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| 1 | Disease profile and plasma neutralizing activity of postvaccination Omicron BA.1 infection in Tianjin,China:a retrospective study显示文摘Dear Editor,SARS-CoV-2 Omicron variant BA.1 first emerged on the Chinese mainland on January 8,2022,in Tianjin and caused a large wave of infections.1 Four rounds of mass testing of its~14 million residents were launched on January 9,12,15,and 20,respectively.As of February 7,2022,a total of 430 individuals were tested positive for Omicron BA.1,with no new infections detected for the following 16 days.In the Chinese mainland,the most delivered vaccines are inactivated vaccines.As of January 8,2022,up to 93.2%of Tianjin’s residents had been vaccinated with at least one dose.2 We investigated the protection conferred by vaccination against Omicron BA.1 by examining the breakthrough infections among vaccinees as compared with unvaccinated cases.Our study population comprised all 430 cases during the outbreak of Omicron BA.1 in Tianjin. | Hong Zheng Yunlong Cao Xiaosu Chen Fengmei Wang Ye Hu Weiliang Song Yangyang Chai Qingqing Gu Yansong Shi Yingmei Feng Shuxun Liu Yan Xie Xiaoliang Sunney Xie Wentao Jiang Zhongyang Shen | 2022 | Cell Research2022，32，8： | 12 |
| 2 | Activated cytotoxic lymphocytes promote tumor progression by increasing the ability of 3LL tumor cells to mediate MDSC chemoattraction via Fas signaling显示文摘Fas/FasL 系统播送细胞内部的 apoptotic 发信号,导致房间 apoptosis。然而,船边交货发信号也除了导致肿瘤房间 apoptosis 施加 non-apoptotic 功能。例如,船边交货发信号导致肺癌症肿瘤房间生产前列腺素 E2 (PGE2 ) 和成员导出 myeloid 的 suppressor 房间(MDSC ) 。激活的细胞毒素的 T 淋巴细胞(CTL ) 导致并且表示 FasL 在房间仍然是的 apoptosis 抵抗的肿瘤上在 CTL 开始的船边交货激活的 FasL,而是效果的高水平大部分不清楚。我们从 OT-1 老鼠净化了激活的 CD8 + T 房间,在肿瘤房间逃跑上评估了船边交货激活的规章的效果并且调查了相关机制。我们发现 CTL 导致了肿瘤细胞分泌 PGE2 和增加肿瘤经由船边交货发信号的 MDSC 的调停房间的 chemoattraction,它对肿瘤生长有利。我们的结果显示 CTL 可以参予肿瘤免疫者避免过程。就我们的知识而言,这是 CTL 在肿瘤逃跑由起一个作用的新奇机制。我们的调查结果含有经由对肿瘤的否定有免疫力的回答的减小提高 antitumor 免疫者反应的策略通过船边交货发信号由 CTL 支持了。 | Fei Yang Yinxiang Wei Zhijian Cai Lei Yu Lingling Jiang Chengyan Zhang Huanmiao Yan Qingqing Wang Xuetao Cao Tingbo Liang Jianli Wang | 2015 | Cellular & Molecular Immunology2015，12，1： | 6 |
| 3 | Adenovirus-mediated LIGHT gene modification in murine B-cell lymphoma elicits a potent antitumor effect显示文摘Here,we investigated the antitumor effect of adenovirus-mediated gene transfer of LIGHT,the tumor-necrosis factor(TNF)superfamily member also known as TNFSF14,in the murine A20 B-cell lymphoma.LIGHT gene modification resulted in upregulated expression of Fas and the accessory molecule-intercellular adhesion molecule-1(ICAM-1)on A20 cells and led to enhanced A20 cell apoptosis.LIGHT-modified A20 cells effectively stimulated the proliferation of T lymphocytes and interferon(IFN)-c production in vitro.Immunization of BALB/c mice with a LIGHT-modified A20 cell vaccine efficiently elicited protective immunity against challenge with the parental tumor cell line.Adenovirus-mediated gene transfer of LIGHT by intratumoral injection exerted a very potent antitumor effect against pre-existing A20 cell lymphoma in BALB/c mice.This adenovirus-mediated LIGHT therapy induced substantial splenic natural killer(NK)and cytotoxic T lymphocyte(CTL)activity,enhanced tumor infiltration by inflammatory cells and increased chemokine expression of CC chemokine ligand 21(CCL21),IFN-inducible protein-10(IP-10)and monokine induced by IFN-c(Mig)from tumor tissues.Thus,adenovirus-mediated LIGHT therapy might have potential utility for the prevention and treatment of B-cell lymphoma. | Guili Hu Yang Liu Hong Li Dekuang Zhao Liuqing Yang Jiangen Shen Xuejun Hong Xuetao Cao Qingqing Wang | 2010 | Cellular & Molecular Immunology2010，7，4： | 3 |
| 4 | Methyltransferase Dot1l preferentially promotes innate IL-6 and IFN-β production by mediating H3K79me2/3 methylation in macrophages显示文摘Epigenetic modification,including histone modification,precisely controls target gene expression.The posttranscriptional regulation of the innate signaling-triggered production of inflammatory cytokines and type I interferons has been fully elucidated,whereas the roles of histone modification alteration and epigenetic modifiers in regulating inflammatory responses need to be further explored.Di/tri-methylation modifications of histone 3 lysine 79(H3K79me2/3)have been shown to be associated with gene transcriptional activation.Disruptor of telomeric silencing-1-like(Dot1l)is the only known exclusive H3K79 methyltransferase and regulates the proliferation and differentiation of tumor cells.However,the roles of Dot1l and Dot1l-mediated H3K79 methylation in innate immunity and inflammatory responses remain unclear.Here,we found that H3K79me2/3 modification levels at the Il6 and Ifnb1 promoters,as well as H3K79me2 modification at the Tnfαpromoter,were increased in macrophages activated by Toll-like receptor(TLR)ligands or virus infection.The innate signals upregulated Dot1l expression in macrophages and THP1 cells.Dot1l silencing or a Dot1l inhibitor preferentially suppressed the production of IL-6 and interferon(IFN)-βbut not of TNFαin macrophages and THP1 cells triggered by TLR ligands or virus infection.Dot1l was recruited to the proximal promoter of the Il6 and Ifnb1 but not Tnfαgene and then mediated H3K79me2/3 modification at the Il6 and Ifnb1 promoters,consequently facilitating the transcription and expression of Il6 and Ifnb1.Thus,Dot1l-mediated selective H3K79me2/3 modifications at the Il6 and Ifnb1 promoters are required for the full activation of innate immune responses.This finding adds new insights into the epigenetic regulation of inflammatory responses and pathogenesis of autoimmune diseases. | Xiang Chen Xingguang Liu Yunkai Zhang Wanwan Huai Qingqing Zhou Sheng Xu Xi Chen Nan Li Xuetao Cao | 2020 | Cellular & Molecular Immunology2020，17，1： | 3 |
| 5 | Induction of Siglec-G by RNA Viruses Inhibits the Innate Immune Response by Promoting RIG-I Degradation显示文摘 | Weilin Chen Chaofeng Han Bin Xie Xiang Hu Qian Yu Liyun Shi Qingqing Wang Dongling Li Jianli Wang Pan Zheng Yang Liu Xuetao Cao | 2013 | Cell2013，，3： | 2 |
| 6 | Simulation and analysis of two-point bending fatigue test of asphalt concrete based on discrete element model显示文摘In order to investigate the fatigue performance ofFrench high modulus asphalt concrete and the correlationbetween Burger's parameters and fatigue life, the virtualmodel of asphalt mixture trapezoidal specimen in the two-pointbending fatigue test was constructed in discrement elementsoftware PFC3D. The initial stiffness and the maximum stresswhen the specimen reached fatigue were calculated. Throughthe comparison between virtual and single field fatigue testcurves, the credibility of simulation in DEM was verified.Then, the impacts of top controlled displacement and Burger'sparameters ( El, E2, η1, η2) on the fatigue life of the specimenwere explored. The simulation results indicate that themaximum stress increases with the increase in the topcontrolled displacement. With the increase of E1 and thedecrease of E2 in Burger's model, the modulus of the asphaltbinder increases, and the fatigue performance of the asphaltmixture enhances, η1 and η22 have limited influence on fatiguelife compared with El and E2. | Cao Qingqing Liu Xiuyu Wang Hao Huang Xiaoming | 2017 | Journal of Southeast University(English Edition)2017，33，3： | 2 |
| 7 | Characteristics of Micro Pore-throat of Tight Oil Reservoir in Permian Lucaogou Formation,Jimsar Sag显示文摘Jimsar Sag is located in the southwest section of the eastern part of the Junggar Basin.It is a typical selfgeneration and self-storage type tight oil reservoir in the deposition period of Permian Lucaogou Formation.The tight oil reservoir rocks have complex mineral compositions and multiple components,which represent a kind of transitional mixed sedimentary rock.According to the relative contents of terrigenous detrital,carbonate | XUE Xiujie CAO Yingchang WANG Jian XI Kelai ZHANG Qingqing | 2015 | Acta Geologica Sinica(English Edition)2015，89，A01： | 2 |
| 8 | A comparison of robot-assisted and fluoroscopy-assisted kyphoplasty in the treatment of multi-segmental osteoporotic vertebral compression fractures显示文摘Osteoporotic vertebral compression fracture(OVCF)has become a major public health issue that becomes more pressing with increasing global aging.Percutaneous kyphoplasty(PKP)is an effective treatment for OVCF.Robot-assisted PKP has been utilized in recent years to improve accuracy and reduce complications.However,the effectiveness of robot-assisted PKP in the treatment of multi-segmental OVCF has yet to be proved.This study was designed to compare the efficacy of robot-assisted and conventional fluoroscopy-assisted multi-segmental PKP.A total of 30 cases with multi-segmental OVCF between April 2019 and April 2021 were included in this study.Fifteen cases were assigned to the robot-assisted PKP group(robot group)and 15 cases to the conventional fluoroscopy-assisted PKP group(conventional fluoroscopy group).The number of fluoroscopic exposures,fluoroscopic dose,operation time,cement leakage rate,visual analog scale(VAS)score,vertebral kyphosis angle(VKA),and height of fractured vertebral body(HFV)were compared between the 2 groups.The number of fluoroscopic exposures,fluoroscopic doses,and cement leakage rates in the robot group were lower than in the conventional fluoroscopy group(P<0.05)while the operative time in the robot group was longer than in the conventional fluoroscopy group(P<0.05).VAS score and VKA were decreased and HFV was increased after surgery in both groups(P<0.05).Therefore,robot-assisted PKP for the treatment of multi-segmental OVCF can reduce the number of fluoroscopic exposures,fluoroscopic doses,and cement leakage compared to conventional treatment.As such,robot-assisted PKP has good application prospects and is potentially more effective in the treatment of multi-segmental OVCF. | Qingqing Li Chaoqin Wu Zhenfei Huang Jiang Cao Jie Chang Guoyong Yin Lipeng Yu Xiaojian Cao Tao Sui | 2022 | The Journal of Biomedical Research2022，36，3： | 2 |
| 9 | Elevated expression of Acid-Sensing ion Channel 3inhibits epilepsy via activation of interneurons显示文摘 | CAO Qingqing WANG Wei GU Juan | 2016 | Molecular Neurobiology2016，53，1： | 1 |
| 10 | Glycolipid iGb3 feedback amplifies innate immune responses via CD1d reverse signaling显示文摘The cross-talk between cellular lipid metabolism and the innate immune responses remains obscure. In addition to presenting lipid antigens to Natural Killer T-cells (NKT cells), the Cluster of Differentiation 1D Glycoprotein (CD1d) might mediate reverse signaling in antigen-presenting cells (APCs). Here we found CD1d deficiency attenuated Toll-like receptor (TLR)-triggered inflammatory innate responses in macrophages and dendritic cells, protecting mice from endotoxin shock. TLR activation in macrophages induced metabolic changes of glycosphingolipids (GSLs), among which glycolipid isoglobotrihexosylceramide (iGb3) was rapidly produced. The endogenously generated iGb3 bound CD1d in endosomal compartments and then synergized with the initially activated TLR signal to induce Tyr332 phosphorylation of CD1d intracellular domain. This led to the recruitment and activation of proline-rich tyrosine kinase 2 (Pyk2). Pyk2 interacted with IκB kinase β (IKKβ) and TANK-binding kinase 1 (TBK1), and enhanced tyrosine phosphorylation of Tyr188/199 of IKKβ and Tyr179 of TBK1 and thus, their activation to promote full activation of TLR signaling. Thus, intracellular CD1d reverse signaling, triggered by endogenous iGb3, amplifies inflammatory innate responses in APCs. Our findings identify a non-canonical function of CD1d reverse signaling activated by lipid metabolite in the innate immune response. | Xingguang Liu Peng Zhang Yunkai Zhang Zheng Wang Sheng Xu Yingke Li Wanwan Huai Qingqing Zhou Xiang Chen Xi Chen Nan Li Peng Wang Yunsen Li Xuetao Cao | 2019 | Cell Research2019，29，1： | 1 |
| 11 | Enhanced induction of dendritic cell maturation and HLA-A*0201-restricted CEA-specific CD8+ CTL response by exosomes derived from IL-18 gene-modified CEA-positive tumor cells显示文摘 | Shengming Dai Xiangyang Zhou Baomei Wang Qingqing Wang Yangxin Fu Taoyong Chen Tao Wan Yizhi Yu Xuetao Cao | 2006 | Journal of Molecular Medicine2006，，12： | 1 |
| 12 | Enhanced induction of dendritic cell maturation and HLA-A*0201-restricted CEA-specific CD8+ CTL response by exosomes derived from IL-18 gene-modified CEA-positive tumor cells显示文摘 | Shengming Dai Xiangyang Zhou Baomei Wang Qingqing Wang Yangxin Fu Taoyong Chen Tao Wan Yizhi Yu Xuetao Cao | 2006 | Journal of Molecular Medicine2006，，12： | 1 |
| 13 | Application of fuzzy clustering method to determining sub-fault planes of earthquake from aftershocks sequence显示文摘Earthquake rupture process generally involves several faults activities instead of a single fault.A new method using both fuzzy clustering and principal component analysis makes it possible to reconstruct three dimensional structure of involved faults in earthquake if the aftershocks around the active fault planes distribute uniformly.When seismic events are given,the optimal faults structures can be determined by our new method.Each of sub-fault planes is fully characterized by its central location,length,width,strike and dip.The resolution determines the number of fault segments needed to describe the earthquake catalog.The higher the resolution,the finer the structure of the reconstructed fault segments.The new method successfully reconstructs the fault segments using synthetic earthquake catalogs.By taking the 28 June 1992 Landers earthquake occured in southern California as an example,the reconstructed fault segments are consistent with the faults already known on geological maps or blind faults that appeared quite frequently in longer-term catalogs. | Fuchang Wang Yongge Wan Huirong Cao Zhitong Jin Qingqing Ren | 2012 | Earthquake Science2012，25，2： | 1 |
| 14 | Aromatic inorganic acid radical显示文摘Stable radicals are challenging to prepare due to their intrinsic high reactivity.Herein,three trisphenolamine radicals were readily synthesized and exhibited unexpected thermal/electrochemical stability and semiconductor property.These three nitroxide radicals could be considered as a class of aromatized nitro groups or HNO3 derivatives.The closed-shell nitro-like and open-shell nitroxide resonance structure contribute to their outstanding stability.Furthermore,the tunable ground states,extremely low band gap and p-type charge transport properties were systematically investigated.More importantly,the work presents the concept of aromatic inorganic acid radical(AIAR)and aggregation-induced radical(AIR)mechanism to understand the intrinsic structureproperty relationship of these radicals.In addition,we provide a novel strategy for the design of stable and low bandgap radicals for organic electronics,magnetics,spintronics,etc. | Jiawen Zhou Weiya Zhu Miao Zeng Qingqing Yang Ping Li Linfeng Lan Junbiao Peng Yuan Li Fei Huang Yong Cao | 2019 | Science China Chemistry2019，62，12： | 1 |
| 15 | Upconversion nanoparticles regulated drug&gas dual-effective nanoplatform for the targeting cooperated therapy of thrombus and anticoagulation显示文摘Thromboembolism is the leading cause of cardiovascular mortality.Currently,for the lack of targeting,short half-life,low bioavailability and high bleeding risk of the classical thrombolytic drugs,pharmacological thrombolysis is usually a slow process based on micro-pumping.In addition,frequently monitoring and regulating coagulation functions are also required during(and after)the process of thrombolysis.To address these issues,a targeted thrombolytic and anticoagulation nanoplatform(UCATS-UK)is developed based on upconversion nanoparticles(UCNPs)that can convert 808 or 980 nm near-infrared(NIR)light into UV/blue light.This nanoplatform can target and enrich in the thrombus site.Synergistic thrombolysis and anticoagulation therapy thus could be realized through the controlled release of urokinase(UK)and nitric oxide(NO).Both in vitro and in vivo experiments have confirmed the excellent thrombolytic and anticoagulative capabilities of this multifunctional nanoplatform.Combined with the unique fluorescent imaging capability of UCNPs,this work is expected to contribute to the development of clinical thrombolysis therapy towards an integrated system of imaging,diagnosis and treatment. | Shichen Liu Yao Sun Teng Zhang Longtao Cao Zhiwei Zhong Haoxin Cheng Qingqing Wang Zhuang Qiu Weimin Zhou Xiaolei Wang | 2022 | Bioactive Materials2022，7，12： | 1 |
| 16 | Type I IFN Inhibits Innate IL-10 Production in Macrophages through Histone Deacetylase 11 by Downregulating MicroRNA-145显示文摘 | Li Lin Jin Hou Feng Ma Pin Wang Xingguang Liu Nan Li Jianli Wang Qingqing Wang Xuetao Cao | 2013 | The Journal of Immunology2013，，7： | 1 |
| 17 | Induction of Siglec-G by RNA Viruses Inhibits the Innate Immune Response by Promoting RIG-I Degradation显示文摘 | Weilin Chen Chaofeng Han Bin Xie Xiang Hu Qian Yu Liyun Shi Qingqing Wang Dongling Li Jianli Wang Pan Zheng Yang Liu Xuetao Cao | 2013 | Cell2013，，3： | 1 |
| 18 | Diabetes education in mainland China—A systematic review of the literature显示文摘 | Qingqing Lou Liaofang Wu Xia Dai Meijuan Cao Yu Ruan | 2011 | Patient Education and Counseling2011，，3： | 1 |
| 19 | Diabetes education in mainland China—A systematic review of the literature显示文摘 | Qingqing Lou Liaofang Wu Xia Dai Meijuan Cao Yu Ruan | 2011 | Patient Education and Counseling2011，，3： | 1 |
| 20 | Pluripotent stem cells secrete Activin A to improve their epiblast competency after injection into recipient embryos显示文摘 | Jinzhu Xiang Suying Cao Liang Zhong Hanning Wang Yangli Pei Qingqing Wei Bingqiang Wen Haiyuan Mu Shaopeng Zhang Liang Yue Genhua Yue Bing Lim Jianyong Han | 2018 | Protein & Cell2018，9，8： | 0 |
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