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| 1 | 1990—2017年中国伤害负担:2017年全球疾病负担研究结果(摘译)显示文摘伤害是全球性的公共卫生挑战,涉及各年龄组和不同性别的人群。过去三十年来,中国经济快速发展,人口老龄化趋势加重,社会呈现出城镇化、机动化和老龄化等特征。随着人们生活环境和生活方式的改变,伤害已跃居人群致死原因第五位,仅排在恶性肿瘤、心脑血管疾病、呼吸系统疾病和心肌梗死之后。据估计,中国每年在伤害方面消耗的直接医疗费用约为650亿元人民币. | 林泽婷(译) 吕来文(译) 黄晓晴(译) 李丽萍(审校) Duan Leilei Ye Pengpeng Juanita A Haagsma Jin Ye Wang Yuan Er Yuliang Deng Xiao Gao Xin Ji Cuirong Wang Linhong Marlena S Bannick W Cli Mountjoy-Venning Caitlin N Hawley Zichen Liu Mari Smith Spencer L James Theo Vos Christopher J L Murray | 2020 | 伤害医学(电子版)2020，9，2： | 15 |
| 2 | Impact of concomitant use of proton pump inhibitors and clopidogrel or ticagrelor on clinical outcomes in patients with acute coronary syndrome显示文摘BackgroundThere 是在质子泵禁止者(PPI ) 和 clopidogrel 之间的可能的不利相互作用上的大争论。另外, PPI 的使用是否少些影响 ticagrelor 遗体的临床的功效,知道。在经皮的冠的干预(一种总线标准) .MethodsWe 回顾地从 “ 分析了数据以后,我们试图与急性冠的症候群(交流)在病人在临床的结果上决定 PPI 和 clopidogrel 或 ticagrelor 的伴随物管理的影响;真实 world” ;,国际,在 2003 和 2014 之间的多中心登记( n = 15,401 )并且在1年的合成主要端点上估计了 PPI 和 clopidogrel 或 ticagrelor 的伴随物管理的影响(所有原因死亡收到 PPI 的病人更老,更经常女性,并且是更可能的有 comorbidities。没有协会为收到 clopidogrel 的病人在 PPI 使用和主要端点之间被观察(调整 HR:1.036;95% CI:0.903-1.189 ) 或 ticagrelor (调整 HR:2.320;95% CI:0.875-6.151 )(P 相互作用 = 0.2004 ) 。同样, PPI 的使用没与所有原因死亡,重新梗塞,或与交流后面的一种总线标准的为与任何一个 clopidogrel 对待的病人或 ticagrelor.ConclusionsIn 病人的严重流血的减少的风险的增加的风险被联系, PPI 的伴随物使用没在收到 clopidogrel 或 ticagrelor 的病人与不利结果的增加的风险被联系。我们的调查结果显示与 clopidogrel 或 ticagrelor 在联合使用 PPI 是合理的,特别在有胃肠的流血的更高的风险的病人。 | Yan YAN Xiao WANG Jing-Yao FAN Shao-Ping NIE Sergio Raposeiras-Roubin Emad Abu-Assi Jose P Simao Henriques Fabrizio D'Ascenzo Jorge Saucedo Jose R Gonzfilez-Juanatey Stephen B Wilton Wouter J Kikkert Ivlin Nufiez-Gil Albert Ariza-Sole Xian-Tao SONG Dimitrios Alexopoulos Christoph Liebetrau Tetsuma Kawaji Claudio Moretti Zenon Huczek Toshiharu Fujii Luis C Correia Masa-aki Kawashiril Sasko Kedev | 2016 | Journal of Geriatric Cardiology2016，13，3： | 12 |
| 3 | Impact of triple antithrombotic therapy in patients with acute coronary syndrome undergoing percutaneous coronary intervention in real-world practice显示文摘为在急性冠的症候群(交流) 和经皮的冠的干预(一种总线标准) 以后的口头的 anticoagulation (OAC ) 上的病人的 ObjectiveThe 最佳的 antithrombotic 政体仍然保持辩论。寻求回顾地在真实世界的 setting.MethodsWe 评估 OAC 正 clopidogrel 的功效和安全与或没有阿司匹林的这研究分析了数据从一国际,在 2003 和 2014 之间的多中心登记(n = 15,401 ) 。有在一种总线标准以后的交流和收到的 OAC 的病人被屏蔽。合成主要端点是 1 年的所有原因死亡,重新梗塞,或分析注册了 642 个病人包括的严重 bleeding.ResultsThe 期末考试有 OAC 和 clopidogrel (双治疗) 的 62 个病人(9.7%) ,和有阿司匹林, OAC 和 clopidogrel (三倍的治疗) 的联合的 580 个病人(90.3%) 。三倍的治疗上的病人更经常是女性的并且是更可能的有 comorbidities。关于在与三倍的治疗病人一起的双治疗之间的主要结束点没有重要差别[17.74% 对 17.24% ;unadjusted 危险比率(HR ) :1.035;95% 信心间隔(CI ) :0.556-1.929;调整 HR:1.026;95% CI:0.544-1.937 ] 。然而,重新梗塞率比三倍的治疗病人在双治疗是显著地更高的(14.52% 对 5.34% ;unadjusted HR:2.807;95% CI:1.329-5.928;调整 HR:2.333;95% CI:1.078-5.047 ) 。另外,在所有原因死亡和严重 bleeding.ConclusionsIn 的二政体之间没有差别有交流后面的一种总线标准并且与 OAC 的一个指示的真实病人,三倍的治疗没与双治疗相比与不利结果的增加的率被联系。而且,它减少了重新梗塞冒险并且没增加严重流血的风险。 | Yan YAN Xiao WANG Jing-Yao FAN Shao-Ping NIE SerGio Raooseiras-Roubin Emad Abu-Assi Jose P Simao Henriques: Fabrizio D'Ascenzo Jorge Saucedo Jose R Gonzalez-Juanate Stephen B Wilton Wouter J Kikkert Ivan Nunez-Gil Albert Ariza-Sole Xian-Tao SONG Dimitrios Alexopoulos Christoph Liebetrau Tetsuma Kawaji Claudio Morettil Zenon Huczek Toshiharu Fujii Luis cL Correia Masa-aki Kawashiri Sasko Kedev | 2017 | Journal of Geriatric Cardiology2017，14，11： | 6 |
| 4 | Reservoir Characteristics and Preservation Conditions of Longmaxi Shale in the Upper Yangtze Block, South China显示文摘The Upper Ordovician-Lower Silurian Longmaxi Shale in the Upper Yangtze block represents one of the most important shale gas plays in China. The shale composition,porosity,organic thermal maturity,and methane sorption were investigated at the Qilongcun section in the Dingshan area,southeastern Sichuan Basin. The results show that the Upper Ordovician-Lower Silurian Longmaxi Shale contains:(1) sapropelic I organic matter;(2) a 40-m thick bedded sequence where total organic carbon(TOC) content is > 2%;(3) a 30-m thick layer at the base of the Longmaxi Shale with a brittle mineral content higher than 50%; and(4) a mean methane adsorption capacity of 1.80 cm^3/g(7 MPa pressure). A positive correlation between TOC and sorbed gas indicates that organic matter content exerts an important control on methane storage capacity. Based on the analysis of the shale reservoir characteristics,the lower member of the Longmaxi Shale can thus be considered a favorable stratum for shale gas exploration and exploitation. It has similar reservoir characteristics with the Longmaxi Shale in the Jiaoshiba area tested with a high-yield industrial gas flow. However,based on tectonic analysis,differences in the level of industrial gas flow between the low-yield study area and the high-yield Jiaoshiba area may result from different tectonic preservation conditions. Evidence from these studies indicates the shale gas potential of the Longmaxi Shale is constrained by the reservoir and preservation conditions. | RAN Bo LIU Shugen Luba JANSA SUN Wei YANG Di WANG Shiyu YE Yuehao Christopher XIAO ZHANHG Jian ZHAI Cangbo LUO Chao ZHANG Changjun | 2016 | Acta Geologica Sinica(English Edition)2016，90，6： | 6 |
| 5 | Meteorin-β/Meteorin like/IL-41 attenuates airway inflammation in house dust mite-induced allergic asthma显示文摘We sought to examine the regulatory effect of Meteorin-β(Metrnβ)/Meteorin like(Metrnl)/IL-41 on lung inflammation in allergic asthma.We found that Metrnβwas elevated significantly in asthmatic patients and in mice with allergic asthma induced by house dust mite(HDM)extract.Upon exposure to HDM,Metrnβwas secreted predominantly by airway epithelial cells and inflammatory cells,including macrophages and eosinophils.The increased Metrnβeffectively blocked the development of airway hyperreactivity(AHR)and decreased inflammatory cell airway infiltration and type 2 cytokine production,which was associated with downregulated DC-mediated adaptive immune responses.Moreover,Metrnβimpaired the maturation and function of bone marrow-derived dendritic cells in vitro.Asthmatic mice adoptively transferred with dendritic cells isolated from Metrnβ-treated allergic mice displayed decreased AHR,airway inflammation,and lung injury.Metrnβalso displayed anti-inflammatory properties in immunodeficient SCID mice with allergic asthma and in in vitro 3D ALI airway models.Moreover,blockade of Metrnβby anti-Metrnβantibody treatment promoted the development of allergic asthma.These results revealed the unappreciated protective roles of Metrnβin alleviating DC-mediated Th2 inflammation in allergic asthma,providing the novel treatment strategy of therapeutic targeting of Metrnβin allergic asthma. | Xun Gao Ting-Fan Leung Gary Wing-Kin Wong Wing-Hung Ko Mengyun Cai Ellie Jiayi He Ida Miu-Ting Chu Miranda Sin-Man Tsang Ben Chung-Lap Chan Jiawei Ling Xiao Fan Liwei Lu Christopher Wai-Kei Lam Chun-Kwok Wong | 2022 | Cellular & Molecular Immunology2022，19，2： | 5 |
| 6 | Narrow bandwidth fiber-optic spectral combs for renewable hydrogen detection显示文摘Hydrogen sensors are of great importance to detect leakage in time because the hydrogen-air mixture is highly flammable.Based on optical fiber-based configurations reported so far,using palladium coating only does not meet stringent performance targets,such as fast response time and limited deactivation caused by poisoning.Here,a palladium-gold alloy-coated optical fiber hydrogen sensor,i.e.,highly tilted fiber Bragg grating(TFBG),was proposed by using its narrow bandwidth cladding modes whose effective refractive index(ERI)extends to 1.0 where the gas measurement is possible,which led to faster specific hydrogen measurement response time(a shorter stabilization time during the association and dissociation phases less than 20s and 30s,respectively)and improved deactivation resistance(higher than 99%per test cycle).Meanwhile,the temperature cross-sensitivity can be eliminated via referencing the'target'spectral combs to the core mode.We are sure that this promising configuration extends research directions for rapid,repeatable and high deactivation-resistance in hydrogen gas detection. | Shunshuo CAI Fu LIU Runlin WANG Yongguang XIAO Kaiwei LI Christophe CAUCHETEUR Tuan GUO | 2020 | Science China(Information Sciences)2020，63，12： | 4 |
| 7 | A high-throughput screening assay for eukaryotic elongation factor 2 kinase inhibitors显示文摘Eukaryotic elongation factor 2 kinase(eEF2K) inhibitors may aid in the development of new therapeutic agents to combat cancer. Purified human e EF2K was obtained from an Escherichia coli expression system and a luminescence-based high-throughput screening(HTS) assay was developed using MH-1 peptide as the substrate. The luminescent readouts correlated with the amount of adenosine triphosphate remaining in the kinase reaction. This method was applied to a large-scale screening campaign against a diverse compound library and subsequent confirmation studies. Nine initial hits showing inhibitory activities on e EF2K were identified from 56,000 synthetic compounds during the HTS campaign, of which, five were chosen to test their effects in cancer cell lines. | Ting Xiao Rui Liu Christopher G.Proud Ming-Wei Wang | 2016 | Acta Pharmaceutica Sinica B2016，6，6： | 2 |
| 8 | Sedimentary environment controls on the accumulation of organic matter in the Upper Ordovician Wufeng–Lower Silurian Longmaxi mudstones in the Southeastern Sichuan Basin of China显示文摘The Upper Ordovician–Lower Silurian mudstones(including the Wufeng, Guanyinqiao and Longmaxi Formations) in the Sichuan Basin are some of the most important shale gas plays in China. In order to enhance our understanding of the process of formation of organic carbon up to 10%, optical, microscopy and geochemical methods have been used to investigate the petrographic and geochemical characteristics of the formation. Firstly, three mudstone lithofacies were identified based on a wide variety of mudstone laminations. These are:(a) indistinctly laminated mudstone;(b) parallellaminated mudstone; and(c) nonparallel-laminated mudstone. Then, combining with the evidence from depocenter migration, Th/U ratios and total organic carbon, the abundant organo-minerallic fabrics suggest that organic carbon was preferentially deposited and preserved in anoxic, low energy and stagnant water conditions during deposition of the Wufeng and Longmaxi Formations. On the contrary, the Guanyinqiao Formation with poor organic carbon was deposited in oxic and high-energy water conditions. | Lei Yang Bo Ran Yu-Yue Han Shu-Gen Liu Yue-Hao Ye Christopher Xiao Wei Sun Di Yang Guo-Dong Xia Shi-Yu Wang | 2019 | Petroleum Science2019，16，1： | 2 |
| 9 | PD-1/PD-L1 Blockade Together With Vaccine Therapy Facilitates Effector T-Cell Infiltration Into Pancreatic Tumors显示文摘 | Kevin C. Soares Agnieszka A. Rucki Annie A. Wu Kelly Olino Qian Xiao Yi Chai Anthony Wamwea Elaine Bigelow Eric Lutz Linda Liu Sheng Yao Robert A. Anders Daniel Laheru Christopher L. Wolfgang Barish H. Edil Richard D. Schulick Elizabeth M. Jaffee Lei Zhen | 2015 | Journal of Immunotherapy2015，，1： | 2 |
| 10 | Characterization of Mediterranean Magnetotactic Bacteria显示文摘Magnetotactic bacteria are a diverse group of motile prokaryotes that are ubiquitous in aquatic habitats and cosmopolitan in distribution. In this study, we collected magnetotactic bacteria from the Mediterranean Sea. A remarkable diversity of morphotypes was observed, including multicellular types that seemed to differ from those previously found in North and South America. Another interesting organism was one with magnetosomes arranged in a six-stranded bundle which occupied one third of the cell width. The magnetosome bundle was evident even under optic microscopy. These cells were connected together and swam as a linear entire unit. Magnetosomes did not always align up to form a straight linear chain. A chain composed of rectangle magnetosomes bent at a posi- tion with an oval crystal. High resolution transmission electron microscopy analysis of the crystal at the pivotal position suggested uncompleted formation of the crystal. This is the first report of Mediterranean magnetotactic bacteria, which should be useful for studies of biogeochemical cycling and geohistory of the Mediterranean Sea. | Lefevre Christopher Bemadac Alain Pradel Nathalie WU Longfei Yu-Zhang Kui XIAO Tian Yonnet Jean-Paul Lebouc Afef SONG Tao Fukumori Yoshihiro | 2007 | Journal of Ocean University of China2007，6，4： | 1 |
| 11 | Interleukin-17 Signaling in Inflammatory, Kupffer Cells, and Hepatic Stellate Cells Exacerbates Liver Fibrosis in Mice显示文摘 | Fanli Meng Kai Wang Tomonori Aoyama Sergei I. Grivennikov YongHan Paik David Scholten Min Cong Keiko Iwaisako Xiao Liu Mingjun Zhang Christoph H. ?sterreicher Felix Stickel Klaus Ley David A. Brenner Tatiana Kisseleva | 2012 | Gastroenterology2012，，3： | 1 |
| 12 | A New Hierarchical Data Cache Architecture for iSCSI Storage Server 显示文摘 | WANG Jun YAO Xiao -yu CHRISTOPHER M | 2009 | IEEE Transactions on Computers2009，58，4： | 1 |
| 13 | Dynamic changes in O-GlcNAcylation regulate osteoclast differentiation and bone loss via nucleoporin 153显示文摘Bone mass is maintained by the balance between osteoclast-induced bone resorption and osteoblast-triggered bone formation.In inflammatory arthritis such as rheumatoid arthritis(RA),however,increased osteoclast differentiation and activity skew this balance resulting in progressive bone loss.O-GlcNAcylation is a posttranslational modification with attachment of a single O-linkedβ-D-N-acetylglucosamine(O-GlcNAc)residue to serine or threonine residues of target proteins.Although O-GlcNAcylation is one of the most common protein modifications,its role in bone homeostasis has not been systematically investigated.We demonstrate that dynamic changes in O-GlcNAcylation are required for osteoclastogenesis.Increased O-GlcNAcylation promotes osteoclast differentiation during the early stages,whereas its downregulation is required for osteoclast maturation.At the molecular level,O-GlcNAcylation affects several pathways including oxidative phosphorylation and cell-cell fusion.TNFαfosters the dynamic regulation of O-GlcNAcylation to promote osteoclastogenesis in inflammatory arthritis.Targeted pharmaceutical or genetic inhibition of O-GlcNAc transferase(OGT)or O-GlcNAcase(OGA)arrests osteoclast differentiation during early stages of differentiation and during later maturation,respectively,and ameliorates bone loss in experimental arthritis.Knockdown of NUP153,an O-GlcNAcylation target,has similar effects as OGT inhibition and inhibits osteoclastogenesis.These findings highlight an important role of O-GlcNAcylation in osteoclastogenesis and may offer the potential to therapeutically interfere with pathologic bone resorption. | Yi-Nan Li Chih-Wei Chen Thuong Trinh-Minh Honglin Zhu Alexandru-Emil Matei Andrea-Hermina Györfi Frederic Kuwert Philipp Hubel Xiao Ding Cuong Tran Manh Xiaohan Xu Christoph Liebel Vladyslav Fedorchenko Ruifang Liang Kaiyue Huang Jens Pfannstiel Min-Chuan Huang Neng-Yu Lin Andreas Ramming Georg Schett Jörg H.W.Distler | 2022 | Bone Research2022，10，4： | 1 |
| 14 | Characterizing the dependence of pure-tone frequency difference limens on frequency, duration, and level显示文摘 | Christophe Micheyl Li Xiao Andrew J. Oxenham | 2012 | Hearing Research (-)2012，，1： | 1 |
| 15 | A novel radiomics signature based on T2-weighted imaging accurately predicts hepatic inflammation in individuals with biopsy-proven nonalcoholic fatty liver disease:a derivation and independent validation study显示文摘Background:Currently,there are no effective methods for assessing hepatic inflammation without resorting to histological examination of liver tissue obtained by biopsy.T2-weighted images(T2WI)are routinely obtained from liver magnetic resonance imaging(MRI)scan sequences.We aimed to establish a radiomics signature based on T2WI(T2-RS)for assessment of hepatic inflammation in people with nonalcoholic fatty liver disease(NAFLD).Methods:A total of 203 individuals with biopsy-confirmed NAFLD from two independent Chinese cohorts with liver MRI examination were enrolled in this study.The hepatic inflammatory activity score(IAS)was calculated by the unweighted sum of the histologic scores for lobular inflammation and ballooning.One thousand and thirty-two radiomics features were extracted from the localized region of interest(ROI)in the right liver lobe of T2WI and,subsequently,selected by minimum redundancy maximum relevance and least absolute shrinkage and selection operator(LASSO)methods.The T2-RS was calculated by adding the selected features weighted by their coefficients.Results:Eighteen radiomics features from Laplacian of Gaussian,wavelet,and original images were selected for establishing T2-RS.The T2-RS value differed significantly between groups with increasing grades of hepatic inflammation(P<0.01).The T2-RS yielded an area under the receiver operating characteristic(ROC)curve(AUROC)of 0.80[95%confidence interval(CI):0.71-0.89]for predicting hepatic inflammation in the training cohort with excellent calibration.The AUROCs of T2-RS in the internal cohort and external validation cohorts were 0.77(0.61-0.93)and 0.75(0.63-0.84),respectively.Conclusions:The T2-RS derived from radiomics analysis of T2WI shows promising utility for predicting hepatic inflammation in individuals with NAFLD. | Zhong-Wei Chen Huan-Ming Xiao Xinjian Ye Kun Liu Rafael S.Rios Kenneth I.Zheng Yi Jin Giovanni Targher Christopher D.Byrne Junping Shi Zhihan Yan Xiao-Ling Chi Ming-Hua Zheng | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 1 |
| 16 | Reducing oil content of fried potato crisps considerably using a 'sweet' pre-treat- ment technique显示文摘 | T T Mai Tran Xiao Dong Chen Christopher Southern | 2007 | Journal of Food Engineering2007，，80： | 1 |
| 17 | Interleukin-17 Signaling in Inflammatory, Kupffer Cells, and Hepatic Stellate Cells Exacerbates Liver Fibrosis in Mice显示文摘 | Fanli Meng Kai Wang Tomonori Aoyama Sergei I. Grivennikov YongHan Paik David Scholten Min Cong Keiko Iwaisako Xiao Liu Mingjun Zhang Christoph H. ?sterreicher Felix Stickel Klaus Ley David A. Brenner Tatiana Kisseleva | 2012 | Gastroenterology2012，，3： | 1 |
| 18 | Treg Cells Expressing the Coinhibitory Molecule TIGIT Selectively Inhibit Proinflammatory Th1 and Th17 Cell Responses显示文摘 | Nicole Joller Ester Lozano Patrick R. Burkett Bonny Patel Sheng Xiao Chen Zhu Junrong Xia Tze G. Tan Esen Sefik Vijay Yajnik Arlene H. Sharpe Francisco J. Quintana Diane Mathis Christophe Benoist David A. Hafler Vijay K. Kuchroo | 2014 | Immunity2014，，4： | 1 |
| 19 | Self‑Generated Buried Submicrocavities for High‑Performance Near‑Infrared Perovskite Light‑Emitting Diode显示文摘ABSTRACT Embedding submicrocavities is an effective approach to improve the light out-coupling efficiency(LOCE)for planar perovskite light-emitting diodes(PeLEDs).In this work,we employ phenethylammonium iodide(PEAI)to trigger the Ostwald ripening for the downward recrystallization of perovskite,resulting in spontaneous formation of buried submicrocavities as light output coupler.The simulation suggests the buried submicrocavities can improve the LOCE from 26.8 to 36.2%for near-infrared light.Therefore,PeLED yields peak external quantum efficiency(EQE)increasing from 17.3%at current density of 114 mA cm^(−2)to 25.5%at current density of 109 mA cm^(−2)and a radiance increasing from 109 to 487 W sr^(−1)m^(−2)with low rolling-off.The turn-on voltage decreased from 1.25 to 1.15 V at 0.1 W sr^(−1)m^(−2).Besides,downward recrystallization process slightly reduces the trap density from 8.90×10^(15)to 7.27×10^(15)cm^(−3).This work provides a self-assembly method to integrate buried output coupler for boosting the performance of PeLEDs. | Jiong Li Chenghao Duan Qianpeng Zhang Chang Chen Qiaoyun Wen Minchao Qin Christopher C.S.Chan Shibing Zou Jianwu Wei Zuo Xiao Chuantian Zuo Xinhui Lu Kam Sing Wong Zhiyong Fan Keyou Yan | 2023 | Nano-Micro Letters2023，15，8： | 1 |
| 20 | Analysis of α and β carbolines in mainstream smoke of reference cigarettes by gas chromatography mass spectrometry 显示文摘 | CHRISTOPHER J S XIAO L Q QING M Z | 2004 | J Chromatogr A2004，1046，12： | 1 |
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