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| 1 | Altered intestinal microbiota associated with colorectal cancer显示文摘The gut microbiota plays an important role in the development and progression of colorectal cancer (CRC). To learn more about the dysbiosis of carcinogenesis, we assessed alterations in gut microbiota in patients with CRC. A total of 23 subjects were enrolled in this study: 9 had CRC (CRC group) and 14 had normal colons (normal group). The microbiome of the mucosal-luminal interface of each subject was sampled and analyzed using 16S rRNA gene amplicon sequencing. We also used Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt) to predict microbial functional profiles. The microbial composition of the mucosal lumen differed between the groups, and the presence of specific bacteria may serve as a potential biomarker for colorectal carcinogenesis. We identified a significant reduction in Eubacterium, which is a butyrate-producing genera of bacteria, and a significant increase in Devosia in the gut microbiota of CRC patients. Different levels of gut microflora in healthy and CRC samples were identified. The observed abundance of bacterial species belonging to Eubacterium and Devosia may serve as a promising biomarker for the early detection of CRC. | Hong Zhang Ying Chang Qingqing Zheng Rong Zhang Cheng Hu Weiping Jia | 2019 | Frontiers of Medicine2019，13，4： | 6 |
| 2 | OsbZIP60-mediated unfolded protein response regulates grain chalkiness in rice显示文摘Grain chalkiness,an undesirable trait caused by complex factors,has great negative impacts on the quality and economic value of rice.However,little is known about the regulatory mechanism of grain chalkiness,particularly the effect of endoplasmic reticulum(ER)stress.Here,a genome-wide association study(GWAS)reveals that the transcription factor Osb ZIP60 is a vital regulator of rice grain chalkiness.Genetic analysis demonstrates that knockout of Osb ZIP60 results in extremely high grain chalkiness and aberrant structure of storage substances.Notably,the expression of unfolded protein response(UPR)genes,such as OsbZIP50,Os Bi P1,Os Bi P2 and Os Bi P3,is up-regulated in the endosperm cells of osbzip60,and overexpression of all these UPR genes causes various degrees of chalkiness.Furthermore,Osb ZIP60 is found to activate the expression of key genes related to grain chalkiness,such as GPA3,FSE1,FLO7,Chalk5,Os NF-YB1,and Os PK2,whose expression is significantly suppressed in osbzip60 and overexpression lines of Osb ZIP50,Os Bi P1,Os Bi P2,and Os Bi P3.Our study provides novel insights into the function of Osb ZIP60 and the role of the UPR pathway in the formation of grain chalkiness in rice. | Weiping Yang Pengkun Xu Juncheng Zhang Shuo Zhang Zhenwei Li Ke Yang Xinyuan Chang Yibo Li | 2022 | Journal of Genetics and Genomics2022，49，5： | 4 |
| 3 | Progress of Jinping Underground laboratory for Nuclear Astrophysics(JUNA)显示文摘Jinping Underground laboratory for Nuclear Astrophysics(JUNA) will take the advantage of the ultra-low background of CJPL lab and high current accelerator based on an ECR source and a highly sensitive detector to directly study for the first time a number of crucial reactions occurring at their relevant stellar energies during the evolution of hydrostatic stars. In its first phase, JUNA aims at the direct measurements of^(25)Mg(p,γ)^(26)Al,^(19)F(p,α)^(16)O,^(13)C(α,n)^(16)O and ^(12)C(α,γ)^(16)O reactions. The experimental setup,which includes an accelerator system with high stability and high intensity, a detector system, and a shielding material with low background, will be established during the above research. The current progress of JUNA will be given. | WeiPing Liu ZhiHong Li JiangJun He XiaoDong Tang Gang Lian Zhu An JianJun Chang Han Chen QingHao Chen XiongJun Chen ZhiJun Chen BaoQun Cui XianChao Du ChangBo Fu Lin Gan Bing Guo GuoZhu He Alexander Heger SuQing Hou HanXiong Huang Ning Huang BaoLu Jia LiYang Jiang Shigeru Kubono JianMin Li KuoAng Li Tao Li YunJu Li Maria Lugaro XiaoBing Luo HongYi Ma ShaoBo Ma DongMing Mei YongZhong Qian JiuChang Qin Jie Ren YangPing Shen Jun Su LiangTing Sun WanPeng Tan Isao Tanihata Shuo Wang Peng Wang YouBao Wang Qi Wu ShiWei Xu ShengQuan Yan LiTao Yang Yao Yang XiangQing Yu Qian Yue Sheng Zeng HuanYu Zhang Hui Zhang LiYong Zhang NingTao Zhang QiWei Zhang Tao Zhang XiaoPeng Zhang XueZhen Zhang ZiMing Zhang Wei Zhao Zuo Zhao Chao Zhou | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，4： | 3 |
| 4 | The protective role of hydrogen-rich saline in experimental liver injury in mice显示文摘 | HanYong Sun Lei Chen WeiPing Zhou Liang Hu Liang Li QianQian Tu YanXin Chang Qu Liu XueJun Sun MengChao Wu HongYang Wang | 2010 | Journal of Hepatology2010，，3： | 2 |
| 5 | Assessing long-term environmental risks of trace elements in phosphate fertilizers显示文摘 | Weiping Chen Andrew C. Chang Laosheng Wu | 2007 | Ecotoxicology and Environmental Safety2007，，1： | 1 |
| 6 | Synthesis, thermal, mechanical and theological properties of muhiwall carbon nanotube/waterborne polyurethane nanocomposite显示文摘 | KUAN HSU-CHIANG M MA CHEN-CHI CHANG WEIPING | 2005 | Composites Science and Technology2005，65，1112： | 1 |
| 7 | Synthesis, thermal, mechanical and rheological properties of multiwall carbon nanotube/waterborne polyurethane nanocomposite显示文摘 | KUAN HSU-CHIANG MA CHEN-CHI M CHANG WEIPING | 2005 | Composites Science and Technology2005，65，1112： | 1 |
| 8 | Environmental risks of trace elements associated with long-term phosphate fertilizers applications: A review显示文摘 | Wentao Jiao Weiping Chen Andrew C. Chang Albert L. Page | 2012 | Environmental Pollution2012，，： | 1 |
| 9 | Multi-factors influencing the spatial distribution of polycyclic aromatic hydrocarbons in soils surrounding drinking water protection zone显示文摘We selected the Guanting Reservoir in Beijing, China as a case where an industrial area locates on the upwind corner to study the influence of human activities and natural processes on the distribution of polycyclic aromatic hydrocarbons (PAHs) in soils. Soil PAH concentrations in the study area follow a log-normal probability distribution function, suggesting that distribution of PAH in soils was affected by human activities. Distribution of PAHs in soils was significantly affected by the point source that high PAH concentrations were observed in near industrial area with an obvious declining trend from the northwest to the southeast which was the prevailing wind direction in this area. Away from the influence of point source, distribution of PAHs in soils was found to significantly correlate with total organic carbon content, while the influences of agricultural land uses and type of soil texture on the total soil PAHs contents and ring compositions were quite limited. The results can provide some evidences and data on the pollutant accumulation in drink water protection area influenced by natural processes and human activities. | Wentao Jiao Tieyu Wang Yonglong Lu Andrew Chang Weiping Chen | 2013 | Journal of Environmental Sciences2013，25，8： | 1 |
| 10 | Diffusion coefficients of some solutes in fcc and liquid Al: critical evaluation and correlation显示文摘 | Yong Du Y.A Chang Baiyun Huang Weiping Gong Zhanpeng Jin Honghui Xu Zhaohui Yuan Yong Liu Yuehui He F.-Y Xie | 2003 | Materials Science & Engineering A2003，，1： | 1 |
| 11 | Cost-benefit analysis of reclaimed wastewater reuses in Beijing显示文摘 | Yupeng Fan Weiping Chen Wentao Jiao Andrew C. Chang | 2015 | Desalination and Water Treatment2015，，5： | 1 |
| 12 | 查看详情显示文摘 | Chang C Z Zhang J Feng X Shen J Zhang Z C Guo MH LiK OuYB WeiP WangLL JiZQ FengY Ji S H Chen X Jia J F Dai X Fang Z Zhang S C He K Wang Y Y Lu L Ma X C Xue Q K | | 0，，： | 1 |
| 13 | On the existence and uniqueness theorems of solutions for the systems of mixed monotone operator equations with applications显示文摘 | Chang shihsen Guo weiping | 1993 | APPL Math - AJ Chinese Universities1993，18，1： | 1 |
| 14 | Effects of cerium on nitrogen metabolism of peach plantlet in vitro显示文摘 | Song Weiping Hong Fashui Wan Zhigang Zhou Yuzhen Gu Fugen Xu Hongoing Yu Mingliang Chang Youhong Zhao Mizhen Su Jiale | 2003 | Biological Trace Element Research2003，，3： | 1 |
| 15 | Arsenic, Cadmium, and Lead in California Cropland Soils: Role of Phosphate and Micronutrient Fertilizers显示文摘 | Chen Weiping Krage Natalie Wu Laosheng Pan Genxing Khosrivafard Maryam Chang Andrew C | 2008 | Journal of Environmental Quality2008，，2： | 1 |
| 16 | Synthesis,thermal,mechanical and theological properties ofmultiwall carbon nanotube/waterborne polyurethane nanocomposite显示文摘 | Kuan Hsuchiang Chenchi M Ma Chang Weiping | 2005 | Composites Science and Technology2005，65，1112： | 1 |
| 17 | Environmental risks of trace elements associated with long-term phosphate fertilizers applications: A review显示文摘 | Wentao Jiao Weiping Chen Andrew C. Chang Albert L. Page | 2012 | Environmental Pollution2012，，： | 1 |
| 18 | Characterizing the solid solution partitioning coefficient and plant uptake factor of As,Cd,and Pb in California croplands显示文摘 | CHEN Weiping LI Lianqing CHANG A C | 2009 | Agriculture Ecosystems & Environment2009，129，123： | 1 |
| 19 | Novel diagnostic approaches for Fanconi anemia (FA) by single-cell sequencing and capillary nano-immunoassay显示文摘Next-generation sequencing technology has been widely utilized for the diagnosis of Fanconi anemia(FA).However,mixed cell sequencing and chimerism of FA patients may lead to unconfirmed genetic subtypes.Herein,we introduced two novel diagnostic methods,including single-cell sequencing and capillary nano-immunoassay.One FA case with FANCM c.4931G>A p.R1644Q and FANCD1 c.6325G>A p.V2109I was studied.The DNA of 28 cells was amplified and eight types of cells were observed after Sanger sequencing.There were two homozygous mutations(FANCM/FANCD1).Furthermore,the capillary nano-immunoassay was conducted to analyze the expression profile of FA-associated proteins.Abnormal FANCM and FANCD1 expressions simultaneously existed.This case was thus diagnosed as FA-D1/FA-M dual subtype.Compared with mixed cell sequencing,single-cell sequencing data shows more accuracy for the FA subtype evaluation,while the capillary nano-immunoassay is a good method to detect the expression profile of abnormal or modified FA protein. | Lixian Chang Xingjie Gao Guangzhen Ji Xuelian Cheng Yao Zou Tao Cheng Weiping Yuan Xiaofan Zhu | 2021 | Blood Science2021，3，1： | 1 |
| 20 | DNAH2 facilitates the homologous recombination repair of Fanconi anemia pathway through modulating FANCD2 ubiquitination显示文摘Fanconi anemia(FA),an X-linked genetic or autosomal recessive disease,exhibits complicated pathogenesis.Previously,we detected the mutated Dynein Axonemal Heavy Chain 2(DNAH2)gene in 2 FA cases.Herein,we further investigated the potential association between DNAH2 and the homologous recombination repair pathway of FA.The assays of homologous recombination repair,mitomycin C(MMC)sensitivity,immunofluorescence,and ubiquitination modification were performed in U2OS and DR-U2OS cell lines.In MMC-treated U2OS cells,the downregulation of the DNAH2 gene increased the sensitivity of cells to DNA inter-strand crosslinks.We also observed the reduced enrichment of FANCD2 protein to DNA damage sites.Furthermore,the ubiquitination modification level of FANCD2 was influenced by the deficiency of DNAH2.Thus,our results suggest that DNAH2 may modulate the cell homologous recombination repair partially by increasing the ubiquitination and the enrichment to DNA damage sites of FANCD2.DNAH2 may act as a novel co-pathogenic gene of FA patients. | Lixian Chang Xingjie Gao Yuxia Wang Chunmin Huang Min Gao Xiaomin Wang Chao Liu Wenqi Wu Wenbin An Yang Wan Aoli Zhang Yingchi Zhang Weiping Yuan Xiaofan Zhu | 2021 | Blood Science2021，3，3： | 0 |
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