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| 1 | Geochemical characteristics of natural gas from mud volcanoes in the southern Junggar Basin显示文摘A number of mud volcanoes exist in the southern Junggar Basin. To date few systematic studies on natural gas geochemistry of mud volcanoes have been conducted in China. In June 1991 and August 2010, the authors investigated the mud volcanoes in the southern Junggar Basin twice, and the mud volcanism weakened gradually as seen from the variations such as the decrease of gas pressure and output, the downthrow and dry up of the mud pool. The volcanic intensity was significantly weaker than that in Taiwan. The natural gas from the mud volcanoes in the southern Junggar Basin has similar geochemical characteristics, indicating the same source or origin. The main component of the mud volcano gas is alkane gas with contents of 91.15%-97.49%, and the gas is high-quality commercial gas since methane dominates in the alkane. The 13C1 values are 49.1‰--40.6‰, which are in accordance with the peak 13C1 frequency of mud volcano gas around the world, and the alkane gas displays positive carbon isotopic series, i.e., 13C1< 13C2< 13C3, suggesting typical thermogenic origin. The helium in the mud volcano gas is typically crust-derived due to the low R/Ra values of 0.011-0.054. The mud volcano gas is coal-derived since the 13C2 values are all greater than 28‰, and C1/C1-4 and 13C1 values are in accordance with those of natural gas derived from the Lower-Middle Jurassic coal-measures. Therefore, alkane gas from mud volcanoes in the southern Junggar Basin is mainly sourced from the Lower-Middle Jurassic coal-measures. | DAI JinXing WU XiaoQi NI YunYan WANG ZeCheng ZHAO ChangYi WANG ZhaoYun LIU GuiXia | 2012 | Science China Earth Sciences2012，55，3： | 13 |
| 2 | Photothermal therapy with regulated Nrf2/NF-κB signaling pathway for treating bacteria-induced periodontitis显示文摘Periodontitis is an inflammatory disease initiated by bacterial infection,developed by excessive immune response,and aggravated by high level of reactive oxygen species(ROS).Hence,herein,a versatile metal-organic framework(MOF)-based nanoplatform is prepared using mesoporous Prussian blue(MPB)nanoparticles to load BA,denoted as MPB-BA.The established MPB-BA nanoplatform serves as a shelter and reservoir for vulnerable immunomodulatory drug BA,which possesses antioxidant,anti-inflammatory and anti-bacterial effects.Thus,MPB-BA can exert its antioxidant,anti-inflammatory functions through scavenging intracellular ROS to switch macrophages from M1 to M2 phenotype so as to relieve inflammation.The underlying molecular mechanism lies in the upregulation of phosphorylated nuclear factor erythroid 2-related factor 2(Nrf2)to scavenge ROS and subsequently inhibit the nuclear factor kappa-B(NF-κB)signal pathway.Moreover,MPB-BA also exhibited efficient photothermal antibacterial activity against periodontal pathogens under near-infrared(NIR)light irradiation.In vivo RNA sequencing results revealed the high involvement of both antioxidant and anti-inflammatory pathways after MPB-BA application.Meanwhile,micro-CT and immunohistochemical staining of p-Nrf2 and p-P65 further confirmed the superior therapeutic effects of MPB-BA than minocycline hydrochloride.This work may provide an insight into the treatment of periodontitis by regulating Nrf2/NF-κB signaling pathway through photothermal bioplatform-assisted immunotherapy. | Yujuan Tian Ying Li Jialin Liu Yi Lin Jian Jiao Bo Chen Wanmeng Wang Shuilin Wu Changyi Li | 2022 | Bioactive Materials2022，7，3： | 3 |
| 3 | Selective laser melting of bulk immiscible alloy with enhanced strength:Heterogeneous microstructure and deformation mechanisms显示文摘To overcome the dimension limits of immiscible alloys produced by traditional techniques and enhance their mechanical properties,bulk Cu-Fe-based immiscible alloy with abundant nanotwins and stacking faults was successfully produced by selective laser melting(SLM).The SLM-produced bulk immiscible alloy displays a heterogeneous microstructure characterized by micro-scaledγ-Fe particles dispersed in fineε-Cu matrix with a high fraction(~92%)of high-angle grain boundaries.Interestingly,abundant nanotwins and stacking faults are generated in the interior of nano-scaledγ-Fe particles embedded withinε-Cu matrix.The heterogeneous interface of soft domains(ε-Cu)and hard domains(γ-Fe)not only induces the geometrically necessary dislocations(GNDs)but also affects the dislocation propagation during plastic deformation.Therefore,the bimodal heterogeneous interface,and the resistance of nanotwins and stacking faults to the propagation of partial dislocation make the bulk immiscible alloy exhibit an enhanced strength of~590 MPa and a good ductility of~8.9%. | Shengfeng Zhou Min Xie Changyi Wu Yanliang Yi Dongchu Chen Lai-Chang Zhang | 2022 | Journal of Materials Science & Technology2022，，9： | 3 |
| 4 | Ag_(3)PO_(4) decorated black urchin-like defective TiO_(2) for rapid and long-term bacteria-killing under visible light显示文摘Both phototherapy via photocatalysts and physical puncture by artificial nanostructures are promising substitutes for antibiotics when treating drug-resistant bacterial infectious diseases.However,the photodynamic therapeutic efficacy of photocatalysts is seriously restricted by the rapid recombination of photogenerated electron-hole pairs.Meanwhile,the nanostructures of physical puncture are limited to two-dimensional(2D)platforms,and they cannot be fully used yet.Thus,this research developed a synergistic system of Ag_(3)PO_(4) nanoparticles(NPs),decorated with black urchin-like defective TiO_(2)(BU-TiO_(2-X)/Ag_(3)PO_(4)).These NPs had a decreased bandgap compared to BU-TiO_(2-X),and BU-TiO_(2)-X/Ag_(3)PO_(4)(3:1)exhibited the lowest bandgap and the highest separation efficiency for photogenerated electron-hole pairs.After combination with BU-TiO_(2-X),the photostability of Ag_(3)PO_(4) improved because the oxygen vacancy of BU-TiO_(2-X) retards the reduction of Ag^(+) in Ag_(3)PO_(4) into Ag^(0),thus reducing its toxicity.In addition,the nanospikes on the surface of BU-TiO_(2-X) can,from all directions,physically puncture bacterial cells,thus assisting the hybrid’s photodynamic therapeutic effects,alongside the small amount of Ag^(+) released from Ag_(3)PO_(4).This achieves synergy,endowing the hybrid with high antibacterial efficacy of 99.76±0.15%and 99.85±0.09%against Escherichia coli and Staphylococcus aureus,respectively,after light irradiation for 20 min followed by darkness for 12 h.It is anticipated that these findings may bring new insight for developing synergistic treatment strategies against bacterial infectious diseases or pathogenic bacterial polluted environments. | Yingde Xu Xiangmei Liu Yufeng Zheng Changyi Li Kelvin Wai Kwok Yeung Zhenduo Cui Yanqin Liang Zhaoyang Li Shengli Zhu Shuilin Wu | 2021 | Bioactive Materials2021，6，6： | 2 |
| 5 | Using tea nanoclusters asβ-lactamase inhibitors to cure multidrug-resistant bacterial pneumonia:A promising therapeutic strategy by Chinese materioherbology显示文摘β-lactamase,a kind of hydrolase in multi-drug resistant pathogens,can hydrolyzeβ-lactam antibiotics and make these kinds of antibiotics invalid.Small-molecular inhibitors about the enzyme and their mechanism are widely investigated but they may result in unavoidable adverse reactions and drug-resistance.Herein,we propose a new therapeutic strategy of Chinese materioherbology,in which herbal medicine or traditional Chinese medicinal herbs can be employed as biological functional materials or refreshed/excited by means of materialogy.Nat-ural tea nanoclusters(TNCs)were extracted from tea to inhibitβ-lactamase.Different from the mechanism of small-molecular inhibitors inhibiting enzymes by binding to the corresponding active sites,the TNCs as a cap cover the protein pocket and create a spatial barrier between the active sites and antibiotics,which was named“capping-pocket”effect.TNCs were combined with amoxicillin sodium(Amo)to treat the methicillin-resistant Staphylococcus aureus(MRSA)pneumonia in mice.This combinatorial therapy remarkably outperforms antibiotic monotherapy in reducing MRSA infections and the associated inflammation in mice.The therapeutic strategy exhibited excellent biosafety,without any side effects,even in piglets.Hence,TNCs have great clinical value in potentiatingβ-lactam antibiotic activity for combatting multi-drug resistant pathogen infections and the'pocket capping'effect can guide the design of new enzyme inhibitors in near future. | Ziao Zhou Jun Li Lei Tan Xiangmei Liu Yufeng Zheng Zhenduo Cui Changyi Li Kelvin Wai Kwok Yeung Zhaoyang Li Yanqin Liang Shengli Zhu Shuilin Wu | 2022 | Fundamental Research2022，2，3： | 1 |
| 6 | Four orchid (Oncidium Gower Ramsey) API/AGL9-1ike MADS-box genes show novel expression patterns and cause different effects on floral transition and formation in Arabidopsis thaliana 显示文摘 | CHANGYY CHIU Y F WU JW | 2009 | Plant Cell Physiol2009，50，8： | 1 |
| 7 | Dexmedetomidineattenuates repeated propofol exposure -induced hip-pocampal apoptosis,PI3K/Akt/Gsk -3(3 signaling disrup-tion ,and juvenile cognitive deficits in neonatal rats 显示文摘 | Wang Y Changyi WU Han B | 2016 | Mol Med Rep2016，14，1： | 1 |
| 8 | Effect of microbial fermentation on the sensory characteristics and chemical compositions of Chinese sweet tea(Lithocarpus litseifolius(Hance)Chun)显示文摘Sweet tea,which has hundreds of years of use among in Chinese folk,is a traditional herbal tea with pleasant sweetness,bitterness and astringency.In the current study,we used traditional microbial fermentation to improve sensory characteristics of sweet tea,especially for the reduction of bitterness and astringency.The dynamic changes of non-volatile,volatile compounds and microbial community were investigated during microbial fermentation.The contents of polyphenols,flavonoids,soluble sugar,soluble protein,catechins and dihydrochalcones decreased significantly while the tea pigments,free amino acids and gallic acid content inversely increased during microbial fermentation.A total of 61 volatile compounds were identified and quantified in sweet tea,of which 20 key compounds were identified as odor active compounds(OAV),including 3 aldehydes,1 ketone,4 alcohols,9 esters,4 alkenes and 3 other compounds.In addition,eight fungi and four bacteria were considered as core microorganisms,such as Aspergillus,Alternaria,Cladosporium,Epicoccum,Itersonilia,Penicillium,Periconia,Wallemia,Aureimonas,Enterobacter,Klebsiella and Stenotrophomonas,which were significantly correlated with non-volatile compounds and flavor compounds.These results provided theoretical guidance for processing of fermented sweet tea. | Weimin Huang Changyi Zhang Zepeng Gu Cheng Li Zhengfeng Fang Zhen Zeng Zhiqing Zhang Bin Hu Hong Chen Wenjuan Wu Tiqiang Wang Xiguo Lan Yuntao Liu | 2022 | Food Bioscience2022，46，2： | 1 |
| 9 | Immunomodulatory effects of IL-12 secreted by Lactococcus lactis on Th1/Th2 balance in ovalbumin (OVA)-induced asthma model mice显示文摘 | Changyi Wu Guang Yang Luis G. Bermúdez-Humarán Qingfeng Pang Yinming Zeng Junke Wang Xinyue Gao | 2006 | International Immunopharmacology2006，，4： | 1 |
| 10 | Highly Regional Genes:graph-based gene selection for single-cell RNA-seq data显示文摘Gene selection is an indispensable step for analyzing noisy and high-dimensional single-cell RNA-seq(scRNA-seq)data.Compared with the commonly used variance-based methods,by mimicking the human maker selection in the 2D visualization of cells,a new feature selection method called HRG(Highly Regional Genes)is proposed to find the informative genes,which show regional expression patterns in the cell-cell similarity network.We mathematically find the optimal expression patterns that can maximize the proposed scoring function.In comparison with several unsupervised methods,HRG shows high accuracy and robustness,and can increase the performance of downstream cell clustering and gene correlation analysis.Also,it is applicable for selecting informative genes of sequencing-based spatial transcriptomic data. | Yanhong Wu Qifan Hu Shicheng Wang Changyi Liu Yiran Shan Wenbo Guo Rui Jiang Xiaowo Wang Jin Gu | 2022 | Journal of Genetics and Genomics2022，49，9： | 0 |
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