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| 1 | Gastric peritoneal carcinomatosis-a retrospective review显示文摘AIM To characterize patients with gastric peritoneal carcinomatosis(PC) and their typical clinical and treatment course with palliative systemic chemotherapy as the current standard of care.METHODS We performed a retrospective electronic chart review of all patients with gastric adenocarcinoma with PC diagnosed at initial metastatic presentation between January 2010 and December 2014 in a single tertiary referral centre.RESULTS We studied a total of 271 patients with a median age of 63.8 years and median follow-up duration of 5.1 mo. The majority(n = 217, 80.1%) had the peritoneum as the only site of metastasis at initial presentation. Palliative systemic chemotherapy was eventually planned for 175(64.6%) of our patients at initial presentation, of which 171 were initiated on it. Choice of first-line regime was in accordance with the National Comprehensive Cancer Network Guidelines for Gastric Cancer Treatment. Thesepatients underwent a median of one line of chemotherapy, completing a median of six cycles in total. Chemotherapy disruption due to unplanned hospitalizations occurred in 114(66.7%), while cessation of chemotherapy occurred in 157(91.8%), with 42 cessations primarily attributable to PC-related complications. Patients who had initiation of systemic chemotherapy had a significantly better median overall survival than those who did not(10.9 mo vs 1.6 mo, P < 0.001). Of patients who had initiation of systemic chemotherapy, those who experienced any disruptions to chemotherapy due to unplanned hospitalizations had a significantly worse median overall survival compared to those who did not(8.7 mo vs 14.6 mo, P < 0.001).CONCLUSION Gastric PC carries a grim prognosis with a clinical course fraught with disease-related complications which may attenuate any survival benefit which palliative systemic chemotherapy may have to offer. As such, investigational use of regional therapies is warranted and required validation in patients with isolated PC to maximize their survival outcomes in the long run. | Hwee Leong Tan Claramae Shulyn Chia Grace Hwei Ching Tan Su Pin Choo David Wai-Meng Tai Clarinda Wei Ling Chua Matthew Chau Hsien Ng Khee Chee Soo Melissa Ching Ching Teo | 2017 | World Journal of Gastrointestinal Oncology2017，9，3： | 6 |
| 2 | Lower circulating irisin is associated with type 2 diabetes mellitus显示文摘 | Jian-Jun Liu Melvin D.S. Wong Wan Ching Toy Clara S.H. Tan Sylvia Liu Xiao Wei Ng Subramaniam Tavintharan Chee Fang Sum Su Chi Lim | 2013 | Journal of Diabetes and Its Complications2013，，4： | 1 |
| 3 | On maximum-likelihood SINR estimation of MPSK in a mul- tiuser fading channel显示文摘 | SOROOSHYARI Siamak TAN Chee Wei POOR H Vincent | 2010 | IEEE Transactions on Vehicular Tech- nology2010，59，8： | 1 |
| 4 | Dynamically loadahle protocol stacks 显示文摘 | Seng Kee Tan Yu Ge Kean Soon Tan Chee Wei Ang | 2004 | Internet Computing IEEE2004，8，2： | 1 |
| 5 | Maximizing sum rate and minimizing MSE on multiuser downlink opti- mality fast algorithms and equivalence via max-rain SINR 显示文摘 | Tan Chee Wei Chiang Mung Srikant R | 2011 | IEEE Trans on Signal Processing2011，59，4： | 1 |
| 6 | An unusual COVID-19 case with over four months of viral shedding in the presence of low neutralizing antibodies: a case report显示文摘The ongoing coronavirus disease 2019(COVID-19)pandemic is a global public health crisis,causing social and economic disasters in many countries.In China,two-consecutive negative results of nucleic acid tests for SARS-CoV-2 from the respiratory samples are required to end the quarantine of COVID-19 patients.However,clinicians face a dilemma in case of patients with long-term viral shedding.This report described an unusual COVID-19 case who had persistent viral RNA positivity for more than 4 months after initial illness in the presence of low neutralizing antibodies,but without prolonged clinical symptoms.Multiple anti-viral drug treatments had no impact and there was no evidence of re-infection.When the patient was self-quarantined at home,no infection occurred to the three family members living with her for 15 to 19 days.Sputum viral culture in BSL-3 laboratory on the 102nd day after symptom onset was negative.From the 129th day on,8 continuous nucleic acid tests of sputum samples showed negative results.The patient was discharged on 137th days since symptom onset.In conclusion,viral RNA shedding in the sputum of the COVID-19 patient may last over 4 months.As no evidence shows the existence of infectious virus,two-consecutive negative nucleic acid tests may not be the prerequisite for ending quarantine of COVID-19 patients with prolonged viral shedding. | Wei Chen Zhiliang Hu Changhua Yi Yun Chi Qingfang Xiong Chee Wah Tan Yongxiang Yi Lin-Fa Wang | 2020 | The Journal of Biomedical Research2020，34，6： | 1 |
| 7 | Intrinsic Subtypes of Gastric Cancer, Based on Gene Expression Pattern, Predict Survival and Respond Differently to Chemotherapy显示文摘 | Iain Beehuat Tan Tatiana Ivanova Kiat Hon Lim Chee Wee Ong Niantao Deng Julian Lee Sze Huey Tan Jeanie Wu Ming Hui Lee Chia Huey Ooi Sun Young Rha Wai Keong Wong Alex Boussioutas Khay Guan Yeoh Jimmy So Wei Peng Yong Akira Tsuburaya Heike Grabsch Han Chon | 2011 | Gastroenterology2011，，2： | 1 |
| 8 | Lower circulating irisin is associated with type 2 diabetes mellitus显示文摘 | Jian-Jun Liu Melvin D.S. Wong Wan Ching Toy Clara S.H. Tan Sylvia Liu Xiao Wei Ng Subramaniam Tavintharan Chee Fang Sum Su Chi Lim | 2013 | Journal of Diabetes and Its Complications2013，，4： | 1 |
| 9 | Intrinsic Subtypes of Gastric Cancer, Based on Gene Expression Pattern, Predict Survival and Respond Differently to Chemotherapy显示文摘 | Iain Beehuat Tan Tatiana Ivanova Kiat Hon Lim Chee Wee Ong Niantao Deng Julian Lee Sze Huey Tan Jeanie Wu Ming Hui Lee Chia Huey Ooi Sun Young Rha Wai Keong Wong Alex Boussioutas Khay Guan Yeoh Jimmy So Wei Peng Yong Akira Tsuburaya Heike Grabsch Han Chon | 2011 | Gastroenterology2011，，2： | 1 |
| 10 | Intrinsic Subtypes of Gastric Cancer, Based on Gene Expression Pattern, Predict Survival and Respond Differently to Chemotherapy显示文摘 | Iain Beehuat Tan Tatiana Ivanova Kiat Hon Lim Chee Wee Ong Niantao Deng Julian Lee Sze Huey Tan Jeanie Wu Ming Hui Lee Chia Huey Ooi Sun Young Rha Wai Keong Wong Alex Boussioutas Khay Guan Yeoh Jimmy So Wei Peng Yong Akira Tsuburaya Heike Grabsch Han Chon | 2011 | Gastroenterology2011，，2： | 1 |
| 11 | Achieving multi-class service differentiation in WDM optical burst switching networks:A probabilistic preemptive burst segmentation scheme显示文摘 | Chee Wei Tan Gurusamy Mohan John Chi-Shing Lui | 2006 | IEEE Journal on Selected Areas in Communications2006，24，12： | 1 |
| 12 | Intrinsic Subtypes of Gastric Cancer, Based on Gene Expression Pattern, Predict Survival and Respond Differently to Chemotherapy显示文摘 | Iain Beehuat Tan Tatiana Ivanova Kiat Hon Lim Chee Wee Ong Niantao Deng Julian Lee Sze Huey Tan Jeanie Wu Ming Hui Lee Chia Huey Ooi Sun Young Rha Wai Keong Wong Alex Boussioutas Khay Guan Yeoh Jimmy So Wei Peng Yong Akira Tsuburaya Heike Grabsch Han Chon | 2011 | Gastroenterology2011，，2： | 1 |
| 13 | A Review of Energy Sources and En- ergy Management System in Electric Vehicles 显示文摘 | Siang Fui Tie Chee Wei Tan | 2013 | Renewable and Sustainable Energy Review2013，，20： | 1 |
| 14 | A comprehensive review of maximum power point tracking algorithms for photovoltaic systems显示文摘 | Nur Atharah Kamarzaman Chee Wei Tan | 2014 | Renewable and Sustainable Energy Reviews2014，，： | 1 |
| 15 | Acute hospital-community hospital care bundle for elderly orthopedic surgery patients:A propensity score-matched economic analysis显示文摘BACKGROUND While Singapore attains good health outcomes,Singapore’s healthcare system is confronted with bed shortages and prolonged stays for elderly people recovering from surgery in acute hospitals.An Acute Hospital-Community Hospital(AHCH)care bundle has been developed to assist patients in postoperative rehabilitation.The core concept is to transfer patients out of AHs when clinically recommended and into CHs,where they can receive more beneficial dedicated care to aid in their recovery,while freeing up bed capacities in AHs.AIM To analyze the AH length of stay(LOS),costs,and savings associated with the AH-CH care bundle intervention initiated and implemented in elderly patients aged 75 years and above undergoing elective orthopedic surgery.METHODS A total of 8621:1 propensity score-matched patients aged 75 years and above who underwent elective orthopedic surgery in Singapore General Hospital(SGH)before(2017-2018)and after(2019-2021)the care bundle intervention period was analyzed.Outcome measures were AH LOS,CH LOS,hospitalization metrics,postoperative 30-d mortality,and modified Barthel Index(MBI)scores.The costs of AH inpatient hospital stay in the matched cohorts were compared using cost data in Singapore dollars.RESULTS Of the 862 matched elderly patients undergoing elective orthopedic surgery before and after the care bundle intervention,the age distribution,sex,American Society of Anesthesiologists classification,Charlson Comorbidity Index,and surgical approach were comparable between both groups.Patients transferred to CHs after the surgery had a shorter median AH LOS(7 d vs 9 d,P<0.001).The mean total AH inpatient cost per patient was 14.9%less for the elderly group transferred to CHs(S$24497.3 vs S$28772.8,P<0.001).The overall AH U-turn rates for elderly patients within the care bundle were low,with a 0%mortality rate following orthopedic surgery.When elderly patients were discharged from CHs,their MBI scores increased significantly(50.9 vs 71.9,P<0.001).CONCLUSION The AH-CH care bundle initiated and implemented in the Department of Orthopedic Surgery appears to be effective and cost-saving for SGH.Our results indicate that transitioning care between acute and community hospitals using this care bundle effectively reduces AH LOS in elderly patients receiving orthopedic surgery.Collaboration between acute and community care providers can assist in closing the care delivery gap and enhancing service quality. | Ivan En-Howe Tan Aik Yong Chok Yun Zhao Yonghui Chen Chee Hoe Koo Junjie Aw Mave Hean Teng Soh Chek Hun Foo Kwok Ann Ang Emile John Kwong Wei Tan Andrew Hwee Chye Tan Marianne Kit Har Au | 2023 | World Journal of Orthopedics2023，14，4： | 0 |
| 16 | Robust Fingerprint Construction Based on Multiple Path Loss Model (M-PLM) for Indoor Localization显示文摘A robust radio map is essential in implementing a fingerprint-based indoor positioning system(IPS).However,the offline site survey to manually construct the radio map is time-consuming and labour-intensive.Various interpolation techniques have been proposed to infer the virtual fingerprints to reduce the time and effort required for offline site surveys.This paper presents a novel fingerprint interpolator using a multi-path loss model(MPLM)to create the virtual fingerprints from the collected sample data based on different signal paths from different access points(APs).Based on the historical signal data,the poor signal paths are identified using their standard deviations.The proposed method reduces the positioning errors by smoothing out the wireless signal fluctuations and stabilizing the signals for those poor signal paths.By consideringmultipath signal propagations from different APs,the inherent noise from these signal paths can be alleviated.Firstly,locations of the signal data with standard deviations higher than the threshold are identified.The new fingerprints are then generated at these locations based on the proposed M-PLM interpolation function to replace the old fingerprints.The proposed technique interpolates virtual fingerprints based on good signal paths with more stable signals to improve the positioning performance.Experimental results show that the proposed scheme enhances the positioning accuracy by up to 44%compared to the conventional interpolation techniques such as the Inverse DistanceWeighting,Kriging,and single Path LossModel.As a result,we can overcome the site survey problems for IPS by building an accurate radio map with more reliable signals to improve indoor positioning performance. | Yun Fen Yong Chee Keong Tan Ian Kim Teck Tan Su Wei Tan | 2023 | Computers, Materials & Continua2023，，1： | 0 |
| 17 | The Efficacy of Plant-Based Ionizers in Removing Aerosol for COVID-19 Mitigation显示文摘Small-sized droplets/aerosol transmission is one of the factors responsible for the spread of COVID-19,in addition to large droplets and surface contamination(fomites).While large droplets and surface contamination can be relatively easier to deal with(i.e.,using mask and proper hygiene measures),aerosol presents a different challenge due to their ability to remain airborne for a long time.This calls for mitigation solutions that can rapidly eliminate the airborne aerosol.Pre-COVID-19,air ionizers have been touted as effective tools to eliminate small particulates.In this work,we sought to evaluate the efficacy of a novel plant-based ionizer in eliminating aerosol.It was found that factors such as the ion concentration,humidity,and ventilation can drastically affect the efficacy of aerosol removal.The aerosol removal rate was quantified in terms of ACH(air changes per hour)and CADR-(clean air delivery rate-)equivalent unit,with ACH as high as 12 and CADR as high as 141 ft^(3)/minute being achieved by a plant-based ionizer in a small isolated room.This work provides an important and timely guidance on the effective deployment of ionizers in minimizing the risk of COVID-19 spread via airborne aerosol,especially in a poorly-ventilated environment. | Ady Suwardi Chin Chun Ooi Dan Daniel Chee Kiang Ivan Tan Hongying Li Ou Yang Zhong Liang Yuanting Karen Tang Jing Yee Chee Anton Sadovoy Shu-Ye Jiang Srinivasan Ramachandran Enyi Ye Chang Wei Kang Wun Chet Davy Cheong Keng Hui Lim Xian Jun Loh | 2021 | Research2021，，1： | 0 |
| 18 | 2021亚太心脏病学会P2Y12受体拮抗剂应用于亚太特殊人群的共识显示文摘高龄、糖尿病(DM)和慢性肾脏疾病(CKD)不仅会增加慢性冠状动脉综合征(CCS)患者缺血事件的风险,还会增加其接受抗血小板治疗期间的出血风险。此类特殊人群可能需要调整治疗方案,尤其是亚洲的特殊人群,往往表现出与西方人群不同的临床特征。关于亚洲人群CCS高风险的分类和急性冠状动脉综合征(ACS)后使用新一代强效P2Y12受体抑制剂(如替格瑞洛和普拉格雷)的国际指南已相继发表。本共识总结了在特殊人群中使用强效P2Y12受体抑制剂的相关证据,提出了在冠状动脉疾病(CAD)特殊人群中应用标准疗程双联抗血小板治疗(DAPT)、短期DAPT和单一抗血小板治疗的推荐意见。本共识的特殊人群包括从ACS过渡至CCS,老年,或患有CKD、DM、多血管CAD和治疗期间发生出血并发症等特征的患者。 | Jack Wei Chieh Tan Derek P Chew Kin Lam Tsui Doreen Tan Dmitry Duplyakov Ayman Hammoudeh 张波 李毅 徐凯 Paul J Ong DoniFirman Habib Gamra Wael Almahmeed Jamshed Dalal Lihua Tan Gabriel Steg Quang N Nguyen Junya Ako Jassim Al Suwaidi Mark Chan Mohamed Sobhy Abdulla Shehab Wacin Buddhari 王祖禄 Alan Yean Yip Fong Bilgehan Karadag Byeong-Keuk Kim Usman Baber Chee Tang Chin 韩雅玲 | 2023 | 中华心血管病杂志2023，51，1： | 0 |
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