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| 1 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 2 | Simultaneous Screening of 733 Pesticide Residues in Fruits and Vegetables by a GC/LC-Q-TOFMS Combination Technique显示文摘In this paper,we report the construction of two accurate mass databases and the development of a combination detection method that simultaneously screens for 733 pesticide and chemical contaminant multi-residues via high-throughput liquid chromatography(LC)-and gas chromatography(GC)-quadru pole-time-of-flight mass spectrometry(Q-TOFMS).This work demonstrates that electronic mass spectral standards may replace chemical-source standard materials as references through one sample preparation and the combination of GC/LC-Q-TOFMS screening.This cutting-edge technique has also replaced multiresidue determination using targeted detection with non-targeted screening.The pesticide residue types,sensitivity,recovery,and reproducibility of this combination technique are evaluated in eight fruit and vegetable matrices.This technique shows three advantages:①In comparison with the discovery capability of a single technique,the combination technique shows an improvement of 51.1%(GC-QTOFMS)and 39.6%(LC-Q-TOFMS),respectively;②the combination technique can satisfy a screening limit lower than 10μg·kg^-1 and meet the requirements of“uniform standards,”although some of the pesticide residues could be optimized to further improve screening sensitivity;③over 488 pesticides with recoveries between 60%-120%and relative standard deviation(RSD)<20%at a spiked level of 10μg·kg^-1 were detected with the combination technique in eight different matrices.From 2012 to 2017,this combination technique was applied in an investigation to screen pesticide residues from 1384 sampling locations for 38138 batched samples covering 18 categories and 134 types of fruits and vegetables obtained from across the mainland of China.After statistical analysis,533 pesticides in 115891 determinations were detected,and the regularity of pesticides in the fruits and vegetables sold on the Chinese market was shown. | Guofang Pang Qiaoying Chang Ruobin Bai Chunlin Fan Zijuan Zhang Hongyuan Yan Xingqiang Wu | 2020 | Engineering2020，6，4： | 11 |
| 3 | Status and development of high-power laser facilities at the NLHPLP显示文摘In this paper, we review the status of the multifunctional experimental platform at the National Laboratory of High Power Laser and Physics(NLHPLP). The platform, including the SG-II laser facility, SG-II 9th beam, SG-II upgrade(SG-II UP) facility, and SG-II 5 PW facility, is operational and available for interested scientists studying inertial confinement fusion(ICF) and a broad range of high-energy-density physics. These facilities can provide important experimental capabilities by combining different pulse widths of nanosecond, picosecond, and femtosecond scales. In addition, the SG-II UP facility, consisting of a single petawatt system and an eight-beam nanosecond system, is introduced including several laser technologies that have been developed to ensure the performance of the facility. Recent developments of the SG-II 5 PW facility are also presented. | Jianqiang Zhu Jian Zhu Xuechun Li Baoqiang Zhu Weixin Ma Xingqiang Lu Wei Fan Zhigang Liu Shenlei Zhou Guang Xu Guowen Zhang Xinglong Xie Lin Yang Jiangfeng Wang Xiaoping Ouyang Li Wang Dawei Li Pengqian Yang Quantang Fan Mingying Sun Chong Liu Dean Liu Yanli Zhang Hua Tao Meizhi Sun Ping Zhu Bingyan Wang Zhaoyang Jiao Lei Ren Daizhong Liu Xiang Jiao Hongbiao Huang Zunqi Lin | 2018 | High Power Laser Science and Engineering2018，6，4： | 8 |
| 4 | Tunable Schottky barrier width and enormously enhanced photoresponsivity in Sb doped SnS2 monolayer显示文摘Doping, which is the intentional introducti on of impurities into a material, can improve the metal-semiconductor interface by reducing Schottky barrier width. Here, we prese nt high-quality two-dime nsional SnS2 nano sheets with well-controlled Sb dopi ng concen tration via direct vapor growth approach and following micromechanical cleavage process. X-ray photoelectro n spectroscopy (XPS) measureme nt dem on strates that Sb contents of the doped samples are approximately 0.22%, 0.34% and 1.21%, respectively, and doping in duces the upward shift of the Fermi level with respect to the pristi ne SnS2. Tran smissio n electro n microscopy (TEM) characterizatio n exhibits that Sb-doped SnS2 nano sheets have a high-quality hexagonal symmetry structure and Sb element is uniformly distributed in the nano sheets. The phototra nsistors based on the Sb-doped SnS2 mono layers show n-type behavior with high mobility which is one order of magn itude higher than that of pristi ne SnS2 phototra nsistors. The photorespo nsivity and exter nal quantum efficiency (EQE) of Sb-S nS2 mono layers phototra nsistors are approximately three orders of magnitude higher than that of pristine SnS2 phototransistor. The results suggest that the method of reducing Shottky barrier width to achieve high mobility and photoresp on sivity is effective, and Sb-doped SnS2 mono layer has significant potential in future nanoelectronic and optoelectronic applications. | Junchi Liu Xiao Liu Zhuojun Chen Lili Miao Xingqiang Liu Bo Li Liming Tang Keqiu Chen Yuan Liu Jingbo Li Zhongming Wei Xidong Duan | 2019 | Nano Research2019，12，2： | 7 |
| 5 | High-performance asymmetric electrodes photodiode based on Sb/WSe2 heterostructure显示文摘Two-dimensional (2D) van der Waals (vdWs) metal-semiconductor heterostructures with atomically sharp interface and matched work functions have recently attracted great attention due to their unique electronic and optoelectronic properties. Here we report the vapor phase epitaxial growth of large-scale vertical Sb/WSe2 metal-semiconductor vdWs heterostructures with uniform stacking orientation. Compared with the growth on S1O2/S1 substrate, the thick ness of Sb nan osheet on WSe2 can be reduced effectively to mono layer. We con struct Sb-WSe2-Au asymmetric electrodes photodiode based on the Sb/WSe2 heterostructures. Electrical transport measurements indicate that the photodiode show obvious rectifying effect. Optoelectronic characterizations show prominent photoresponse with a high photoresposivity of 364 mA/W, a fast response time of less than 8 ms, a large open-circuit voltage of 0.27 V and a maximum electrical power output of 0.11 nW. The direct growth of high-quality metal-semiconductor vdWs heterostructures may open up new realms in 2D functional electronics and optoelectronics. | Xiao Liu Guangzhuang Sun Peng Chen Junchi Liu Zhengwei Zhang Jia Li Huifang Ma Bei Zhao Ruixia Wu Weiqi Dang Xiangdong Yang Chen Dai Xuwan Tang Zhuojun Chen Lili Miao Xingqiang Liu Bo Li Yuan Liu Xidong Duan | 2019 | Nano Research2019，12，2： | 5 |
| 6 | Tire Defect Detection on Impurities显示文摘According to X-ray image texture tire characteristics and abnormal distribution of the gray area,this paper studies a real-time defect detection method about the sidewall of tire.On the basis of the texture distribution characteristics of X-ray tire,we extract the cord information of the tire image by maximizing the distance of the categories after the gray value correction,then we use the morphology method and statistics method to process the image so that we can get the location and the size of impurities.We can classify the tires into different grades by the information.Compared with other methods,our method has the advantage that meets the needs of tire industry. | ZHANG Mao-qiang GUO Qiang YANG Xingqiang | 2014 | Computer Aided Drafting,Design and Manufacturing2014，24，1： | 3 |
| 7 | Tectonically-controlled Evolution of the Late Cenozoic Nihewan Basin, North China Craton: Constraints from Stratigraphy, Mineralogy, and Geochemistry显示文摘The Late Cenozoic basins in the Weihe–Shanxi Graben, North China Craton are delineated by northeast-striking faults. The faults have, since a long time, been related to the progressive uplift and northeastward expansion of the Tibetan Plateau. To show the relation between the basins and faults, two Pliocene–Pleistocene stratigraphic sections(Chengqiang and Hongyanangou) in the southern part of the Nihewan Basin at the northernmost parts of the graben are studied herein. Based on the sedimentary sequences and facies, the sections are divided into three evolutionary stages, such as alluvial fan-eolian red clay, fan delta, and fluvial, with boundaries at ~2.8 and ~1.8 Ma. Paleocurrent indicators, the composition of coarse clastics, heavy minerals, and the geochemistry of moderate–fine clastics are used to establish the temporal and spatial variations in the source areas. Based on features from the middlenorthern basin, we infer that the Nihewan Basin comprises an old NE–SW elongate geotectogene and a young NW–SE elongate subgeotectogene. The main geotectogene in the mid-north is a half-graben bounded by northeast-striking and northwest-dipping normal faults(e.g., Liulengshan Fault). This group of faults was mainly affected by the Pliocene(before ~2.8–2.6 Ma) NW–SE extension and controlled the deposition of sediments. In contrast, the subgeotectogene in the south was affected by northwest-striking normal faults(e.g., Huliuhe Fault) that were controlled by the subsequent weak NE–SW extension in the Pleistocene. The remarkable change in the sedimentary facies and provenance since ~1.8 Ma is possibly a signal of either weak or strong NE–SW extension. This result implies that the main tectonic transition ages of ~2.8–2.6 Ma and ~1.8 Ma in the Weihe–Shanxi Graben are affected by the Tibetan Plateau in Pliocene–Pleistocene. | LIU Jin CHEN Xingqiang CHI Zhenqing WANG Yong MIN Longrui LI Tingdong | 2018 | Acta Geologica Sinica(English Edition)2018，92，2： | 2 |
| 8 | First report of microcystin production in Microcystis smithii Komrek and Anagnostidis(Cyanobacteria) from a water bloom in Eastern China显示文摘A water bloom sample collected from Lake Dishui in Shanghai was characterized.The morphological identification showed that Micorcystis wesenbergii and Micorcystis smithii were the main component of the bloom.Five strains of M.smithii were successfully isolated.Their 16S rRNA gene sequences based phylogenetic tree showed that the five strains of M.smithii intermixed with strains of other morphospecies in Microcystis.A fragment of mcy gene encoding for microcystin synthetase was detected in one of the five M.smithii strains(CHAB 2183),indicating its potential of microcystin production.High performance liquid chromatography analysis confirmed M.smithii CHAB 2183 to produce microcystin-RR as 1550 μg per gram dry weight cells.The present investigation,for the first time,reported the isolated strains of M.smithii and microcystin production from M.smithii. | Yang Liu Wenhua Tan Xingqiang Wu Zhongxing Wu Gongliang Yu Renhui Li | 2011 | Journal of Environmental Sciences2011，23，1： | 2 |
| 9 | Does Religion Matter to Owner-Manager Agency Costs? Evidence from China显示文摘 | Xingqiang Du | 2013 | Journal of Business Ethics2013，，2： | 2 |
| 10 | Spatiotemporal dynamics of cell abundance,colony size and intracellular toxin concentrations of pelagic and benthic Microcystis in Lake Caohai,China显示文摘Lake Caohai has experienced extensive Microcystis blooms in recent years,and to improve its water quality,the local government carried out a series of water control measures.To better understand the dynamics of both pelagic and benthic Microcystis and their characteristics in Lake Caohai,we conducted a 1-year investigation from December 2015to December 2016 to gain a seasonal outlook on the distribution and dynamics of cell abundance,colony size and intracellular microcystins(MCs)of Microcystis.The results indicated that the Microcystis bloom occupied primarily the northeastern region and then moved gradually from lakeshore to lake center.The perennial southwesterly winds and the water inflow from northeast to southwest in Lake Caohai determined the spatiotemporal distribution of pelagic Microcystis.Benthic Microcystis was mainly distributed in the northeastern region in summer,occupied the lake center in autumn and then occupied the southeastern region in winter,determined by the sedimentation of pelagic Microcystis and the death of benthic Microcystis.Small colonies(20-60μm)overwintered more easily in both water column and sediment.The concentrations of intracellular toxin of benthic Microcystis were observed to be significantly higher than those of pelagic Microcystis.This might be because Microcystis synthesized large amount of MCs to acclimate to an unfavorable benthic environment.This knowledge on the dynamics of Microcystis expands our understanding of mechanisms underpinning the formation of Microcystis blooms. | Bing Feng Chunbo Wang Xingqiang Wu Cuicui Tian Meng Zhang Yingying Tian Bangding Xiao | 2019 | Journal of Environmental Sciences2019，31，10： | 1 |
| 11 | Temperature-dependent self-assembly of near-infrared (NIR) luminescent Zn 2 Ln and Zn 2 Ln 3 (Ln=Nd, Yb or Er) complexes from the flexible Salen-type Schiff-base ligand显示文摘 | Tiezheng Miao Zhao Zhang Weixu Feng Peiyang Su Heini Feng Xingqiang Lü Daidi Fan Wai-Kwok Wong Richard A. Jones Chengyong Su | 2014 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy2014，，： | 1 |
| 12 | Nitrogenand phosphorus uptake and yield of wheat and maize in-tercropped with poplar 显示文摘 | Dai Xiaoqin Li Peng Guo Xingqiang | 2008 | Arid Land Research andManagement2008，22，4： | 1 |
| 13 | Coupling non-isothermal trickle-bed reactor with catalyst pellet models to understand the reaction and diffusion in gas oil hydrodesulfurization显示文摘In this work,a trickle-bed reactor coupled with catalyst pellet model is employed to understand the effects of the temperature and catalyst pellet structures on the reaction-diffusion behaviors in gas oil hydrodesulfurization(HDS).The non-isothermal reactor model is determined to be reasonable due to non-negligible temperature variation caused by the reaction heat.The reaction rate along the reactor is mainly dominated by the temperature,and the sulfur concentration gradient in the catalyst pellet decreases gradually along the reactor,leading to the increased internal effectiveness factor.For the fixed catalyst bed volume,there exists a compromise between the catalyst reaction rate and effectiveness factor.Under commonly studied catalyst pellet size of 0.8-3 mm and porosity of 0.4-0.8,an optimization of the temperature and catalyst pellet structures is carried out,and the optimized outlet sulfur content decreases to 7.6 wppm better than the commercial level at 0.96 mm of the catalyst pellet size and 0.40 of the catalyst porosity. | Xingqiang Zhao Changfeng Yang Mengke Lu Yao Shi Gang Qian Xinggui Zhou Xuezhi Duan | 2020 | Chinese Journal of Chemical Engineering2020，28，4： | 1 |
| 14 | Multinuclear NIR luminescent 1,4 - BDC bridged Schiff - base complexes of Nd(Ⅲ)显示文摘 | Lu Xingqiang Bi Weiyu Chai Wenli | 2009 | Polyhedron2009，28，： | 1 |
| 15 | Rural wastewater irrigation and nitrogen removal by the paddy wetland system in the Tai Lake Region of China显示文摘 | Li Song Li Hua Liang Xingqiang | 2009 | Journal of Soils and Sediments Protection Risk Assessment&Rem2009，9，5： | 1 |
| 16 | Asymmetric Tris-Heteroleptic Cyclometalated Phosphorescent Iridium(III)Complexes:An Emerging Class of Metallophosphors显示文摘CONSPECTUS:The rapid developments of cutting-edge research on photofunctional organic semiconductor materials are greatly promoting the progress of science and technology.As one of the most important organic semiconductor materials,phosphorescent iridium(III)complexes are a promising class of organometallic emitters because of their rich emissive excited states together with excellent chemical stability,which have been widely used in various fields,such as organic electroluminescence,solar cells,photo-catalysis,biosensing,bioimaging,cancer therapy,etc.The exploration of highly efficient phosphorescent iridium(III)complexes showing various structural features is blooming quickly.In general,the traditional iridium(III)phosphors usually contain at least two identical cyclometalating bidentate ligands.These iridophosphors with two identical bidentate ligands are termed as the bis-heteroleptic complex Ir((L1)2L2),where L denotes the free ligand or the deprotonated form of the free ligand.Those with three identical ligands are called homoleptic complex Ir(L)3.Recently,the iridium(III)complexes Ir(L1L2L3)supported by three different(cyclometalating)ligands are emerging as a novel and interesting category of phosphors.This class of iridophosphors usually refers to tris-heteroleptic cyclometalated phosphorescent iridium(III)complexes,and they usually show the asymmetry in their molecular structures.Compared with the case for the traditional iridium(III)phosphors,the independent ligand control provides tris-heteroleptic iridium(III)phosphors with more flexible molecular design/synthesis and excited-state fine-tuning ability,thereby resulting in more rich and appealing excited states and potential multifunctional applications.In this Account,we will highlight our recent efforts on the asymmetric tris-heteroleptic cyclometalated iridium(III)phosphors including the molecular design strategies,chemical synthesis,excited-state tuning,and structure−property relationships as well as their applications,especially in organic electroluminescence.Specifically,the molecular design of tris-heteroleptic iridium(III)phosphors focuses on the independent ligand design including the following three aspects:(1)the substituent functionalization engineering(SFE);(2)the ligand skeleton engineering(LSE);(3)the double metalation engineering(DME).For SFE,we mainly introduce the substituent based on the main-group element into the ligand of iridophosphors and also investigate the influence of the substituent position on the emissive excited states of iridophosphors.For instance,the main-group elements show unique electronic effects,which could contribute to the manipulation of the photoelectric properties of complexes(e.g.,balanced charge transport ability,improved utilization of excitons,etc.).For LSE,different types of aromatic skeleton or various lengths ofπconjugation of the ligands are also examined for the effective tuning of their excited states.For DME,the type and spatial orientation of the bridging/franking ligand will be considered.At the same time,the related optoelectronic applications(e.g.,electroluminescence,optical power limiting,etc.)of this novel class of versatile iridophosphors are also discussed.Finally,we give some perspectives on this fascinating topic and also try to provide some potential research opportunities based on the current stage of asymmetric tris-heteroleptic cyclometalated phosphorescent iridium(III)complexes.It is believed that the emerging asymmetric tris-heteroleptic cyclometalated iridophosphors will open an important avenue for designing novel metallophosphor-based materials with tunable and appealing photophysical properties,thus offering new probabilities for potential multifunctional applications. | Peng Tao Xingqiang Lü Guijiang Zhou Wai-Yeung Wong | 2022 | Accounts of Materials Research2022，3，8： | 1 |
| 17 | Aerosol laser time-of-flight mass spectrometer for the on-line measurement of secondary organic aerosol in smog chamber显示文摘 | HUANG Mingqiag LIU Xingqiang HU Changjin | 2014 | Measurement2014，55，： | 1 |
| 18 | Linear alkylbenzene sulfonate (LAS) in water of Lake Dianchi—spatial and seasonal variation, and kinetics of biodegradation显示文摘 | Zhi Wang Bangding Xiao Xingqiang Wu Xinhai Tu Yingcai Wang Xiaolei Sun Lirong Song | 2010 | Environmental Monitoring and Assessment (-)2010，，1： | 1 |
| 19 | Review on metal halide perovskite-based optoelectronic synapses显示文摘With the progress of both photonics and electronics,optoelectronic synapses are considered potential candidates to challenge the von Neumann bottleneck and the field of visual bionics in the era of big data.They are also regarded as the basis for integrated artificial neural networks(ANNs)owing to their flexible optoelectronic tunable properties such as high bandwidth,low power consumption,and high-density integration.Over the recent years,following the emergence of metal halide perovskite(MHP)materials possessing fascinating optoelectronic properties,novel MHP-based optoelectronic synaptic devices have been exploited for numerous applications ranging from artificial vision systems(AVSs)to neuromorphic computing.Herein,we briefly review the application prospects and current status of MHP-based optoelectronic synapses,discuss the basic synaptic behaviors capable of being implemented,and assess their feasibility to mimic biological synapses.Then,we focus on the two-terminal optoelectronic synaptic memristors and three-terminal transistor synaptic phototransistors(SPTs),the two essential apparatus structures for optoelectronic synapses,expounding their basic features and operating mechanisms.Finally,we summarize the recent applications of optoelectronic synapses in neuromorphic systems,including neuromorphic computing,high-order learning behaviors,and neuromorphic vision systems,outlining their potential opportunities and future development directions as neuromorphic devices in the field of artificial intelligence(AI). | XITONG HONG XINGQIANG LIU LEI LIAO XUMING ZOU | 2023 | Photonics Research2023，11，5： | 1 |
| 20 | Improving Voltage Output with PZT Beam Array for MEMS-based Vibration Energy Harvester:Theory and Experiment显示文摘 | Wen Zhiyu Deng Licheng Zhao Xingqiang | 2015 | Microsystem Technologies2015，21，2： | 1 |
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