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| 1 | Cationic nanocarriers induce cell necrosis through impairment of Na^+/K^+-ATPase and cause subsequent inflammatory response显示文摘有积极表面费用的 Nanocarriers 以他们限制了他们的临床的应用的毒性著名。位于他们的毒性下面的机制例如煽动性的反应的正式就职,仍然保持大部分未知。在我们发现了 cationic nanocarriers 的那注射的现在的学习,包括 cationic liposomes, PEI,和 chitosan,导致了坏死的房间的快速的外观。cationic nanocarriers 导致的房间坏死依赖于他们的积极表面费用,但是不要求 RIP1 和 Mlkl。相反,细胞内部的 Na + 超载被发现伴随房间死亡。在文化媒介或有 Na +/K+-ATPase 阳离子绑定地点禁止者 ouabain 的房间的预告的处理的 Na + 的弄空,从房间坏死的保护的房间。而且,有 cationic nanocarriers 的处理在 vitro 并且在 vivo 禁止了 Na +/K+-ATPase 活动。计算模拟证明 cationic 搬运人能与 Na +/K+-ATPase 的阳离子绑定地点交往。有 ouabain 的小剂量的老鼠 pretreated 在 cationic nanocarriers 的致命的剂量的注射以后显示出改进幸存。进一步的分析建议 cationic nanocarriers 和 mitochondrial DNA 的产生的漏导致的那房间坏死能在 vivo 触发严重发炎,它被包含 TLR9 并且 MyD88 发信号的一条小径调停。一起拿,我们的结果揭示由此的新奇机制 cationic nanocarriers 通过和 mitochondrial 的随后的暴露的和 Na +/K+-ATPase, 的相互作用导致尖锐房间坏死是的联系损坏的分子的模式调停的一个关键事件煽动性的回答。我们的学习为评估 nanocarriers 的 biocompatibility 并且为药交货设计更好、更安全的有重要含意。 | Xiawei Wei Bin Shao Zhiyao He Tinghong Ye Min Luo Yaxiong Sang Xiao Liang Wei Wang Shuntao Luo Shengyong Yang Shuang Zhang Changyang Gong Maling Gou Hongxing Deng Yinglan Zhao Hanshuo Yang Senyi Deng Chengjian Zhao Li Yang Zhiyong Qian Jiong Li Xun Sun Jiahuai Han Chengyu Jiang Min Wu Zhirong Zhang | 2015 | Cell Research2015，25，2： | 21 |
| 2 | Large-scale analysis of small RNAs derived from traditional Chinese herbs in human tissues显示文摘Plant-derived microRNAs have recently been reported to function in human blood and tissues. Controversy was immediately raised due to possible contamination and the lack of large sample sizes. Here, we report thousands of unique small RNAs derived from traditional Chinese medicine(TCM) herbs found in human blood cells and mouse lung tissues using a large-scale analysis.We extracted small RNAs from decoctions of 10 TCM plants(Ban Zhi Lian, Chai Hu, Chuan Xin Lian, Di Ding Zi Jin, Huang Qin, Jin Yin Hua, Lian Qiao, Pu Gong Ying, Xia Ku Cao, and Yu Xing Cao) and obtained millions of RNA sequences from each herb. We also obtained RNA-Seq data from the blood cells of humans who consumed herbal decoctions and from the lung tissues of mice administered RNAs from herbal decoctions via oral gavage. We identified thousands of unique small RNA sequences in human blood cells and mouse lung tissues. Some of these identified small RNAs from Chuan Xin Lian and Hong Jing Tian could be mapped to the genomes of the herbs, confirming their TCM plant origin. Small RNAs derived from herbs regulate mammalian gene expression in a sequence-specific manner, and thus are a superior novel class of herbal drug components that hold great potential as oral gene-targeted therapeutics, highlighting the important role of herbgenomics in their development. | Fengming Huang Jianchao Du Zhu Liang Zhichao Xu Jiantao Xu Yan Zhao Yexuan Lin Song Mei Quan He Jindong Zhu Qiang Liu Yanxu Zhang Yuhao Qin Wei Sun Jingyuan Song Shilin Chen Chengyu Jiang | 2019 | Science China(Life Sciences)2019，62，3： | 14 |
| 3 | Hundred-Joule-level,nanosecond-pulse Nd:glass laser system with high spatiotemporal beam quality显示文摘A 100-J-level Nd:glass laser system in nanosecond-scale pulse width has been constructed to perform as a standard source of high-fluence-laser science experiments. The laser system, operating with typical pulse durations of 3–5 ns and beam diameter 60 mm, employs a sequence of successive rod amplifiers to achieve 100-J-level energy at 1053 nm at3 ns. The frequency conversion can provide energy of 50-J level at 351 nm. In addition to the high stability of the energy output, the most valuable of the laser system is the high spatiotemporal beam quality of the output, which contains the uniform square pulse waveform, the uniform flat-top spatial fluence distribution and the uniform flat-top wavefront. | Sensen Li Yulei Wang Zhiwei Lu Lei Ding Yi Chen Pengyuan Du Dexin Ba Zhenxing Zheng Xin Wang Hang Yuan Chengyu Zhu Weiming He Dianyang Lin Yongkang Dong Dengwang Zhou Zhenxu Bai Zhaohong Liu Can Cui | 2016 | High Power Laser Science and Engineering2016，4，1： | 3 |
| 4 | A LOSSLESS COMPRESSION ALGORITHM OF REMOTE SENSING IMAGE FOR SPACE APPLICATIONS显示文摘A simple and adaptive lossless compression algorithm is proposed for remote sensing image compression,which includes integer wavelet transform and the Rice entropy coder.By analyzing the probability distribution of integer wavelet transform coefficients and the characteristics of Rice entropy coder,the divide and rule method is used for high-frequency sub-bands and low-frequency one.High-frequency sub-bands are coded by the Rice entropy coder,and low-frequency coefficients are predicted before coding.The role of predictor is to map the low-frequency coefficients into symbols suitable for the entropy coding.Experimental results show that the average Compression Ratio(CR) of our approach is about two,which is close to that of JPEG 2000.The algorithm is simple and easy to be implemented in hardware.Moreover,it has the merits of adaptability,and independent data packet.So the algorithm can adapt to space lossless compression applications. | Sui Yuping Yang Chengyu Liu Yanjun Wang Jun Wei Zhonghui He Xin | 2008 | Journal of Electronics(China)2008，25，5： | 3 |
| 5 | New Small Shelly Fossils(Acanthocassis and Xinlispina Gen.Nov.) from the Fortunian Stage(Early Cambrian) in Southern China显示文摘We describe new material of three-dimensionally phosphatized small shelly fossils Acanthocassis and Xinlispina gen.nov.from the Fortunian Stage(early Cambrian) of southern Shaanxi and northern Sichuan Provinces.The new materials allow description of the delicate morphology of these skeletons, and also their skeletogenesis.Acanthocassis and Xinlispina have comparable morphological features: a main branch and radially arranged sub-branches.They differ from each other in many details, e.g., the presence of a single central branch only in Xinlispina, and the presence of small nodes only in Acanthocassis.Acanthocassis cannot be a naked anthopolyp or hydropolyp because of the more-or-less stiffened cuticle and the absence of a mouth.Acanthocassisand Xinlispina differ from coeval sponge spicules and chancelloriid sclerites and rosettes of crossed pedicellariae of echinoderms, and might be cuticular ornaments of animals of unclear affinities.They occur in the first small shelly fossil assemblage zone, and could be adopted as auxiliary fossils for biostratigraphic correlation in southern China. | SHAO Tiequan LIU Yunhuan WANG Qi ZHANG Huaqiao TANG Hanhua CAO Xi HE Huahua ZHANG Yanan LI Yuan ZHENG Panlin ZHU Chengyu HU Jiaxi | 2015 | Acta Geologica Sinica(English Edition)2015，89，5： | 2 |
| 6 | Identification of prognostic biomarkers in hepatitis B virus-related hepatocellular carcinoma and stratification by integrative multi-omics analysis显示文摘 | Ruoyu Miao Haitao Luo Huandi Zhou Guangbing Li Dechao Bu Xiaobo Yang Xue Zhao Haohai Zhang Song Liu Ying Zhong Zhen Zou Yan Zhao Kuntao Yu Lian He Xinting Sang Shouxian Zhong Jiefu Huang Yan Wu Rebecca A. Miksad Simon C. Robson Chengyu Jiang Yi Zhao Haita | 2014 | Journal of Hepatology2014，，： | 2 |
| 7 | Tandem Biocatalysis by CotA-TJ102@UIO-66-NH2 and Novozym 435 for Highly Selective Transformation of HMF into FDCA显示文摘2,5-Furandicarboxylic acid (FDCA) is a potential biorenewable chemical for applications including plastics, polyamides, drugs, etc. The selective biosynthesis of FDCA from 5-hydroxymethylfurfural (HMF) by a speci c enzyme poses a great challenge. In this study, we reported an e cient strategy to produce FDCA from HMF by the tandem biocatalysis of laccase (CotA-TJ102@UIO-66-NH 2 ) and Novozym 435. For the rst step, a nanoparticle metal organic framework was synthesized as a carrier to immobilize CotA-TJ102@UIO-66-NH 2 , which was assigned for the production of 5-formyl-2-furancarboxylic acid (FFCA) and featured an enzyme loading of 255.54 mg/g, speci c activity of 135.90 U/mg, and solid loading ratio of 99.65%. Under optimal conditions, an ideal FFCA yield of 98.5% was achieved, and the CotA-TJ102@UIO-66-NH2 pre- sented a high recycling capacity after 10 cycles. For the second step, Novozym 435 was applied for the further conversion of FFCA into FDCA, presenting a high FDCA yield of 95.5% under the optimized conditions. Novozym 435 also exhibited a high recyclability after eight cycles. As a result, the tandem biocatalysis strategy provided a 94.2% FDCA yield from HMF, indicating its excellence as a method for FDCA production. | Xin Chang Chengyu Zhang Lan Gao Xiao Liu Shengping You Wei Qi Kang Wang Xin Guo Rongxin Su Han Lu Zhimin He | 2019 | Transactions of Tianjin University2019，25，5： | 2 |
| 8 | Tailoring the wettability of patterned silicon surfaces with dual-scale pillars:from hydrophilieity to superhydrophobicity显示文摘 | He Yang Jiang Chengyu Yin Hengxu | | 0，，： | 1 |
| 9 | Finite element method analysis and control stratagem for machining deformation of thin-walled components显示文摘 | He Ning Wang Zhigang Jiang Chengyu | 2003 | Journal of Materials Processing Technology2003，139，1： | 1 |
| 10 | Growth and characterization of ternary A1GaN ahoy nanocones across the entire composition range 显示文摘 | He Chengyu Wu Qiang Wang Xizhang | 2011 | ACS Nano2011，5，2： | 1 |
| 11 | Finite Element Method Analysis and Control Stratagem for Machining Deformation of Thin-walled Components 显示文摘 | He Ning Wang Zhigang Jiang Chengyu Zhang Bing | 2003 | Journal of Materials Processing Technology2003，139，： | 1 |
| 12 | Large-scale Patterning of Hydrophobic Silicon Nanostructure Arrays Fabricated by Dual Lithography and Deep Reactive Ion Etching显示文摘We describe a simple but efficient technique to fabricate large-scale arrays of highly ordered silicon nanostructures. By coupling dual lithography using light of 351.1 nm wavelength with deep reactive ion etching(DRIE), silicon nanostructures of excellent regularity and uniform coverage were achieved. The proposed nanofabrication method not only simplified the nanofabrication process but also produced highaspect-ratio(higher than 15) nanostructures. The scalloping problem was also controlled by regulating DRIE parameters. The process is rapid, cheap, examined to optimize the fabrication process, and has the potential to be scaled up to large areas. The contact angle of a water droplet atop the surface is larger than 150?.Moreover, by coupling black silicon process with DRIE-based microfabrication, three-dimensional nano/nano dual-scale structures which show robust and stable hydrophobicity have been achieved. This process opens new application possibilities in optical, photoelectric, microelectronic, catalytic and biomedical applications. | Zhibo Ma Chengyu Jiang Weizheng Yuan Yang He | 2013 | Nano-Micro Letters2013，5，1： | 1 |
| 13 | Synthesis of Tribolure,the Common Aggregation Pheromone of Four Tribolium Flour Beetles显示文摘Herein we report a synthesis of the natural tribolure,an aggregation pheromone which consists of(4R,8S)-,(4R,8R)-,(4S,8S)-,and(4S,8R)-4,8-dimethyldecanals in a ratio of 4/4/1/1,from(R)-4-methyl-δ-valerolactone,a by-product of the degradation of steroidal sapogenins.Merging the stereoisomers of the same ratios into one synthetic target and using the same chiron for the construction of the C4 stereocenters are notable features of this synthesis. | Chao Wang Chengyu He Yong Shi Hua Xiang Weisheng Tian | 2015 | Chinese Journal of Chemistry2015，33，6： | 0 |
| 14 | Triaxial mechanical properties and precursors of instability damage in rocks with different laminar dip angles显示文摘To investigate the mechanical failure characteristics of volcanic breccia with different bedding dip angles in deep layers,triaxial compression experiments were conducted on specimens taken from volcanic rock layers in the Junggar Basin,Xinjiang.By changing the confining pressure,we compared the mechanical properties,acoustic emission characteristics,and fractal features of the acoustic emission sequence for volcanic breccia with different bedding dip angles.The research results indicate that as the bedding dip angle increases,peak strength,internal friction angle,and cohesion exhibit a“U-shaped”variation pattern.The correlation dimension of the acoustic emission amplitude was calculated using the G-P algorithm,revealing that volcanic breccia exhibits fractal characteristics.Furthermore,a positive correlation between the correlation dimension and the bedding dip angle was observed.When the stress of the test specimen reaches 0.8σ_(c),there is a significant decrease in the fractal dimension,serving as a criterion for predicting the failure of the specimen.By analyzing the changes in fractal dimension at different stress levels,the slope of the fractal dimension△D<-0.5 can be used as a precursor to failure for test specimens with a bedding dip angle of 15°≤β≤45°.Similarly,when the bedding dip angle of the specimen is 0°≤β<15°or 45°<β≤90°,△D<0 can be considered as a precursor to specimen failure.This study provides theoretical references for understanding the failure patterns of volcanic rock. | SUN Xiaoming SHI Fukun DING Jiaxu TAO Zhigang HE Linsen YANG Liu ZHANG Yong MIAO Chengyu | 2024 | Journal of Mountain Science2024，21，2： | 0 |
| 15 | Insight into the improvement mechanism of Co-Pi-modified hematite nanowire photoanodes for solar water oxidation显示文摘The composite photoanodes composed by cobalt phosphate catalyst(Co-Pi) modified semiconductor have been widely used for solar water splitting,but the improvement mechanism has not been experimentally confirmed.Here we use transient photoelectrochemical measurements and impedance spectroscopy to investigate the effect of Co-Pi catalyst on hematite nanowire photoanode.It is found that under illumination the Co-Pi catalyst can efficiently promote the transfer of photo-generated holes to the Co-Pi layer by increasing the electrical conductivity of the composite structure under a low potential.The Co-Pi catalyst can recombine with photo-generated electrons to reduce the surface recombination efficiency of photo-generated holes and electrons under a high potential.These results provide important new understanding of the performance improvement mechanism for the Co-Pi-modified semiconductor nanowire composite photoanodes. | Xu Zhou Chunyan Wang Fulin Liu Chengyu He Shiming Zhang | 2021 | Chinese Chemical Letters2021，32，10： | 0 |
| 16 | 3D-printed Lunar regolith simulant-based geopolymer composites with bio-inspired sandwich architectures显示文摘Over time,natural materials have evolved to be lightweight,high-strength,tough,and damage-tolerant due to their unique biological structures.Therefore,combining biological inspiration and structural design would provide traditional materials with a broader range of performance and applications.Here,the application of an ink-based three-dimensional(3D)printing strategy to the structural design of a Lunar regolith simulant-based geopolymer(HIT-LRS-1 GP)was first reported,and high-precision carbon fiber/quartz sand-reinforced biomimetic patterns inspired by the cellular sandwich structure of plant stems were fabricated.This study demonstrated how different cellular sandwich structures can balance the structure–property relationship and how to achieve unprecedented damage tolerance for a geopolymer composite.The results presented that components based on these biomimetic architectures exhibited stable non-catastrophic fracture characteristics regardless of the compression direction,and each structure possessed effective damage tolerance and anisotropy of mechanical properties.The results showed that the compressive strengths of honeycomb sandwich patterns,triangular sandwich patterns,wave sandwich patterns,and rectangular sandwich patterns in the Y-axis(Z-axis)direction were 15.6,17.9,11.3,and 20.1 MPa(46.7,26.5,23.8,and 34.4 MPa),respectively,and the maximum fracture strain corresponding to the above four structures could reach 10.2%,6.7%,5.8%,and 5.9%(12.1%,13.7%,13.6%,and 13.9%),respectively. | Siqi Ma Yuqi Jiang Shuai Fu Peigang He Chengyue Sun Xiaoming Duan Dechang Jia Paolo Colombo Yu Zhou | 2023 | Journal of Advanced Ceramics2023，12，3： | 0 |
| 17 | Sorption and desorption of sex hormones in soil-and sediment-water systems:A review显示文摘Sex hormones are a group of potent endocrine disruptors that can be released into agricultural soils and sediment via wastewater discharge and manure fertilization.Sorption represents a critical determinant for the transport potential and risks of sex hormones in the environment.Therefore,this study reviewed the sorption and desorption mechanisms of sex hormones in soil-and sedimentwater systems,and summarized the effects of various factors on sorption and desorption processes.A total of 359 set of sorption data were collected from the literature.Sex hormones were mostly described by the linear model.The sorption magnitudes(logKoc)of estrogens,androgens,and progestins were in the range of 2.77–3.90,2.55–4.18,and 2.61–4.39,respectively.The average logKoc values of the sex hormones were significantly correlated with their logKow values(R^(2)=0.13,p<0.05),while the R^(2) values were much lower than those when fewer sex hormones were included for analysis.In addition,the Kd values of most sex hormones were significantly correlated with the OC%of soils and sediment(R^(2)=0.16–0.99,p<0.05),but were insignificantly correlated with the particle size distribution and surface area.These results indicated that hydrophobic partitioning interaction and other specific interactions are responsible for sex hormone uptake in soil-and sediment-water systems.The sorption of sex hormones in soil-and sediment-water systems can also be affected by other environmental variables,including pH,temperature,and ionic strength.Future studies should focus on the coupled leaching-sorption processes in manure-water-soil systems under field-scale conditions. | Xiong Dai Xingjian Yang Bihai Xie Jiajia Jiao Xiuping Jiang Chengyu Chen Zhen Zhang Zhili He Hang Lin Weisong Chen Yongtao Li | 2022 | Soil Ecology Letters2022，4，1： | 0 |
| 18 | Chromo-chemodosimetric detection for Fe^(2+) by Fenton reagent-induced chromophore-decolorizing of halogenated phenolsulfonphthalein derivatives显示文摘A commercially-available sulfonphthalein derivative was demonstrated to be a chemodosimeter for Fe2+ and its sensing behavior was further investigated by UV-vis spectroscopy in aqueous media under the optimum conditions.In the presence of chlorophenol red (CPR) and H2O2,the absorption maximum at 435 nm decreased upon addition of Fe2+,resulting in a significant color change of the CPR solution from yellow to colorless.The chemosensor system did not show significant responses to a series of other metal ions including Al3+,Zn2+,Cd2+,Hg2+,Mn2+,Co2+,Fe3+,Ni2+,Cu2+,La3+,Ce4+,Th4+,Pd2+,Pb2+,Sb3+,Cr3+,Au3+,Ag+,Nd3+,Sm3+,alkali and alkaline earth metal cations,allowing for highly selective naked-eye detection of Fe2+.Quantitative analysis was carried out kinetically for practicable the Fe2+ assay when either fixed time method or the initial rate method was applied.When the detecting time was set,the decrease of absorbance signal was linear with Fe2+ concentration in the range of 0 to 7.50 × 10-5 mol L-1 and the regression equation was ΔA = 0.00759 + 0.00593CFe with a correlation coefficient r = 0.9953.The chemodosimetric system has employed an irreversible Fenton reagent-promoted oxidation of the CPR free chromophore and the hydroxyl radicals were generated in the presence of both Fe2+ and hydrogen peroxide.The mechanistic interpretation of the signaling process was partially confirmed by the radical scavenging experiment and the FT-IR analysis of the intermediates formed at different reaction periods. | ZHENG Kuan,LAI ChengYue,HE LiPing & LI Fang Key Laboratory of Green Chemistry and Technology,Ministry of Education College of Chemistry,Sichuan University,Chengdu 610064,China | 2010 | Science China Chemistry2010，53，6： | 0 |
| 19 | Instability mechanism of mining roadway passing through fault at different angles in kilometre-deep mine and control measures of roof cutting and NPR cables显示文摘The angle α between the fault strike and the axial direction of the roadway produces different damage characteristics. In this paper, the research methodology includes theoretical analyses, numerical simulations and field experiments in the context of the Daqiang coal mine located in Shenyang, China. The stability control countermeasure of 'pre-splitting cutting roof + NPR anchor cable'(PSCR-NPR) is simultaneously proposed. According to the different deformation characteristics of the roadway, the faults are innovatively classified into three types, with α of type I being 0°-30°, α of type II being 30°-60°, and α of type III being 60°-90°. The full-cycle stress evolution paths during mining roadway traverses across different types of faults are investigated by numerical simulation. Different pinch angles α lead to high stress concentration areas at different locations in the surrounding rock. The non-uniform stress field formed in the shallow surrounding rock is an important reason for the instability of the roadway. The pre-cracked cut top shifted the high stress region to the deep rock mass and formed a low stress region in the shallow rock mass. The high prestressing NPR anchor cable transforms the non-uniform stress field of the shallow surrounding rock into a uniform stress field. PSCR-NPR is applied in the fault-through roadway of Daqiang mine. The low stress area of the surrounding rock was enlarged by 3-7 times, and the cumulative convergence was reduced by 45%-50%. It provides a reference for the stability control of the deep fault-through mining roadway. | SUN Xiaoming WANG Jian ZHAO Wenchao MING Jiang ZHANG Yong LI Zhihu MIAO Chengyu GUO Zhibiao HE Manchao | 2024 | Journal of Mountain Science2024，21，1： | 0 |
| 20 | The fractal or scaling perspective on progressively generated intra-urban clusters from street junctions显示文摘The underlying complexity of urban space can be manifested by its fractal forms and scaling statistics.This paper examines these characteristics at the intra-urban scale through the lens of clustered street junctions(including road ends)in two Chinese metropolitan areas:Beijing and Shenzhen.We derived the cluster sets with Euclidean distance thresholds starting at 100 meters(m)and ending at 1000 m,and outlined each cluster using a concave-hull method to maintain their original irregular shapes.Within each delimited cluster,we examined four urban attributes:gross domestic product,number of street nodes,polygon area,and population.Our analysis revealed that power law distribution applied to almost every cluster set in terms of the four attributes,but varied from one attribute to another or from city to city,represented primarily byfluctuated power law exponents and ht-index values whose profiles along with the cluster growth can effectively characterize the urban structure.Additionally,we computed the spectrum of intra-urban scaling exponents with cluster size increments,contributing new insights into the allometric relationships between urban configuration and function. | Biao He Renzhong Guo Minmin Li Ying Jing Zhigang Zhao Wei Zhu Chen Zhang Chengyue Zhang Ding Ma | 2023 | International Journal of Digital Earth2023，16，1： | 0 |
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