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| 1 | Analysis of DC Grid Prospects in China显示文摘随着化石能源的日益枯竭,中国已将发展可再生能源提升至重要地位,并逐步实现能源结构的战略性调整。分析可再生能源发电的间歇性与不稳定性特点,以及可再生能源发电集中并网带来的稳定性问题,提出通过建设广域覆盖的直流电网以有效解决可再生能源集中并网的有功波动问题。建设全国性的直流骨干输电网,不仅可更有效地利用可再生能源,也将积极推动坚强智能电网的建设。与交流系统相比,直流电网在未来城市配电、微网等领域也有较大的优势。根据中国国情,对直流电网在中国建设的可行性进行了具体分析,并提出中国直流电网主干结构设想图,指出了直流电网建设的一些关键技术问题,为中国直流电网建设提供参考。 | WEN Jialiang WU Rui Peng Chang Wang Yu | 2012 | 中国电机工程学报2012，32，13： | 172 |
| 2 | Effect of endotoxin on fibronectin synthesis of rat primary cultured hepatocytes显示文摘EfectofendotoxinonfibronectinsynthesisofratprimaryculturedhepatocytesJIAJinBin,HANDeWu,XURuiLing,GAOFei,ZHAOLongFeng,ZHA... | JIA JinBin, HAN DeWu, XU RuiLing, GAO Fei, ZHAO LongFeng, ZHAO YuanChang, YAN JinPin and MA XueHuiKeywords liver cirrhosis endotoxins fibronectin/analysis liver/cytology cells, cultured lipopolysaccharide | 1998 | World Journal of Gastroenterology1998，4，4： | 14 |
| 3 | Prolonged manganese exposure induces severe deficits in lifespan,development and reproduction possibly by altering oxidative stress response in Caenorhabditis elegans显示文摘We examined the possible multiple defects induced by acute and prolonged exposure to high levels of manganese(Mn) solution by monitoring the endpoints of lifespan,development,reproduction,and stress response.Our data suggest that acute exposure(6 h) to Mn did not cause severe defects of life span,development,and reproduction,similarly,no significant defect could be found in animals exposed to a low concentration of Mn(2.5 μmol/L) for 48 h.In contrast,prolonged exposure(48 h) to high Mn concentrations(75 and 200 μmol/L) resulted in significant defects of life span,development,and reproduction,as well as the increase of the percentage of population with hsp-16.2::gfp expression indicating the obvious induction of stress responses in exposed animals.Moreover,prolonged exposure(48 h) to high concentrations(75 and 200 μmol/L) of Mn decreased the expression levels of antioxidant genes of sod-1,sod-2,sod-3,and sod-4 compared to control.Therefore,prolonged exposure to high concentrations of Mn will induce the severe defects of life span,development,and reproduction in nematodes possibly by affecting the stress response and expression of antioxidant genes in Caenorhabditis elegans. | XIAO Jing | 2009 | Journal of Environmental Sciences2009，21，6： | 13 |
| 4 | Distinct characteristics and new prognostic scoring system for Chinese patients with Waldenstr(o)m macroglobulinemia显示文摘 | Yi Shuhua Cui Rui Li Zengjun An Gang Qi Junyuan Zou Dehui Zhang Peihong Chen Huishu Wang Jianxiang Chang Hong Qiu Lugui | 2014 | Chinese Medical Journal2014，，12： | 12 |
| 5 | Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer显示文摘Metastasis,the development of secondary malignant growths at a distance from a primary tumor,is the cause of death for 90%of cancer patients,but little is known about how metastatic cancer cells adapt to and colonize new tissue environments.Here,using clinical samples,patient-derived xenograft(PDX)samples,PDX cells,and primary/metastatic cell lines,we discovered that liver metastatic colorectal cancer(CRC)cells lose their colon-specific gene transcription program yet gain a liver-specific gene transcription program.We showed that this transcription reprogramming is driven by a reshaped epigenetic landscape of both typical enhancers and super-enhancers.Further,we identified that the liver-specific transcription factors FOXA2 and HNF1A can bind to the gained enhancers and activate the liver-specific gene transcription,thereby driving CRC liver metastasis.Importantly,similar transcription reprogramming can be observed in multiple cancer types.Our data suggest that reprogrammed tissue-specific transcription promotes metastasis and should be targeted therapeutically. | Shuaishuai Teng Yang Eric Li Ming Yang Rui Qi Yiming Huang Qianyu Wang Yanmei Zhang Shanwen Chen Shasha Li Kequan Lin Yang Cao Qunsheng Ji Qingyang Gu Yujing Cheng Zai Chang Wei Guo Pengyuan Wang Ivan Garcia-Bassets Zhi John Lu Dong Wang | 2020 | Cell Research2020，30，1： | 11 |
| 6 | Gene and mutation independent therapy via CRISPR-Cas9 mediated cellular reprogramming in rod photoreceptors显示文摘 | Zhu, Jie Ming, Chang Fu, Xin Duan, Yaou Duc Anh Hoang Rutgard, Jeffrey Zhang, Runze Wang, Wenqiu Hou, Rui Zhang, Daniel Zhang, Edward Zhang, Charlotte Hao, Xiaoke Xiong, Wenjun Zhang, Kang | 2017 | Cell Research2017，27，6： | 11 |
| 7 | Sequencing of p53 mutation in established human hepatocellular carcinoma cell line of HHC4 and HHC15 in nude mice显示文摘INTRODUCTIONAlthoughtheetiopathologyofhumanhepatocelularcarcinoma(hHCC)isstilunknown,alotofevidencestronglysuggestedthatinfec... | YANG Shan Min, ZHOU Hong, CHEN Rui Chuan, WANG Yu Fang, CHEN Fu, ZHANG Chang Gong, ZHEN Yun, YAN Jiang Hua and SU Jin Hua | 1998 | World Journal of Gastroenterology1998，4，6： | 11 |
| 8 | Onset of the Meissner effect at 65 K in Fe Se thin film grown on Nb-doped Sr TiO_3 substrate显示文摘We report the Meissner effect studies on an Fe Se thin film grown on Nb-doped Sr Ti O3 substrate by molecular beam epitaxy. Two-coil mutual inductance measurement clearly demonstrates the onset of diamagnetic screening at 65 K, which is consistent with the gap opening temperature determined by previous angle-resolved photoemission spectroscopy results. The applied magnetic field causes a broadening of the superconducting transition near the onset temperature, which is the typical behavior for quasi-two-dimensional superconductors. Our results provide direct evidence that Fe Se thin film grown on Nb-doped Sr Ti O3 substrate has an onset TC* 65 K,which is the highest among all iron-based superconductors discovered so far. | Zuocheng Zhang Yi-Hua Wang Qi Song Chang Liu Rui Peng K.A.Moler Donglai Feng Yayu Wang | 2015 | Science Bulletin2015，60，14： | 10 |
| 9 | Olivine-norite rock detected by the lunar rover Yutu-2 likely crystallized from the SPA-impact melt pool显示文摘Chang’E-4 landed in the South Pole-Aitken(SPA)basin,providing a unique chance to probe the composition of the lunar interior.Its landing site is located on ejecta strips in Von Karm´an crater that´possibly originate from the neighboring Finsen crater.A surface rock and the lunar regolith at 10 sites along the rover Yutu-2 track were measured by the onboard Visible and Near-Infrared Imaging Spectrometer in the first three lunar days of mission operations.In situ spectra of the regolith have peak band positions at 1 and 2μm,similar to the spectral data of Finsen ejecta from the Moon Mineralogy Mapper,which confirms that the regolith’s composition of the landing area is mostly similar to that of Finsen ejecta.The rock spectrum shows similar band peak positions,but stronger absorptions,suggesting relatively fresh exposure.The rock may consist of 38.1±5.4%low-Ca pyroxene,13.9±5.1%olivine and 48.0±3.1%plagioclase,referred to as olivine-norite.The plagioclase-abundant and olivine-poor modal composition of the rock is inconsistent with the origin of the mantle,but representative of the lunar lower crust.Alternatively,the rock crystallized from the impact-derived melt pool formed by the SPA-impact event via mixing the lunar crust and mantle materials.This scenario is consistent with fast-cooling thermal conditions of a shallow melt pool,indicated by the fine to medium-sized texture(<3 mm)of the rock and the SPA-impact melting model[Icarus 2012;220:730–43]. | Honglei Lin Zhiping He Wei Yang Yangting Lin Rui Xu Chi Zhang Meng-Hua Zhu Rui Chang Jinhai Zhang Chunlai Li Hongyu Lin Yang Liu Sheng Gou Yong Wei Sen Hu Changbin Xue Jianfeng Yang Jie Zhong Xiaohui Fu Weixing Wan Yongliao Zou | 2020 | National Science Review2020，7，5： | 9 |
| 10 | AduoLa Fuzhenglin Down-regulates Microwave-induced Expression of β_1-adrenergic Receptor and Muscarinic Type 2 Acetylcholine Receptor in Myocardial Cells of Rats显示文摘This paper is aimed to study the effect of ADL on expression ofβ1-AR and M2-AchR in myocardial cells of rats exposed to microwave radiation.Immunohistochemistry,Western blot and image analysis were used to detect the expression ofβ1-AR and M2-AchR in myocardial cells at 7 and 14 | ZHANG Jing PENG Rui Yun GAO Ya Bing WANG Shui Ming YANG Lei Lei ZHAO Li DONG Ji YAO Bin Wei CHANG Gong Min XIONG Lu | 2014 | Biomedical and Environmental Sciences2014，27，3： | 9 |
| 11 | Distribution characteristics of poly-and perfluoroalkyl substances in the Yangtze River Delta显示文摘In this work, a method was developed and optimized for the analysis of polyfluoroalkyl and/or perfluoroalkyl substances(PFASs) content in surface water and sediment samples with high instrumental response and good separation. Surface water and sediment samples were collected from the Yangtze River Delta(YRD) to analyze the distribution characteristics of perfluoroalkyl carboxylic acids(PFCAs), perfluoroalkane sulfonic acids(PFSAs), perfluoroalkyl phosphonic acids(PFPAs), perfluoroalkyl phosphinic acids(PFPiAs), and polyfluoroalkyl phosphoric acid diesters(di PAPs). The results showed that the total concentrations of PFCAs and PFSAs in YRD varied from 31 to 902 ng/L. PFCAs(≥ 11 carbons) and PFSAs(≥ 10 carbons atoms) were not detected in any surface water samples. The mean concentrations of all PFCAs and PFSAs in surface water from the sampling areas decreased in the following order:Yangtze river(191 ng/L) ≈ Taihu lake(189 ng/L) > Huangpu river(122 ng/L) ≈ Qiantang river(120 ng/L) > Jiaxing urban river(100 ng/L). Strong significant(p < 0.05) correlations between the concentrations of many of the compounds were found in the sampling areas, suggesting a common source for these compounds. Only perfluorooctanoic acid(PFOA) was observed in all sediment samples, at concentrations varying from 0.02 to 1.35 ng/g. Finally, detection rates of two di PAPs were only 8% and 10%, respectively and the concentration of di PAPs was two to three times lower compared to PFCAs and PFSAs. | Binghui Zheng Xiaolei Liu Rui Guo Qing Fu Xingru Zhao Shanjun Wang Sheng Chang Xing Wang Mengjiao Geng Guang Yang | 2017 | Journal of Environmental Sciences2017，29，11： | 8 |
| 12 | Optimal 3D deformation measuring in inclined geosynchronous orbit SAR differential interferometry显示文摘Three dimensional(3D) deformation can be obtained by using differential interferometric synthetic aperture radar(D-In SAR) technique with the cross-heading tracks data of low earth orbit(LEO) SAR. However,this method has drawbacks of the low temporal sampling rate and the limited area and accuracy for 3D deformation retrieval. To address the aforementioned problems, by virtue of a geosynchronous(GEO) SAR platform,this paper firstly demonstrates the expressions of 3D deformation and the corresponding errors in GEO SAR multi-angle processing. An optimal multi-angle data selection method based on minimizing position dilution of precision(PDOP) is proposed to obtain a good 3D deformation retrieval accuracy. Moreover, neural network is utilized for analyzing the accuracy of the retrieved 3D deformation under different orbit configurations and geo-locations. Finally, the proposed methods and the theoretical analysis are verified by simulation experiments.A 3D deformation retrieval accuracy of the order of centimeter-level or even millimeter-level can be obtained by using the selected optimal multi-angle data. | Cheng HU Yuanhao LI Xichao DONG Rui WANG Chang CUI | 2017 | Science China(Information Sciences)2017，60，6： | 8 |
| 13 | Expression of Recombinant Human Lysozyme-tachyplesin I(hLYZ-TP I)in Pichia Pastoris and Analysis of Antibacterial Activity显示文摘Antimicrobial peptides(AMPs)are making headlines in science because they demonstrate superior microbicidal characteristics compared to synthetic and semi-synthetic antibiotics [1].Importantly,AMPs kill pathogens via a different mechanism compared to antibiotics [2].Therefore, | GAO Yu ZHAO Hong Lei FENG Xin ZHAI Rui Dong ZHU Seng DU Chong Tao SUN Chang Jiang LEI Lian Cheng | 2013 | Biomedical and Environmental Sciences2013，26，4： | 7 |
| 14 | Applications of two-way satellite time and frequency transfer in the BeiDou navigation satellite system显示文摘A two-way satellite time and frequency transfer(TWSTFT) device equipped in the BeiDou navigation satellite system(BDS)can calculate clock error between satellite and ground master clock. TWSTFT is a real-time method with high accuracy because most system errors such as orbital error, station position error, and tropospheric and ionospheric delay error can be eliminated by calculating the two-way pseudorange difference. Another method, the multi-satellite precision orbit determination(MPOD)method, can be applied to estimate satellite clock errors. By comparison with MPOD clock estimations, this paper discusses the applications of the BDS TWSTFT clock observations in satellite clock measurement, satellite clock prediction, navigation system time monitor, and satellite clock performance assessment in orbit. The results show that with TWSTFT clock observations, the accuracy of satellite clock prediction is higher than MPOD. Five continuous weeks of comparisons with three international GNSS Service(IGS) analysis centers(ACs) show that the reference time difference between BeiDou time(BDT) and golbal positoning system(GPS) time(GPST) realized IGS ACs is in the tens of nanoseconds. Applying the TWSTFT clock error observations may obtain more accurate satellite clock performance evaluation in the 104 s interval because the accuracy of the MPOD clock estimation is not sufficiently high. By comparing the BDS and GPS satellite clock performance, we found that the BDS clock stability at the 103 s interval is approximately 10.12, which is similar to the GPS IIR. | ShanShi Zhou XiaoGong Hu Li Liu Rui Guo LingFeng Zhu ZhiQiao Chang ChengPan Tang XiuQiang Gong Ran Li Yang Yu | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，10： | 6 |
| 15 | Endocan-expressing microvessel density as a prognostic factor for survival in human gastric cancer显示文摘AIM: To investigate the expression of endocan in tumour vessels and the relationships between endocan and the expression of vascular endothelial growth factor(VEGF) and prognosis in gastric cancer.METHODS: This study included 142 patients with confirmed gastric cancer in a single cancer centre between 2008 and 2009. Clinicopathologic features were determined, and an immunohistochemical analysis of endocan-expressing microvessel density(MVD)(endocan-MVD), VEGF and vascular endothelial growth factor receptor 2(VEGFR2) was performed. Potential relationships between endocan-MVD and clinicopathological variables were assessed using a Student's t-test or an analysis of variance test. Spearman's rank correlation was applied to evaluate the relationship between endocan-MVD and the expression of VEGF/VEGFR2. long-term survival of these patients was analysed using univariate and multivariate analyses.RESULTS: Positive staining of endocan was observed in most of the gastric cancer tissues(108/142) and in fewer of the normal gastric tissues. Endocan-MVD was not associated with gender or histological type(P > 0.05), while endocan-MVD was associated with tumour size,Borrmann type, tumour differentiation, tumour invasion, lymph node metastasis and TNM stage(P < 0.05). According to the Spearman's rank correlation analysis, endocan-MVD had a positive correlation with VEGF(r = 0.167, P = 0.047) and VEGFR2(r = 0.410, P = 0.000). The univariate analysis with a log-rank test indicated that the patients with a high level of endocan-MVD had a significantly poorer overall survival rate than those with a low level of endocan-MVD(17.9% vs 64.0%, P = 0.000). The multivariate analysis showed that a high level of endocan-MVD was a valuable prognostic factor.CONCLUSION: Endocan-MVD significantly correlates with the expression of VEGF and VEGFR2 and is a valuable prognostic factor for survival in human gastric cancer. | Yuan Chang Wei Niu Pei-long lian xian-qiang Wang Zhi-xin Meng Yi liu Rui Zhao | 2016 | World Journal of Gastroenterology2016，22，23： | 6 |
| 16 | A Facile Synthesis of β-Cyclodextrin Monoaldehyde显示文摘β -Cyclodextrin (β -CD) was directly oxidized in high yield to the corresponding monoaldehyde by cyclized 2-iodoxybenzoic acid (IBX) in DMSO. | Jing HU Cheng Feng YE Yong De ZHAO Jun Biao CHANG Rui Yun GUO(Lanzhou Institute of Chemical Physics, Chinese Academy of Scences Lanzhou 730000)(Henan Institute of Chemistry, Zhengzhou 450002) | 1999 | Chinese Chemical Letters1999，10，4： | 6 |
| 17 | Treatment of malignant digestive tract obstruction by combined intraluminal stent installation and intra-arterial drug infusion显示文摘AIM To study the palliative treatment of malignant obstrution of digestive tract with placement of intraluminal stent combined with intra-arterial infusion of chemotherapeutic drugs.METHODS A total of 281 cases of digestive tract malignant obstruction were given per oral (esophagus,stomach, duodenum and jejunum), per anal (colon and rectum ) and percutaneous transhepatic ( biliary )installation of metallic stent. Among them, 205 cases received drug infusion by cannulation of tumor supplying artery with Seldingers technique.RESULTS Altogether 350 stents were installed in 281 cases, obstructive symptoms were relieved or ameliorated after installation. Occurrence of restenotic obstruction was 8 - 43 weeks among those with intraarterial drug infusion, which was later than 4 - 26 weeks in the group with only stent installation. The average survival time of the former group was 43 (3 - 105) weeks,which was significantly longer than 15 (3- 24) weeks of the latter group.CONCLUSION Intraluminal placement of stent combined with intra-arterial infusion chemotherapy is one of the effective palliative therapies for malignant obstruction of the digestive tract with symptomatic as well as etiological treatment. | Ai-Wu Mao Zhong-Du Gao Jia-Yu Xu Ren-Jie Yang Xiang-Seng Xiao Ting-Hui Jiang Wei-Jun Jiang Department of Interventional Radiology,Shanghai S.T,Luke’s Hospital,768 Yu Yuan Road,Shanghai 200050,ChinaDepartment of Gastroenterology Rui Jin Hospital,Shanghai Second Medical University,Departrnent of Tumor Hospital,Beijing Medical UniversityDepartment of Imaging Chang Zheng Hospital,Shanghai Second Military Medical University | 2001 | World Journal of Gastroenterology2001，7，4： | 6 |
| 18 | Cetylpyridinium chloride mouth rinses alleviate experimental gingivitis by inhibiting dental plaque maturation显示文摘Oral rinses containing chemotherapeutic agents, such as cetylpyridinium chloride(CPC), can alleviate plaque-induced gingival infections, but how oral microbiota respond to these treatments in human population remains poorly understood. Via a doubleblinded, randomised controlled trial of 91 subjects, the impact of CPC-containing oral rinses on supragingival plaque was investigated in experimental gingivitis, where the subjects, after a 21-day period of dental prophylaxis to achieve healthy gingivae, received either CPC rinses or water for 21 days. Within-subject temporal dynamics of plaque microbiota and symptoms of gingivitis were pro?led via 16 S ribosomal DNA gene pyrosequencing and assessment with the Mazza gingival index.Cetylpyridinium chloride conferred gingival bene?ts, as progression of gingival in?ammation resulting from a lack of dental hygiene was signi?cantly slower in the mouth rinse group than in the water group due to inhibition of 17 gingivitis-enriched bacterial genera. Tracking of plaque α and β diversity revealed that CPC treatment prevents acquisition of new taxa that would otherwise accumulate but maintains the original biodiversity of healthy plaques. Furthermore, CPC rinses reduced the size, local connectivity and microbiota-wide connectivity of the bacterial correlation network, particularly for nodes representing gingivitisenriched taxa. The ?ndings of this study provide mechanistic insights into the impact of oral rinses on the progression and maturation of dental plaque in the natural human population. | Fei Teng Tao He Shi Huang Cun-Pei Bo Zhen Li Jin-Lan Chang Ji-Quan Liu Duane Charbonneau Jian Xu Rui Li Jun-Qi Ling | 2016 | International Journal of Oral Science2016，8，3： | 6 |
| 19 | Straw strip mulching in a semiarid rainfed agroecosystem achieves winter wheat yields similar to those of full plastic mulching by optimizing the soil hydrothermal regime显示文摘Straw strip mulching(SM)is a new mulching technology.From 2012 to 2018,SM’s effects on soil moisture and temperature and production performances were compared with other mulching practices,using three treatments:full-cover plastic mulch(PM),no mulch with wheat sown in rows as the control(CK),and SM with 50%to 59%of the field area mulched.Compared with CK,on average over six growing seasons,SM and PM increased grain yield by 27.0%and 21.7%,straw yield by 21.6%and 22.6%,kernels ha;by 26.6%and 19.0%,net income by 29.8%and-25.0%,soil temperature at 5 cm by-1.5°C and 0.2°C from overwintering to maturity,and soil water storage at 0–200 cm by 25 and 22 mm,respectively.The increase in soil moisture in SM and PM was greater in the early period(overwintering to jointing)than in the later period(booting to maturity)and at 0 to 120 cm than at 120–200 cm in the early period.Although the mean evapotranspiration of whole growth period across six seasons was similar among treatments,SM and PM increased water consumption during the key formation period of yield components after overwintering by 16 and 32 mm,respectively,while reducing it before overwintering.Compared with CK,SM and PM had the effects of warming during overwintering and cooling after jointing.By increasing water consumption after overwintering and ratio of transpiration to evapotranspiration and providing favorable soil temperature for multiple growth stages and more sufficient soil moisture,SM and PM promoted vegetative growth and increased kernels ha^(-1),the main mechanisms by which SM and PM increased grain yield relative to CK.Relative to PM,SM is a more economically beneficial and environment-friendly technology for dryland wheat production. | Yuwei Chai Qiang Chai Rui Li Yawei Li Changgang Yang Hongbo Cheng Lei Chang Shouxi Chai | 2022 | The Crop Journal2022，10，3： | 6 |
| 20 | Bi-level Nasal Positive Airway Pressure(BiPAP)versus Nasal Continuous Positive Airway Pressure(CPAP)for Preterm Infants with Birth Weight Less Than 1500g and Respiratory Distress Syndrome Following INSURE Treatment:A Two-center Randomized Controlled Trial显示文摘The present study aimed to examine the effectiveness of bi-level positive airway pressure(BiPAP)versus continuous positive airway pressure(CPAP)in preterm infants with birth weight less than 1500 g and respiratory distress syndrome(RDS)following intubation-surfactant-extubation(INSURE)treatment.A two-center randomized control trial was performed.The primary outcome was the reintubation rate of infants within 72 h of age after INSURE.Secondary outcomes included bronchopulmonary dysplasia(BPD),necrotizing enterocolitis(NEC),retinopathy of prematurity(ROP)and incidences of adverse events.Lung function at one year of corrected age was also compared between the two groups.There were 140 cases in the CPAP group and 144 in the BiPAP group.After INSURE,the reintubation rates of infants within 72 h of age were 15%and 11.1%in the CPAP group and the BiPAP group,respectively(P>0.05).Neonates in the BiPAP group was on positive airway pressure(PAP)therapy three days less than in the CPAP group(12.6 d and 15.3 d,respectively,P<0.05),and on oxygen six days less than in the CPAP group(20.6 d and 26.9 d,respectively,P<0.05).Other outcomes such as BPD,NEC,ROP and feeding intolerance were not significantly different between the two groups(P>0.05).There was no difference in lung function at one year of age between the two groups(P>0.05).In conclusion,after INSURE,the reintubation rate of infants within 72 h of age was comparable between the BiPAP group and the CPAP group.BiPAP was superior to CPAP in terms of shorter durations(days)on PAP support and oxygen supplementation.There were no differences in the incidences of BPD and ROP,and lung function at one year of age between the two ventilation methods. | Rui PAN Gao-yan CHEN Jing WANG Zhao-xian ZHOU Ping-ying ZHANG Li-wen CHANG Zhi-hui RONG | 2021 | Current Medical Science2021，41，3： | 6 |
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