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| 1 | Jagged-1/Notch3 signaling transduction pathway is involved in apelin-13-induced vascular smooth muscle cells proliferation显示文摘apelin/apelin 受体(APJ, apelinangiotensin 像受体 1 ) 系统是一最新 deorphanized G 联合蛋白质的受体系统。是重要规章的因素的 apelin 和 APJ 在心血管的系统被表示。我们的以前的研究显著地表明了那 apelin-13 刺激脉管的光滑的肌肉房间(VSMC ) 增长。在这份报纸,我们的数据建议表明 transduction 小径的 Jagged-1/Notch3 被支持 Cyclin D1 的表示涉及 apelin-13-induced VSMC 增长。结果显示 apelin-13 在集中依赖者和时间依赖者礼貌刺激 VSMC 和 Jagged-1 和 Notch3 的表示的增长。apelin-13 导致的 Jagged-1 和 Notch3 的增加的表示能被细胞外的调整信号的蛋白质 kinase (英皇家空军之阶级最低之兵) 废除封锁。PD98059 (英皇家空军之阶级最低之兵禁止者) 能禁止 apelin-13 导致的 Jagged-1/Notch3 的激活。用小介入 RNA 的 Notch3 的下面规定禁止 Cyclin D1 的表示并且阻止 apelin-13-induced VSMC 增长。在结论, Jagged-1/Notch3 发信号 transduction 小径涉及 apelin-13 导致的 VSMC 增长。 | Lifang Li Lanfang Li Feng Xie Zidong Zhang Yu Guo Guotao Tang Deguan Lv Qixuan Lu Linxi Chen Jian Li | 2013 | Acta Biochimica et Biophysica Sinica2013，45，10： | 18 |
| 2 | Apelin-13 promotes cardiomyocyte hypertrophy via PI3K-Akt-ERK1/2-p70S6K and PI3K-induced autophagy显示文摘Apelin 高度在左室的肥大 Sprague Dawley 老鼠建模的老鼠被表示,并且它在心血管的系统起一个关键作用。这研究是澄清 apelin-13 是否在 H9c2 老鼠 cardiomyocytes 支持肥大并且调查它的内在的机制的目的。cardiomyocyte 肥大被测量 H9c2 房间的直径,体积,和蛋白质内容观察。autophagy 的激活被由传播电子显微镜学观察 autophagosomes 的形态学评估,观察由轻显微镜学的 LC3 的 subcellular 本地化,并且由西方的污点分析检测 LC3 的联系膜的形式。表明小径的 phosphatidylinositol 3-kinase (PI3K ) 被识别,蛋白质表示用西方的污点分析被检测。结果表明 apelin-13 增加了 H9c2 房间的直径,体积,和蛋白质内容并且支持了 PI3K, Akt, ERK1/2,和 p70S6K 的 phosphorylation。Apelin-13 激活 PI3K-Akt-ERK1/2-p70S6K 小径。PI3K 禁止者 LY294002, Akt 禁止者 1701-1, ERK1/2 禁止者 PD98059 稀释了房间直径的增加,体积,蛋白质内容由 apelin-13 导致了。Apelin-13 增加了 autophagosomes 并且起来调整 beclin 的表情 1 并且 LC3-II/I 短暂地并且稳定地。autophagy 禁止者 3MA 改善了被 apelin-13 导致的房间直径,体积,和蛋白质内容的增加。这些结果建议 apelin-13 经由 PI3K-Akt-ERK1/2-p70S6K 和导致 PI3K 的 autophagy 支持 H9c2 老鼠 cardiomyocyte 肥大。 | Feng Xie Wei Liu Fen Feng Xin Li Lu He Deguan Lv Xuping Qin Lifang Li Lanfang Li Linxi Chen | 2015 | Acta Biochimica et Biophysica Sinica2015，47，12： | 9 |
| 3 | Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling显示文摘室的肥大是心血管的疾病的事件的一个强大、独立的预言者。低剂量的乙酰水杨酸酸(阿司匹林) 的脉管的性质通过血小板 cyclooxygenase 的不可逆的抑制提供心血管的好处 1;然而,可能的 anti-hypertrophic 性质和阿司匹林的潜在的机制没详细被调查。在这研究,健康野类型的雄的老鼠随机被划分成三个组并且使遭到了到横向的大动脉的收缩(TAC ) 或假冒的操作。操作 TAC 的老鼠与低剂量的阿司匹林的人的等价物被对待(10 mg 吗? | Samuel Chege Gitau Xuelian Li Dandan Zhao Zhenfeng Guo Haihai Liang Ming Qian Lifang Lv Tianshi Li Bozhi Xu Zhiguo Wang Yong Zhang Chaoqian Xu Yanjie Lu Zhiming Du Hongli Shan Baofeng Yang | 2015 | Frontiers of Medicine2015，9，4： | 6 |
| 4 | Color-tunable ultralong organic phosphorescence materials for visual UV-light detection显示文摘Ultralong organic phosphorescence(UOP)materials have roused considerable attention in the field of photonics and optoelectronics owing to the feature of long-lived emission lifetimes.However,to develop UOP materials with color-tunability is still a formidable challenge.Here,we report a class of UOP materials containing carbonyl,amino or amide groups,exhibiting colortunable persistent luminescence ranging from blue(458 nm)to yellow-green(508 nm)under different UV wavelength excitation.Taken theoretical and experimental results together,we conclude that the excitation dependent color-tunable UOP emission is ascribed to multiple emission centers from single molecular and aggregated states in crystal.Given color-tunable UOP feature,these materials are used to successfully realize visual UV-light detection.This finding not only provides a strategy to design new organic phosphorescent molecules with colorful emission,but also extends the scope of the applications of purely organic phosphorescent materials. | Lifang Bian Huili Ma Wenpeng Ye Anqi Lv He Wang Wenyong Jia Long Gu Huifang Shi Zhongfu An Wei Huang | 2020 | Science China Chemistry2020，63，10： | 3 |
| 5 | Interaction Between Variations in Dopamine D2 and Serotonin 2A Receptor is Associated with Short-Term Response to Antipsychotics in Schizophrenia显示文摘Dear Editor,Schizophrenia is a chronic and debilitating brain disorder,which has a strong genetic component with heritability ranging from 66%to 85%[1,2].Currently,antipsychotic drugs remain the most effective treatment for the psychotic symptoms of schizophrenia[3].Because of the severe sideeffects of first-generation antipsychotics(FGAs),secondgeneration antipsychotics(SGAs)have become more widely used in the treatment of schizophrenia. | Liansheng Zhao Huijuan Wang Yamin Zhang Jinxue Wei Peiyan Ni Hongyan Ren Gang Li Qiang Wang Gavin P Reynolds Weihua Yue Wei Deng Hao Yan Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Yinfei Li Hua Yu Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Jeremy Coid Dai Zhang Chao Chen Tao Li Chinese Antipsychotics Pharmacogenomics Consortium | 2019 | Neuroscience Bulletin2019，35，6： | 3 |
| 6 | Testing the role of genetic variation of the MC4R gene in Chinese population in antipsychotic-induced metabolic disturbance显示文摘Antipsychotic-induced metabolic disturbance(AIMD) is a common adverse effect of antipsychotics with genetics partly underpinning variation in susceptibility among schizophrenia patients. Melanocortin4 receptor(MC4 R) gene, one of the candidate genes for AIMD, has been under-studied in the Chinese patients. We conducted a pharmacogenetic study in a large cohort of Chinese patients with schizophrenia. In this study, we investigated the genetic variation of MC4 R in Chinese population by genotyping two SNPs(rs489693 and rs17782313) in 1,991 Chinese patients and examined association of these variants with the metabolic effects that were often observed to be related to AIMD. Metabolic measures, including body mass index(BMI), waist circumference(WC), glucose, triglyceride, high-density lipoprotein(HDL), and low-density lipoprotein(LDL) levels were assessed at baseline and after 6-week antipsychotic treatment. We found that interaction of SNP×medication status(drug-na?ve/medicated) was significantly associated with BMI, WC, and HDL change %, respectively. Both SNPs were significantly associated with baseline BMI and WC in the medicated group. Moderate association of rs489693 with WC, Triglyceride, and HDL change % were observed in the whole sample. In the drug-na?ve group, we found recessive effects of rs489693 on BMI gain more than 7%, WC and Triglyceride change %, with AA incurring more metabolic adverse effects. In conclusion, the association between rs489693 and the metabolic measures is ubiquitous but moderate. Rs17782313 is less involved in AIMD. Two SNPs confer risk of AIMD to patients treated with different antipsychotics in a similar way. | Yamin Zhang Hongyan Ren Qiang Wang Wei Deng Weihua Yue Hao Yan Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Dai Zhang Liansheng Zhao Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Tao Li Chinese Antipsychotics Pharmacogenomics Consortium | 2019 | Science China(Life Sciences)2019，62，4： | 3 |
| 7 | All-in-One Deposition to Synergistically Manipulate Perovskite Growth for High-Performance Solar Cell显示文摘Nonradiative recombination losses originating from crystallographic distortions and issues occurring upon interface formation are detrimental for the photovoltaic performance of perovskite solar cells.Herein,we incorporated a series of carbamide molecules(urea,biuret,or triuret)consisting of both Lewis base(-NH2)and Lewis acid(-C=O)groups into the perovskite precursor to simultaneously eliminate the bulk and interface defects.Depending on the different coordination ability with perovskite component,the incorporated molecules can either modify crystallization dynamics allowing for large crystal growth at low temperature(60℃),associate with antisite or undercoordinated ions for defect passivation,or accumulate at the surface as an energy cascade layer to enhance charge transfer,respectively.Synergistic benefits of the above functions can be obtained by rationally optimizing additive combinations in an all-in-one deposition method.As a result,a champion efficiency of 21.6%with prolonged operational stability was achieved in an inverted MAPbI3 perovskite solar cell by combining biuret and triuret additives.The simplified all-in-one fabrication procedure,adaptable to different types of perovskites in terms of pure MAPbI3,mixed perovskite,and all-inorganic perovskite,provides a cost-efficient and reproducible way to obtain high-performance inverted perovskite solar cells. | Yifan Lv Hui Zhang Jinpei Wang Libao Chen Lifang Bian Zhongfu An Zongyao Qian Guoqi Ren Jie Wu Frank Nuesch Wei Huang | 2020 | Research2020，，1： | 2 |
| 8 | Health promotion on tuberculosis control program im-plementation effect research显示文摘 | Lv Guangbo LiHua1 YueGongWei Wang Lifang etal | 2012 | Journal of medical animalcontrol2012，28，4： | 1 |
| 9 | Temporospatial inhibition of Erk signaling is required for lymphatic valve formation显示文摘Intraluminal lymphatic valves(LVs)and lymphovenous valves(LVs)are critical to ensure the unidirectional flow of lymphatic fluid.Morphological abnormalities in these valves always cause lymph or blood reflux,and result in lymphedema. | Yaping Meng Tong Lv Junfeng Zhang Weimin Shen Lifang Li Yaqi Li Xin Liu Xing Lei Xuguang Lin Hanfang Xu Anming Meng Shunji Jia | 2023 | Signal Transduction and Targeted Therapy2023，8，10： | 0 |
| 10 | Research on the Seismic Activity of the Lower Yangtze River-South Yellow Sea Seismic Zone显示文摘The Lower Yangtze River-South Yellow Sea Seismic Zone,located at the southeast of the Northern China Seismic Zone, characterized by moderate-strong earthquakes, is an intensive earthquake zone,which is controlled by a series of faults within the Lower Yangtze River-South Yellow Sea Seismic Zone. This article counts and calculates the bvalue,V 4 and energy density value of medium-small earthquakes by taking full advantage of the latest data from regional seismic stations,reviews data of historical earthquakes and seismic structure,and discusses the relationship between spatial distribution of the b-value, historical strong earthquakes and spatial distribution of energy density of medium-small earthquakes,and further investigates the seismic activity of the Lower Yangtze River- South Yellow Sea Seismic Zone. This article obtains seismic activity parameters of the Lower Yangtze River-South Yellow Sea Seismic Zone as calculation parameters for probabilistic seismic hazard analysis,and discusses the trend of this seismic zone in the next one hundred years and deduces the potential seismic hazard region within this seismic zone,which provides references and methods for long-term prediction on seismic activity. The research results are significant to seismic zoning, seismic safety evaluation of engineering sites and long-term prediction of seismic activity. | Xie Zhuojuan Lv Yuejun Peng Yanju Lan Jingyan Zhang Lifang | 2013 | Earthquake Research in China2013，27，2： | 0 |
| 11 | Methods for Estimating Mean Annual Rate of Earthquakes in Moderate and Low Seismicity Regions显示文摘Two kinds of methods for determining seismic parameters are presented,that is,the potential seismic source zoning method and grid-spatially smoothing method. The Gaussian smoothing method and the modified Gaussian smoothing method are described in detail, and a comprehensive analysis of the advantages and disadvantages of these methods is made. Then,we take central China as the study region,and use the Gaussian smoothing method and potential seismic source zoning method to build seismic models to calculate the mean annual seismic rate. Seismic hazard is calculated using the probabilistic seismic hazard analysis method to construct the ground motion acceleration zoning maps. The differences between the maps and these models are discussed and the causes are investigated. The results show that the spatial smoothing method is suitable for estimating the seismic hazard over the moderate and low seismicity regions or the hazard caused by background seismicity; while the potential seismic source zoning method is suitable for estimating the seismic hazard in well-defined seismotectonics. Combining the spatial smoothing method and the potential seismic source zoning method with an integrated account of the seismicity and known seismotectonics is a feasible approach to estimate the seismic hazard in moderate and low seismicity regions. | Peng Yanju Zhang Lifang Lv Yuejun Xie Zhuojuan | 2012 | Earthquake Research in China2012，26，3： | 0 |
| 12 | Analysis on Completeness of Small Earthquake Data in the Northeast Seismic Zone and Its Influence on Seismicity Parameters显示文摘Taking the northeast seismic zone as an example and based on the magnitude-frequency distribution principles of the G-R relationship and the study on the temporal and spatial distribution characteristics of the minimum magnitude of completeness M C in each time interval,this paper makes a statistical analysis on the seismicity parameters of the research area and explores the influence of the completeness of small earthquake data on the seismicity parameters and seismic hazard analysis.It shows that the completeness analysis of the regional small earthquakes data provides a possible means for obtaining more accurate seismicity parameters that can better represent the actual regional seismicity level for areas of low seismicity.The research methods of this article and its conclusion can be used as a reference for the completeness analysis of earthquake data and seismic activity research. | Xie Zhuojuan Lv Yuejun Peng Yanju Zhang Lifang | 2013 | Earthquake Research in China2013，27，3： | 0 |
| 13 | The Method of Spatially Smoothed Seismicity Parameters in Consideration of Seismotectonic Background and Its Application to Seismic Hazard Estimation显示文摘In this study, the North China seismic region was selected as the study area, and evaluation of seismic hazard using the spatial smoothing seismicity model was performed. Firstly, the study area is divided into grids, and some parameters (e.g. b-value, M0, Mu, azimuth and M-L relationship) for each seismotectonic model were assigned. Secondly, using elliptical smoothing based on a seismotectonic background model, the statistical earthquake incidence rate in each grid is successively calculated. Lastly, the relevant ground motion attenuation relationship is chosen to assess seismic hazard of general sites. The maps for the distribution of horizontal peak ground acceleration with 10% probability of exceedance in 50 years were obtained by using the seismic hazard analysis method based on grid source. This seismicity model simplifies the methodology of probabilistic seismic hazard analysis, especially appropriate for those places where seismic tectonics is not yet clearly known. This method can provide valuable references for seismic zonation and seismic safety assessment for significant engineering projects. | Zhang Lifang Lv Yuejun Peng Yanju Ma Xiaoling Cui Manfeng | 2013 | Earthquake Research in China2013，27，1： | 0 |
| 14 | Bulk GaN-based SAW resonators with high quality factors for wireless temperature sensor显示文摘Surface acoustic wave(SAW)resonator with outstanding quality factors of 4829/6775 at the resonant/anti-resonant frequencies has been demonstrated on C-doped semi-insulating bulk GaN.The impact of device parameters including aspect ratio of length to width of resonators,number of interdigital transducers,and acoustic propagation direction on resonator performance have been studied.For the first time,we demonstrate wireless temperature sensing from 21.6 to 120℃ with a stable temperature coefficient of frequency of–24.3 ppm/℃ on bulk GaN-based SAW resonators. | Hongrui Lv Xianglong Shi Yujie Ai Zhe Liu Defeng Lin Lifang Jia Zhe Cheng Jie Yang Yun Zhang | 2022 | Journal of Semiconductors2022，43，11： | 0 |
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