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| 1 | Rice St#pe Virus Interferes with S-acylation of Remorin and Induces Its Autophagic Degradation to Facilitate Virus Infection显示文摘 | Shuai Fu Yi Xu Chenyang Li Yi Li dianxiang Wu Xueping Zhou | 2018 | Molecular Plant2018，11，2： | 10 |
| 2 | Wheat breeding history reveals synergistic selection of pleiotropic genomic sites for plant architecture and grain yield显示文摘Diversity surveys of crop germplasm are important for gaining insights into the genomic basis for plant architecture and grain yield improvement,which is still poorly understood in wheat.In this study,we exome sequenced 287 wheat accessions that were collected in the past 100 years.Population genetics analysis identified that 6.7%of the wheat genome falls within the selective sweeps between landraces and cultivars,which harbors the genes known for yield improvement.These regions were asymmetrically distributed on the A and B subgenomes with regulatory genes being favorably selected.Genome-wide association study(GWAS)identified genomic loci associated with traits for yield potential,and two underlying genes,TaARF12 encoding an auxin response factor and TaDEP1 encoding the G-proteinγ-subunit,were located and characterized to pleiotropically regulate both plant height and grain weight.Elite single-nucleotide haplotypes with increased allele frequency in cultivars relative to the landraces were identified and found to have accumulated over the course of breeding.Interestingly,we found that TaARF12 and TaDEP1 function in epistasis with the classical plant height Rht-1 locus,leading to propose a“Green Revolution”-based working model for historical wheat breeding.Collectively,our study identifies selection signatures that fine-tune the gibberellin pathway during modern wheat breeding and provides a wealth of genomic diversity resources for the wheat research community. | Aili Li Chenyang Hao Zhenyu Wang Shuaifeng Geng Meiling Jia Fang Wang Xiang Han Xingchen Kong Lingjie Yin Shu Tao Zhongyin Deng Ruyi Liao Guoliang Sun Ke Wang Xingguo Ye Chengzhi Jiao Hongfeng Lu Yun Zhou Dengcai Liu Xiangdong Fu Xueyong Zhang Long Mao | 2022 | Molecular Plant2022，15，3： | 4 |
| 3 | Fast integration and accumulation of beneficial breeding alleles through an AB–NAMIC strategy in wheat显示文摘Wheat(Triticum aestivum)is among the most important staple crops for safeguarding the food security of the growing world population.To bridge the gap between genebank diversity and breeding programs,we developed an advanced backcross-nested association mapping plus inter-crossed population(AB-NAMIC)by crossing three popular wheat cultivars as recurrent founders to 20 germplasm lines from a mini core collection.Selective backcrossing combined with selection against undesirable traits and extensive crossing within and between sub-populations created new opportunities to detect unknown genes and increase the frequency of beneficial alleles in the AB-NAMIC population.We performed phenotyping of 590 AB-NAMIC lines and a natural panel of 476 cultivars for six consecutive growing seasons and genotyped these 1066 lines with a 660K SNP array.Genome-wide association studies of both panels for plant development and yield traits demonstrated improved power to detect rare alleles and loci with medium genetic effects in AB-NAMIC.Notably,genome-wide association studies in AB-NAMIC detected the candidate gene TaSWEET6-7B(TraesCS7B03G1216700),which has high homology to the rice SWEET6b gene and exerts strong effects on adaptation and yield traits.The commercial release of two derived AB-NAMIC lines attests to its direct applicability in wheat improvement.Valuable information on genome-wide association studymapping,candidate genes,and their haplotypes for breeding traits are available through WheatGAB.Our research provides an excellent framework for fast-tracking exploration and accumulation of beneficial alleles stored in genebanks. | Chengzhi Jiao Chenyang Hao Tian Li Abhishek Bohra Lanfen Wang Jian Hou Hongxia Liu Hong Liu Jing Zhao Yamei Wang Yunchuan Liu Zhiwei Wang Xin Jing Xiue Wang Rajeev K.Varshney Junjie Fu Xueyong Zhang | 2023 | Plant Communications2023，4，3： | 3 |
| 4 | Suppressing thermal quenching via defect passivation for efficient quasi-2D perovskite light-emitting diodes显示文摘Emission thermal quenching is commonly observed in quasi-2D perovskite emitters,which causes the severe drop in luminescence eficiency for the quasi-2D perovskite light-emitting diodes(Pel EDs)during practical operations.However,this issue is often neglected and rarely studied,and the root cause of the thermal quenching has not been completely revealed now.Here,we develop a passivation strategy via the 2,7-dibromo-9,9-bis(3'-diethoxylphosphorylpropyl-fluorene to investigate and suppress the thermal quenching.The agent can effectively passivate coordination-unsaturated Pb2+defects of both surface and bulk of the flm without affecting the perovskite crysaliation,which helps to more truly demonstrate the important role of defects in thermal quenching.And our results reveal the root cause that the quenching will be strengthened by the defect promoted exciton-phonon coupling.Ultimately,the PeL EDs with defect passivation achieve an improved external quantum efficiengy(EQE)over 22%and doubled operation lifetime at room temperature,and can maintain about 85%of the initial EQE at 85℃,much higher than 17%of the control device.These findings provide an important basis for fabricating practical PeLEDs for lighting and displays. | Dezhong Zhang Yunxing Fu Hongmei Zhan Chenyang Zhao Xiang Gao Chuanjiang Qin Lixiang Wang | 2022 | Light(Science & Applications)2022，11，4： | 1 |
| 5 | Simulation and experimental study on the surface morphology and energy lost of the target material under non-overlapping impact of angular particles显示文摘In order to further understand the effect of solid impurities on pipeline wall during erosion,the particle impact process without fluid was extracted for specific study.The effect of multi-impact particles on the wall of pipeline was studied experimentally and simulated.In this experiment,an improved ejection apparatus was implemented to carry out multi-impacts non-overlapping impingement by rhombic particles made of high speed steel(W18Cr4V)on the AA6061 aluminum alloy plate through changing particle angle,incident angle,orientation angle and impact velocity.As a result,each particle's penetration depth was investigated and particles' rebound trajectory can be described through this experiment as well as surface morphology of the target material after impingement.The ductile damage criterion,shear damage criterion and MSFLD damage criterion were jointly implemented in ABAQUS/CAE software to simulate the whole process of collision which proved to be effective by getting consistent result compared with experimental data.It is found that under the condition of continuous non-overlapping impact,the target material produces a small work hardening effect in the impact area by converting kinetic energy of moving particles into internal energy of plate so as to reduce the penetration depth of each impact particle. | Xuewen Cao Chenyang Fu Zhenqiang Xie Chao Wu Xiaoyang Sun | 2021 | Chinese Journal of Chemical Engineering2021，34，1： | 1 |
| 6 | Comprehensive analysis of complement-associated molecular features in hepatocellular carcinoma显示文摘The complement cascade plays a“complementing”role in human immunity.However,the potential roles of complement system in impacting molecular and clinical features of hepatocellular carcinoma(HCC)remain unclear.In this study,eleven public datasets are analyzed to compare the complement status between normal and cancerous samples based on 18 classical complement-associated genes.The complement scores are constructed to quantify complement signatures of individual tumors.HCC patients in the The Cancer Genome Atlas(TCGA)cohort are focused to perform systematical analyses between complement status and immune infiltration,miRNA expression,DNA methylation,clinicopathological features,and drug response.The results show that the complement scores in normal tissues are dramatically higher than those of tumor tissues.Tumor samples in the TCGA cohort are classified into complement score-low and score-high groups.Pathway analysis reveals that tumor-promoting pathways are typically inhibited in complement score-high group.This study also shows that tumor-killing immune cells,such as CD8^(+)T cells and natural killer cells are abundant and tumor-suppressing miRNAs are upregulated in complement score-high samples.In addition,we identify that complement scores are negatively correlated with certain clinical features,including pathological grade,clinical-stage,and portal vein invasion.Moreover,various molecular features together with complement scores are found to be correlated with response to anti-cancer drugs.This study provides a comprehensive and multidimensional analysis conducive to understanding the role of complement in cancer. | Run Huang Guiqi Zhu Xiutao Fu Weiren Liu Chenyang Tao Jun Gao Weifeng Qu Yuan Fang Xifei Jiang Zhenbin Ding Jian Zhou Yinghong Shi Jia Fan Zheng Tang | 2022 | Acta Biochimica et Biophysica Sinica2022，54，11： | 0 |
| 7 | Rice3K56 is a high-quality SNP array for genome-based genetic studies and breeding in rice(Oryza sativa L.)显示文摘Single nucleotide polymorphism(SNP)genotyping arrays provide an optimal high-throughput platform for genetic research and molecular breeding programs in both animals and plants.In this study,a highquality and custom-designed Rice3K56 SNP array was developed with the resequencing data of 3024 rice accessions worldwide,which was then tested extensively in 192 representative rice samples.Printed on the Gene Titan chips of Affymetrix Axiom each containing 56,606 SNP markers,the Rice3K56 array has a high genotyping reliability(99.6%),high and uniform genome coverage(an average of 6.7-kb between adjacent SNPs),abundant polymorphic information and easy automation,compared with previously developed rice SNP arrays.When applied in rice varietal differentiation,population diversity analysis,gene mapping of 13 complex traits by a genome-wide association study analysis(GWAS),and genome selection experiments in a recombinant inbred line and a multi-parent advanced generation inter-cross populations,these properties of the Rice3K56 array were well demonstrated for its power and great potential to be a highly efficient tool for rice genetic research and genomic breeding. | Chaopu Zhang Min Li Lunping Liang Jun Xiang Fan Zhang Chenyang Zhang Yizhen Li Jing Liang Tianqing Zheng Fanlin Zhang Hua Li Binying Fu Yingyao Shi Jianlong Xu Bingchuan Tian Zhikang Li Wensheng Wang | 2023 | The Crop Journal2023，11，3： | 0 |
| 8 | A Severe Seasonal Influenza Epidemic During 2017–2018 in China After the 2009 Pandemic Influenza: A Modeling Study显示文摘Influenza viruses continue to cause epidemics worldwide every year.However,due to the lack of an effective assessment for the severity of influenza epidemics,it was extremely difficult to take preventative measures.Data were extracted from infectious diseases reports from 2011–2018.Joinpoint regression model and susceptible-exposed-infectious-recovered model were built to understand the characteristics and processes of the epidemic.The reported incidence of influenza was 1,913,698 from January 2011 to February 2018,with an average-yearly-reported-incidence-rate of 19.21 per 100,000.However,there had been a substantial nationwide epidemic of influenza after September 2017,when the average yearly reported incidence rate was 87.29 per 100,000 and an annual percentage change of 48.1%.The hemagglutinin genes of most influenza A(H1N1 and H3N2)viruses from the period of the epidemic had lower homology to those before August 2017.All the hemagglutinin of the recommended A(H3N2,H1N1)and B(Victoria)viruses for vaccines 2017/2018 had low matches with the epidemic viruses.The basic reproduction number was 1.53.The vaccination benefit was linearly related to vaccination coverage,while the quarantine measure had only significantly benefited when over 60%of the quarantined population.The most severe epidemic of influenza in China since 2011 occurred during the period from September 2017 to February 2018.Compared to quarantine,influenza vaccination is more effective way to prevent influenza,and strategies to increase vaccination coverage should be taken for the prevention of severe epidemics of influenza. | Xiaofang Fu Yuqing Zhou Jie Wu Xiaoxiao Liu Cheng Ding Chenyang Huang Min Deng Dongyan Shi Chencheng Wang Kaijin Xu Jingjing Ren Bing Ruan Lanjuan Li Shigui Yang | 2019 | Infectious Microbes & Diseases2019，1，1： | 0 |
| 9 | Large scalable,ultrathin and self-cleaning cellulose aerogel film for daytime radiative cooling显示文摘Passive cooling strategy shows great potential in mitigating global warming and reducing energy consumption.Because of the high emissivity in the atmospheric transparency window(λ≈8–13μm),cellulose is considered as a good candidate for radiative cooling.However,traditional cellulose coolers generally show poor solar reflection and can be polluted by dust outside,thereby resulting in poor daytime cooling efficiency.To address these drawbacks,we developed sustainable cellulose nanowhiskers(CNWs)/ZnO composite aerogel films with favorable optical performance,mechanical robustness,and self-cleaning function for efficient daytime radiative cooling,which can be achieved via freeze casting and hot-pressing process.Due to formation of multi-level porous structure and chemical bonds(Si-O-C/Si-O-Si),such aerogel film exhibited high solar reflectance(97%)and high infrared emittance(92.5%).It achieved a sub-ambient temperature drop of 6.9℃under direct sunlight in hot weather.Most importantly,the surface roughness and low surface energy enable cellulose aerogel film hydrophobicity(contact angle=133°),thereby resulting in an anti-dust function.This work provides insight into the design of sustainable thermal regulating materials to realize carbon neutrality. | Chenyang Cai Yuanbo Sun Yi Chen Zechang Wei Yibo Wang Fuling Chen Wanquan Cai Jiawen Ji Yuxin Ji Yu Fu | 2023 | Journal of Bioresources and Bioproducts2023，8，4： | 0 |
| 10 | Nomogram for Predicting the Severity of Coronary Artery Disease in Young Adults≤45 Years of Age with Acute Coronary Syndrome显示文摘Background:A non-invasive predictive model has not been established to identify the severity of coronary lesions in young adults with acute coronary syndrome(ACS).Methods:In this retrospective study,1088 young adults(≤45 years of age)first diagnosed with ACS who underwent coronary angiography were enrolled and randomized 7:3 into training or testing datasets.To build the nomogram,we determined optimal predictors of coronary lesion severity with the Least Absolute Shrinkage and Selection Operator and Random Forest algorithm.The predictive accuracy of the nomogram was assessed with calibration plots,and performance was assessed with the receiver operating characteristic curve,decision curve analysis and the clinical impact curve.Results:Seven predictors were identified and integrated into the nomogram:age,hypertension,diabetes,body mass index,low-density lipoprotein cholesterol,mean platelet volume and C-reactive protein.Receiver operating characteristic analyses demonstrated the nomogram’s good discriminatory performance in predicting severe coronary artery disease in young patients with ACS in the training(area under the curve 0.683,95%confidence interval[0.645–0.721])and testing(area under the curve 0.670,95%confidence interval[0.611–0.729])datasets.The nomogram was also well-calibrated in both the training(P=0.961)and testing(P=0.302)datasets.Decision curve analysis and the clinical impact curve indicated the model’s good clinical utility.Conclusion:A simple and practical nomogram for predicting coronary artery disease severity in young adults≤45 years of age with ACS was established and validated. | Xulin Hong Duanbin Li Xinrui Yang Guosheng Fu Chenyang Jiang Wenbin Zhang | 2022 | Cardiovascular Innovations and Applications2022，7，3： | 0 |
| 11 | Investigation of unique hue setting changes with ageing显示文摘Clromatic sensitivity along the protan, deutan, and tritan lines and the loci of the unique hues (red, green, yellow, blue) for a very large sample (n = 185) of colour-normal observers ranging from 18 to 75 years of age are assessed. Visual judgments are obtained under normal viewing conditions using colour patches on self-luminous display under controlled adaptation conditions. Trivector discrimination thresholds show an increase as a function of age along the protan, deutan, and tritan axes, with the largest increase present along the tritan line, less pronounced shifts in unique hue settings are also observed. Based on the chromatic (protan, deutan, tritan) thresholds and using scaled cone signals, we predict the unique hue changes with ageing. A dependency on age for unique red and unique yellow for predicted hue angle is found. We conclude that the chromatic sensitivity deteriorates significantly with age, whereas the appearance of unique hues is much less affected, remaining almost constant despite the known changes in the ocular media. | Chenyang Fu Kaida Xiao Dimosthenis Karatzas Sophie Wuerger | 2011 | Chinese Optics Letters2011，9，5： | 0 |
| 12 | Formal Analysis on an Extended Security Model for Database Systems显示文摘In order to develop highly secure database systems to meet the requirements for class B2,the BLP (Bell-LaPudula) model is extended according to the features of database systems. A method for verifying security model for database systems is pro-posed. According to this method,an analysis by using Coq proof assistant to ensure the correctness and security of the extended model is introduced. Our formal security model has been verified secure. This work demonstrates that our verification method is effective and sufficient. | ZHU Hong ZHU Yi LI Chenyang SHI Jie FU Ge WANG Yuanzhen | 2008 | Wuhan University Journal of Natural Sciences2008，13，5： | 0 |
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