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| 1 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 2 | Liquid-phase Separation in Rapid Solidification of Undercooled Fe-Co-Cu Melts显示文摘The homogeneous liquid was separated into two phases,(Fe,Co)-rich L1 and Cu-rich L2,once the melt was undercooled below a liquid-phase separation temperature T sep.If the duration from T sep to T s1(solidification temperature of L1 phase),termed the liquid-phase separation interval t,exceeded a critical value,an egg-type structure was observed.By utilizing differential thermal analyses(DTA),the solidification process of the undercooled Fe-Co-Cu alloys was studied.Additionally,an immiscible boundary was obtained,which was a convex parabola with a symmetrical axis of x Cu =0.52.Depending on the relative amounts of L1 and L2,the minor phase was nucleated firstly to form liquid droplets and separated from the original liquids at the beginning of liquid-phase separation. | Ning Liu Feng Liu Zheng Chen Gencang Yang Changlin Yang Yaohe Zhou | 2012 | Journal of Materials Science & Technology2012，28，7： | 7 |
| 3 | Standardized Operational Protocol for Human Brain Banking in China显示文摘With the progress of society, there is an increasing need to tackle disorders of the central nervous system. Human brain tissue, unlike animal tissues, is an irreplaceable resource for the study of neurological diseases (1)Aimed at scientific research and education, the roles of human brain tissue repositories are to acquire brain tissue from donors, prepare, process, and preserve collected samples,provide tissue to specific eligible facilities, and determine the characteristics of each tissue sample. | Wenying Qiu Hanlin Zhang Aimin Bao Keqing Zhu Yue Huang Xiaoxin Yan Jing Zhang Chunjiu Zhong Yong Shen Jiangning Zhou Xiaoying Zheng Liwei Zhang Yousheng Shu Beisha Tang Zhenxin Zhang Gang Wang Ren Zhou Bing Sun Changlin Gong Shumin Duan Chao Ma | 2019 | Neuroscience Bulletin2019，35，2： | 6 |
| 4 | Interannual variability of thermal front west of Luzon Island in boreal winter显示文摘Interannual variability of thermal front west of Luzon Island during the winter of 1993–2013 is examined with the method of singular value decomposition(SVD) and a suite of satellite measurements in this paper. It is found that both the area and intensity of the thermal front west of Luzon Island show apparent interannual variability.Further study based on SVD shows that the interannual variability of the thermal front is highly associated with El Ni?o and Southern Oscillation(ENSO), and the correlation coefficient between Ni?o3.4 index and the first Principal Component(PC1) of thermal front can reach –0.65. The mechanism can be described as follows. In El Ni?o(La Ni?a) years, the East Asian winter monsoon(EAWM) is weakened(enhanced), inducing weaker(stronger) local wind stress curl(WSC) west of Luzon Island, and resulting in weakened(enhanced) Luzon cold eddy, which finally leads to the weakening(enhancement) of the thermal front. | SUN Ruili LING Zheng CHEN Changlin YAN Yunwei | 2015 | Acta Oceanologica Sinica2015，34，11： | 2 |
| 5 | Synthesis of NiO nanowires by an oxidation route显示文摘 | Yongjie Zhan Changlin Zheng Yingkai Liu | 2003 | Mater Lett2003，57，： | 1 |
| 6 | Synthesis and Characterization of Rutile SnO2 Nanorods显示文摘 | Liu Yinkai Zheng Changlin Wang Wenzhong | 2001 | Advanced Materials2001，，13： | 1 |
| 7 | Biochemical properties of K_(11,48)-branched ubiquitin chains显示文摘As one of the most widely existing post-translational modification models, ubiquitination regulates diverse cellular activities. In eukaryotes, K_(11,48)-branched ubiquitin chains play key roles in cell cycle and protein quality control. However, the structural and biochemical properties of K_(11,48)-branched ubiquitin chains have not been well examined. Here we employed the synthetic linkage-and length-defined K_(11,48)-branched ubiquitin chains to examine their binding and hydrolysis properties in vitro. Quantitatively affinity determination of ubiquitin chains to the proteasome ubiquitin receptor S5 a indicated that the S5 a exhibited preference binding to K_(11,48)-branched chains over K_(11)-linked chains, but not K_(48)-conjugated chains. In addition, deubiquitination experiments were carried out and the results showed that K_(11,48)-branched chains were preferably hydrolyzed by proteasome-associated deubiquitinase Rpnll than homotypic K_(11) or K_(48)-linked chains. | Lu-Jun Liang Yanyan Si Shan Tang Dongliang Huang Zhipeng A.Wang Changlin Tian Ji-Shen Zheng | 2018 | Chinese Chemical Letters2018，29，7： | 1 |
| 8 | Synthesis and characterization of rutile SnO2 nanorod显示文摘 | Liu Yingkai Zheng Changlin Wang Wenzhong | 2001 | Advanced Materials2001，，13： | 1 |
| 9 | Chemical protein synthesis-assisted high-throughput screening strategies for D-peptides in drug discovery显示文摘D-peptides are recognized as a new class of synthetic chemical drugs and they possess many interesting advantages such as high enzymatic stability,improved oral bioavailability,as well as high binding affinity and specificity.Recently,D-peptide drugs have been attracting increasing attention in both academic and industrial researches over recent years.One D-peptide etelcalcetide has even entered the market that targets the calcium(Ca2+)-sensing receptor(CaSR) to fight secondary hyperparathyroidism.Effective discovery and optimization of D-peptide ligands that can bind to various disease-related targets with high specificity and potency is of great importance for the development of D-peptide drugs.This review surveys the recent method development in this area especially the chemical protein synthesis-assisted high-throughput screening strategies for D-peptide ligands and their application in drug discovery. | Ying Li Xiuxiu Cao Changlin Tian Ji-Shen Zheng | 2020 | Chinese Chemical Letters2020，31，9： | 1 |
| 10 | Chemically synthesized histone H2A Lys13 di-ubiquitination promotes binding of 53BP1 to nucleosomes显示文摘 | Jia-Bin Li Yun-Kun Qi Qiao-Qiao He Hua-Song Ai San-ling Liu Jia-Xing Wang Ji-Shen Zheng Lei Liu Changlin Tian | 2018 | Cell Research2018，28，2： | 1 |
| 11 | Synthesis of NiO nanowires by an oxidation route 显示文摘 | ZHAN Yongjie ZHENG Changlin LIU Yingkai | 2003 | Materials Letters2003，57，： | 1 |
| 12 | Warm water wake off northeast Vietnam in the South China Sea显示文摘Due to orographic blockage, a weak wind wake occurs in summer off northeast Vietnam in the South China Sea. Under the wind wake, warm water is observed from both high-resolution satellite data and hydrographic observations. The wake of warm water forms in June, continues to mature in July and August, starts to decay in September, and disappears in October. The warm water wake also shows robust diurnal variation – it intensifies during the day and weakens in the night. Warm water wakes can be generated through wind-induced mixing and thermal(latent heat flux) processes. In this paper, a mixed layer model is used to evaluate the relative importance of the two processes on seasonal and diurnal timescales, respectively. The results demonstrate that thermal processes make a greater contribution to the wake than wind-induced mixing processes on a seasonal timescale, while the warm water wake is dominated by wind-induced mixing processes on a diurnal timescale. | YAN Yunwei CHEN Changlin LING Zheng | 2014 | Acta Oceanologica Sinica2014，33，11： | 1 |
| 13 | Winter coastal upwelling off northwest Borneo in the South China Sea显示文摘Winter coastal upwelling off northwest Borneo in the South China Sea(SCS) is investigated by using satellite data, climatological temperature and salinity fields and reanalysis data. The upwelling forms in December, matures in January, starts to decay in February and almost disappears in March. Both Ekman transport induced by the alongshore winter monsoon and Ekman pumping due to orographic wind stress curl are favorable for the upwelling. Transport estimates demonstrate that the month-to-month variability of Ekman transport and Ekman pumping are both consistent with that of winter coastal upwelling, but Ekman transport is two times larger than Ekman pumping in January and February. Under the influence of El Ni?o-Southern Oscillation(ENSO), the upwelling shows remarkable interannual variability: during winter of El Ni?o(La Ni?a) years, an anticyclonic(a cyclonic) wind anomaly is established in the SCS, which behaves a northeasterly(southwesterly) anomaly and a positive(negative) wind stress curl anomaly off the northwest Borneo coast, enhancing(reducing) the upwelling and causing anomalous surface cooling(warming) and higher(lower) chlorophyll concentration. The sea surface temperature anomaly(SSTA) associated with ENSO off the northwest Borneo coast has an opposite phase to that off southeast Vietnam, resulting in a SSTA seesaw pattern in the southern SCS in winter. | YAN Yunwei LING Zheng CHEN Changlin | 2015 | Acta Oceanologica Sinica2015，34，1： | 1 |
| 14 | Investigation of the 12 orientations variants of nanoscale Al precipitates in eutectic Si of Al-7Si-0.6Mg alloy显示文摘Various orientations and diffraction patterns from nanoscale Al precipitates in eutectic Si were investigated by high-resolution transmission electron microscopy combined with transition matrix and stereographic projection.It was found that the Al precipitates had 12 variants,all orientation relationships can be expressed as:(001)Al//{111}Si,[110]Al//<110>Si.Further,a new diffraction pattern model from Al precipitates was established under[111]Si zone axis,which was in good agreement with the experiment data.The microstructure,adhesion strength and electronic structure of the interface between Al precipitate and Si matrix were studied by first-principles calculation and experimental observation.The results show that the covalent bonds are formed between interfacial Al and Si atoms,which play a key role in interfacial bind strength.Based on the Griffith fracture theory,the cracks tend to form and expand in the interior of Al precipitates firstly,and the interfaces can act as a protective layer to prevent crack propagation.Therefore,the nanoscale Al precipitates will improve the toughness of eutectic Si particles by releasing part of stress through lattice distortion.In addition,the stretched nanoscale Al precipitates can act as effective heterogeneous nucleation sites for high density deformation nanotwins in eutectic Si during deformation,which significantly improved the deformability of eutectic Si. | Yifan Wang Yanli Lu Jing Zhang Wenchao Yang Changlin Yang Pan Wang Xiaoqing Song Zheng Chen | 2021 | Journal of Materials Science & Technology2021，，8： | 1 |
| 15 | Multi-site anchoring of single-molecule for efficient and stable perovskite solar cells with lead shielding显示文摘The emergence of perovskite solar cells(PSCs) has greatly promoted the progress of photovoltaic technologies.The rapid development of PSCs has been driven by the advances in optimizing perovskite films and their adjacent interfaces.However,the polycrystalline perovskite layers in most highly efficient PSCs still contain various defects that greatly limit photovoltaic performance and stability of the devices.Herein,we introduce a multifunctional additive ethylene diamine tetra methylene phosphonic sodium(EDTMPS) with multiple anchor points into the precursor of perovskite to improve the efficiency and stability of PSCs and provide in-situ protection of lead leakage.The addition of EDTMPS acts as a crystal growth controller and passivation agent for perovskite films,thereby slowing down the crystallization rate of the film and obtaining high-quality perovskite films.Our study also provides an insight into how the modifier modulate the interfacial energy level arrangement as well as affect transfer of charge carriers and their recombination under photoinduced excitation.As a result,the power conversion efficiency(PCE) of single subcell with a working area of 0.255 cm^(2) increases significantly from 20.03% to 23.37%.Moreover,we obtained a PCE of 19.16% for the 25 cm^(2) module.Importantly,the unencapsulated EDTMP-modified PSCs exhibit better operational and thermal stability,as well as in-situ absorption of leaked lead ions. | Zhengyan He Shufang Zhang Yushuang Gao Quanming Geng Xiangrui Jia Shuo Yang Zhiqiang Zhang Yanpu Zheng Yanqiang Hu Changlin Yao Qi Zhang | 2023 | Journal of Energy Chemistry2023，，12： | 0 |
| 16 | Equilibria between the K^+ binding and cation vacancy conformations of potassium channels显示文摘Dear Editor, Potassium channels are integral membrane proteins that selectively con duct K^+ ions across cell membra ne (Hille, 2001). They play essential roles in maintaining cellular ionic homoeostasis and generating action membrane potentials in excitable cells. The mechanism of K^+ selectivity has been evaluated in many biophysical and physiological studies (Zhou et al., 2001;Liu et al., 2015;Schewe et al., 2016). A highly con served signature seque nee, TVGYG, in the selectivity filter of potassium channels (e.g., KcsA) is known to coordinate K^+ ions (Zhou et al., 2001). Carbonyls of these residues point toward the pore, forming four continuous ion binding sites (S1-S4) and resulting in higher selectivity for K^+ over Na^+(Zhou et al., 2001). The NaK channel from Bacillus cereus is a norvselective cation channel that shares high structural homology with KcsA (Shi et al., 2006). Owing to a distinctive primary sequenee of 63TVGDG67, the selectivity filter of NaK preserves only two ion binding sites, allocated similarly as S3 and S4 in KcsA (Alam and Jiang, 2009a, b). Remarkably, the D66Y and N68D double mutations of NaK channel (Fig. S1) transform it into a K^+ selective channel (termed as NaK2K)(Sauer et al., 2013). Crystal structure of NaK and NaK2K have revealed distinet binding coordination of Na^+ and K^+ ions in their selectivity filter (Figs. S2 and S3)(Alam and Jiang, 2009a, b;Sauer et al., 2013). However, dynamics of the NaK and NaK2K selectivity filter with the bind泊g of Na+ or K^+ are still elusive. Especially, it has been known that the membrane environment is highly diverse from deterge nt micelles, which was con sidered to in flue nee the structure and functi on of membrane protei ns dramatically (Cross et al., 2011). Thus, it is necessary to study the cation and binding properties of NaK NaK2K channels in lipid bilayers. | Yao He Bo Zhang Hao Dong Penglin Xu Xiaoying Cai Ting Zhou Mu Yu Jun Liang Xiao Zheng Changlin Tian | 2019 | Protein & Cell2019，10，7： | 0 |
| 17 | Chemical Synthesis of Structurally Defined Phosphorylated Ubiquitins Suggests Impaired Parkin Activation by Phosphorylated Ubiquitins with a Non-Phosphorylated Distal Unit显示文摘Mutations in genes encoding PINK1(PTEN-induced kinase 1)and Parkin(E3 ubiquitin ligase)are identified in familial Parkinson’s disease.However,it remains unclear whether the phosphorylated Ub chains activate wild-type Parkin(w-Parkin)or phosphorylated Parkin(p-Parkin),with the consequent expulsion of the damaged mitochondria. | Man Pan Qingyun Zheng Shuai Gao Qian Qu Yuanyuan Yu Ming Wu Huan Lan Yulei Li Sanling Liu Jiabin Li Demeng Sun Lining Lu Tian Wang Wenhao Zhang Jiawei Wang Yiming Li Hong-Gang Hu Changlin Tian Lei Liu | 2019 | CCS Chemistry2019，1，5： | 0 |
| 18 | Breeding and Cultivation Techniques of Fly Fire,an Elite Variety of Malus micromalus显示文摘Fly fire is an elite variety of North American Begonia( Malus micromalus),which is characterized with dark red flowers,red young leaves,red peel,red bark,large flower amount,long flowering period and long fruit bearing period. It is propagated mainly through grafting,and is suitable for popularization and application in the landscape of the Yangtze River basin and north of the Yangtze River. | Changlin LI Li JIN Fuyuan SU Yanxing YAO Xian PEI Chengxiang ZHENG Xianbao LIU Fazhi CHEN Yang QIN Hongying LIU Shoukun YANG | 2018 | Agricultural Biotechnology2018，7，3： | 0 |
| 19 | Recent advances in chemical protein synthesis:method developments and biological applications显示文摘The central dogma of modern biology underscores the pivotal roles proteins play in diverse biological processes,the study of which necessitates advanced methods to produce proteins with precision and versatility.Chemical protein synthesis,a powerful approach utilizing chemical reactions for the de novo construction of structurally accurate proteins,has emerged as a transformative tool for studying proteins and generating protein derivatives/mimics inaccessible by natural biological machinery,including post-translationally modified proteins,proteins comprised of unnatural amino acids,as well as mirror-image proteins.This review summarizes recent strides in synthetic method developments for chemical protein synthesis,including innovative techniques in solid-phase peptide synthesis,the challenges presented by difficult sequences in either synthesis or folding and the exploration of novel ligation reactions using both chemical and enzymatic methods.Furthermore,the review also delves into newly developed protocols for site-selective protein modifications and the generation of stapled or macrocyclized peptides/miniproteins,highlighting the power of chemical methods to make structurally diverse proteins.Recent applications of synthetic proteins in investigating post-translational modifications(phosphorylation,lipidation,glycosylation,ubiquitination,etc.),mirror-image biological processes and drug development are further discussed.Together,these topics provide a comprehensive overview of the current landscape of chemical protein synthesis. | Suwei Dong Ji-Shen Zheng Yiming Li Huan Wang Gong Chen Yongxiang Chen Gemin Fang Jun Guo Chunmao He Honggang Hu Xuechen Li Yanmei Li Zigang Li Man Pan Shan Tang Changlin Tian Ping Wang Bian Wu Chuanliu Wu Junfeng Zhao Lei Liu | 2024 | Science China Chemistry2024，67，4： | 0 |
| 20 | Total chemical synthesis of bivalently modified H3 by improved three-segment native chemical ligation显示文摘The H3 bivalent modifications of trimethylationat Lys9 and acetylation at Lys18(H3-K9 Me3-K18 Ac) were identified to collectively recruit TRIM33 in the nodal signaling pathway.To understand the underlying mechanism of TRIM33 recruitment,the nucleosome core particles(NCPs) containing full-length H3-K9 Me3-K18 Ac were indispensable samples.Herein we developed a pseudo dipeptide strategy to efficiently prepare peptide segments,facilitating the chemical synthesis of H3-K9 Me3-K18 Ac at a tens of milligram scale.The synthetic H3-K9 Me3-K18 Ac was then examined by CD spectroscopy,which demonstrated a prominent shift compared to recombinant H3.Finally,bivalently modified NCPs were assembled and verified by gel mobility shift assay with good homogeneity. | Yong Zheng Fangming Wu Shenglong Ling Jia-Bin Li Changlin Tian | 2020 | Chinese Chemical Letters2020，31，5： | 0 |
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