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| 1 | Transdermal drug delivery systems in diabetes management: A review显示文摘Diabetes mellitus is a chronic disease in which there is an insufficient production of insulin by the pancreas, or the insulin produced is unable to be utilized effectively by the body. Diabetes affects more than 415 million people globally and is estimated to strike about 642 million people in 2040. The WHO reported that diabetes will become the seventh biggest cause of mortality in 2030. Insulin injection and oral hypoglycemic agents remain the primary treatments in diabetes management. These often present with poor patient compliance. However, over the last decade, transdermal systems in diabetes management have gained increasing attention and emerged as a potential hope in diabetes management owing to the advantages that they offer as compared to invasive injection and oral dosage forms. This review presents the recent advances and developments in transdermal research to achieve better diabetes management. Different technologies and approaches have been explored and applied to the transdermal systems to optimize diabetes management. Studies have shown that these transdermal systems demonstrate higher bioavailability compared to oral administration due to the avoidance of first-pass hepatic metabolism and a sustained drug release pattern. Besides that, transdermal systems have the advantage of reducing dosing frequency as drugs are released at a predetermined rate and control blood glucose level over a prolonged time, contributing to better patient compliance. In summary, the transdermal system is a field worth exploring due to its significant advantages over oral route in administration of antidiabetic drugs and biosensing of blood glucose level to ensure better clinical outcomes in diabetes management. | Li Ching Ng Manish Gupta | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，1： | 9 |
| 2 | Recent Developments of Genomic Research in Soybean显示文摘大豆是有象高种子蛋白质那样的唯一、重要的特点的重要现金庄稼并且给执行共生的氮固定的内容,和能力上油。栽培大豆的一个参考染色体在 2010 被建立,列在后面由整个染色体野、栽培的大豆就职重新定序。这些努力揭示了大豆染色体的唯一的特征并且帮助理解它的进化。在野、栽培的大豆染色体之间的变化印射被执行。这些 genomic 变化可能与驯服和人的选择的过程有关。野大豆 germplasms 展出了高 genomic 差异并且可以因此是新奇基因 / 等位基因的重要来源。genomic 数据的累积将帮助精制基因地图并且帮助功能的基因的鉴定。在这评论,我们从整个染色体的定序工程总结主要调查结果并且在大豆研究和繁殖节目上讨论可能的影响。象 transcriptomic 和 epigenomic 研究那样的一些新兴的区域将被介绍。另外,我们也公布了将帮助大豆 genomic 数据的采矿的一些有用生物信息学工具。 | Ching Chan Man-Wah Li Fuk-Ling Wong Hon-Ming Lam | 2012 | Journal of Genetics and Genomics2012，39，7： | 8 |
| 3 | Incidence and Phenotype of Inflammatory Bowel Disease Based on Results From the Asia-Pacific Crohn’s and Colitis Epidemiology Study显示文摘 | Siew C. Ng Whitney Tang Jessica Y. Ching May Wong Chung Mo Chow A.J. Hui T.C. Wong Vincent K. Leung Steve W. Tsang Hon Ho Yu Mo Fong Li Ka Kei Ng Michael A. Kamm Corrie Studd Sally Bell Rupert Leong H. Janaka de Silva Anuradhani Kasturiratne M.N.F. Mufeen | 2013 | Gastroenterology2013，，1： | 6 |
| 4 | Palliative surgery for Krukenberg tumors—12-year experience and review of the literature显示文摘AIM To determine the clinical characteristics of patients undergoing palliative surgery for Krukenberg tumors,including disease presentation,outcomes,and prognostic factors.METHODS This was a retrospective clinical study of all patients who underwent palliative surgery for Krukenberg tumors between January 2004 and December 2015.Patient information was obtained from inpatient and outpatient case notes as well as the hospital electronic records.Patients who underwent potential y curative resection,and patients with Krukenberg tumors who did not undergo surgery were also excluded from the study.Palliative surgery was defined as those performed for either alleviation of symptoms or for asymptomatic patients for whom surgical removal of the tumors were deemed necessary following a multidisciplinary consensus.Tumors were diagnosed pre-operatively by computed tomography scans and all had histologic confirmation of the surgical specimens.RESULTS Over the study duration,38 female patients underwent palliative surgery for Krukenberg tumors at our institution.Mean age was 54.2±11.7 years.The colon was the most frequent primary source of metastases(n=21)followed by the stomach(n=4).Prophylactic palliative surgery was performed for eight(21.1%)asymptomatic patients.Median post-operative length of stay was 8 d(IQR 6-12 d).Five patients(13.2%)experienced postoperative complications,although high grade morbidity was only seen in one patient(2.6%).Median overall survival from surgery was 17 mo(95%CI:12.1-21.9)at a median follow-up duration of 12 mo(IQR 8-17mo).The median survival was shorter for patients who underwent emergency surgery,younger patients,those with a colorectal primary,larger tumors,or synchronous peritoneal or hepatic metastases.CONCLUSION Pal iative surgery for Krukenberg tumors can be performed safely with acceptable complication rates.Bilateral oophorectomy should be performed to prevent the risk of symptomatic contralateral tumors. | Isaac Seow-En Gwen Hwarng Grace Hwei Ching Tan Leonard Ming Li Ho Melissa Ching Ching Teo | 2018 | World Journal of Clinical Oncology2018，9，1： | 5 |
| 5 | The fundamental performance of FAST with 19-beam receiver at L band显示文摘The Five-hundred-meter Aperture Spherical radio Telescope(FAST) has passed national acceptance and finished one pilot cycle of ‘Shared-Risk’ observations. It will start formal operation soon. In this context, this paper describes testing results of key fundamental parameters for FAST, aiming to provide basic support for observation and data reduction of FAST for scientific researchers. The 19-beam receiver covering 1.05–1.45 GHz was utilized for most of these observations. The fluctuation in electronic gain of the system is better than 1% over 3.5 hours, enabling enough stability for observations. Pointing accuracy,aperture efficiency and system temperature are three key parameters for FAST. The measured standard deviation of pointing accuracy is 7.9′′, which satisfies the initial design of FAST. When zenith angle is less than 26.4°, the aperture efficiency and system temperature around 1.4 GHz are ~0.63 and less than 24 K for central beam, respectively. The sensitivity and stability of the 19-beam backend are confirmed to satisfy expectation by spectral HI observations toward NGC 672 and polarization observations toward 3 C 286. The performance allows FAST to take sensitive observations for various scientific goals, from studies of pulsars to galaxy evolution. | Peng Jiang Ning-Yu Tang Li-Gang Hou Meng-Ting Liu Marko Krco Lei Qian Jing-Hai Sun Tao-Chung Ching Bin Liu Yan Duan You-Ling Yue Heng-Qian Gan Rui Yao Hui Li Gao-Feng Pan Dong-Jun Yu Hong-Fei Liu Di Li Bo Peng Jun Yan FAST Collaboration | 2020 | Research in Astronomy and Astrophysics2020，20，5： | 5 |
| 6 | Near‑Instantaneously Self‑Healing Coating toward Stable and Durable Electromagnetic Interference Shielding显示文摘Durable electromagnetic interference(EMI)shielding is highly desired,as electromagnetic pollution is a great concern for electronics’stable performance and human health.Although a superhydrophobic surface can extend the service lifespan of EMI shielding materials,degradation of its protection capability and insufficient self-healing are troublesome issues due to unavoidable physical/chemical damages under long-term application conditions.Here,we report,for the first time,an instantaneously self-healing approach via microwave heating to achieve durable shielding performance.First,a hydrophobic 1H,1H,2H,2H-perfluorooctyltriethoxysilane(POTS)layer was coated on a polypyrrole(PPy)-modified fabric(PPy@POTS),enabling protection against the invasion of water,salt solution,and corrosive acidic and basic solutions.Moreover,after being damaged,the POTS layer can,for the first time,be instantaneously self-healed via microwave heating for a very short time,i.e.,4 s,benefiting from the intense thermal energy generated by PPy under electromagnetic wave radiation.This self-healing ability is also repeatable even after intentionally severe plasma etching,which highlights the great potential to achieve robust and durable EMI shielding applications.Significantly,this approach can be extended to other EMI shielding materials where heat is a triggering stimulus for healing thin protection layers.We envision that this work could provide insights into fabricating EMI shielding materials with durable performance for portable and wearable devices,as well as for human health care. | Lihua Zou Chuntao Lan Songlin Zhang Xianhong Zheng Zhenzhen Xu Changlong Li Li Yang Fangtao Ruan Swee Ching Tan | 2021 | Nano-Micro Letters2021，13，11： | 3 |
| 7 | Viral-Human Chimeric Transcript Predisposes Risk to Liver Cancer Development and Progression显示文摘 | Chi-Chiu Lau Tingting Sun Arthur K.K. Ching Mian He Jing-Woei Li Alissa M. Wong Ngai Na Co Anthony W.H. Chan Pik-Shan Li Raymond W.M. Lung Joanna H.M. Tong Paul B.S. Lai Henry L.Y. Chan Ka-Fai To Ting-Fung Chan Nathalie Wong | 2014 | Cancer Cell2014，，3： | 2 |
| 8 | Antidiabetic Therapies Affect Risk of Pancreatic Cancer显示文摘 | Donghui Li Sai–Ching J. Yeung Manal M. Hassan Marina Konopleva James L. Abbruzzese | 2009 | Gastroenterology2009，，2： | 2 |
| 9 | Cathelicidins in inflammation and tissue repair: Potential therapeutic applications for gastrointestinal disorders显示文摘Cathelicidins,主人防卫肽的一个家庭,高度在感染,发炎并且创伤愈合期间被表示。这些肽不仅举办用途广泛的抗菌剂活动,而且由在 diseased 纸巾改变 cytokine 反应和煽动性的房间的 chemoattraction 调制发炎。在这个连接,老鼠 cathelicidin 被表明了通过提高粘液生产并且减少支持 inflammatory cytokines 的生产在冒号阻止发炎。另外, cathelicidins 支持创伤在受伤纸巾通过 re-epithelialization 和 angiogenesis 的刺激愈合。在胃的溃疡的一个动物模型,老鼠 cathelicidin 支持溃疡由在 vitro 并且在 vivo 导致胃的上皮的房间的增长愈合。在结论, cathelicidins 在在胃肠的 mucosa 和另外的机关操作发炎和组织修理的复杂集成的天生的免疫系统代表受动器分子的一个重要的组。 | William Ka Kei WU Clover Ching Man WONG Zhi Jie LI Lin ZHANG Shun Xiang REN Chi Hin CHO | 2010 | Acta Pharmacologica Sinica2010，31，9： | 2 |
| 10 | Applications of bio-derived/bio-inspired materials in the field of interfacial solar steam generation显示文摘Interfacial solar steam generation(ISSG)system has attracted extensive attention as a sustainable desalination technology because of its cost efficiency and zero fossil-energy consumption.Aiming at optimizing the desalination properties,materials and system design have been the current research focus.Recently,many novel bio-derived/bio-inspired design strategies were proposed owing to their highly efficient structures inherited from nature,which were fine-tuned over eons of evolution,as well as their low cost and ease of treatment.In this review,we are going to systematically report recent progress of various bio-derived/bio-inspired strategies in terms of optical design,wetting,thermal management,and overall system design,presenting an overview of the current challenges of bio-inspired materials in ISSG system and other application fields.This article is intended to provide a comprehensive review of recent developments about bio-derived/bio-inspired materials in ISSG system and conclude with suggestions regarding further research directions for performance enhancement through design of bio-derived/bio-inspired materials. | Yang Geng Kai Jiao Xu Liu Peijin Ying Omololu Odunmbaku Yaoxin Zhang Swee Ching Tan Ling Li Wei Zhang Meng Li | 2022 | Nano Research2022，15，4： | 2 |
| 11 | Apolipoprotein E enhances microRNA-146a in monocytes and macrophages to suppress nuclear factor-κB-driven inflammation and atherosclerosis显示文摘 | Li K Ching D Luk FS | 2015 | Cire Res2015，117，1： | 1 |
| 12 | Ventriculoperitoneal shunt survival in children who require additional abdominal surgery – are our estimations of the additional risk accurate?显示文摘 | Angela Li Ching Gill Humphrey Ian D. Kamaly-Asl | 2014 | British Journal of Neurosurgery2014，，： | 1 |
| 13 | DPF-A Perceptual Distance Function for Image Retrieval 显示文摘 | LI Bei-tao CHANG Edward WU Ching Tung | 2006 | 15(6) :141-1482006，15，6： | 1 |
| 14 | Development of a corpus of Mandarin sentences in babble with homogeneity optimized via psychometric evaluation显示文摘 | Xin Xi Teresa Y.C. Ching Fei Ji Yang Zhao Jia-Nan Li John Seymour Meng-Di Hong Ai-Ting Chen Harvey Dillon | 2012 | International Journal of Audiology2012，，5： | 1 |
| 15 | Apolipoprotein E Enhances MicroRNA-146a in Monocytes and Macrophages to Suppress Nuclear Factor- KB-Driven Inflammation and Atherosclerosis显示文摘 | Li K Ching D Luk FS | 2015 | Circ Res2015，117，1： | 1 |
| 16 | Role of microRNA-95 in the anticancer activity of Brucein D in hepatocellular carcino- ma显示文摘 | Xiao Z Ching Chow S Han Li C | 2014 | Eur J Pharmacol2014，，728： | 1 |
| 17 | Significance of face velocity fluctuation in relation to laboratory fume hood performance显示文摘 | Li Ching Rong Fung Huang Chih Chieh Chen | 2010 | Industrial Health2010，48，： | 1 |
| 18 | An accurate power control strategy for power electronics interfaced distributed generation units operating in a low voltage multibus microgrid 显示文摘 | Li Y W Ching N K | 2009 | IEEE Transactions on Power Electronics2009，24，12： | 1 |
| 19 | miR-124 is frequently down- regulated in medulloblastoma and is a negative regulator of SLC 16A1 显示文摘 | Li KK Pang JC Ching AK | 2009 | Hum Pathol2009，40，9： | 1 |
| 20 | A lasermicromachined multi - modal resonating power transducer for wireless sensing systems 显示文摘 | Ching Neil N H Wong H Y Li Wen J | 2002 | Sensors and Actuators A2002，9798，： | 1 |
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