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| 1 | De novo characterization of the root transcriptome of a traditional Chinese medicinal plant Polygonum cuspidatum显示文摘Various active components have been extracted from the root of Polygonum cuspidatum.However,the genetic basis for their activity is virtually unknown.In this study,25600002 short reads (2.3 Gb) of P.cuspidatum root transcriptome were obtained via Illumina HiSeq 2000 sequencing.A total of 86418 unigenes were assembled de novo and annotated.Twelve,18,60 and 54 unigenes were respectively mapped to the mevalonic acid (MVA),methyl-D-erythritol 4-phosphate (MEP),shikimate and resveratrol biosynthesis pathways,suggesting that they are involved in the biosynthesis of pharmaceutically important anthraquinone and resveratrol.Eighteen potential UDP-glycosyltransferase unigenes were identified as the candidates most likely to be involved in the biosynthesis of glycosides of secondary metabolites.Identification of relevant genes could be important in eventually increasing the yields of the medicinally useful constituents of the P.cuspidatum root.From the previously published transcriptome data of 19 non-model plant taxa,1127 shared orthologs were identified and characterized.This information will be very useful for future functional,phylogenetic and evolutionary studies of these plants. | HAO DaCheng MA Pei MU Jun CHEN ShiLin XIAO PeiGen PENG Yong HUO Li XU LiJia SUN Chao | 2012 | Science China(Life Sciences)2012，55，5： | 36 |
| 2 | Suitable growing zone and yield potential for late-maturity type of Yongyou japonica/indica hybrid rice in the lower reaches of Yangtze River, China显示文摘Late-maturity type of Yongyou japonica/indica hybrids series(LMYS) have shown great yield potential, and are being widely planted in the lower reaches of Yangtze River, China. Knowledge about suitable growing zone and evaluation of yield advantage is of practical importance for LMYS in this region. Fifteen LMYS, two high-yielding inbred japonica check varieties(CK-J) and two high-yielding hybrid indica check varieties(CK-I) were grown at Xinghua(119.57°E, 33.05°N) of Lixiahe region, Yangzhou(119.25°E, 32.30°N) of Yanjiang region, Changshu(120.46°E, 31.41°N) of Taihu Lake region, and Ningbo(121.31°E, 29.45°N) of Ningshao Plain in 2013 and 2014. The results showed that maturity dates of the 15 were later than the secure maturity date at Xinghua and 6, 14 and 15 LMYS were mature before the secure maturity date at Yangzhou, Changshu and Ningbo, respectively. One variety was identified as high-yielding variety among LMYS(HYYS) at Yangzhou, 8 HYYS in 2013 and 9 HYYS in 2014 at Changshu, 9 HYYS at Ningbo. HYYS here referred to the variety among LMYS that was mature before the secure maturity date and had at least 8% higher grain yield than both CK-J and CK-I at each experimental site. Grain yield of HYYS at each experimental site was about 12.0 t ha–1 or higher, and was significantly higher than CK varieties. High yield of HYYS was mainly attributed to larger sink size due to more spikelets per panicle. Plant height of HYYS was about 140 cm, and was significantly higher than check varieties. Significant positive correlations were recorded between duration from heading to maturity stage and grain yield, and also between whole growth periods and grain yield. HYYS had obvious advantage over check varieties in biomass accumulation and leaf area duration from heading to maturity stage. Comprehensive consideration about safe maturity and yield performance of LMYS at each experimental site, Taihu Lake region(representative site Changshu) and Ningshao Plain(representative site Ningbo) were thought suitable growing zones for LMYS in the lower reaches of Yangtze River. The main factors underlying high yield ofHYYS were larger sink size, higher plant height, longer duration from heading to maturity stage and whole growth periods, and higher biomass accumulation and leaf area duration during grain filling stage. | WEI Huan-he | 2016 | Journal of Integrative Agriculture2016，15，1： | 13 |
| 3 | Petroleum Migration Direction of the Silurian Paleo-pools in the Tarim Basin, Northwest China显示文摘摘要:在这份报纸获得的结果显示 carbazole 类型混合物有高热的稳定性并且也在氧化和简历降级显示出稳定性。这种混合物仍然在分析干燥沥青样品有高集中和完全的分发,证明他们在学习 paleo 水池的石油移植是特别地有用的。在期间盆在在 Tarim 盆的 Tazhong 和 Tabei 区域的志留纪的油气体水池形成是第一阶段的(在志留纪时期的结束) 并且在 Awati 区域的秒阶段(在里面二叠) ,石油经历了长途的迁居。在志留纪的结束在在 Tazhong 的志留纪 paleo 水池的形成期间高举,石油主要在 Manjiaer 来自更低、中间的寒武纪的来源岩石下垂。石油向首先在 Tazhong 进入志留纪水库床的西南南方移居了。然后,它进一步沿着结构的带的高度从西北在志留纪以内移居了到东南到在 Tazhong 的志留纪 pinchout 边界的区域。在 Tabei 高举,在期间水池形成第一阶段,石油也从在 Manjiaer 的更低、中间的寒武纪的来源岩石下垂。它移植了西北进入在 Tabei 的志留纪水库床第一高举,然后迁居在志留纪水库以内在一样的方向继续,最后,石油在更高的位置被套住。在在志留纪的秒阶段水池形成期间,在在 Awati 附近的区域的床下垂,石油主要在 Awati 来自降低中间的寒武纪的来源岩石下垂。石油通过主要路径在 sag 附近在所有方向从产生中心移居了到志留纪水库,并且石油最后在更高的地点被套住。 | LIU Luofu ZHAO Yande HUO Hong CHEN Lixin CHEN Yuanzhuang ZHAO Suping LI Chao LI Shuangwen GUO Yongqiang LI Yan Key Lab for Hydrocarbon Accumulation Mechanism in the China University of Petroleum,Ministry of Education Basin and Reservoir Research Center, China University of Petroleum,Beijing 102249, China | 2008 | Acta Geologica Sinica(English Edition)2008，82，1： | 12 |
| 4 | Formation mechanism of streamer discharges in liquids:a review显示文摘Streamer discharges in liquids have received lots of attention with respect to their considerable applications invarious disciplines. Much effort has been spent to understand the basis of streamer ignition and propagation in dielectricliquids, but a comprehensive mechanism is far from conclusive. In this review, based on an introduction to the streamerphysics and experimentally observed characteristics in various liquids, the authors emphasise on the current status ofstreamer discharge ignition mechanisms and present their understanding for each theory. | Anbang Sun Chao Huo Jie Zhuang | 2016 | High Voltage2016，1，2： | 7 |
| 5 | Prevalence and treatment of hypertension in China: impacts of 2017 American College of Cardiology/American Heart Association High Blood Pressure Guideline显示文摘The definition, recommended treatment thresholds and targets of hypertension have been updated in the recent 2017 American College of Cardiology/American Heart Association(ACC/AHA) Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults. However,the impacts of this guideline on Chinese population are currently unknown. In this study, we aim to provide updated data in China using criteria from the updated guideline. A multistage, stratified sampling method was used to obtain a representative sample of 50,171 adults aged 18 years and above.Hypertension was defined as an average systolic blood pressure !130 mm Hg, or an average diastolic blood pressure !80 mm Hg, or self-reported use of antihypertensive medications in past 2 weeks. The weighted prevalence of hypertension was 60.1%(95% confidence interval [CI] 59.3%–61.0%). The treatment rate and recommended treatment rate were 16.8%(95% CI 16.1%–17.6%) and 53.7%(95% CI52.6%–54.9%), respectively; the gap was more prominent among men and participants from rural areas.Hence, the adoption of the 2017 ACC/AHA guideline will lead to a substantial increase in both prevalence and number of patients needing treatment in China. The applicability of this guideline should be carefully evaluated based on evidence from Chinese population. | Chao Yang Jinwei Wang Bixia Gao Yan Zhang Fang Wang Luxia Zhang Minghui Zhao Yong Huo | 2018 | Science Bulletin2018，63，8： | 7 |
| 6 | Morphological and physiological traits of large-panicle rice varieties with high filled-grain percentage显示文摘Understanding the morphological and physiological traits associated with improved filling efficiency in large-panicle rice varieties is critical to devise strategies for breeding programs and cultivation management practices.Information on such traits,however,remains limited.Two large-panicle varieties with high filled-grain percentage(HF) and two check large-panicle varieties with low filled-grain percentage(LF) were field-grown in 2012 and 2013.The number of spikelets per panicle of HF and LF both exceeded 300,and the filled-grain percentage(%) of HF was approximately 90,while that of LF was approximately 75 over the two years.The results showed that when the values were averaged across two years,HF yielded 12.91 ha^(-1),while LF yielded 11.01 ha^(-1).HF had a greater leaf area duration,biomass accumulation and transport of carbohydrates stored in the culm to the grains from heading to maturity compared with LF.HF exhibited a higher leaf photosynthetic rate,more green leaves on the culm,and higher root activity during filling phase,especially during the middle and late filling phases,in relative to LF.The length of HF for upper three leaves was significantly higher than that of LF,while the angle of upper three leaves on the main culm was less in both years.Meanwhile,specific leaf weight of HF was significantly higher when compared with LF.In addition,the grain filling characteristics of HF and LF were investigated in our study.Our results suggested that a higher leaf photosynthetic rate and root activity during filling phase,greater biomass accumulation and assimilate transport after heading,and longer,thicker and more erect upper three leaves were important morphological and physiological traits of HF,and these traits could be considered as selection criterion to develop large-panicle varieties with high filled-grain percentage. | MENG Tian-yao WEI Huan-he LI Chao DAI Qi-gen XU Ke HUO Zhong-yang WEI Hai-yan GUO Bao-wei ZHNAG Hong-cheng | 2016 | Journal of Integrative Agriculture2016，15，8： | 6 |
| 7 | Correlation analysis between the chemical contents and bioactivity for the quality control of Alismatis Rhizoma显示文摘In order to clarify regions of production and to discriminate processing methods, quantitative and qualitative analyses for saccharides and terpenes in 35 batches of Alismatis Rhizoma were performed.Methodologies included HPLC–PDA, HPLC–VWD and UHPLC–MSn, combined with principal component analysis(PCA) and partial least squares regression techniques(PLSR). The inhibitory effects of triterpenes and Alismatis Rhizoma extracts on lipase activity were evaluated in vitro. PLSR analysis revealed significant positive correlations(R2= 0.5795) between the contents of triterpenes 10, 14, 15, 18 and 22 and the inhibitory effects of Alismatis Rhizoma. The present study establishes an effective method for simultaneous determination of multiple components, and identifies key bioactive triterpenes. These results can be used for systematic and novel analytical strategies for the quality control of Alismatis Rhizoma production. | Xiaoxv Gao Chengpeng Sun Zhenglong Yu Jian Cang Xiangge Tian Xiaokui Huo Lei Feng Xinguang Liu Chao Wang Baojing Zhang Xiaochi Ma | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 4 |
| 8 | Severe human infection with a novel avian-origin influenza A(H7N4) virus显示文摘Human infections with influenza H7 subtypes, such as H7N9, have raised concerns worldwide. Here, we report a human infection with a novel influenza A(H7N4) virus. A 68 years-old woman with cardiovascular and cholecystic comorbidities developed rapidly progressed pneumonia with influenza-like-illness as initial symptom, recovered after 23 days-hospitalization including 8 days in ICU. Laboratory indicators for liver and blood coagulation dysfunction were observed. Oseltamivir phosphate, glucocorticoids and antibiotics were jointly implemented, with nasal catheterization of oxygen inhalation for this patient.We obtained the medical records and collected serial respiratory and blood specimens from her. We collected throat, cloacal and/or feces samples of poultry and wild birds from the patient's backyard, neighborhood, local live poultry markets(LPMs) and the nearest lake. All close contacts of the patient were followed up and sampled with throat swabs and sera. Influenza viruses and other respiratory pathogens were tested by real-time RT-PCR, viral culturing and/or sequencing for human respiratory and bird samples. Micro-neutralizing assay was performed for sera. A novel reassortant wild bird-origin H7N4 virus is identified from the patient and her backyard poultry(chickens and ducks) by sequencing, which is distinct from previously-reported avian H7N4 and H7N9 viruses. At least four folds increase of neutralizing antibodies to H7N4 was detected in her convalescent sera. No samples from close contacts, wild birds or other poultry were tested positive for H7N4 by real-time RT-PCR. | Xiang Huo Lun-biao Cui Cong Chen Dayan Wang Xian Qi Ming-hao Zhou Xiling Guo Fengming Wang William J. Liu Weirong Kong Daxin Ni Ying Chi Yiyue Ge Haodi Huang Feifei Hu Chao Li Xiang Zhao Ruiqi Ren Chang-jun Bao George F. Gao Feng-Cai Zhu | 2018 | Science Bulletin2018，63，16： | 4 |
| 9 | An assessment of the genetic diversity of pear(Pyrus L.)germplasm resources based on the fruit phenotypic traits显示文摘Germplasm resources are an important basis for genetic breeding and analysis of complex traits,and research on genetic diversity is conducive to the exploration and creation of new types of germplasm.In this study,the distribution frequency,coefficient of variation,Shannon-Wiener index,and variance and cluster analyses were used to analyze the diversity and trait differences of 39 fruit phenotypic traits from 570 pear accessions,which included 456 pear accessions from 11 species and 114 interspecific hybrid cultivars that had been stored in the National Germplasm Repository of Apple and Pear(Xingcheng,China).The comprehensive evaluation indices were screened by correlation,principal component and regression analyses.A total of 132 variant types were detected in 28 categorical traits of pear germplasm fruit,which indicate a rich diversity.The diversity indices in decreasing order were:fruit shape(1.949),attitude of calyx(1.908),flesh texture type(1.700),persistency of calyx(1.681),russet location(1.658),relief of area around eye basin(1.644),flavor(1.610)and ground color(1.592).The coefficient of variation of titratable acidity in the 11 numerical traits of pear germplasm fruit was as high as 128.43%,which could more effectively reflect the differences between pear accessions.The phenotypic differentiation coefficient V_(st)(66.4%)among the five cultivated pear species,including Pyrus bretschneideri(White Pear),P.pyrifolia(Sand Pear),P.ussuriensis(Ussurian Pear),P.sinkiangensis(Xinjiang Pear),and P.communis(European Pear),was higher than the within population phenotypic differentiation coefficient V_(st)(33.6%).The variation among populations was the main source of variation in pear fruit traits.A hierarchical cluster analysis divided the 389 accessions of six cultivated pear species,including P.pashia(Himalayan Pear),into six categories.There were certain characteristics within the populations,and the differences between populations were not completely clustered by region.For example,Sand Pear cultivars from Japan and the Korean Peninsula clustered together with those from China.Most of the White Pear cultivars clustered with the Sand Pear,and a few clustered with the Ussurian Pear cultivars.The Ussurian Pear and European Pear cultivars clustered separately.The Xinjiang Pear and Himalayan Pear did not cluster together,and neither did the cultivars.Seventeen traits,three describing fruit weight and edible rate(fruit diameter,fruit length and fruit core size),five describing outer quality and morphological characteristics(over color,amount of russeting,dot obviousness,fruit shape,and stalk length),and nine describing inner quality(flesh color,juiciness of flesh,aroma,flavor,flesh texture,flesh texture type,soluble solid contents,titratable acidity,and eating quality)were selected from the 39 traits by principal component and stepwise regression analyses.These 17 traits could reflect 99.3%of the total variation and can be used as a comprehensive evaluation index for pear germplasm resources. | ZHANG Ying CAO Yu-fen HUO Hong-liang XU Jia-yu TIAN Lu-ming DONG Xing-guang QI Dan LIU Chao | 2022 | Journal of Integrative Agriculture2022，21，8： | 4 |
| 10 | DDX3X regulates cell survival and cell cycle during mouse early embryonic development显示文摘DDX3X is a highly conserved DEAD-box RNA helicase that participates in RNA transcription,RNA splicing,and mRNA transport,translation,and nucleo-cytoplasmic transport.It is highly expressed in metaphaseⅡ(MⅡ)oocytes and is the predominant DDX3 variant in the ovary and embryo.However,whether it is important in mouse early embryo development remains unknown.In this study,we investigated the function of DDX3X in early embryogenesis by cytoplasmic microinjection with its siRNA in zygotes or single blastomeres of 2-cell embryos.Our results showed that knockdown of Ddx3x in zygote cytoplasm led to dramatically diminished blastocyst formation,reduced cell numbers,and an increase in the number of apoptotic cells in blastocysts.Meanwhile,there was an accumulation of p53 in RNAi blastocysts.In addition,the ratio of cell cycle arrest during 2-cell to 4-cell transition increased following microinjection of Ddx3x siRNA into single blastomeres of 2-cell embryos compared with control.These results suggest that Ddx3x is an essential gene associated with cell survival and cell cycle control in mouse early embryos,and thus plays key roles in normal embryo development. | Qian Li Pan Zhang Chao Zhang Ying Wang Ru Wan Ye Yang Xuejiang Guo Ran Huo Min Lin Zuomin Zhou Jiahao Sha | 2014 | The Journal of Biomedical Research2014，28，4： | 4 |
| 11 | Distributing disciplinarian of ground motion parameters on an earth fissure site during strong earthquakes显示文摘To investigate the distributing disciplinarian of ground motion parameters on the earth fissure site during strong earthquakes,a series of shaking table tests were designed and conducted based on 1:15 scaled models.Test results showed significant differences in the ground motion parameters(including ground motion intensity indices,spectrum characteristics and strong motion duration)between the hanging-wall and footwall caused by the earth fissure.Acceleration response,displacement response and Arias Intensity response on both sides of earth fissure indicated that the earth fissure site on the hanging-wall was destroyed more seriously.The distributing disciplinarian of amplification factors showed clear'hangingwall and footwall effects',which were more remarkable nearby the fissure zones.The low-frequency component of the seismic wave was richer after selectively filtering in the soil medium.By comparing the predominant period and mean period of the hanging-wall and footwall,it was found that vibration frequency on the hanging-wall was greater than that on the footwall.Minimum values of strong motion duration were recorded on the hanging-wall close to the fissure and increased from the fissure to both sides. | Xiong Zhongming Zhang Chao Huo Xiaopeng Chen Xuan J.Jorge Ochoa | 2020 | Earthquake Engineering and Engineering Vibration2020，19，3： | 4 |
| 12 | POA-FPRMs: Power Optimization Approach of Fixed Polarity Reed-Muller Expressions for Incompletely Specified Boolean Functions显示文摘Fixed polarity Reed-Muller(RM)expression(FPRM)has several practical applications due to its multitude of properties.In order to generate an FPRM with minimum power,based on a genetic algorithm,we propose a Power optimization approach(POA-FPRMs)of Fixed Polarity RM expressions for incompletely specified Boolean functions.Simulation results on MCNC benchmark circuits show that POAFPRMs can effectively reduce power,compared with the traditional polarity optimization approach,where the don't care terms are neglected. | HE Zhenxue XIAO Limin HUO Zhisheng WANG Chao LIU Jia WANG Xiang | 2019 | Chinese Journal of Electronics2019，28，6： | 3 |
| 13 | Development of machine learning multi-city model for municipal solid waste generation prediction显示文摘Integrated management of municipal solid waste(MSW)is a major environmental challenge encountered by many countries.To support waste treatment/management and national macroeconomic policy development,it is essential to develop a prediction model.With this motivation,a database of MSW generation and feature variables covering 130 cities across China is constructed.Based on the database,advanced machine learning(gradient boost regression tree)algorithm is adopted to build the waste generation prediction model,i.e.,WGMod.In the model development process,the main influencing factors on MSW generation are identified by weight analysis.The selected key influencing factors are annual precipitation,population density and annual mean temperature with the weights of 13%,11%and 10%,respectively.The WGMod shows good performance with R^(2)=0.939.Model prediction on MSW generation in Beijing and Shenzhen indicates that waste generation in Beijing would increase gradually in the next 3–5 years,while that in Shenzhen would grow rapidly in the next 3 years.The difference between the two is predominately driven by the different trends of population growth. | Wenjing Lu Weizhong Huo Huwanbieke Gulina Chao Pan | 2022 | Frontiers of Environmental Science & Engineering2022，16，9： | 3 |
| 14 | A highly selective fluorescent probe for real-time imaging of UDP-glucuronosyltransferase 1A8 in living cells and tissues显示文摘Uridine diphosphate(UDP)-glucuronosyltransferases(UGTs)are enzymes involved in the biotransformation of important endogenous compounds such as steroids,bile acids,and hormones as well as exogenous substances including drugs,environmental toxicants,and carcinogens.Here,a novel fluorescent probe BDMP was developed based on boron-dipyrromethene(BODIPY)with high sensitivity for the detection of UGT1A8.The glucuronidation of BDMP not only exhibited a redemission wavelength(lex/lem=500/580 nm),but also displayed an excellent UGT1A8-dependent fluorescence signal with a good linear relationship with UGT1A8 concentration.Based on this perfect biocompatibility and cell permeability,BDMP was successfully used to image endogenous UGT1A8 in human cancer cell lines(LoVo and HCT15)in real time.In addition,BDMP could also be used to visualize UGT1A8 in tumor tissues.These results suggested that BDMP is a promising molecular tool for the investigation of UGT1A8-mediated physiological function in humans. | Mingyue Zhu Zhenhao Tian Lingling Jin Xiaokui Huo Chao Wang Jingnan Cui Yan Tian Xiangge Tian Lei Feng | 2022 | Frontiers of Chemical Science and Engineering2022，16，1： | 3 |
| 15 | The first data release(DR1) of the LAMOST regular survey显示文摘The Large sky Area Multi-Object Fiber Spectroscopic Telescope(LAMOST) general survey is a spectroscopic survey that will eventually cover approximately half of the celestial sphere and collect 10 million spectra of stars, galaxies and QSOs. Objects in both the pilot survey and the first year regular survey are included in the LAMOST DR1. The pilot survey started in October 2011 and ended in June 2012, and the data have been released to the public as the LAMOST Pilot Data Release in August 2012. The regular survey started in September 2012, and completed its first year of operation in June 2013. The LAMOST DR1 includes a total of 1202 plates containing 2 955 336 spectra, of which 1 790 879 spectra have observed signalto-noise ratio(SNR) ≥ 10. All data with SNR ≥ 2 are formally released as LAMOST DR1 under the LAMOST data policy. This data release contains a total of 2 204 696 spectra, of which 1 944 329 are stellar spectra, 12 082 are galaxy spectra and 5017 are quasars. The DR1 not only includes spectra, but also three stellar catalogs with measured parameters: late A,FGK-type stars with high quality spectra(1 061 918 entries), A-type stars(100 073 entries), and M-type stars(121 522 entries). This paper introduces the survey design, the observational and instrumental limitations, data reduction and analysis, and some caveats. A description of the FITS structure of spectral files and parameter catalogs is also provided. | A-Li Luo Yong-Heng Zhao Gang Zhao Li-Cai Deng Xiao-Wei Liu Yi-Peng Jing Gang Wang Hao-Tong Zhang Jian-Rong Shi Xiang-Qun Cui Yao-Quan Chu Guo-Ping Li Zhong-Rui Bai Yue Wu Yan Cai Shu-Yun Cao Zi-Huang Cao Jeffrey L.Carlin Hai-Yuan Chen Jian-Jun Chen Kun-Xin Chen Li Chen Xue-Lei Chen Xiao-Yan Chen Ying Chen Norbert Christlieb Jia-Ru Chu Chen-Zhou Cui Yi-Qiao Dong Bing Du Dong-Wei Fan Lei Feng Jian-Ning Fu Peng Gao Xue-Fei Gong Bo-Zhong Gu Yan-Xin Guo Zhan-Wen Han Bo-Liang He Jin-Liang Hou Yong-Hui Hou Wen Hou Hong-Zhuan Hu Ning-Sheng Hu Zhong-Wen Hu Zhi-Ying Huo Lei Jia Fang-Hua Jiang Xiang Jiang Zhi-Bo Jiang Ge Jin Xiao Kong Xu Kong Ya-Juan Lei Ai-Hua Li Chang-Hua Li Guang-Wei Li Hai-Ning Li Jian Li Qi Li Shuang Li Sha-Sha Li Xin-Nan Li Yan Li Yin-Bi Li Ye-Ping Li Yuan Liang Chien-Cheng Lin Chao Liu Gen-Rong Liu Guan-Qun Liu Zhi-Gang Liu Wen-Zhi Lu Yu Luo Yin-Dun Mao Heidi Newberg Ji-Jun Ni Zhao-Xiang Qi Yong-Jun Qi Shi-Yin Shen Huo-Ming Shi Jing Song Yi-Han Song Ding-Qiang Su Hong-Jun Su Zheng-Hong Tang Qing-Sheng Tao Yuan Tian Dan Wang Da-Qi Wang Feng-Fei Wang Guo-Min Wang Hai Wang Hong-Chi Wang Jian Wang Jia-Ning Wang Jian-Ling Wang Jian-Ping Wang Jun-Xian Wang Lei Wang Meng-Xin Wang Shou-Guan Wang Shu-Qing Wang Xia Wang Ya-Nan Wang You Wang Yue-Fei Wang You-Fen Wang Peng Wei Ming-Zhi Wei Hong Wu Ke-Fei Wu Xue-Bing Wu Yu-Zhong Wu Xiao-Zheng Xing Ling-Zhe Xu Xin-Qi Xu Yan Xu Tai-Sheng Yan De-Hua Yang Hai-Feng Yang Hui-Qin Yang Ming Yang Zheng-Qiu Yao Yong Yu Hui Yuan Hai-Bo Yuan Hai-Long Yuan Wei-Min Yuan Chao Zhai En-Peng Zhang Hua-Wei Zhang Jian-Nan Zhang Li-Pin Zhang Wei Zhang Yong Zhang Yan-Xia Zhang Zheng-Chao Zhang Ming Zhao Fang Zhou Xu Zhou Jie Zhu Yong-Tian Zhu Si-Cheng Zou Fang Zuo | 2015 | Research in Astronomy and Astrophysics2015，15，8： | 2 |
| 16 | Arenobufagin is a novel isoform-specific probe for sensing human sulfotransferase 2A1显示文摘Human cytosolic sulfotransferase 2 A1(SULT2A1) is an important phase II metabolic enzyme. The detection of SULT2A1 is helpful for the functional characterization of SULT2A1 and diagnosis of its related diseases. However, due to the overlapping substrate specificity among members of the sulfotransferase family, it is difficult to develop a probe substrate for selective detection of SULT2A1. In the present study, through characterization of the sulfation of series of bufadienolides, arenobufagin(AB) was proved as a potential probe substrate for SULT2A1 with high sensitivity and specificity. Subsequently, the sulfation of AB was characterized by experimental and molecular docking studies. The sulfate-conjugated metabolite was identified as AB-3-sulfate.The sulfation of AB displayed a high selectivity for SULT2A1 which was confirmed by in vitro reaction phenotyping assays. The sulfation of AB by human liver cytosols and recombinant SULT2A1 both obeyed Michaelis-Menten kinetics, with similar kinetic parameters. Molecular docking was performed to understand the interaction between AB and SULT2A1, in which the lack of interaction with Met-137 and Tyr-238 of SULT2A1 made it possible to eliminate substrate inhibition of AB sulfation. Finally, the probe was successfully used to determine the activity of SULT2A1 and its isoenzymes in tissue preparations of human and laboratory animals. | Xiangge Tian Chao Wang Peipei Dong Yue An Xinyu Zhao Weiru Jiang Gang Wang Jie Hou Lei Feng Yan Wang Guangbo Ge Xiaokui Huo Jing Ning Xiaochi Ma | 2018 | Acta Pharmaceutica Sinica B2018，8，5： | 2 |
| 17 | Mechanism of Silurian Hydrocarbon Pool Formation in the Tarim Basin显示文摘There are three formation stages of Silurian hydrocarbon pools in the Tarim Basin. The widely distributed asphaltic sandstones in the Tazhong (central Tarim) and Tabei (northern Tarim) areas are the results of destruction of hydrocarbon pools formed in the first-stage,and the asphaltic sandstones around the Awati Sag were formed in the second-stage. The hydrocarbon migration characteristics reflected by the residual dry asphalts could represent the migration characteristics of hydrocarbons in the Silurian paleo-pools,while the present movable oil in the Silurian reservoirs is related to the later-stage (the third-stage) hydrocarbon accumulation. | Liu Luofu Chen Yuanzhuang Chen Lixin Pang Xiongqi Xie Qilai Huo Hong Zhao Suping Li Chao Li Shuangwen Guo Yongqiang Zhao Yande Li Yan | 2007 | Petroleum Science2007，4，4： | 2 |
| 18 | Inverted U-Shaped Associations between Glycemic Indices and Serum Uric Acid Levels in the General Chinese Population:Findings from the China Cardiometabolic Disease and Cancer Cohort(4C)Study显示文摘Objective The relationship between serum uric acid(SUA)levels and glycemic indices,including plasma glucose(FPG),2-hour postload glucose(2 h-PG),and glycated hemoglobin(HbA1 c),remains inconclusive.We aimed to explore the associations between glycemic indices and SUA levels in the general Chinese population.Methods The current study was a cross-sectional analysis using the first follow-up survey data from The China Cardiometabolic Disease and Cancer Cohort Study.A total of 105,922 community-dwelling adults aged≥40 years underwent the oral glucose tolerance test and uric acid assessment.The nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive models.Results A total of 30,941 men and 62,361 women were eligible for the current analysis.Generalized additive models verified the inverted U-shaped association between glycemic indices and SUA levels,but with different inflection points in men and women.The thresholds for FPG,2 h-PG,and HbA1 c for men and women were 6.5/8.0 mmol/L,11.0/14.0 mmol/L,and 6.1/6.5,respectively(SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices).Conclusion An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes,while the inflection points were reached earlier in men than in women. | ZHU Yuan Yue ZHENG Rui Zhi WANG Gui Xia CHEN Li SHI Li Xin SU Qing XU Min XU Yu CHEN Yu Hong YU Xue Feng YAN Li WANG Tian Ge ZHAO Zhi Yun QIN Gui Jun WAN Qin CHEN Gang GAO Zheng Nan SHEN Fei Xia LUO Zuo Jie QIN Ying Fen HUO Ya Nan LI Qiang YE Zhen ZHANG Yin Fei LIU Chao WANG You Min WU Sheng Li YANG Tao DENG Hua Cong ZHAO Jia Jun CHEN Lu Lu MU Yi Ming TANG Xu Lei HU Ru Ying WANG Wei Qing NING Guang LI Mian LU Jie Li BI Yu Fang | 2021 | Biomedical and Environmental Sciences2021，34，1： | 2 |
| 19 | ITS sequence analysis used for molecular identification of the Bupleurum species from northwestern China显示文摘 | Yang ZY Chao Z Huo KK | | 0，，： | 1 |
| 20 | ITS sequence analysis used for molecular identification of the Bupleurum species from northwestern China显示文摘 | Yang Zhiye Chao Zhi Huo Keke | 2007 | Phytomedicine2007，14，： | 1 |
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