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| 1 | Dysfunction of PLA2G6 and CYP2C44-associated network signals imminent carcinogenesis from chronic inflammation to hepatocellular carcinoma显示文摘很少长期的发炎怎么贡献 hepatocellular 癌(HCC ) 的前进被知道,特别癌症的开始。揭开从长期的发炎的批评转变到在网络水平的 HCC 和分子的机制,我们用我们的动态网络 biomarker (DNB ) 分析了土拨鼠肝炎 virus/c-myc 鼠标和匹配年龄的 wt-C57BL/6 鼠标的时间系列 proteomic 数据模型。DNB 分析显示在转基因的老鼠的出生以后的第 5 月是癌症开始的批评时期,就在批评转变前,它与临床的症状一致。同时,联系 DNB 的网络在批评转变前后显示出蛋白质表示和 coexpression 层次的激烈的倒置。DNB, PLA2G6 和 CYP2C44 的二个成员,与他们的联系差别一起表示了蛋白质,被发现导致 arachidonic 酸新陈代谢的机能障碍,进一步通过短暂受体潜力隧道的煽动性的调停人规定激活煽动性的回答,并且最后导致肝 detoxification 和恶意的转变的缺陷到癌症。作为一个 c-Myc 目标, PLA2G6 断然在表示与 c-Myc 相关,显示出从减少到在 carcinogenesis 期间增加的一个趋势,与在批评转变的最小的点或付小费给的点。相应 PLA2G6 和 c-Myc 的如此的趋势也在人的 hepatocarcinogenesis 期间被观察,与在高级 dysplastic 小瘤(就在 carcinogenesis 前的一个阶段) 的最小的点。我们的学习暗示 PLA2G6 可能在 hepatocarcinogenesis 期间作为象著名 c-Myc 一样的 oncogene 工作,当 PLA2G6 和 c-Myc 的 downregulation 能是显示逼近的 carcinogenesis 的一个警告信号时。 | Meiyi Li Chen Li Wei-Xin Liu Conghui Liu Jingru Cui Qingrun Li Hong Ni Yingcheng Yang Chaochao Wu Chunlei Chen Xing Zhen Tao Zeng Mujun zhao Lei Chen Jiarui Wu Rong Zeng Luonan Chen | 2017 | Journal of Molecular Cell Biology2017，9，6： | 12 |
| 2 | Isolation and characterization of Toxoplasma gondii strains from stray cats revealed a single genotype in Beijing, China显示文摘 | Weifeng Qian Hui Wang Chunlei Su Dan Shan Xia Cui Na Yang Chaochao Lv Qun Liu | 2012 | Veterinary Parasitology (-)2012，，3： | 2 |
| 3 | Tailoring spin mixtures by ion-enhanced Maxwell magnetic coupling in colortunable organic electroluminescent devices显示文摘In this work,we show that the spin dynamics of excitons can be dramatically altered by Maxwell magnetic field coupling,together with an ion-enhanced,low-internal-splitting-energy organic semiconducting emitter.By employing a unique,alternating current(AC)-driven organic electroluminescent(OEL)device architecture that optimizes this magnetic field coupling,almost complete control over the singlet-to-triplet ratio(from fluorescent to phosphorescent emission in a single device)is realized.We attribute this spin population control to magnetically sensitive polaron–spin pair intersystem crossings(ISCs)that can be directly manipulated through external driving conditions.As an illustration of the utility of this approach to spin-tailoring,we demonstrate a simple hybrid(double-layer)fluorescence–phosphorescence(F–P)device using a polyfluorene-based emitter with a strong external Zeeman effect and ion-induced long carrier diffusion.Remarkable control over de-excitation pathways is achieved by controlling the device-driving frequency,resulting in complete emission blue–red color tunability.Picosecond photoluminescence(PL)spectroscopy directly confirms that this color control derives from the magnetic manipulation of the singlet-totriplet ratios.These results may pave the way to far more exotic organic devices with magnetic-field-coupled organic systems that are poised to usher in an era of dynamic spintronics at room temperature. | Junwei Xu Yue Cui Gregory M.Smith Peiyun Li Chaochao Dun Linqi Shao Yang Guo Hongzhi Wang Yonghua Chen David L.Carroll | 2018 | Light(Science & Applications)2018，7，1： | 2 |
| 4 | Suppressing trap states and energy loss by optimizing vertical phase distribution through ternary strategy in organic solar cells显示文摘Suppressing the trap-state density and the energy loss via ternary strategy was demonstrated.Favorable vertical phase distribution with donors(acceptors)accumulated(depleted)at the interface of active layer and charge extraction layer can be obtained by introducing appropriate amount of polymer acceptor N2200 into the systems of PBDB-T:IT-M and PBDB-TF:Y6.In addition,N2200 is gradiently distributed in the vertical direction in the ternary blend film.Various measurements were carried out to study the effects of N2200 on the binary systems.It was found that the optimized morphology especially in vertical direction can significantly decrease the trap state density of the binary blend films,which is beneficial for the charge transport and collection.All these features enable an obvious decrease in charge recombination in both PBDB-T:IT-M and PBDB-TF:Y6 based organic solar cells(OSCs),and power conversion efficiencies(PCEs)of 12.5%and 16.42%were obtained for the ternary OSCs,respectively.This work indicates that it is an effective method to suppress the trap state density and thus improve the device performance through ternary strategy. | Pengqing Bi Shaoqing Zhang Tong Xiao Minghuan Cui Zhihao Chen Junzhen Ren Chaochao Qin Guanghao Lu Xiaotao Hao Jianhui Hou | 2021 | Science China Chemistry2021，64，4： | 1 |
| 5 | Seaweed Fiber Fabricated with Agar Alkali-Free Extracted from Gracilaria lemaneiformis显示文摘The sulfate groups in agar structure played a good role in the formation of fiber.However,commercially available agar is usually extracted from red algae by alkali treatment to decrease the content of sulfate group for the purpose of high gel strength.In this paper,an alkali-free method of agar extraction from Gracilaria lemaneiformis was proposed for the wet-spinning purpose.This method is environmentally friendly,reduces the extraction steps,saves energy,and reduces the production cost of agar fiber.The improved agar preparation process not only has higher agar yield,but also has higher molecular weight and sulfate group content,which is beneficial to the preparation and forming of fiber and makes the fiber have higher mechanical strength and elongation.Therefore,this extraction technology has broad application prospect in the textile field. | Yuzhi Wu Cunzhen Geng Chaochao Cui Zhefeng Xin Yanzhi Xia Zhixin Xue | 2023 | Journal of Renewable Materials2023，11，3： | 0 |
| 6 | Tuning coherent phonon dynamics in two-dimensional phenylethylammonium lead bromide perovskites显示文摘Organic-inorganic layered perovskites are two-dimensional quantum well layers in which the layers of lead halide octahedra are stacked between the organic cation layers.The packing geometry of the soft organic molecules and the stiff ionic crystals induce structural deformation of the inorganic octahedra,generating complex lattice dynamics.Especially,the dielectric confinement and ionic sublattice lead to strong coupling between the photogenerated excitons and the phonons from the polar lattice which intensively affects the properties for device applications.The anharmonicity and dynamic disorder from the organic cations participate in the relaxation dynamics coupled with excitations.However,a detailed understanding of this underlying mechanism remains obscure.This work investigates the electron–optical phonon coupling dynamics by employing ultrafast pump-probe transient absorption spectroscopy.The activated different optical phonon modes are observed via systematic studies of(PEA)_(2)PbBr_(4) perovskite films on the ultrafast lattice vibrational dynamics.The experimental results indicate that solvent engineering has a significant influence on lattice vibrational modes and coherent phonon dynamics.This work provides fresh insights into electron-optical phonon coupling for emergent optoelectronics development based on layered perovskites. | Minghuan Cui Chaochao Qin Zhongpo Zhou Yuanzhi Jiang Shichen Zhang Zeye Yuan Mingjian Yuan Kun Yu Yuhai Jiang Yufang Liu | 2023 | Nano Research2023，16，2： | 0 |
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