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| 1 | Design of Bionic Saw Blade for Corn Stalk Cutting显示文摘 | Honglei Jia | 2013 | Journal of Bionic Engineering2013，10，4： | 20 |
| 2 | MiR-124 retards bladder cancer growth by directly targeting CDK4显示文摘MicroRNAs (miRNAs ) 是由绑定充当基因表示的否定管理者到目标 mRNAs 的 3-untranslated 区域(3UTR ) 的非编码的小 RNA 的一个类。以便在膀胱癌症调查 miR-124 的生理的角色, miR-124 的目标基因被 TargetScan 预言软件,和 cyclin 依赖的 kinase (CDK4 ) ,作为房间周期的一个管理者被含有,为进一步的学习被选择。MiR-124 能显著地镇压由在 vitro 在 CDK4 的 3UTR 指向它的有约束力的地点的 CDK4 表示。在两根膀胱癌症房间线和纸巾, miR-124 的表示是显著地下面调整的,当 CDK4 表示是起来调整的时。在移植 HT1197 房间的 miR-124 的宫外的表示在老鼠肿瘤异种皮移植导致了肿瘤生长的延迟。并且 miR-124 和 CDK4 的表示证明在这些异种皮移植纸巾的明显的反的关联,它是也在人的膀胱癌症观察到组织取样。一起拿,我们的结果强烈建议 miR-124 能逮捕房间周期并且由直接指向 CDK4 制止膀胱癌症的生长。 | Ting Zhang Jingyao Wang Xiaofeng Zhai Hongjie Changying Li Jiwu Chang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，12： | 12 |
| 3 | An intelligent coastline interpretation of several types of seacoasts from TM/ETM+ images based on rules显示文摘A coastline is defined as the average spring tide line. Different types of seacoast, such as sandy, silty, and biological coast, have different indicators of interpretation. It is very difficult to develop a universal method for interpreting all shorelines. Therefore, the sandy, the silty, and the biological coast are regarded as research objects, and with data mining technology, found the rules of interpretation of those three types of coastlines. Then, an intelligent coastline interpretation method based on rules was proposed. Firstly, the rules for extracting the waterline in Landsat TM/ETM+(Thematic Mapper/Enhanced Thematic Mapper Plus) imagery were discovered. Then, through analyzing the features of sandy, silty and biological coast, the indicators of interpreting different types of shoreline were determined. According to the indicators, the waterline could be corrected to the real coastline. In order to verify the validity of the proposed algorithms, three Landsat TM/ETM+ imageries were selected for case studies. The experimental results showed that the proposed methods could interpret the coastlines of sandy, silty, and biological coasts with high precision and without human intervention, which exceeded three pixels. | WANG Changying ZHANG Jie SONG Pingjian | 2014 | Acta Oceanologica Sinica2014，33，7： | 7 |
| 4 | Correlation of Gut Microbiome Between ASD Children and Mothers and Potential Biomarkers for Risk Assessment显示文摘Variation of maternal gut microbiota may increase the risk of autism spectrum disorders(ASDs) in offspring. Animal studies have indicated that maternal gut microbiota is related to neurodevelopmental abnormalities in mouse offspring, while it is unclear whether there is a correlation between gut microbiota of ASD children and their mothers. We examined the relationships between gut microbiome profiles of ASD children and those of their mothers, and evaluated the clinical discriminatory power of discovered bacterial biomarkers. Gut microbiome was profiled and evaluated by 16S ribosomal RNA gene sequencing in stool samples of 59 mother–child pairs of ASD children and 30 matched mother–child pairs of healthy children. Significant differences were observed in the gut microbiome composition between ASD and healthy children in our Chinese cohort. Several unique bacterial biomarkers, such as Alcaligenaceae and Acinetobacter, were identified. Mothers of ASD children had more Proteobacteria, Alphaproteobacteria, Moraxellaceae, and Acinetobacter than mothers of healthy children. There was a clear correlation between gut microbiome profiles of children and their mothers; however, children with ASD still had unique bacterial biomarkers, such as Alcaligenaceae, Enterobacteriaceae, and Clostridium. Candidate biomarkers discovered in this study had remarkable discriminatory power. The identified patterns of mother–child gut microbiome profiles may be important for assessing risks during the early stage and planning of personalized treatment and prevention of ASD via microbiota modulation. | Ning Li Junjie Yang Jiaming Zhang Cheng Liang Ying Wang Bin Chen Changying Zhao Jingwen Wang Guangye Zhang Dongmei Zhao Yi Liu Lehai Zhang Jun Yang Guimei Li Zhongtao Gai Lei Zhang Guoping Zhao | 2019 | Genomics, Proteomics & Bioinformatics2019，17，1： | 6 |
| 5 | Preparation of Starch Succinate WITH INTERMEDIATE DS BY AQUEOUS SLURRY REACTION显示文摘The succinylation of cornstarch by slurry reaction has been studied using sodium hydroxide as catalyst. Several reaction parameters afJecting the succinylation were investigated including the concentration of starch in water, the ratio of succinic anhydride to starch, the reaction time and the reaction temperature. The favorable conditions for an intermediate degree of substitution (DS) and reasonably high reaction efficiency (RE) are pH 8.5~9.0, 50% starch by weight to water, succinic anhydride to starch I/I (w/w), reaction time 4h, reaction temperature 30 ℃Under these conditions, the DS of 0.45 and RE of 28% were achieved. The addition of an adequate amount of crosslinking agent imparted starch succinate water absorbency. | ZHU Changying WANG Bin ZHAO Fukai CAO Yurong WANG Linfu XU Jiayi Department of Chemistry, NanKai University, Tianjin, 300071, China | 2001 | Chinese Journal of Reactive Polymers2001，10，2： | 5 |
| 6 | An automatic detection of green tide using multi-windows with their adaptive threshold from Landsat TM/ETM plus image显示文摘Since the atmospheric correction is a necessary preprocessing step of remote sensing image before detecting green tide, the introduced error directly affects the detection precision. Therefore, the detection method of green tide is presented from Landsat TM/ETM plus image which needs not the atmospheric correction. In order to achieve an automatic detection of green tide, a linear relationship(y =0.723 x+0.504) between detection threshold y and subtraction x(x=λ_(nir)–λ_(red)) is found from the comparing Landsat TM/ETM plus image with the field surveys.Using this relationship, green tide patches can be detected automatically from Landsat TM/ETM plus image.Considering there is brightness difference between different regions in an image, the image will be divided into a plurality of windows(sub-images) with a same size firstly, and then each window will be detected using an adaptive detection threshold determined according to the discovered linear relationship. It is found that big errors will appear in some windows, such as those covered by clouds seriously. To solve this problem, the moving step k of windows is proposed to be less than the window width n. Using this mechanism, most pixels will be detected[n/k]×[n/k] times except the boundary pixels, then every pixel will be assigned the final class(green tide or sea water) according to majority rule voting strategy. It can be seen from the experiments, the proposed detection method using multi-windows and their adaptive thresholds can detect green tide from Landsat TM/ETM plus image automatically. Meanwhile, it avoids the reliance on the accurate atmospheric correction. | WANG Changying CHU Jialan TAN Meng SHAO Fengjing SUI Yi LI Shujing | 2017 | Acta Oceanologica Sinica2017，36，11： | 3 |
| 7 | Epidemiological Investigation of an Inhalational Anthrax Patient Traveling for Medical Treatment in Beijing Municipality,China,August 2021显示文摘Summary What is already known about this topic?Inhalational anthrax,also known as pulmonary anthrax,is an infectious disease caused by Bacillus anthracis.The patients are usually infected by inhaling aerosolized B.anthracis spores from dead animals or animal products.Compared to cutaneous anthrax,inhalational anthrax is rare and deadly and few cases in China were reported.What is added by this report?This report covers all information of clinical features,laboratory testing,and epidemiological characteristics as well as exposure history of a recent primary inhalational anthrax patient who was seeking medical treatment in Beijing Municipality in August 2021.New laboratory techniques,including second-generation sequencing,polymerase chain reaction,and rapid test for serum antibody,played an important role in the process.What are the implications for public health practice?The information provided in this report,including the correct sample type,epidemiological investigation details,and application of the new diagnostic criteria of anthrax,could assist public health professionals in dealing with anthrax epidemics. | Changying Lin Xiangfeng Dou Daitao Zhang Yinqi Sun Huiqiang Han Chunzhi Chen Xiaojun Zhang Shuang Li Yanwei Chen Hongbin Zhang Bin Wang Zhichao Liang Xin Zhang Feng Wei Jiangli Wang Feng Liu Quanyi Wang Jian Shi Peng Yang | 2022 | China CDC weekly2022，4，1： | 3 |
| 8 | Vibrio parahaemolyticus O10:K4:An Emergent Serotype with Pandemic Virulence Traits as Predominant Clone Detected by Whole-Genome Sequence Analysis--Beijing Municipality,China,2021显示文摘Introduction:Vibrio parahaemolyticus(V.parahaemolyticus)is a common foodborne pathogen which causes gastroenteritis in humans,especially the O3:K6 pandemic clone which is still a prominent serotype in Beijing,China.In this study,we observed a novel serotype O10:K4 isolated from clinical diarrhea cases,which became the most prevalent clone in 2021.Methods:73 clinical isolates were collected through sentinel hospitals’surveillance in 2021.Serum agglutination testing and antimicrobial susceptibility testing were conducted.Whole genome sequencing was applied to characterize 73 V.parahaemolyticus strains and complete phylogenetic analysis.Results:Seven serotypes were identified among 73 strains.O10:K4 was the most common serotype(83.6%),followed by O2:KUT,O4:KUT,and O1:KUT.Multilocus sequence typing divided the 73 isolates into 10 sequence types(STs)with ST3 as the most prevalent,which covered all O10:K4 strains.Most isolates were sensitive to common antimicrobial agents apart from colistin.All the O10:K4 isolates were positive for the thermostable direct hemolysin gene,toxRS/new,and orf8,and negative for the TDH-related hemolysin gene.The whole genome sequencing-single nucleotide polymorphism phylogenetic analysis revealed O10:K4 strains formed a main genetic lineage,which was genetically distinct from other serotypes.We also demonstrated the presence of two type III secretion system genes(T3SS1 and T3SS2)andβlactamase resistance gene blaCARB-22 in all O10:K4 strains.Conclusions:The study confirmed the emergence of V.parahaemolyticus O10:K4 possessing virulence factors similar to the O3:K6 pandemic clone,which may have enabled them to become prevalent in Beijing,China. | Ying Huang Bing Lyu Xin Zhang Yi Tian Changying Lin Lingyu Shen Hanqiu Yan Daitao Zhang Lei Jia Mei Qu Quanyi Wang | 2022 | China CDC weekly2022，4，22： | 2 |
| 9 | A thermal actuated switchable dry adhesive with high reversibility for transfer printing显示文摘Transfer printing based on switchable adhesive that heterogeneously integrates materials is essential to develop novel electronic systems,such as flexible electronics and micro LED displays.Here,we report a robust design of a thermal actuated switchable dry adhesive,which features a stiff sphere embedded in a thermally responsive shape memory polymer(SMP)substrate and encapsulated by an elastomeric membrane.This construct bypasses the unfavorable micro-and nano-fabrication processes and yields an adhesion switchability of over1000 by combining the peel-rate dependent effect of the elastomeric membrane and the thermal actuation of the sub-surface embedded stiff sphere.Experimental and numerical studies reveal the underlying thermal actuated mechanism and provide insights into the design and operation of the switchable adhesive.Demonstrations of this concept in stamps for transfer printing of fragile objects,such as silicon wafers,silicon chips,and inorganic micro-LED chips,onto challenging non-adhesive surfaces illustrate its potential in heterogeneous material integration applications,such as flexible electronics manufacturing and deterministic assembly. | Shun Zhang Hongyu Luo Suhao Wang Zhou Chen Shuang Nie Changying Liu Jizhou Song | 2021 | International Journal of Extreme Manufacturing2021，3，3： | 2 |
| 10 | Simultaneous removal of ammonia, P and COD from anaerobically digested piggery wastewater using an integrated process of chemical precipitation and air stripping显示文摘 | Xuejun Quan Changying Ye Yanqi Xiong Jinxin Xiang Fuping Wang | 2010 | Journal of Hazardous Materials2010，，1： | 2 |
| 11 | Design, Synthesis and Biological Activity of Tetrazole-bearing Uric Acid Transporter 1 Inhibitors显示文摘 | CAI Wenqing LIU Wei XIE Yafei WU Jingwei LIU Yuqiang LIU Changying XU Weiren TANG Lida WANG Jianwu ZHAO Guilong | 2017 | Chemical Research in Chinese Universities2017，33，1： | 2 |
| 12 | Extensively Drug-Resistant(XDR)Salmonella Typhi Outbreak by Waterborne Infection——Beijing Municipality,China,January-February 2022显示文摘Summary What is already known about this topic?Typhoid fever remains a major public health problem in developing countries.Waterborne typhoid fever affects an estimated 27 million people worldwide each year.Decades of indiscriminate antibiotic usage has driven the emergence and spread of multidrug-resistant(MDR)and even extensively drug-resistant(XDR)Salmonella Typhi(S.Typhi)strains. | Yu Wang Dan Lu Yingying Jin Huanxin Wang Bing Lyu Xin Zhang Ying Huang Gaolin Shu Baiwei Liu Changying Lin Hao Zhao Mingqiang Zhao Lingyu Shen Zhiyong Gao Daitao Zhang Quanyi Wang Mei Qu Lei Jia | 2022 | China CDC weekly2022，4，12： | 1 |
| 13 | Coastline Interpretation from Multispectral Remote Sensing Images Using an Association Rule Algorithm显示文摘 | Wang Changying Zhang Jie Ma Yi | | 0，，24： | 1 |
| 14 | Shock spectra and dam- age boundary curves for nonlinear package cushioning system 显示文摘 | Wang Zhiwei Hu Changying | 1999 | Packaging Technology and Science1999，12，5： | 1 |
| 15 | Chromosome-level Genomes Reveal the Genetic Basis of Descending Dysploidy and Sex Determination in Morus Plants显示文摘Multiple plant lineages have independently evolved sex chromosomes and variable karyotypes to maintain their sessile lifestyles through constant biological innovation.Morus notabilis,a dioecious mulberry species,has the fewest chromosomes among Morus spp.,but the genetic basis of sex determination and karyotype evolution in this species has not been identified.In this study,three high-quality genome assemblies were generated for Morus spp.[including dioecious M.notabilis(male and female)and Morus yunnanensis(female)]with genome sizes of 301–329 Mb and were grouped into six pseudochromosomes.Using a combination of genomic approaches,we found that the putative ancestral karyotype of Morus species was close to 14 protochromosomes,and that several chromosome fusion events resulted in descending dysploidy(2n=2x=12).We also characterized a~6.2-Mb sex-determining region on chromosome 3.Four potential male-specific genes,a partially duplicated DNA helicase gene(named MSDH)and three Ty3_Gypsy long terminal repeat retrotransposons(named MSTG1/2/3),were identified in the Y-linked area and considered to be strong candidate genes for sex determination or differentiation.Population genomic analysis showed that Guangdong accessions in China were genetically similar to Japanese accessions of mulberry.In addition,genomic areas containing selective sweeps that distinguish domesticated mulberry from wild populations in terms of flowering and disease resistance were identified.Our study provides an important genetic resource for sex identification research and molecular breeding in mulberry. | Zhongqiang Xia Xuelei Dai Wei Fan Changying Liu Meirong Zhang Peipei Bian Yuping Zhou Liang Li Baozhong Zhu Shuman Liu Zhengang Li Xiling Wang Maode Yu Zhonghuai Xiang Yu Jiang Aichun Zhao | 2022 | Genomics, Proteomics & Bioinformatics2022，20，6： | 1 |
| 16 | Packaging regulation and migration investigation in China显示文摘 | WANG Zhiwei WU Yumei HU Changying | | 0，，4： | 1 |
| 17 | A systematic study on the stability of UV ink photoinitiators in food simulants using GC显示文摘 | WANG Zhiwei HUANG Xiuling HU Changying | | 0，，03： | 1 |
| 18 | Factors affecting migration of contaminants from paper through polymer coating into food simulants显示文摘 | HUANG Xiuling WANG Zhiwei HU Changying | | 0，，： | 1 |
| 19 | Development of software for spectral imaging data acquisition using LabVIEW显示文摘 | WANG Weilin LI Changying TOLLNER E | 2012 | Computers and Electronics in Agriculatre2012，84，11： | 1 |
| 20 | Factors affecting migration of contaminants from paper through polymer coating into food simulants显示文摘 | HUANG Xiuling WANG Zhiwei HU Changying | | 0，，： | 1 |
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