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| 1 | The impact of endplate fracture on postoperative vertebral height loss and kyphotic deformity during treatment of osteoporotic vertebral compression fractures with balloon kyphoplasty显示文摘This retrospective study investigated the impact of endplate fracture on postoperative vertebral height loss and kyphotic deformity in 144 patients with osteoporotic vertebral compression fracture(OVCF),who received balloon kyphoplasty.Patients were divided into four groups:Group 1 had no superior endplate fracture,Group 2 had fractures on the anterior portion of the superior endplate,Group 3 had fractures on the posterior portion of the superior endplate,and Group 4 had complete superior endplate fractures.Anterior and middle vertebral body height,vertebral compression ratio,vertebral height loss rate,and kyphosis Cobb angle of each patient were measured and visual analogue scale(VAS) and Oswestry disability index(ODI) scores were recorded.The anterior vertebral height and kyphosis deformity of all groups significantly improved after the surgery,whereas substantial anterior vertebral height loss and increased Cobb angle were observed in all patients at the last follow-up.Although the vertebral height loss rate and the Cobb angle in Group 2,3 and 4 were larger compared with Group 1 at the last follow-up,only the vertebral height loss rate in Group 4 and the increase in the Cobb angle in Group 2 and 4 were statistically different from those in Group 1.The VAS and ODI scores in all groups measured after the surgery and at the last follow-up were significantly lower compared with preoperative scores,but there was no significant difference among these groups.Balloon kyphoplasty significantly improved vertebral fracture height and kyphosis.Vertebral height loss and increased kyphotic deformity were observed in OVCF patients with endplate fractures after the surgery.Postoperative aggravation of kyphosis was observed in Group 2.Furthermore,severe vertebral height loss and increased kyphotic deformity were confirmed in Group 4 after the surgery.Our results suggested that postoperative vertebral height loss and aggravation of kyphosis may be associated with biomechanical changes in the vertebral body caused by endplate fracture.Therefore,surgery should not only restore compressed vertebral body height and correct kyphosis,but also correct the deformity of endplate to achieve an effective treatment of OVCF patients with endplate fracture. | Qingqing Li Long Xiao Jianwei Zhang Jin Fan Wei Zhou Guoyong Yin Yongxin Ren | 2016 | The Journal of Biomedical Research2016，30，5： | 5 |
| 2 | Deciphering primate retinal aging at single-cell resolution显示文摘Dear Editor, The retina is a light-sensitive highly-organized tissue,which is vulnerable to aging and age-related retinal diseases.Specifically,progressive retinal degeneration leads to visual function deterioration and vision impairment in the elderly(Lin et al.,2016).In diseases such as age-related macular degeneration(AMD),retinitis pigmentosa(RP)and diabetic retinopathy(DR),pathological process lacking effective treatments profoundly and negatively impact on the quality of life in the elderly(Lin et al.,2016;Chen et al.,2019).Thus,an in-depth molecular assessment of the mechanisms driv-ing retinal aging is of urgent scientific and medical importance. | Si Wang Yuxuan Zheng Qingqing Li Xiaojuan He Ruotong Ren Weiqi Zhang Moshi Song Huifang Hu Feifei Liu Guoqiang Sun Shuhui Sun Zunpeng Liu Yang Yu Piu Chan Guo-Guang Zhao Qi Zhou Guang-Hui Liu Fuchou Tang Jing Qu | 2021 | Protein & Cell2021，12，11： | 4 |
| 3 | Preparation of ZrB_(2)-MoSi_(2) high oxygen resistant coating using nonequilibrium state powders by self-propagating high-temperature synthesis显示文摘To achieve high oxygen blocking structure of the ZrB_(2)-MoSi_(2) coating applied on carbon structural material,ZrB_(2)-MoSi_(2) coating was prepared by spark plasma sintering(SPS)method utilizing ZrB_(2)-MoSi_(2) composite powders synthesized by self-propagating high-temperature synthesis(SHS)technique as raw materials.The oxygen blocking mechanism of the ZrB_(2)-MoSi_(2) coatings at 1973 K was investigated.Compared with commercial powders,the coatings prepared by SHS powders exhibited superior density and inferior oxidation activity,which significantly heightened the structural oxygen blocking ability of the coatings in the active oxidation stage,thus characterizing higher oxidation protection efficiency.The rise of MoSi_(2) content facilitated the dispersion of transition metal oxide nanocrystals(5-20 nm)in the SiO_(2) glass layer and conduced to the increasing viscosity,thus strengthening the inerting impact of the compound glass layer in the inert oxidation stage.Nevertheless,the ZrB_(2)-40 vol% MoSi_(2) coating sample prepared by SHS powders presented the lowest oxygen permeability of 0.3% and carbon loss rate of 0.29×10^(6)g·cm^(-2)·s^(-1).Owing to the gradient oxygen partial pressure inside the coatings,the Si-depleted layer was developed under the compound glass layer,which brought about acute oxygen erosion. | Menglin ZHANG Xuanru REN Mingcheng ZHANG Songsong WANG Li WANG Qingqing YANG Hongao CHU Peizhong FENG | 2021 | Journal of Advanced Ceramics2021，10，5： | 2 |
| 4 | Habitat restoration is the greatest challenge for population recovery of Hainan gibbons(Nomascus hainanus)显示文摘Hainan gibbons are among the world’s most critically endangered primates,with a remaining population of only 35 individuals distributed across 5 social groups in the Bawangling Branch of the Hainan Tropical Rainforest National Park,China.Habitat conversion and forest fragmentation over the past 40 years have reduced their geographical distribution by 95%.In the absence of a quantitative assessment of the availability of remaining suitable habitat,it is unclear whether this species can survive to the end of this century.We used behavioral observations,ArcGIS,remote sensing,stereo optical imagery,and MaxEnt modeling to identify patterns of Hainan gibbon range use and compare changes in the distribution of suitable forest types and areas of forest fragmentation over the past 20 years(2000–2020).The results indicate that the combined range of the 5 extant Hainan gibbon groups totaled 14.89 km2.The home range of the smallest group(Group E,3 individuals)was 1.51 km2,which likely represents the minimum home range size for this species.The remaining area of highly suitable and moderately suitable habitat totals 26.9 km2.However,habitat connectivity across the gibbon range is very low(less than 0.5),limiting the ability of Hainan gibbons to move between forest patches.The results of this study indicate that the availability of suitable habitat in Bawangling is insufficient to allow for future Hainan gibbon population growth.Therefore,immediate action must be taken to restore,reforest,and establish ecological corridors to reconnect areas of suitable habitat for these critically endangered gibbons. | Qingqing HE Shasha YAN Paul A.GARBER Baoping REN Xvming QI Jiang ZHOU | 2023 | Integrative Zoology2023，18，4： | 2 |
| 5 | Effects of sleep deprivation on polysomnography and executive function in patients with depression显示文摘 | Lu Yingzhi Ren Qingtao Zong Li Wu Yingli Zhang Qinfeng Ma Xiuqing Pu Jinyu Dong Hanzhen Liu Qingqing Tang Yunxiang Song Lisheng Chen Xingshi Pan Xiao Cui Yi | 2014 | Chinese Medical Journal2014，，18： | 2 |
| 6 | Self-assembled FeS-based cascade bioreactor with enhanced tumor penetration and synergistic treatments to trigger robust cancer immunotherapy显示文摘Major challenges for cancer treatment are how to effectively eliminate primary tumor and sufficiently induce immunogenic cell death(ICD)to provoke a robust immune response for metastasis control.Here,a self-assembled cascade bioreactor was developed to improve cancer treatment with enhanced tumor penetration and synergistic therapy of starvation,chemodynamic(CDT)and photothermal therapy.Ultrasmall Fe S-GOx nanodots were synthesized with glucose oxidase(GOx)as template and induced by paclitaxel(PTX)to form self-assembling Fe S-GOx@PTX(FGP)via hydrophobic interaction.After accumulated at tumor sites,FGP disassembles to smaller Fe S-GOx for enhanced deep tumor penetration.GOx maintains high enzymatic activity to catalyze glucose with assistant of oxygen to generate hydrogen peroxide(H2O2)as starvation therapy.Fenton reaction involving the regenerated H_(2)O_(2) in turn produced more hydroxyl radicals for enhanced CDT.Following near-infrared laser at 808 nm,FGPs displayed pronounced tumor inhibition in vitro and in vivo by the combination therapy.The consequent increased exposure to calreticulin amplified ICD and promoted dendritic cells maturation.In combination with anti-CTLA4 checkpoint blockade,FGP can absolutely eliminate primary tumor and avidly inhibit distant tumors due to the enhanced intratumoral infiltration of cytotoxic T lymphocytes.Our work presents a promising strategy for primary tumor and metastasis inhibition. | Hao Ren Jiahui Yong Qingqing Yang Zhen Yang Zhangya Liu Yan Xu Hao Wang Xing Jiang Wenjun Miao Xueming Li | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 2 |
| 7 | Application of fuzzy clustering method to determining sub-fault planes of earthquake from aftershocks sequence显示文摘Earthquake rupture process generally involves several faults activities instead of a single fault.A new method using both fuzzy clustering and principal component analysis makes it possible to reconstruct three dimensional structure of involved faults in earthquake if the aftershocks around the active fault planes distribute uniformly.When seismic events are given,the optimal faults structures can be determined by our new method.Each of sub-fault planes is fully characterized by its central location,length,width,strike and dip.The resolution determines the number of fault segments needed to describe the earthquake catalog.The higher the resolution,the finer the structure of the reconstructed fault segments.The new method successfully reconstructs the fault segments using synthetic earthquake catalogs.By taking the 28 June 1992 Landers earthquake occured in southern California as an example,the reconstructed fault segments are consistent with the faults already known on geological maps or blind faults that appeared quite frequently in longer-term catalogs. | Fuchang Wang Yongge Wan Huirong Cao Zhitong Jin Qingqing Ren | 2012 | Earthquake Science2012，25，2： | 1 |
| 8 | Specific generation of nitric oxide in mitochondria of cancer cell for selective oncotherapy显示文摘Nitric oxide(NO)gas therapy,especially,L-arginine(L-Arg)-based NO treatment strategies have attracted extensive attention in the field of oncotherapy.However,current strategies are unable to differentiate well between normal cells and cancer cells,which may lead to unpredictable toxicity.Motivated by the fact that mitochondria of cancer cells can express excessive nitric oxide synthetase(NOS),herein,a nanozyme-based NO generator,cerium oxide(CeO_(2))-AT,is fabricated to specifically catalyze the production of NO in cancer cells for selective tumor treatment.In this system,after being endocytosed into cancer cells,the generator can produce a number of NO under the catalysis of NOS in mitochondria of cancer cells,which can disrupt the mitochondrial respiratory chain of tumor cells and further induce cell apoptosis.In addition,the generator with catalase(CAT)-like activity can catalyze H_(2)O_(2)to produce O_(2),which can promote the generation of NO and improve the performance of NO gas therapy.What is more,our system has no obvious impact on the viability of normal cells owing to the less production of NO.Our work paves a new way for the development of highly selective NO-based treatment particularly useful for the safe and specific cancer therapy. | Mengyu Sun Yanjuan Sang Qingqing Deng Zhengwei Liu Jinsong Ren Xiaogang Qu | 2022 | Nano Research2022，15，6： | 1 |
| 9 | Synthesis and application ofmodified vegetable oils in water-repellent finishing ofcotton fabrics 显示文摘 | REN Qingqing ZHAO Tao | 2010 | Carbohydrate Polymers2010，80，： | 1 |
| 10 | β-decay Study of Tz=-3/2Proton-rich Nucleus 29S显示文摘The exotic decay of nuclei far from the stability has recently become a hot topic of nuclear structure research.The nuclide 29S is not well investigated in the A=4n+1,Tz=-3/2series of strong+β-delayed proton precursors.The decay schemes of these nuclei are characterized | ZHONG Fupeng XU Xinxing LIN Chengjian WANG Jiansong LI Zhihuan YANG Lei MA Nanru WANG Dongxi WEN Peiwei SUN Lijie WU Hongyi LUO Diwen WU Chenguang JIANG Ying LIU Yang ZANG Hongliang LIANG Pengfei LI Pengjie LI Xiaojing ZHAO Qingqing SHI Guozhu MA Junbing MA Peng YU Gongming Dipikap Patel BAI Zhen YANG Feng JIA Huiming ZHANG Huanqiao WANG Jianguo YANG Yanyun MA Weihu HU Qiang JIN Shuya ZHOU Xiaohong LI Ren HOU Dongsheng LIU Minliang HU Zhengguo MA Xinwen YANG Weiqing GAO Zhihao DUAN Fangfang YU Yuechao WANG Yufeng WANG Peng ZHOU Qingwu CUI Danteng WANG Xiang HU Liyuan PAN Min ZHANG Gaolong WANG Xiaoyu | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 11 | Interface electronic engineering of molybdenum sulfide/MXene hybrids for highly efficient biomimetic sensors显示文摘Interface regulation plays a key role in the electrochemical performance for biosensors.By controlling the interfacial interaction,the electronic structure of active species can be adjusted effectively at micro and nano-level,which results in the optimal reaction energy barrier.Herein,we propose an interface electronic engineering scheme to design a strongly coupled 1T phase molybdenum sulfide(1T-MoS2)/MXene hybrids for constructing an efficient electrocatalytic biomimetic sensor.The local electronic and atomic structures of the 1T-MoS2/Ti3C2TX are comprehensively studied by synchrotron radiation-based X-ray photoelectron spectroscopy(XPS),as well as X-ray absorption spectroscopy(XAS)at atomic level.Experiments and theoretical calculations show that there are interfacial stresses,atomic defects and adjustable bond-length between MoS2/MXene nanosheets,which can significantly promote biomolecular adsorption and rapid electron transfer to achieve excellent electrochemical activity and reaction kinetics.The 1T-MoS2/Ti3C2TX modified electrode shows ultra high sensitivity of 1.198μA/μM for dopamine detection with low limit of 0.05μM.We anticipate that the interface electronic engineering investigation could provide a basic idea for guiding the exploration of advanced biosensors with high sensitivity and low detection limit. | Pengfei Wu Tingting You Qingyuan Ren Hongyan Xi Qingqing Liu Fengjuan Qin Hongfei Gu Yu Wang Wensheng Yan Yukun Gao Wenxing Chen Penggang Yin | 2023 | Nano Research2023，16，1： | 0 |
| 12 | Origin and chromatin remodeling of young X/Y sex chromosomes in catfish with sexual plasticity显示文摘Assembly of a complete Y chromosome is a significant challenge in animals with an XX/XY sex-determination system.Re cently,we created YY-supermale yellow catfish by crossing XY males with sex-reversed XY females,providing a valuable model for Y-chromosome assembly and evolution.Here,we assembled highly homomorphic Y and X chromosomes by sequencing genomes of the YY supermale and XX female in yellow catfish,reve aling their nucleotide divergences with only less than 1%and with the same gene compositions.The sex-determining region(SDR)was identified to locate within a physical distance of0.3 Mb by FSTscanning.Strikingly,the incipient sex chromosomes were revealed to originate via autosome-autosome fusion and were characterized by a highly rearranged region with an SDR downstream of the fusion site.We found that the Y chromosome was at a very early stage of differentiation,as no clear evidence of evolutionary strata and classical structure features of recombination suppression for a rather late stage of Y-chromosome evolution were observed.Significantly,a number of sex-antagonistic mutations and the accumulation of repetitive elements were discovered in the SDR,which might be the main driver of the initial establishment of recombination suppression between young X and Y chromosomes.Moreover,distinct three-dimensional chromatin organizations of the Y and X chromosomes were identified in the YY supermales and XX females,as the X chromosome exhibited denser chromatin structure than the Y chromosome,while they respectively have significantly spatial interactions with female-and male-related genes compared with other autosomes.The chromatin configuration of the sex chromosomes as well as the nucleus spatial organization of the XX neomale were remodeled after sex reversal and similar to those in YY supermales,and a male-specific loop containing the SDR was found in the open chromatin region.Our results elucidate the origin of young sex chromosomes and the chromatin remodeling configuration in the catfish sexual plasticity. | Gaorui Gong Yang Xiong Shijun Xiao Xi-Yin Li Peipei Huang Qian Liao Qingqing Han Qiaohong Lin Cheng Dan Li Zhou Fan Ren Qi Zhou Jian-Fang Gui Jie Mei | 2023 | National Science Review2023，10，2： | 0 |
| 13 | Free-space beam shaping and steering based on a silicon optical phased array显示文摘In this study,we present a method for free-space beam shaping and steering based on a silicon optical phased array,which addresses the theoretical limitation of traditional bulk optics.We theoretically analyze the beam propagation properties with changes in the applied phase.Different beam profiles can be shaped by varying the phase combination,while a high-order quasi-Bessel beam can be generated with a cubic change to the phase modulation.The simulated results are validated further experimentally,and they match one another well.Beam steering can be achieved with a field of view as large as 140°,which has potential benefits for practical applications.The presented method is expected to have broad application prospects for optical communications,free-space optical interconnects,and light detection and ranging. | WENBO REN QINGQING LIANG JIJUN FENG HAIPENG LIU JIANHUA HU SHUO YUAN XINCHENG XIA WEI JIANG QIWEN ZHAN HEPING ZENG | 2023 | Photonics Research2023，11，12： | 0 |
| 14 | Modified R-CODOX-M/IVAC chemotherapy regimens in Chinese patients with untreated sporadic Burkitt lymphoma显示文摘Objective:To characterize modified R-CODOX-M/IVAC-based chemotherapy to lower the severe adverse events in Chinese adult patients with sporadic Burkitt lymphoma.Methods:We enrolled a retrospective cohort including 123 adult patients with untreated sporadic Burkitt lymphoma from August 2008 to September 2019 at Sun Yat-sen University Cancer Center.We studied a dose-modified and long-course R-CODOX-M/IVAC regimen utilizing a low dose of 1.0 g/m2/cycle cyclophosphamide,2 g/m2/cycle methotrexate,4,500 mg/m2/cycle ifosfamide,and 4.0 g/m2/cycle cytarabine.Forty-nine patients with low risk disease underwent 4–6 cycles of dose-modified R-CODOX-M-based chemotherapy.Seventy-four patients with high risk disease underwent 6–8 cycles of dose-modified alternating R-CODOX-M/IVAC regimens.Results:The objective remission was 87.0%.The event-free survival rate and overall survival at 3 years were 81.2%and 92.1%,respectively.Major grade 3–4 adverse events included leukopenia(91.9%),anemia(58.5%),thrombocytopenia(73.2%),and febrile neutropenia(48.8%).A total of 26.0%and 37.4%of patients received red blood cell and platelet transfusions,respectively.We observed 4 cases(3.3%)of septic shock after chemotherapy.Two treatment-related deaths occurred from severe infection.Conclusions:The modified R-CODOX-M/IVAC chemotherapy regimen was effective for sporadic Burkitt lymphoma in the Chinese population,with a lower toxicity than standard regimens. | Meiting Chen Zhao Wang Xiaojie Fang Yuyi Yao Quanguang Ren Zegeng Chen Ying Tian Fei Pan Xiaoqian Li Zhiming Li Qingqing Cai He Huang Tongyu Lin | 2021 | Cancer Biology & Medicine2021，18，3： | 0 |
| 15 | On the Three Themes of The Rocking-Horse Winner显示文摘Lawrence is a literary giant in the history of English literature in the 20th century.He has created a large number of works in his life.The Rocking-Horse Winner is a famous short story in his later years,which reveals the distortion of humanity caused by the expansion of capitalist desire for money.By analysing the three themes,help readers understand this short story deeply. | REN Qingqing | 2022 | US-China Foreign Language2022，20，2： | 0 |
| 16 | Establishing a Social Governance Model Based on Collaboration,Participation,and Common Interests:Value,Structure and Roadmap显示文摘The 19th National Congress of the Communist Party of China(CPC)put forward the proposal of establishing a social governance model based on collaboration,participation,and common interests,with the aim of developing new approaches to social governance and further modernizing China’s social system and capacity for governance.As a structuralized social relation addressing diversified governance bodies,the model has consolidated the social governance innovations achieved since the 18th CPC National Congress.Focusing on three dimensions—'value,''structure'and'roadmap,'this paper tries to interpret the value connotations and defining features behind the model and explores its development roadmap.Such a social governance model is a response to political,social and public value appeals,and an adjustment to the order of governance bodies,resource allocations and the benefit distribution structure.Its construction is a systematic and long-term project,which should aim continuously at satisfying people’s ever-higher needs,perfecting laws and regulations,cultivating a pool of specialized organizations and talents,exerting the technology advantages of the Internet in governance,and promoting socialization,legalization,specialization and intellectualization in social development. | Yan Kegao Ren Binbin Ai Qingqing(译) | 2019 | Contemporary Social Sciences2019，4，1： | 0 |
| 17 | Molecular imaging:design mechanism and bioapplications显示文摘Molecular imaging is a non-invasive method to image and analyze the concentration and activity of functional biomolecules in cells or in vivo at molecular level,and plays an increasing role in deep understanding of biological processes,early and accurate diagnosis of diseases,and evaluation of treatment.Nowadays,numerous novel molecular imaging probes have been developed,involving every biomedical imaging modality,such as optical imaging,photoacoustic imaging,magnetic resonance imaging,single-photon-emission computed tomography,and positron emission tomography.In this review,we summarize the development of current state-of-the-art molecular imaging probes.We introduce the design strategies of molecular probes and detailed imaging modalities,and highlight the properties of probes and biomedical imaging applications in cells and in vivo,including disease diagnosis,drug tracking,and imaging-guided surgery.Then we discuss the perspectives and challenges in this emerging field.We expect this review could inspire more effective molecular imaging probes to be developed,achieving the goal towards clinical practices. | Lanlan Chen Yifan Lyu Xuan Zhang Liting Zheng Qingqing Li Ding Ding Fengming Chen Yihao Liu Wei Li Yutong Zhang Qiuling Huang Zhiqiang Wang Tiantian Xie Qiang Zhang Yingyu Sima Ke Li Shuai Xu Tianbing Ren Mengyi Xiong Ying Wu Jibin Song Lin Yuan Huanghao Yang Xiao-Bing Zhang Weihong Tan | 2023 | Science China Chemistry2023，66，5： | 0 |
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