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| 1 | Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1显示文摘Ferroptosis is a non-apoptotic regulated cell death caused by iron accumulation and subsequent lipid peroxidation.Currently,the therapeutic role of ferroptosis on cancer is gaining increasing interest.Baicalin an active component in Scutellaria baicalensis Georgi with anticancer potential various cancer types;however,the effects of baicalein on bladder cancer and the underlying molecular mechanisms remain largely unknown.In the study,we investigated the effect of baicalin on bladder cancer cells5637 and KU-19-19.As a result,we show baicalin exerted its anticancer activity by inducing apoptosis and cell death in bladder cancer cells.Subsequently,we for the first time demonstrate baicalin-induced ferroptotic cell death in vitro and in vivo,accompanied by reactive oxygen species(ROS) accumulation and intracellular chelate iron enrichment.The ferroptosis inhibitor deferoxamine but not necrostatin-1,chloroquine(CQ),N-acetyl-L-cysteine,L-glutathione reduced,or carbobenzoxy-valyl-alanyl-aspartyl-[O-methyl]-fluoromethylketone(Z-VAD-FMK) rescued baicalin-induced cell death,indicating ferroptosis contributed to baicalin-induced cell death.Mechanistically,we show that ferritin heavy chain1(FTH1) was a key determinant for baicalin-induced ferroptosis.Overexpression of FTH1 abrogated the anticancer effects of baicalin in both 5637 and KU19-19 cells.Taken together,our data for the first time suggest that the natural product baicalin exerts its anticancer activity by inducing FTH1-dependent ferroptosis,which will hopefully provide a prospective compound for bladder cancer treatment. | Na Kong Xiaying Chen Jiao Feng Ting Duan Shuiping Liu Xueni Sun Peng Chen Ting Pan Lili Yan Ting Jin Yu Xiang Quan Gao Chengyong Wen Weirui Ma Wencheng Liu Mingming Zhang Zuyi Yang Wengang Wang Ruonan Zhang Bi Chen Tian Xie Xinbing Sui Wei Tao | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 23 |
| 2 | Curcumenol triggered ferroptosis in lung cancer cells via lncRNA H19/miR-19b-3p/FTH1 axis显示文摘Curcumenol,an effective ingredient of Wenyujin,has been reported that exerted its antitumor potential in a few cancer types.However,the effect and molecular mechanism of curcumenol in lung cancer are largely unknown.Here,we found that curcumenol induced cell death and suppressed cell proliferation in lung cancer cells.Next,we demonstrated that ferroptosis was the predominant method that contributed to curcumenol-induced cell death of lung cancer in vitro and vivo for the first time.Subsequently,using RNA sequencing,we found that the long non-coding RNA H19(lncRNA H19)was significantly downregulated in lung cancer cells treated with curcumenol,when compared to untreated controls.Overexpression of lncRNA H19 eliminated the anticancer effect of curcumenol,while lncRNA H19 knockdown promoted ferroptosis induced by curcumenol treatment.Mechanistically,we showed that lncRNA H19 functioned as a competing endogenous RNA to bind to miR-19b-3p,thereby enhanced the transcription activity of its endogenous target,ferritin heavy chain 1(FTH1),a marker of ferroptosis.In conclusion,our data show that the natural product curcumenol exerted its antitumor effects on lung cancer by triggering ferroptosis,and the lncRNA H19/miR-19b-3p/FTH1 axis plays an essential role in curcumenol-induced ferroptotic cell death.Therefore,our findings will hopefully provide a valuable drug for treating lung cancer patients. | Ruonan Zhang Ting Pan Yu Xiang Mingming Zhang Han Xie Zimao Liang Bi Chen Cong Xu Jing Wang Xingxing Huang Qianru Zhu Ziming Zhao Quan Gao Chengyong Wen Wencheng Liu Weirui Ma Jiao Feng Xueni Sun Ting Duan Elaine Lai-Han Leung Tian Xie Qibiao Wu Xinbing Sui | 2022 | Bioactive Materials2022，7，7： | 8 |
| 3 | Nested-loop Mechanism Based Modular Multilevel Converter Topology and Optimal Design显示文摘普通模块化多电平换流器(modular multilevelconverter,MMC)拓扑中,因子模块数量较多,系统需采集和处理的信息量大,导致控制系统硬件构成复杂。提出一种基于循环嵌套机理的MMC拓扑,其电平输出能力得到显著提升。通过上下两组子模块的协调投切,相对于普通MMC拓扑,新型拓扑输出相同电平数所需的子模块及控制设备数量大幅减少。阐述该新型拓扑的构成方式及基本参数选取原则;针对循环嵌套结构,设计相应的模块协调控制策略;分别以模块用量最小化和换流器运行损耗最小化为目标,优化设计拓扑构成方案。在RTDS中搭建换流器模型,仿真结果表明,新型拓扑具备更强的电平输出能力,并达到大幅减少子模块数量、简化控制系统硬件构成的目标。 | LIU Xinghua ZHAO Chengyong PENG Maolan GUO Chunyi ZHANG Baoshun | 2013 | 中国电机工程学报2013，33，9： | 7 |
| 4 | Low-temperature activation of methane over rare earth metals promoted Zn/HZSM-5 zeolite catalysts in the presence of ethylene显示文摘At low temperature of 723 K, methane can be easily activated in the presence of ethylene in the feed, and converted to higher hydrocarbons (C2–C4) and aromatics (C6–C10), through its reaction over rare metals modified Zn/HZSM-5 zeolite catalysts without undesirable carbon oxides formation. Methane can get 37.3% conversion over the above catalysts under low temperature, and the catalysts show a longer lifetime than usual metal supported HZSM-5 zeolite catalysts without adding any rare earth metals. The effects of methane activation over various rare earth metal promoted Zn/HZSM-5 catalysts on the products and influences of several reaction conditions such as temperature, catalyst lifetime and molar ratio of CH4/C2H4 have been discussed. | Hengqiang Zhang Aiguo Kong Yongjie Ding Chengyong Dai Yongkui Shan | 2011 | Journal of Natural Gas Chemistry2011，20，3： | 4 |
| 5 | Drilling Force and Temperature of Bone under Dry and Physiological Drilling Conditions显示文摘Many researches on drilling force and temperature have been done with the aim to reduce the labour intensiveness of surgery, avoid unnecessary damage and improve drilling quality. However, there has not been a systematic study of mid- and high-speed drilling under dry and physiological conditions(injection of saline). Furthermore, there is no consensus on optimal drilling parameters. To study these parameters under dry and physiological drilling conditions, pig humerus bones are drilled with medical twist drills operated using a wide range of drilling speeds and feed rates. Drilling force and temperature are measured using a YDZ-II01 W dynamometer and a NEC TVS-500 EX thermal infrared imager, respectively, to evaluate internal bone damage. To evaluate drilling quality, bone debris and hole morphology are observed by SEM(scanning electron microscopy). Changes in drilling force and temperature give similar results during drilling such that the value of each parameter peaks just before the drill penetrates through the osteon of the compact bone into the trabeculae of the spongy bone. Drilling temperatures under physiological conditions are much lower than those observed under dry conditions, while a larger drilling force occurs under physiological conditions than dry conditions. Drilling speed and feed rate have a significant influence on drilling force, temperature, bone debris and hole morphology. The investigation of the effect of drilling force and temperature on internal bone damage reveals that a drilling speed of 4500 r/min and a feed rate of 50 mm/min are recommended for bone drilling under physiological conditions. Drilling quality peaks under these optimal parameter conditions. This paper proposes the optimal drilling parameters under mid- and high-speed surgical drilling, considering internal bone damage and drilling quality, which can be looked as a reference for surgeons performing orthopedic operations. | XU Linlin WANG Chengyong JIANG Min HE Huiyu SONG Yuexian CHEN Hanyuan SHEN Jingnan ZHANG Jiayong | 2014 | Chinese Journal of Mechanical Engineering2014，27，6： | 3 |
| 6 | Effects of modified kaolin on the crystallization property of PP/Kaolin nanocomposites显示文摘Modified kaolin-filled polypropylene was prepared by blending different kinds of modified kaolin intercalated master batches with polypropylene.The microstructure of PP/Kaolin was studied with X-ray diffraction (XRD) patterns and transmission electron microscopy (TEM) photos.The effects of the organic kaolin master batches on the crystallization property of polypropylene were investigated by means of non-isothermal differential scanning calorimetry analysis (DSC) and polarized light microscopy (PLM).Non-isothermal crystallization kinetics of polypropylene was studied by the use of modified Avrami Equation improved by Jeziorny.The results indicate that some organic kaolin can be exfoliated by polypropylene,proved by an in-visible 001 peak on XRD pattern and individual layer on transmission electron microscopy (TEM) photos,and the heterogeneous nucleus increased with the addition of modified kaolin,proved by the PLM photos.The filled polypropylene crystallizes fastest at 395 K.The results also show that organic kaolin master batches not only can effectively accelerate the heterogeneous nucleation of polypropylene but also can increase the rate of crystallizing point and the temperature of crystallization.However,the rate constant of crystallization remains unchanged. | LIU Xuening HU Nan ZHANG Hongtao HA Chengyong YANG Zhizhong | 2005 | Science China Chemistry2005，48，4： | 3 |
| 7 | Microstructure of Hardened Steel at High Temperature and High Strain Rate显示文摘In high-speed machining,hardened steel materials are subjected to high temperatures and high strain rates.Under these conditions,the composition and microstructure of the material may change,and phenomena,such as thermal softening,emerge.These effects are difficult to detect by only observing the chip morphology.Here,using a microscopic detection method,the dynamic mechanical behavior and microstructure of SDK11 hardened steel(62HRC)is investigated at high temperature and high strain-rate,and the relationship between strain hardening,thermal softening,and strain-rate strengthening is determined.The metallographic phases of specimens treated using a split-Hopkinson pressure bar,and″chips″generated during high-speed machining at high temperature and high strain rate state are compared.The results indicate that the phase composition at low temperature and low strain rate differs from that at high temperature and high strain rate.It is further concluded that shear slip occurs at high temperature and high strain rate,and the shear behavior is more pronounced at higher strain rates. | Ding Feng Tang Dewen Wang Chengyong Zhang Fenglin Zheng Lijuan | 2017 | Transactions of Nanjing University of Aeronautics and Astronautics2017，34，4： | 2 |
| 8 | Haplotype-resolved genome of diploid ginger (Zingiber officinale) and its unique gingerol biosynthetic pathway显示文摘Ginger(Zingiber officinale),the type species of Zingiberaceae,is one of the most widespread medicinal plants and spices.Here,we report a high-quality,chromosome-scale reference genome of ginger‘Zhugen’,a traditionally cultivated ginger in Southwest China used as a fresh vegetable,assembled from PacBio long reads,Illumina short reads,and high-throughput chromosome conformation capture(Hi-C)reads.The ginger genome was phased into two haplotypes,haplotype 1(1.53 Gb with a contig N50 of 4.68 M)and haplotype 0(1.51 Gb with a contig N50 of 5.28 M).Homologous ginger chromosomes maintained excellent gene pair collinearity.In 17,226 pairs of allelic genes,11.9%exhibited differential expression between alleles.Based on the results of ginger genome sequencing,transcriptome analysis,and metabolomic analysis,we proposed a backbone biosynthetic pathway of gingerol analogs,which consists of 12 enzymatic gene families,PAL,C4H,4CL,CST,C3’H,C3OMT,CCOMT,CSE,PKS,AOR,DHN,and DHT.These analyses also identified the likely transcription factor networks that regulate the synthesis of gingerol analogs.Overall,this study serves as an excellent resource for further research on ginger biology and breeding,lays a foundation for a better understanding of ginger evolution,and presents an intact biosynthetic pathway for species-specific gingerol biosynthesis. | Hong-Lei Li Lin Wu Zhaoming Dong Yusong Jiang Sanjie Jiang Haitao Xing Qiang Li Guocheng Liu Shuming Tian Zhangyan Wu Bin Wu Zhexin Li Ping Zhao Yan Zhang Jianmin Tang Jiabao Xu Ke Huang Xia Liu Wenlin Zhang Qinhong Liao Yun Ren Xinzheng Huang Qingzhi Li Chengyong Li Yi Wang Baskaran Xavier-Ravi Honghai Li Yang Liu Tao Wan Qinhu Liu Yong Zou Jianbo Jian Qingyou Xia Yiqing Liu | 2021 | Horticulture Research2021，8，1： | 2 |
| 9 | CO_2 sensing properties and mechanism of PrFeO_3 and NdFeO_3 thick film sensor显示文摘The CO_2 sensing of PrFeO_3 and NdFeO_3 sensors were investigated. Experimental results show that the resistances for PrFeO_3 and NdFeO_3 in CO_2 gas are larger than those in air and the responses for PrFeO_3and NdFeO_3 sensors increase with an increase in room-temperature relative humidity. When exposed to1000 ppm CO_2, the response of PrFeO_3 thick film based on nano-powders annealed at 700℃can reach8.44 at 160℃for the background of wet air with 58%of room-temperature relative humidity (RH),which is much larger than the corresponding value (3.03) in wet air with 25%RH. The sensing response S of NdFeO_3 thick-film sensor based on nano-powders annealed at 600℃to 3000 ppm CO_2 at the operating temperature 200℃can reach 2.36 for the background of wet air with 72%RH, which is larger than the corresponding value (1.83) in the air with 25%RH. Compared with other CO_2 sensing materials, the PrFeO_3 sensor has larger response at lower operating temperature for CO_2 gas and may be used as a new CO_2 sensing material. | Yanping Chen Dandan Wang Hongwei Qin Heng Zhang Zhongli Zhang Guangjun Zhou Chengyong Gao Jifan Hu | 2019 | Journal of Rare Earths2019，37，1： | 2 |
| 10 | A systematic review of radiofrequency ablation versus percutaneous ethanol injection for small hepatocellular carcinoma up to 3 cm显示文摘 | Ai Shen Hua Zhang Chengyong Tang Yong Chen Yefei Wang Chao Zhang Zhongjun Wu | 2013 | J Gastroenterol Hepatol2013，，5： | 2 |
| 11 | Electrical contacts in monolayer blue phosphorene devices显示文摘半导体的单层(ML ) 蓝色 phosphorene (BlueP ) 与 ML 黑 phosphorene (BP ) 分享类似的稳定性,并且它最近有在 Au 表面上是成年的。潜在的 ML BlueP 设备经常与金属要求直接接触启用搬运人的注射。第一次,用 ab initio,电子结构计算和量搬运模拟我们在与在一只领域效果晶体管(联邦货物税) 跨越一个宽工作函数范围的金属的接触执行 ML BlueP 的界面的性质的系统的研究配置。ML BlueP 由于和五金属的强壮的相互作用经历了 metallization。与 0.42 的一个卡住的因素由于导致金属的差距状态(米格机) 在 ML BlueP 联邦货物税有强壮的费密水平(FLP ) ,卡住。分别地, ML BlueP 与 0.22, 0.22,和 0.80 eV 的电子 Schottky 障碍高度(SBH ) 与 Sc, Ag,和磅电极形成 n 类型 Schottky 接触并且与有 0.61 和 0.79 eV 的洞 SBH 的 Au 和 Pd 电极的 p 类型 Schottky 接触分别地。米格机被在 ML BlueP 和金属电极之间插入 graphene 消除,从强壮的 FLP 由转变伴随了到弱 FLP。我们的学习不仅提供卓见进 ML BlueP 金属接口,而且在 ML BlueP 设备的设计帮助。 | Jingzhen Li Xiaotian Sun Chengyong Xu Xiuying Zhang Yuanyuan Pan Meng Ye Zhigang Song Ruge Quhe Yangyang Wang Han Zhang Ying Guo Jinbo Yang Feng Pan Jing Lu | 2018 | Nano Research2018，11，4： | 2 |
| 12 | Theories and Methods of Landscape Architecture Heritage Protection显示文摘This paper firstly made an overview of foreign and domestic theories and methods of landscape architecture heritage protection.It studied the landscape architecture heritage from policies and regulations,investment management,talent cultivation,and popular science education.Then,it discussed problems of landscape architecture heritage protection in China:lack of legislation,weak awareness of heritage resources,overdevelopment of heritage resources,and vacancy in management and monitoring of heritage resources.Finally,it came up with recommendations that competent authorities of Chinese government should attach greater importance to heritage management,talent cultivation,and fund input,integrate with advanced management methods of developed countries,and exploring a landscape architecture heritage protection and management mode suitable for national conditions of China at levels of thought,methods,and technology. | SHI Chengyong ZHANG Pei TANG Ying | 2016 | Journal of Landscape Research2016，8，6： | 1 |
| 13 | Temperature-dependent self-assembly of near-infrared (NIR) luminescent Zn 2 Ln and Zn 2 Ln 3 (Ln=Nd, Yb or Er) complexes from the flexible Salen-type Schiff-base ligand显示文摘 | Tiezheng Miao Zhao Zhang Weixu Feng Peiyang Su Heini Feng Xingqiang Lü Daidi Fan Wai-Kwok Wong Richard A. Jones Chengyong Su | 2014 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy2014，，： | 1 |
| 14 | Interference well testing analysis when responding well is producing显示文摘 | Li Chengyong Zhang Ran Liu Qiguo Zhang Liehui | 2005 | Well Testing and Production Technology2005，26，2： | 1 |
| 15 | Properties of Granite Grinding Surface显示文摘 | Qin Z Wang Chengyong Wei X Zhang F L and Wei X | 2001 | Key Engineering Materials2001，，202203： | 1 |
| 16 | Analysis of dual-Infeed HVDC with LCC-HVDC and VSC-HVDC显示文摘 | Guo Chunyi Zhang Yi Gole A M Zhao Chengyong | 2012 | IEEE Transactions on Power Delivery2012，27，3： | 1 |
| 17 | The research of SM topology with DC fault tolerance in MMC-HVDC显示文摘 | ZHANG Jianpo ZHAO Chengyong | 2015 | IEEE Trans on Power Delivery2015，30，3： | 1 |
| 18 | Antibodies against low-density lipoprotein receptor-related protein 4 induce myasthenia gravis显示文摘 | Shen Chengyong Lu Yisheng Zhang Bin Figueiredo Dwight Bean Jonathan Jung Jiung Wu Haitao Barik Arnab Yin Dong-Min Xiong Wen-Cheng Mei Lin | 2013 | Journal of Clinical Investigation2013，，12： | 1 |
| 19 | Correction:Haplotype-resolved genome of diploid ginger (Zingiber officinale)and its unique gingerol biosynthetic pathway显示文摘After online publication of the article 1,the authors noticed the affiliation“College of Landscape Architecture and Life Science/Institute of Special Plants,Chongqing University of Arts and Sciences,Yongchuan,Chongqing,China”for author Yiqing Liu was missing. | Hong-Lei Li Lin Wu Zhaoming Dong Yusong Jiang Sanjie Jiang Haitao Xing Qiang Li Guocheng Liu Shuming Tian Zhangyan Wu Bin Wu Zhexin Li Ping Zhao Yan Zhang Jianmin Tang Jiabao Xu Ke Huang Xia Liu Wenlin Zhang Qinhong Liao Yun Ren Xinzheng Huang Qingzhi Li Chengyong Li Yi Wang Baskaran Xavier-Ravi Honghai Li Yang Liu Tao Wan Qinhu Liu Yong Zou Jianbo Jian Qingyou Xia Yiqing Liu | 2021 | Horticulture Research2021，8，1： | 1 |
| 20 | Solid polymer electrolyte comprised of lithium salt / ether functionalized ammonium-based polymeric ionic liquid with bis(fluorosulfonyl) imide显示文摘 | Zhang Heng Liu Chengyong Zheng Liping | 2015 | Electrochimica Acta2015，159，3： | 1 |
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