(PTA 20–30%),and group IV(PTA<20%).The main outcome measures were 28 day effectiveness;90 day liver transplantation-free survival;change of biochemical parameters;and CER.Results:DPMAS+PE treatment was associated with significantly higher 28 day effectiveness and 90 day liver transplantation-free survival compared with PE treatment in patients with group I liver failure.Clearance of serum total bilirubin(TBIL),AST,and creatinine(Cr)were significantly higher in the DPMAS+PE group than in the PE group.For subjects with group I liver failure,DPMAS+PE treatment had advantages of lower CER values and better cost-effectiveness.Conclusions:Compared with comprehensive medical treatment and PE alone,DPMAS with halfdose sequential PE treatment more effectively improved TBIL,AST,and Cr in HBV-ACLF patients,improved 28 day effectiveness and 90 day survival rates in patients with group I liver failure,and was more cost effective.DPMAS+PE is a viable NBAL approach for treatment of HBV-ACLF. | Cichun Wu Wenting Peng Da Cheng Huimin Gu Fei Liu Shifang Peng Lei Fu | 2023 | Journal of Clinical and Translational Hepatology2023，11，2： | 5 |
| 2 | Possible mechanisms underlying treatment of Alzheimer’s disease with Traditional Chinese Medicine: active components, potential targets and synthetic pathways of Bulao Elixir显示文摘OBJECTIVE: To elucidate the mechanisms underlying the treatment of Alzheimer’s disease(AD) with Traditional Chinese Medicine(TCM), by examining the active components, potential targets and synthetic pathways of Bulao Elixir(BLE).METHODS: The Absorption, Distribution, Metabolism, Excretion(ADME)/Toxicology(T) calculation was used to screen the active components of Bulao Elixir. Based on the TCM Systems Pharmacology Analysis Platform(TCMSP database) and a text mining tool(GoPubMed database), we predicted and screened the active components of Bulao Elixir and its therapeutic targets for AD. Using the Database for Annotation, Visualization and Integrated Discovery(DAVID), we obtained the targets for AD. Cytoscape software was used to establish a network map of the active component-target and target-pathway of Bulao Elixir. Gene function, related biological processes and signaling pathways were analyzed using the DAVID database.RESULTS: Twelve active components were selected from 196 components of Bulao Elixir. Among 2209 targets, 102 effective targets were selected, and 30 important targets were identified via matching with the disease targets. After further analysis, 14 core targets were identified. Enrichment analysis revealed that most of these important targets were involved in multiple biological processes, including apoptosis, inflammatory reactions, and cell regulation cycles. The synthetic pathways for AD treatment were identified after analyzing and confirming the relevant pathways, providing potentially useful information for diagnosis and treatment methods for AD.CONCLUSION: The current study elucidated the potential treatment mechanisms of Bulao Elixir in AD using network pharmacology, providing a foundation for further clarification of its treatment targets. | Ren Beida Cheng Fafeng Wang Xueqian Wan Yuxiang Ji Wenting Du Xin Zhang Shuang Liu Shilling Ma Chongyang Xiong Yiliang Hao Gaoting Wang Qingguo | 2020 | Journal of Traditional Chinese Medicine2020，40，3： | 4 |
| 3 | Dendrocalamus latiflorus and its component rutin exhibit glucose-lowering activities by inhibiting hepatic glucose production via AKT activation显示文摘The potential medicinal value of Ma bamboo(Dendrocalamus latiflorus), one of the most popular and economically important bamboo species in China, has been underestimated. In the present study, we found that D. latiflorus leaf extract(DLE) reduced fasting blood glucose levels, body weight,and low-density lipoprotein cholesterol with low liver toxicity in db/db mice. In addition, gene expression profiling was performed and pathway enrichment analysis showed that DLE affected metabolic pathways.Importantly, DLE activated the AKT signaling pathway and reduced glucose production by downregulating glucose-6-phosphatase(G6 PC) and phosphoenolpyruvate carboxykinase 1(PCK1) expression. Moreover, network pharmacology analysis identified rutin as an active component in DLE through targeting insulin growth factor 1 receptor(IGF1 R), an upstream signaling transducer of AKT. Due to its hypoglycemic effects and low toxicity, DLE may be considered an adjuvant treatment option for type 2 diabetes patients. | Kun Luo Wenting Huang Liansheng Qiao Xiaoling Zhang Di Yan Zhiyu Ning Chengmei Ma Honglei Dang Dong Wang Hongyan Guo Lan Xie Jing Cheng | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 4 |
| 4 | Evaluation of the immunomodulatory effects of anti-COVID-19 TCM formulae by multiple virus-related pathways显示文摘Dear Editor,The coronavirus infectious disease 2019(COVID-19)outbreak is seriously endangering human health.Most patients with severe COVID-19 are characterized by sustained cytokine production and hyper-inflammation,which is known as cytokine storm syndrome.1-3 Elaborating the anti-inflammatory response is crucial to these patients,and interieukin-6(IL6)inhibitors and steroids have been recommended in clinical practice.1 However,after the cytokine storm phase,the host immune response to sepsis may develop into a protracted immunosuppressive phase. | Liansheng Qiao Wenting Huang Xiaoling Zhang Hongyan Guo Dong Wang Quansheng Feng Ronghua Jin Lan Xie Weimin Li Jing Cheng | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 4 |
| 5 | Therapeutic window of Qingkailing injection for focal cerebral ischemia/reperfusion injury显示文摘The time window in which a drug is effective varies between drugs. The present study investigated the therapeutic window of Qingkailing injection for focal cerebral ischemia/reperfusion in mice. Animals underwent middle cerebral artery occlusion and were injected with Qingkailing (1.5, 3, 6 mL/kg). Infarct volume and neurological function were assessed after 24 hours of ischemia. In addition, to establish the therapeutic time window, mice were injected with 3 mL/kg Qingkailing at 0, 1, 3, 4, 6, 9 and 12 hours after occlusion. Results revealed that Qingkailing injection significantly reduced infarct volume and improved neurological function in model mice after cerebral infarction for up to 9 hours, demonstrating that the therapeutic window of Qingkailing injection can extend to 9 hours for cerebral ischemia/reperfusion in mice. | Fafeng Cheng Wenting Song Xianggen Zhong Yi Lu Shaoying Guo Dong Wang Weipeng Zhao Qingguo Wang | 2011 | Neural Regeneration Research2011，6，21： | 3 |
| 6 | Planning for distributed wind generation under active management mode显示文摘 | Jietan Zhang Hong Fan Wenting Tang Maochun Wang Haozhong Cheng Liangzhong Yao | 2013 | International Journal of Electrical Power and Energy Systems2013，，： | 2 |
| 7 | Bio-remediation of acephate–Pb(Ⅱ) compound contaminants by Bacillus subtilis FZUL-33显示文摘Removal of Pb^(2+)and biodegradation of organophosphorus have been both widely investigated respectively. However, bio-remediation of both Pb^(2+)and organophosphorus still remains largely unexplored. Bacillus subtilis FZUL-33, which was isolated from the sediment of a lake, possesses the capability for both biomineralization of Pb^(2+)and biodegradation of acephate. In the present study, both Pb^(2+)and acephate were simultaneously removed via biodegradation and biomineralization in aqueous solutions.Batch experiments were conducted to study the influence of p H, interaction time and Pb^(2+)concentration on the process of removal of Pb2+. At the temperature of 25°C, the maximum removal of Pb^(2+)by B. subtilis FZUL-33 was 381.31 ± 11.46 mg/g under the conditions of p H 5.5, initial Pb^(2+)concentration of 1300 mg/L, and contact time of 10 min. Batch experiments were conducted to study the influence of acephate on removal of Pb^(2+)and the influence of Pb2+on biodegradation of acephate by B. subtilis FZUL-33. In the mixed system of acephate–Pb2+, the results show that biodegradation of acephate by B. subtilis FZUL-33 released PO43+, which promotes mineralization of Pb2+. The process of biodegradation of acephate was affected slightly when the concentration of Pb2+was below 100 mg/L. Based on the results, it can be inferred that the B. subtilis FZUL-33 plays a significant role in bio-remediation of organophosphorus-heavy metal compound contamination. | Wenting Lin Zhen Huang Xuezhen Li Minghua Liu Yangjian Cheng | 2016 | Journal of Environmental Sciences2016，28，7： | 2 |
| 8 | Pyrene-tiaraed pillar[5]arene:Strong intramolecular excimer emission applicable for photo-writing显示文摘A pyrene-tiaraed pillar[5]a re ne derivative was synthesized,which showed a concentration-independent intensive excimer emission.Photolysis of the pyrene-tiaraed pillar[5]arene led to a switch from excimer to monomer emission,applicable to photo-writing. | Chao Peng Wenting Liang Jiecheng Ji Chunying Fan Kuppusamy Kanagaraj Wanhua Wu Guo Cheng Dan Su Zhihui Zhong Cheng Yang | 2021 | Chinese Chemical Letters2021，32，1： | 1 |
| 9 | Solubility of Li2CO3 in Na-K-Li-Cl brines from 20 to 90 ℃ 显示文摘 | CHENG Wenting LI Zhibao CHENG Fangqing | 2013 | Journal of Chemical Thermodynamics2013，67，： | 1 |
| 10 | Overexpression of CmSOS1 confers waterlogging tolerance in Chrysanthemum显示文摘Plants experiencing hypoxia(a shortage of oxygen)are unable to maintain aerobic respiration,which leads to an energy and carbohydrate deficit.The pervasive and rapid accumulation of ethylene is an early and reliable response to hypoxic stress(Sasidharan and Voesenek 2015),producing an uptick in the accumulation of reactive oxygen species(ROS).This in turn triggers apoptosis in root cortex cells,eventually leading to the formation of lysigenous aerenchyma,a tissue from which ethylene is readily lost(Loreti et al.2016).In plants exposed to prolonged waterlogging,group VII ethylene response factors operate to activate the suite of genes required to establish anaerobic metabolism(Gibbs et al.2011);some of these genes are also modulated by ROS(Narsai et al.2011;Sasidharan and Voesenek 2015).The transcriptional activation of genes encoding group VII ethylene response factors is regulated by the hypoxia response attenuator 1(HRA1)protein(Pucciariello and Perata 2017).A link between the oxygen sensing and ROS signaling has been established involving the hypoxia‐responsive universal stress protein 1(HRU1),which interacts with the respiratory burst oxidase homolog D(RBOHD)(Gonzali et al.2015).Salinity also tends to induce ROS production(You and Chan 2015). | Lijun Wang Jiaojiao Gao Zixin Zhang Weimiao Liu Peilei Cheng Wenting Mu Tong Su Sumei Chen Fadi Chen Jiafu Jiang | 2020 | Journal of Integrative Plant Biology2020，62，8： | 1 |
| 11 | Oscillator-Based Reconfigurable Sinusoidal Signal Generator for ADC BIST 显示文摘 | HSIN Wenting CHENG Wulin BIN Daliu | 2007 | Electron Test2007，23，： | 1 |
| 12 | Development of a concentration method for detection of tobacco mosaic virus in irrigation water显示文摘Tobacco mosaic virus(TMV) causes significant yield loss in susceptible crops irrigated with contaminated water. However, detection of TMV in water is difficult owing to extremely low concentrations of the virus. Here, we developed a simple method for the detection and quantification of TMV in irrigation water. TMV was reliably detected at concentrations as low as 10 viral copies/μL with real-time PCR. The sensitivity of detection was further improved using polyethylene glycol 6000(PEG6000, MW 6000) to concentrate TMV from water samples. Among the 28 samples from Shaanxi Province examined with our method, 17 were tested positive after virus concentration. Infectivity of TMV in the original water sample as well as after concentration was confirmed using PCR. The limiting concentration of TMV in water to re-infect plants was determined as 102 viral copies/mL. The method developed in this study offers a novel approach to detect TMV in irrigation water, and may provide an effective tool to control crop infection. | Wei Chen Wenting Liu Honghong Jiao Huawei Zhang Julong Cheng Yunfeng Wu | 2014 | Virologica Sinica2014，29，3： | 1 |
| 13 | Citrus fruits are rich in flavonoids for immunoregulation and potential targeting ACE2显示文摘The most recent outbreak of 2019 novel coronavirus,named as COVID-19,caused pneumonia epidemic in Wuhan with 2121 deaths cases as of February 20th 2020.Identification of effective antiviral agents to combat the novel coronavirus is urgently needed.Citrus fruit peel or wild citrus are rich in flavonoids,and clinically documented for roles in relief of cough and promotion of digestive health.Therefore,citrus fruits are assumed to possess antivirus activities or enhance the host immunity.A previous study found that hesperetin could act as a high potent inhibitor of SARS-CoV 3CLpro.We determined six flavonoid compounds’content in three citrus species by using LC-MS technique.The content of naringin and naringenin was at higher levels in pummelo.Hesperetin and hesperidin were highly accumulated in mandarin and sweet orange.The subsequent in vitro and in vivo experiments indicated that naringin could inhibit the expression of the proinflammatory cytokines(COX-2,iNOS,IL-1βand IL-6)induced by LPS in Raw macrophage cell line,and may restrain cytokine through inhibiting HMGB1 expression in a mouse model.The results revealed that naringin may have a potential application for preventing cytokine storm.We simulated molecular docking to predict the binding affinity of those flavonoids to bind Angiotensin-converting enzyme 2(ACE 2),which is a receptor of the coronavirus.Consideration of the potential anti-coronavirus and anti-inflammatory activity of flavonoids,the citrus fruit or its derived phytochemicals are promising in the use of prevention and treatment of SARS-CoV-2 infection. | Wenting Liu Weikang Zheng Liping Cheng Ming Li Jie Huang Shuzheng Bao Qiang Xu Zhaocheng Ma | 2022 | Natural Products and Bioprospecting2022，12，1： | 1 |
| 14 | Effects of zero-valent iron added in the flooding or drainage process on cadmium immobilization in an acid paddy soil显示文摘Zero-valent iron(ZVI)is a promising material for the remediation of Cd-contaminated paddy soils.However,the effects of ZVI added during flooding or drainage processes on cadmium(Cd)retention remain unclear.Herein,Cd-contaminated paddy soil was incubated for 40days of flooding and then for 15 days of drainage,and the underlying mechanisms of Cd immobilization coupled with Fe/S/N redox processes were investigated.The addition of ZVI to the flooding process was more conducive to Cd immobilization.Less potential available Cd was detected by adding ZVI before flooding,which may be due to the increase in paddy soil pH and newly formed secondary Fe minerals.Moreover,the reductive dissolution of Fe minerals promoted the release of soil colloids,thereby increasing significantly the surface sites and causing Cd immobilization.Additionally,the addition of ZVI before flooding played a vital role in Cd retention after soil drainage.In contrast,the addition of ZVI in the drainage phase was not conducive to Cd retention,which might be due to the rapid decrease in soil pH that inhibited Cd adsorption and further immobilization on soil surfaces.The findings of this study demonstrated that Cd availability in paddy soil was largely reduced by adding ZVI during the flooding period and provide a novel insight into the mechanisms of ZVI remediation in Cd-contaminated paddy soils. | Hanbing Meng Shiwen Hu Zebin Hong Wenting Chi Guojun Chen Kuan Cheng QiWang Tongxu Liu Fangbai Li Kexue Liu Yang Yang | 2024 | Journal of Environmental Sciences2024，，4： | 0 |
| 15 | Interaction potential of two nonidentical ground-state atoms显示文摘We study the interaction potential of two nonidentical ground-state atoms coupled to a scalar field in a vacuum by separately calculating the contributions of vacuum fluctuations and those of the radiation reaction of the atoms.Both cases of atoms in a free space and in parallel or vertical alignment to a reflecting boundary are considered.For the former case,we find that the leading-order interaction potential in the regionλA?L?λB exhibits the same separationdependence as that in the region L?λA?λB,where L,λA andλB are respectively the interatomic separation and the transition wavelengths of two atoms withλA?λB.For the latter case,we find that boundary-induced modifications are very remarkable when L?z,with z characterizing the separation between the two-atom system and the boundary.Particularly,when L further satisfies L?λA and L?λB,the interaction potential in the parallel-and the verticalalignment cases respectively scales as z4L-7 and z2L-5,the L-dependence of which is one order higher than those of two atoms in regions where L?z and meanwhile L?λA or/and L?λB.Our results suggest that retardation for the interaction potential of two nonidentical atoms with remarkably distinctive transition frequencies happens only when the interatomic separation is much greater than the transition wavelengths of both atoms. | Yan Peng Shijing Cheng Wenting Zhou | 2023 | Communications in Theoretical Physics2023，75，8： | 0 |
| 16 | Experimental investigation and cost assessment of the salt production by solar assisted evaporation of saturated brine显示文摘The technical feasibility and economy of solar heat collection-forced evaporation process are the keys to its practicality,especially its application in strong brine treatment.The operation cost of applying solar collection in salt manufacturing through depth evaporation of brine has been studied.For Na^+,K^+,Mg^(2+)//Cl^-,SO_4^(2-)-H_2O salt–water system,most of the Na Cl and all of the Carnallite were separated.The operation cost reached the optimum when the heat collection and evaporation were controlled at 75 and 55°C,respectively.When the solar radiation amount was 19557 kJ·m^(-2)·d^(-1),the solar collector area for producing Carnallite was about 34.27 m^2·(t salt)^(-1),and the operation cost was 13 USD?(t salt)^(-1).The energy consumption of salt manufacturing is at least 25%higher than that of natural evaporation.Regarding the economy,the solar assisted salt manufacturing process is recommended to be performed at a production scale of more than 20 tons per day. | Jing Zhao Huaigang Cheng Xiao Wang Wenting Cheng Fangqin Cheng | 2018 | Chinese Journal of Chemical Engineering2018，26，4： | 0 |
| 17 | Deep Learning‑Assisted Quantitative Susceptibility Mapping as a Tool for Grading and Molecular Subtyping of Gliomas显示文摘This study aimed to explore the value of deep learning(DL)-assisted quantitative susceptibility mapping(QSM)in glioma grading and molecular subtyping.Forty-two patients with gliomas,who underwent preoperative T2 fluid-attenuated inversion recovery(T2 FLAIR),contrast-enhanced T1-weighted imaging(T1WI+C),and QSM scanning at 3.0T magnetic resonance imaging(MRI)were included in this study.Histopathology and immunohistochemistry staining were used to determine glioma grades,and isocitrate dehydrogenase(IDH)1 and alpha thalassemia/mental retardation syndrome X-linked gene(ATRX)subtypes.Tumor segmentation was performed manually using Insight Toolkit-SNAP program(www.itksnap.org).An inception convolutional neural network(CNN)with a subsequent linear layer was employed as the training encoder to capture multi-scale features from MRI slices.Fivefold cross-validation was utilized as the training strategy(seven samples for each fold),and the ratio of sample size of the training,validation,and test dataset was 4:1:1.The performance was evalu-ated by the accuracy and area under the curve(AUC).With the inception CNN,single modal of QSM showed better perfor-mance in differentiating glioblastomas(GBM)and other grade gliomas(OGG,grade II–III),and predicting IDH1 mutation and ATRX loss(accuracy:0.80,0.77,0.60)than either T2 FLAIR(0.69,0.57,0.54)or T1WI+C(0.74,0.57,0.46).When combining three modalities,compared with any single modality,the best AUC/accuracy/F1-scores were reached in grading gliomas(OGG and GBM:0.91/0.89/0.87,low-grade and high-grade gliomas:0.83/0.86/0.81),predicting IDH1 mutation(0.88/0.89/0.85),and predicting ATRX loss(0.78/0.71/0.67).As a supplement to conventional MRI,DL-assisted QSM is a promising molecular imaging method to evaluate glioma grades,IDH1 mutation,and ATRX loss. | Wenting Rui Shengjie Zhang Huidong Shi Yaru Sheng Fengping Zhu YiDi Yao Xiang Chen Haixia Cheng Yong Zhang Ababikere Aili Zhenwei Yao Xiao‑Yong Zhang Yan Ren | 2023 | Phenomics2023，3，3： | 0 |
| 18 | The existence of a nonclassical TCA cycle in the nucleus that wires the metabolic-epigenetic circuitry显示文摘The scope and variety of the metabolic intermediates from the mitochondrial tricarboxylic acid(TCA)cycle that are engaged in epigenetic regulation of the chromatin function in the nucleus raise an outstanding question about how timely and precise supply/consumption of these metabolites is achieved in the nucleus.We report here the identification of a nonclassical TCA cycle in the nucleus(nTCA cycle).We found that all the TCA cycle-associated enzymes including citrate synthase(CS),aconitase 2(ACO2),isocitrate dehydrogenase 3(IDH3),oxoglutarate dehydrogenase(OGDH),succinyl-CoA synthetase(SCS),fumarate hydratase(FH),and malate dehydrogenase 2(MDH2),except for succinate dehydrogenase(SDH),a component of electron transport chain for generating ATP,exist in the nucleus.We showed that these nuclear enzymes catalyze an incomplete TCA cycle similar to that found in cyanobacteria.We propose that the nTCA cycle is implemented mainly to generate/consume metabolic intermediates,not for energy production.We demonstrated that the nTCA cycle is intrinsically linked to chromatin dynamics and transcription regulation.Together,our study uncovers the existence of a nonclassical TCA cycle in the nucleus that links the metabolic pathway to epigenetic regulation. | Xujun Liu Wenzhe Si Lin He Jianguo Yang Yani Peng Jie Ren Xiaoping Liu Tong Jin Huajing Yu Zihan Zhang Xiao Cheng Wenting Zhang Lu Xia Yunchao Huang Yue Wang Shumeng Liu Lin Shan Yu Zhang Xiaohan Yang Haixia Li Jing Liang Luyang Sun Yongfeng Shang | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 0 |
| 19 | Lignocellulosic fraction-induced niche differentiation within dissimilatory iron reducing bacterial groups in a paddy soil显示文摘Responses of soil DIRB to lignocellulosic fractions during a 6-week microcosm incubation were investigated.Anaeromyxobacter,Bacillus,and Clostridium maintained their domi-nance throughout the incubation.Distinct DIRB groups proliferated under specific lignocellulosic fraction amendments.Limits of insufficient ferric iron on the proliferation varied by DIRB group.Dissimilatory iron reducing bacteria(DIRB)are phylogenetically and physi-ologically diverse in paddy soils,where iron reduction closely couples with the oxidation of rice straw-derived carbon in the straw returning scenarios.However,few studies have addressed the niche differentiation within DIRB groups during the degradation of lignocellulosic fractions of rice straw.This study conducted a 6-week microcosm incubation experiment to reveal the distinct responses of DIRB groups under specific lignocellulosic fraction amendments with and without ferrihydrite(Fh)addition in a flooded paddy Ultisol.Results showed that the total absolute abundance of the 19 detected DIRB groups did not vary significantly during the incubation.Anaeromyxobacter,Bacillus,and Clostridium were the dominant DIRB groups for all lignocellulosic treatments whereas Thermincola was dominant but only under xylan amendment with Fh addition.DIRB-nodes in the co-occurrence networks of bacterial community mainly belonged to Anaeromyxobacter and Bacillus.Clostridium and Thermincola,Alkaliphilus and Anaeromyxobacter,and Alicyclobacillus,Desulfobulbus,and Desulfosporosinus were specifically proliferated under xylan,cellulose,and lignin amendments,respectively.Whether the proliferation was limited by insufficient ferric iron varied by bacterial group.These findings suggested the lignocellulosic fraction-induced niche differentiation within DIRB groups,which advanced our understanding of the ecology of DIRB in paddy soils under straw returning. | Yunbin Jiang Wenting Hu Kailou Liu Shangshu Huang Fengwu Zhou Cheng Han Huan Deng Wenhui Zhong | 2024 | Soil Ecology Letters2024，6，1： | 0 |
| 20 | Perceiving the connection between the bone healing process and biodegradation of biodegradable metal implants through precise bioadaptability principle显示文摘The implants made of metallic biomaterials help healing the bone fracture but also affect the bone repair process.As proposed in Matter 4(2021)2548–2650 by Wang et al.,a precisely adaptable biomaterial ought to recapitulate the targeted tissue with spatiotemporal precision and hierarchical accuracy,ranging from atoms and molecules(genes,proteins,etc.)to cells(including organelles)and to tissues and organs.In comparison to traditional bio-inert metallic bone implants such as Co-based alloys and Ti alloys,biodegradable metal(Mg and Zn alloys)bone implants had been developed and might arise many unexpected variables in the bone repair,due to their bioactive nature.In this paper,the bone repair without and with the presence of metallic implants is compared.Thereafter,the perspectives concerning the interactions between the bone tissues and biodegradable metal implants are put forward,and how to better mimic in vivo biodegradation by in vitro experiments is proposed for further research and development of biodegradable metals. | Yufeng Zheng Xiao Liu Danni Shen Wenting Li Yan Cheng Ming Yang Yuhui Kou Baoguo Jiang | 2023 | Journal of Materials Science & Technology2023，，16： | 0 |
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