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| 1 | Shear wave velocity structure of the crust and upper mantle underneath the Tianshan orogenic belt显示文摘From April, 2003 to September, 2004, a passive broadband seismic array consisting of 60 stations was deployed over the Tianshan orogenic belt by State Key Laboratory of Earthquake Dynamics, Institute of Geology, China Earthquake Administration. Among them, 51 stations make up an about 500-km-long profile across the Tianshan Mountains from Kuytun to Kuqa. The receiver function profile and S-wave velocity structure of the crust and upper mantle down to 100 km deep are obtained by using the re-ceiver function method (Liu et al. 1996, 2000). The main results can be summarized as follows: (1) A clear mountain root does not exist beneath the Tianshan Mountains, and the crust-mantle boundaries underneath the stations mostly have transitional structures. This implies that the material differentia-tion between the crust and mantle is not yet accomplished and the orogenic process is still going on. (2) The crust beneath the Tianshan Mountains has laterally blocked structures in direction perpendicular to the mountain strike, and the crust-mantle boundary has a clear dislocation structure. Both of them correspond to each other. (3) The offsets of the Moho discontinuity are highly correlated to the tectonic borders on the surface and that corresponding to the frontal southern Tianshan fault reaches to 14 km. This manifests that large vertical divergent movement took place between different blocks. This sup-ports the discontinuous model of the Tianshan orogeny, and the Tarim block subduction is restricted only to the southern side of the South Tianshan. (4) Inside the upper and middle crust of the Tianshan Mountains exist several low-velocity bodies correlated with high seismicity located on the moun-tain-basin jointures on both sides of the mountain and between different blocks, and the low-velocity bodies on the mountain-basin jointures are inclined obviously to the mountain. This implies that the low-velocity bodies may be correlated closely to the thrust and subduction of the basins on both sides of the mountain, the splicing of adjacent blocks and the fast uplift of the Tianshan Mountains. | LI Yu LIU QiYuan CHEN JiuHui LI ShunCheng GUO Biao LAI YuanGen | 2007 | Science China Earth Sciences2007，50，3： | 16 |
| 2 | Multigene editing via CRISPR/Cas9 guided by a single-sgRNA seed in Arabidopsis显示文摘We report that a solo single-guide RNA(sg RNA) seed is capable of guiding Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR)/CRISPRàassociated 9(CRISRP/Cas_9) to simultaneously edit multiple genes At RPL_(10)A, At RPL_(10)B and At RPL_(10)C in Arabidopsis. Our results also demonstrate that it is possible to use CRISPR/Cas_9 technology to create At RPL_(10) triple mutants which otherwise cannot be generated by conventional genetic crossing. Compared to other conventional multiplex CRISPR/Cas systems, a single sg RNA seed has the advantage of reducing off-target gene-editing. Such a gene editing system might be also applicable to modify other homologous genes, or even less-homologous sequences for multiple gene-editing in plants and other organisms. | Zhiming Yu Qiyuan Chen Weiwei Chen Xian Zhang Fengling Mei Pengcheng Zhang Mei Zhao Xiaohong Wang Nongnong Shi Stephen Jackson Yiguo Hong | 2018 | Journal of Integrative Plant Biology2018，60，5： | 10 |
| 3 | Shape-Controlled Synthesis of Mn_(3)O_(4) Nanocrystals and Their Catalysis of the Degradation of Methylene Blue显示文摘Various sizes and shapes of Mn_(3)O_(4) nanocrystals have been prepared in a one-pot synthesis in extremely dilute solution by soft template self-assembly. To better control size and shape, the effects of varying the growth time, reaction temperature, surfactant, and manganese source were examined. The average size of octahedral Mn_(3)O_(4) crystallites was found to be related to the reaction time, while higher reaction temperature (150 °C) and the use of a cetyltrimethylammonium bromide/poly(vinylpyrrolidone) (CTAB/PVP) mixture allowed construction of a better-defined octahedral morphologies. When PVP or poly(ethylene oxide)-poly(propylene oxide) (P123) was used as template, large-scale agglomeration resulting in loss of the octahedral morphology occurred and crystallites with a quasi-spherical shape were obtained. The nano-octahedral crystallites were shown to be an efficient catalyst for the oxidation of methylene blue. | Pengqu Zhang Yonggong Zhan Bingxin Cai Chenchun Hao Jun Wang Chunxiao Liu Zhoujun Meng Zhoulan Yin Qiyuan Chen | 2010 | Nano Research2010，3，4： | 9 |
| 4 | The Effect of Tide on the Global Climate Change显示文摘The differential rotation between the solid and fluid spheres caused by tidal force could explain the 1500 to 1800-year cycle of the world's temperature. Strong tide increases the vertical and horizontal mixing of water in the oceans, drawing the cold Pacific water from the depths to the surface and the warm water from the west to the east, where it cools or warms the atmosphere above, absorbs or releases CO2 to decrease or increase greenhouse effect and to make La Nina or El Nino occur in the global. The moon's declination and obliquity of the ecliptic affect the tidal intensity. The exchange of tidal energy and tide-generating force caused by the sun, moon and major planets makes the earth's layers rotate in different speeds. The differenti-al rotation between solid and fluid of the earth is the basic reason for El Nino and global climate change. | YANG Xuexiang, CHEN Zhen and CHEN Dianyou( College of Ceo - exploration Science and Technology, Jilin University, Changchun 130026, P. R. China)Qiao Qiyuan(National Astronomical Observatory, Chinese Academy of Science, Beijing 100012, P. R. China) | 2002 | Global Geology2002，7，1： | 7 |
| 5 | 3D printed silk-gelatin hydrogel scaffold with different porous structure and cell seeding strategy for cartilage regeneration显示文摘Hydrogel scaffolds are attractive for tissue defect repair and reorganization because of their human tissue-like characteristics.However,most hydrogels offer limited cell growth and tissue formation ability due to their submicron-or nano-sized gel networks,which restrict the supply of oxygen,nutrients and inhibit the proliferation and differentiation of encapsulated cells.In recent years,3D printed hydrogels have shown great potential to overcome this problem by introducing macro-pores within scaffolds.In this study,we fabricated a macroporous hydrogel scaffold through horseradish peroxidase(HRP)-mediated crosslinking of silk fibroin(SF)and tyramine-substituted gelatin(GT)by extrusion-based low-temperature 3D printing.Through physicochemical characterization,we found that this hydrogel has excellent structural stability,suitable mechanical properties,and an adjustable degradation rate,thus satisfying the requirements for cartilage reconstruction.Cell suspension and aggregate seeding methods were developed to assess the inoculation efficiency of the hydrogel.Moreover,the chondrogenic differentiation of stem cells was explored.Stem cells in the hydrogel differentiated into hyaline cartilage when the cell aggregate seeding method was used and into fibrocartilage when the cell suspension was used.Finally,the effect of the hydrogel and stem cells were investigated in a rabbit cartilage defect model.After implantation for 12 and 16 weeks,histological evaluation of the sections was performed.We found that the enzymatic cross-linked and methanol treatment SF5GT15 hydrogel combined with cell aggregates promoted articular cartilage regeneration.In summary,this 3D printed macroporous SF-GT hydrogel combined with stem cell aggregates possesses excellent potential for application in cartilage tissue repair and regeneration. | Qingtao Li Sheng Xu Qi Feng Qiyuan Dai Longtao Yao Yichen Zhang Huichang Gao Hua Dong Dafu Chen Xiaodong Cao | 2021 | Bioactive Materials2021，6，10： | 6 |
| 6 | Synthesis and electrochemical properties of Al-doped LiVPO_4F cathode materials for lithium-ion batteries显示文摘Al-doped LiVPO4F cathode materials LiAlxV1-xPO4F were prepared by two-step reactions based on a car-bothermal reduction (CTR) process. The properties of the Al-doped LiVPO4F were investigated by X-ray diffraction (XRD),scanning electron microscopy (SEM),and electrochemical measurements. XRD studies show that the Al-doped LiVPO4F has the same triclinic structure (space group p1 ) as the undoped LiVPO4F. The SEM images exhibit that the particle size of Al-doped LiVPO4F is smaller than that of the undoped LiVPO4F and that the smallest particle size is only about 1 μm. The Al-doped LiVPO4F was evaluated as a cathode material for secondary lithium batteries,and exhibited an improved reversi-bility and cycleability,which may be attributed to the addition of Al3+ ion by stabilizing the triclinic structure. | ZHONG Shengkui YIN Zhoulan WANG Zhixing CHEN Qiyuan | 2007 | Rare Metals2007，26，5： | 6 |
| 7 | Crustal structure beneath the Qilian Orogen Zone from multiscale seismic tomography显示文摘The Qilian Orogen Zone(QOZ), located in the north margin of the Tibetan Plateau, is the key area for understanding the deformation and dynamics process of Tibet. Numerous geological and geophysical studies have been carried out on the mechanics of the Tibetan Plateau deformation and uplift; however, the detailed structure and deformation style of the Qilian Orogen Zone have remained uncertain due to poor geophysical data coverage and limited resolution power of inversion algorithms. In this study, we analyze the P-wave velocity structure beneath the Qilian Orogen Zone, obtained by applying multi-scale seismic tomography technique to P-wave arrival time data recorded by regional seismic networks. The seismic tomography algorithm used in this study employs sparsity constraints on the wavelet representation of the velocity model via L1-norm regularization. This algorithm can deal efficiently with uneven-sampled volumes, and can obtain multi-scale images of the velocity model. Our results can be summarized as follows:(1) The crustal velocity structure is strongly inhomogeneous and consistent with the surface geological setting. Significant low-velocity anomalies exist in the crust of northeastern Tibet, and slight high-velocity anomalies exist beneath the Qaidam Basin and Alxa terrane.(2)The Qilian Orogen Zone can be divided into two main parts by the Laji Shan Faults: the northwestern part with a low-velocity feature, and the southeastern part with a high-velocity feature at the upper and middle crust.(3) Our tomographic images suggest that northwestern and southeastern Qilian Orogen Zones have undergone different tectonic processes. In the northwest Qilian Orogen Zone, the deformation and growth of the Northern Tibetan Plateau has extended to the Heli Shan and Beida Shan region by northward overthrusting at the upper crust and thickening in the lower crust. We speculate that in the southeast Qilian Orogen Zone the deformation and growth of the Northern Tibet Plateau were of strike-slip style at the upper crust; in the lower crust, the evidence suggests ductile shear extrusion style and active frontage extension to the Alxa terrane.(4) The multi-scale seismic tomography technique provides multiscale analysis and sparse constraints, which has allowed to us obtain stable, high-resolution results. | Biao Guo JiuHui Chen QiYuan Liu ShunCheng Li | 2019 | Earth and Planetary Physics2019，3，3： | 5 |
| 8 | First experimental constraints on WIMP couplings in the effective field theory framework from CDEX显示文摘We present weakly interacting massive particles(WIMPs) search results performed using two approaches of effective field theory from the China Dark Matter Experiment(CDEX), based on the data from both CDEX-1B and CDEX-10 stages. In the nonrelativistic effective field theory approach, both time-integrated and annual modulation analyses were used to set new limits for the coupling of WIMP-nucleon effective operators at 90% confidence level(C.L.) and improve over the current bounds in the low mχregion. In the chiral effective field theory approach, data from CDEX-10 were used to set an upper limit on WIMP-pion coupling at 90% C.L. We for the first time extended the limit to the m_(χ)<6 GeV/c^(2) region. | Yi Wang Zhi Zeng Qian Yue LiTao Yang KeJun Kang YuanJing Li Mehment Agartioglu HaiPeng An JianPing Chang JingHan Chen YunHua Chen JianPing Cheng Cheng Yi Chiang WenHan Dai Zhi Deng ChangHao Fang XinPing Geng Hui Gong QiuJu Guo XuYuan Guo HongJian He Li He ShengMing He JinWei Hu TuChen Huang HanXiong Huang HaiTao Jia LiPing Jia Xi Jiang HauBin Li JianMin Li Jin Li MingXuan Li RenMingJie Li Xia Li YuLan Li Bin Liao FongKay Lin ShinTed Lin ShuKui Liu YanDong Liu Yu Liu YuanYuan Liu ZhongZhi Liu Hao Ma YuCai Mao QiYuan Nie JinHua Ning Hui Pan NingChun Qi Jie Ren XiChao Ruan ChangSong Shang Vivek Sharma Ze She Lakhwinder Singh Monoj Kumar Singh TianXi Sun ChangJian Tang WeiYou Tang Yang Tian GuangFu Wang Li Wang Qing Wang Yu Chen Wang YunXiang Wang Zhen Wang Henry Tsz-King Wong ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue YuLu Yan Nan Yi ChunXu Yu HaiJun Yu JianFeng Yue Ming Zeng BingTao Zhang Lei Zhang FengShou Zhang ZhenYu Zhang KangKang Zhao MingGang Zhao JiFang Zhou ZuYing Zhou JingJun Zhu | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，8： | 3 |
| 9 | A field-effect approach to directly profiling the localized states in monolayer MoS2显示文摘A fundamental understanding of the charge transport mechanism in two-dimensional semiconductors(e.g., MoS2) is crucial for fully exploring their potential in electronic and optoelectronic devices. By using monolayer graphene as the barrier-free contact to MoS2, we show that the field-modulated conductivity can be used to probe the electronic structure of the localized states. A series of regularly distributed plateaus were observed in the gate-dependent transfer curves. Calculations based on the variable-range hopping theory indicate that such plateaus can be attributed to the discrete localized states near mobility edge. This method provides an effective approach to directly profiling the localized states in conduction channel with an ultrahigh resolution up to 1 meV. | Hao Wu Yuan Liu Zeyu Deng Hung-Chieh Cheng Dehui Li Jian Guo Qiyuan He Sen Yang Mengning Ding Yun-Chiao Huang Chen Wang Yu Huang Xiangfeng Duan | 2019 | Science Bulletin2019，64，15： | 2 |
| 10 | Toll-like receptor 9 defciency induces osteoclastic bone loss via gut microbiota-associated systemic chronic inflammation显示文摘Toll-like receptors(TLRs)play pivotal roles in inflammation and provide important links between the immune and skeletal systems.Although the activation of TLRs may affect osteoclast differentiation and bone metabolism,whether and how TLRs are required for normal bone remodeling remains to be fully explored.In the current study,we show for the first time that TLR9^(-/-)mice exhibit a low bone mass and low-grade systemic chronic inflammation,which is characterized by the expansion of CD4^(+)T cells and increased levels of inflammatory cytokines,including TNFα,RANKL,and IL1β.The increased levels of these cytokines significantly promote osteoclastogenesis and induce bone loss.Importantly,TLR9 deletion alters the gut microbiota,and this dysbiosis is the basis of the systemic inflammation and bone loss observed in TLR9^(-/-)mice.Furthermore,through single-cell RNA sequencing,we identified myeloid-biased hematopoiesis in the bone marrow of TLR9^(-/-)mice and determined that the increase in myelopoiesis,likely caused by the adaptation of hematopoietic stem cells to systemic inflammation,also contributes to inflammation-induced osteoclastogenesis and subsequent bone loss in TLR9^(-/-)mice.Thus,our study provides novel evidence that TLR9 signaling connects the gut microbiota,immune system,and bone and is critical in maintaining the homeostasis of inflammation,hematopoiesis,and bone metabolism under normal conditions. | Peng Ding Qiyuan Tan Zhanying Wei Qiyu Chen Chun Wang Luyue Qi Li Wen Changqing Zhang Chen Yao | 2022 | Bone Research2022，10，3： | 2 |
| 11 | RAMAN SPECTRAL STUDY ON ISOPOLYTUNGSTATES IN AQUEOUS SOLUTION显示文摘INTRODUCTIONAlargenumberofstudieshavebendoneinthefieldoftheaqueouschemistryofisopolytungstateusingnumerousexperimentalmetho... | Liu, Shijun Chen, Qiyuan Zhang, Pingmin Li, Songqin | 1998 | 中国有色金属学会会刊:英文版1998，8，4： | 2 |
| 12 | Characteristics of scales formed from pressure leaching of Yuanjiang laterite显示文摘 | Kui Liu Qiyuan Chen Huiping Hu Zhiying Ding Zhoulan Yin | 2011 | Hydrometallurgy2011，，1： | 2 |
| 13 | Heat capacity of potassium tungstates K2WnO3n+1(n=2,3,4) at temperature from 273 K to 979 K显示文摘 | Chen Qiyuan Liu Shijun Zang Pingmin | 1999 | J Chem Thermodynamics1999，31，4： | 1 |
| 14 | Extraction behavior and mechanism of Cu(11) in ammoniacal sulfate solution with diketone显示文摘 | HU Jiugang CHEN Qiyuan HU Huiping | 2012 | HydrometaUurgy2012，，： | 1 |
| 15 | Modified transmission line model to investigate non-Ohmic contact behavior and its application on GaN显示文摘 | Yanjie Wang Weixi Chen Qiyuan Wei | 2007 | Journal of Applied Physics2007，101，8： | 1 |
| 16 | Determination of the standard enthalpy of formation of paratungstate a ion显示文摘 | Liu Shijun Chen Qiyuan Zhang Pingmin | 2001 | The Journal of chemical thermodynamics2001，，33： | 1 |
| 17 | Standard enthalpy of formation of sodium paratungstate Na10H2W12·27H2O(s)显示文摘 | Chen Qiyuan Liu Shijun Zhang Pingmin | 2000 | Thermochmica Acta2000，353，： | 1 |
| 18 | Study on kinetics of the thermal decompositions of ammonium molybdates 显示文摘 | Yin Zhoulan Li Xinhai Chen Qiyuan | 2000 | Thermochimica Acta2000，352，1： | 1 |
| 19 | Solvent extrac-tion of copper from ammoniacal chloride solutions by steri-cally hinderedβ-diketone extractants显示文摘 | Fu Weng Chen Qiyuan Hu Huiping | 2011 | Separation andPurification Technology2011，80，： | 1 |
| 20 | Identification of Arsenato Antimonates in Copper Anode Slimes 显示文摘 | Wang Xuewen Chen Qiyuan Yin Zhoulan | 2006 | Hydrometallurgy2006，84，34： | 1 |
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