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| 1 | Compound Danshen injection improves endotoxin-induced microcirculatory disturbance in rat mesentery显示文摘AIM: To investigate the effect of compound Danshen injection on lipopolysaccharide (LPS)-induced rat mesenteric microcirculatory dysfunctions and the underlying possible mechanism by an inverted intravital microscope and high-speed video camera system. METHODS: LPS was continuously infused through the jugular artery of male Wistar rats at the dose of 2 mg/kg per hour. Changes in mesenteric microcirculation,such as diameters of arterioles and venules,velocity of RBCs in venules,leukocyte rolling,adhesion and emigration,free radicals released from post-capillary venules,FITC- albumin leakage and mast cell degranulation,were observed through an inverted intravital microscope assisted with CCD camera and SIT camera. Meanwhile,the expression of adhesion molecules CD11b/CD18 and the production of free radical in neutrophils,and the expression of intercellular adhesion molecule 1 (ICAM-1) in human umbilical vein endothelial cells (HUVECs) were quantified by flow cytometry (FACS) in vitro. RESULTS: The continuous infusion with LPS resulted in a number of responses in microcirculation,including a significant increase in the positive region of venulestained with Monastral blue B,rolling and adhesion of leukocytes,production of oxygen radical in venular wall,albumin efflux and enhanced mast cell degranulation in vivo,all of which,except for the leukocyte rolling,were attenuated by the treatment with compound Danshen injection. Experiments performed in vitro further revealed that the expression of CD11b/CD18 and the production of oxygen free radical in neutrophils,and the expression of ICAM-1 in HUVECs were increased by exposure to LPS,and they were attenuated by compound Danshen injection. CONCLUSION: These results suggest that compound Danshen injection is an efficient drug with multi-targeting potential for improving the microcirculatory disturbance. | Jing-Yan Han Yoshinori Horie Soichiro Miura, Yasutada Akiba Jun Guo Dan Li Jing-Yu Fan Yu-Ying Liu Bai-He Hu Li-Hua An Xin Chang Man Xu De-An Guo Kai Sun Ji-Ying Yang Shu-Ping Fang Ming-Ji Xian Masahiro Kizaki Hiroshi Nagata Toshifumi Hibi | 2007 | World Journal of Gastroenterology2007，13，26： | 26 |
| 2 | First experimental constraints on WIMP couplings in the effective field theory framework from CDEX显示文摘We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the China Dark Matter Experiment(CDEX), based on the data from both CDEX-1B and CDEX-10 stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, data from CDEX-10 were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)<6 GeV/c^(2) region. | Yi Wang Zhi Zeng Qian Yue LiTao Yang KeJun Kang YuanJing Li Mehment Agartioglu HaiPeng An JianPing Chang JingHan Chen YunHua Chen JianPing Cheng Cheng Yi Chiang WenHan Dai Zhi Deng ChangHao Fang XinPing Geng Hui Gong QiuJu Guo XuYuan Guo HongJian He Li He ShengMing He JinWei Hu TuChen Huang HanXiong Huang HaiTao Jia LiPing Jia Xi Jiang HauBin Li JianMin Li Jin Li MingXuan Li RenMingJie Li Xia Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu Yu Liu YuanYuan Liu ZhongZhi Liu Hao Ma YuCai Mao QiYuan Nie JinHua Ning Hui Pan NingChun Qi Jie Ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang Li Wang Qing Wang Yu Chen Wang YunXiang Wang Zhen Wang Henry Tsz-King Wong ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue YuLu Yan Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue Ming Zeng BingTao Zhang Lei Zhang FengShou Zhang ZhenYu Zhang KangKang Zhao MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，8： | 3 |
| 3 | Progress of Jinping Underground laboratory for Nuclear Astrophysics(JUNA)显示文摘Jinping Underground laboratory for Nuclear Astrophysics(JUNA) will take the advantage of the ultra-low background of CJPL lab and high current accelerator based on an ECR source and a highly sensitive detector to directly study for the first time a number of crucial reactions occurring at their relevant stellar energies during the evolution of hydrostatic stars. In its first phase, JUNA aims at the direct measurements of^(25)Mg(p,γ)^(26)Al,^(19)F(p,α)^(16)O,^(13)C(α,n)^(16)O and ^(12)C(α,γ)^(16)O reactions. The experimental setup,which includes an accelerator system with high stability and high intensity, a detector system, and a shielding material with low background, will be established during the above research. The current progress of JUNA will be given. | WeiPing Liu ZhiHong Li JiangJun He XiaoDong Tang Gang Lian Zhu An JianJun Chang Han Chen QingHao Chen XiongJun Chen ZhiJun Chen BaoQun Cui XianChao Du ChangBo Fu Lin Gan Bing Guo GuoZhu He Alexander Heger SuQing Hou HanXiong Huang Ning Huang BaoLu Jia LiYang Jiang Shigeru Kubono JianMin Li KuoAng Li Tao Li YunJu Li Maria Lugaro XiaoBing Luo HongYi Ma ShaoBo Ma DongMing Mei YongZhong Qian JiuChang Qin Jie Ren YangPing Shen Jun Su LiangTing Sun WanPeng Tan Isao Tanihata Shuo Wang Peng Wang YouBao Wang Qi Wu ShiWei Xu ShengQuan Yan LiTao Yang Yao Yang XiangQing Yu Qian Yue Sheng Zeng HuanYu Zhang Hui Zhang LiYong Zhang NingTao Zhang QiWei Zhang Tao Zhang XiaoPeng Zhang XueZhen Zhang ZiMing Zhang Wei Zhao Zuo Zhao Chao Zhou | 2016 | Science China(Physics,Mechanics & Astronomy)2016，59，4： | 3 |
| 4 | Characteristics of reactivity and structures of palm kernel shell (PKS) biochar during CO_2/H_2O mixture gasification显示文摘Palm kernel shell(PKS)biochars with different levels of carbon conversion were initially prepared using a tube furnace,after which the reactivity of each sample was assessed with a thermogravimetric analyzer under a CO_2 atmosphere.The pore structure and carbon ordering of each biochar also examined,employing a surface area analyzer and a Raman spectroscopy.Thermogravimetric results showed that the gasification index R_sof the PKS biochar decreased from 0.0305 min^(-1) at carbon conversion(x)=20% to 0.0278 min^(-1)at x=40%.The expansion of micropores was the dominant process during the pore structure evolution,ad mesopores with sizes ranging from 6 to 20,48 to 50 nm were primarily generated during gasification under a CO_2/H_2O mixture.The proportion of amorphous carbon in the PKS biochar decreased significantly as x increased,suggesting that the proportion of ordered carbon was increased during the CO_2/H_2O mixed gasification.A significantly reduced total reaction time was observed when employing a CO_2/intermittent H_2O process along with an 83.46% reduction in the steam feed,compared with the amount required using a CO_2/H_2O atmosphere. | Guozhang Chang Ximin Yan Pengyu Qi Mei An Xiude Hu Qingjie Guo | 2018 | Chinese Journal of Chemical Engineering2018，26，10： | 3 |
| 5 | Wind Tunnel Experiments and Numerical Study on Performance Characteristics of an H-type Vertical Axis Wind Turbine in the Spanwise Direction显示文摘The aerodynamic forces and vortex characteristics of an H-type Vertical Axis Wind Turbine(VAWT)become complicated because of dynamic stall,particularly in the three-dimensional impact on the blade spanwise direction.This study focused on the evaluation of the aerodynamic performance and vortex characteristics of an H-type VAWT in the spanwise direction by numerical simulations and wind tunnel experiments.Pressure acting on the blade surface was obtained from multiport pressure measurement devices by wind tunnel.Meanwhile,the vortex field around different blade sections was investigated through numerical simulations.The stall behavior was analysed by comparing the results of numerical simulations and experiments.As a result,the tangential force of single blade was mainly contributed at the chordwise position of x/c≤0.4 c and the power of single blade was mainly contributed at the azimuthal angle range of 60°≤θ≤150°in the blade section position region of 0≤z/(H/2)≤0.7.At the section position of z/(H/2)=0.5,the initial flow separation was found at the suction side and progressed forward to the leading edge.With the increase of the tip speed ratios,the decreasing position of the averaged local power coefficient of each section was closer to the middle section of z/(H/2)=0,and the attenuation speed became faster.The power coefficient reductions at the blade section position of z/(H/2)=0.9 were 38.29%,46.78%and 56.42%when the tip speed ratios were 1.38,2.19 and 2.58,respectively.The results of this study provided a better understanding of the development of the performance characteristics and vortex characteristics of H-type VAWT. | ZHANG Yanfeng LI Qing’an ZHU Xinyu SONG Xiaowen CAI Chang GUO Zhiping | 2021 | Journal of Thermal Science2021，30，3： | 2 |
| 6 | Triterpenoid Saponins from the Seeds of Aesculus chinensis and Their Cytotoxicities显示文摘Six new triterpenoid saponins,aesculusosides A-F(1-6),together with 19 known ones,were isolated from the seeds of Aesculus chinensis.The new structures were elucidated through extensive spectroscopic analyses and by comparison with previously reported data.Some of the isolates were evaluated for their cytotoxic activities against MCF-7 cell line by an MTT assay,and compounds 15,16,19,and 23-25 exhibited inhibitory activities against MCF-7 with IC50 values ranging from 7.1 to 31.3μM. | Jin-Tang Cheng Shi-Tao Chen Cong Guo Meng-Jiao Jiao Wen-Jin Cui Shu-Hui Wang Zhe Deng Chang Chen Sha Chen Jun Zhang An Liu | 2018 | Natural Products and Bioprospecting2018，8，1： | 2 |
| 7 | Electrodeposition of Ni-Co/Al2O3 composite coating by pulse reverse method under ultrasonic condition显示文摘 | Chang L M Guo H F An M Z | 2008 | Material Letters2008，，62： | 1 |
| 8 | Electrodeposition of Ni-Co/Al2O3 composite coating by pulse reverse method under ultrasound condition显示文摘 | Chang L M Guo H F An M Z | | 0，，19： | 1 |
| 9 | Microstructure and properties of Ni-Co/nano-Al2 O3 composite coatings by pulse reversal current electrodeposition显示文摘 | Chang L M An M Z Guo H F | 2006 | Applied Surface Science2006，253，4： | 1 |
| 10 | Microstructure andproperties of Ni-Co/nano-Al203 composite coatings by pulse reversal current electrodeposition 显示文摘 | CHANG L M AN M Z GUO H F | 2006 | Applied Surface Science2006，253，： | 1 |
| 11 | Applied Surface Science显示文摘 | Chang L M An M Z Guo | 2006 | 253(4):21322006，253，4： | 1 |
| 12 | Cell atlas of CCl_(4)-induced progressive liver fibrosis reveals stage-specific responses显示文摘Chronic liver injury leads to progressive liver fibrosis and ultimately cirrhosis,a major cause of morbidity and mortality worldwide.However,there are currently no effective anti-fibrotic therapies available,especially for latestage patients,which is partly attributed to the major knowledge gap regarding liver cell heterogeneity and cellspecific responses in different fibrosis stages.To reveal the multicellular networks regulating mammalian liver fibrosis from mild to severe phenotypes,we generated a single-nucleus transcriptomic atlas encompassing 49919nuclei corresponding to all main liver cell types at different stages of murine carbon tetrachloride(CCl_(4))-induced progressive liver fibrosis.Integrative analysis distinguished the sequential responses to injury of hepatocytes,hepatic stellate cells and endothelial cells.Moreover,we reconstructed the cell-cell interactions and gene regulatory networks implicated in these processes.These integrative analyses uncovered previously overlooked aspects of hepatocyte proliferation exhaustion and disrupted pericentral metabolic functions,dysfunction for clearance by apoptosis of activated hepatic stellate cells,accumulation of pro-fibrotic signals,and the switch from an anti-angiogenic to a pro-angiogenic program during CCl_(4)-induced progressive liver fibrosis.Our dataset thus constitutes a useful resource for understanding the molecular basis of progressive liver fibrosis using a relevant animal model. | Peng-Cheng Guo Jing Zuo Ke-Ke Huang Guang-Yao Lai Xiao Zhang Juan An Jin-Xiu Li Li Li Liang Wu Yi-Ting Lin Dong-Ye Wang Jiang-Shan Xu Shi-Jie Hao Yang Wang Rong-Hai Li Wen Ma Yu-Mo Song Chang Liu Chuan-Yu Liu Zhen Dai Yan Xu Amar Deep Sharma Michael Ott Qing Ou-Yang Feng Huo Rong Fan Yong-Yin Li Jin-Lin Hou Giacomo Volpe Long-Qi Liu Miguel A.Esteban Yi-Wei Lai | 2023 | Zoological Research2023，44，3： | 1 |
| 13 | Electrodeposition of Ni - Co/ Al2O3 composite coating by pulse reverse method under ultrasonic condition显示文摘 | Chang L M Guo H F An M Z | 2008 | Materials Letters2008，62，19： | 1 |
| 14 | Multiple expansions of C4 plant biomass in East Asia since 7 Ma coupled with strengthened monsoon circulation 显示文摘 | An Z S Huang Y S Liu W G Guo Z T Clemens S Li L Prell W Ning Y F Cai Y J Zhou W J Lin B H Zhang Q L Cao Y N Qiang X K Chang H Wu Z K | 2005 | Geology2005，33，9： | 1 |
| 15 | Microstructure and properties of Ni--Co/nano-A1203 composite coatings by pulse reversal current electrodeposition 显示文摘 | CHANG L M AN M Z GUO H F | 2006 | Applied Surface Science2006，253，4： | 1 |
| 16 | Microstructure and Properties of Ni-Co/nano-Al2O3 Composite Coatings by Pulse Reversal Current Eleetrodeposition 显示文摘 | Chang L M An M Z Guo H F | 2006 | Applied Surface Science2006，253，4： | 1 |
| 17 | High‐intensity focused ultrasound combined with herpes simplex virus thymidine kinase gene‐loaded ultrasound‐targeted microbubbles improved the survival of rabbits with VX2 liver tumor显示文摘 | Shi‐Ji Zhou Sheng‐Wei Li Ji‐Jian Wang Zuo‐Jin Liu Guo‐Bing Yin Jian‐Ping Gong Chang‐An Liu | 2012 | 2012 (9-10)2012，，9： | 1 |
| 18 | Microstructure and properties of Ni-Co/nano-Al2O3 composite coatings by pulse reversal current electrodeposition 显示文摘 | CHANG L M AN M Z GUO H F | 2006 | Applied Surface Science2006，253，： | 1 |
| 19 | Up-and Down-regulated Leukemia-related Protein 16 Affects ERα Expression and Prolactin Secretion by GH3 Cells显示文摘Prolactinoma is an estrogen‐related tumor and leukemia‐related protein 16(LRP16)is correlated with the progression of estrogen‐related tumors,but the regulatory mechanism between LRP16 and prolactinoma remain unclear.This study demonstrates a variation in LRP16 with estrogen receptorα(ERα)in prolactinoma models and the up and downregulation effects of LRP16 on prolactin secretion of pituitary adenomas cells(GH_3cells).In our study,50 male SD rats(30‐day‐old) | SU Xing WU Zhi Qiang YANG Xiao Jiang WANG An Ping ZHAO Kun WU Tao Guang SUN Yi SUN Jie CHANG Zheng Yao GUO Xiao Yong GUO Qing Hua MU Yi Ming | 2017 | Biomedical and Environmental Sciences2017，30，12： | 1 |
| 20 | Microstructure and Properties of Ni-Co/nano-AI203 Composite Coatings by Pulse Reversal Current Electrodeposition显示文摘 | Chang L M An M Z Guo H F | 2006 | Applied Surface Science2006，253，4： | 1 |
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