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| 1 | Normoalbuminuric diabetic kidney disease显示文摘 | Chao Chen Chang Wang Chun Hu Yachun Han Li Zhao Xuejing Zhu Li Xiao Lin Sun | 2017 | Frontiers of Medicine2017，11，3： | 38 |
| 2 | Short-term entecavir therapy of chronic severe hepatitis B显示文摘BACKGROUND:Chronic severe hepatitis B patients often have limited survival.This investigation aimed to evaluate the short-term effects of nucleoside analog therapy on chronic severe hepatitis B. METHODS:We retrospectively,randomly collected the data of 129 chronic severe hepatitis B patients:55 were treated with entecavir,and the remaining 74 were not treated with nucleoside analogues. RESULTS:No significant difference in short-term survival rate was found between the group treated with entecavir and that treated without nucleoside analogues.Although entecavir greatly reduced HBV replication in different periods of therapy(P<0.001),the model for end-stage liver disease(MELD)score and liver function(alanine aminotransferase,albumin,bilirubin,prothrombin time) showed no significant change.No significant differences were found in MELD scores and liver function in patients with different HBV DNA levels(≤104copies/ml,>10 4 to<10 6 copies/ml,≥10 6 copies/ml).Nor correlation was observed between HBV DNA levels and MELD scores in different periods of therapy(P>0.05).The HBV DNA levels of patients who survived for over 3 months or less than 3 months were not significantly different either.However, the MELD score and parameters of liver function(albumin, bilirubin,prothrombin time)were different between the two groups(P<0.05).CONCLUSION:These results suggest that short-term suppression of HBV replication may not slow down the progression of liver failure in patients with chronic severe hepatitis B. | Chen, Jun Han, Jian-Hua Liu, Chun Yu, Ren-He Li, Fa-Zhao Li, Qun-Fang Gong, Guo-Zhong | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，3： | 31 |
| 3 | Expression of insulin-like growth factor Ⅱ and its receptor in hepatocellular carcinogenesis显示文摘INTRODUCTIONInsulin-like growth factor Ⅱ(IGF-Ⅱ) is a mitogenic peptide of 74 kD and is mostly synthesized in fetal liver tissue .IGF-Ⅱ is believed to play an important role in fetal growth and development and is involved in cellular proliferation and differentiation[1-5]. Recently ,several researchers have reported increased expression of the IGF-Ⅱgene in human hepatocellular carcinoma (HCC) and adjacent non-cancerous liver tissues [6-10]. | Zi Rong Fan Dong Hua Yang Jun Cui Han Rong Qin Chun Chi Huang Department of Gastroenterology, Zhujiang Hospital. The First Military Medical University, Guangzhou 510282.Guangdong Province. China | 2001 | World Journal of Gastroenterology2001，7，2： | 24 |
| 4 | Laparoscopic radical cystectomy with orthotopic ileal neobladder in the female: report of 14 cases显示文摘背景膀胱癌是在中国的最普通的恶意的 urological 肿瘤。我们在场我们有在有到 2008 年 2月的从2003年2月的膀胱 carcinoma.Methods 的女病人的 orthotopic ileal neobladder 的 laparoscopic 激进分子囊切除术(纵向冗余码校验)的初步的经验和结果,有膀胱癌的 14 个女病人与 orthotopic ileal neobladder 经历了纵向冗余码校验。九个这些病人经历了子宫切除和卵巢切除术,和子宫和卵巢的附器的另外的 5 有的保藏。当需要时,标准双边的骨盆的 lymphadenectomy 被与子宫切除和卵巢切除术 laparoscopically 被完成的激进的囊切除术跟随。肿瘤被一 4-5 厘米移开更低的中线腹的切口,由 ileal neobladder 和 ureter-neobladder 的身体外的吻合的构造列在后面。neobladder 在在 14 个病人的吝啬的起作用的时间和血损失是的 laparoscope.Results 下面被吻合到尿道的树桩 350.2 分钟和 349.8 ml, respectively.Postoperative 复杂并发症在 1 个病人在 1 耐心、小袋阴道的管包括了 uretero 小袋 anastomotic 苛评。所有病人的后续时间从 3 ~ 60 个月,并且 12 个病人被跟随在上面为半年里的超过 6 个月和完成的频尿。一耐心的有的偶尔的白天尿不能自制和 2 有的夜间不能自制。经历了 hystectomy 和卵巢切除术的二个病人在一年以后有 voiding 困难,它被断断续续的 self-catheterization 对待。neobladder 和剩余尿的吝啬的体积分别地是 333.6 ml 和 31.2 ml。外科的边缘是为所有病人免费的肿瘤。一个病人有骨头转移并且死在有在女病人的 orthotopic ileal neobladder 的 operation.Conclusions 纵向冗余码校验以后的 11 个月是有低病态和可接受的 neobladder 功能的一个技术上可行、安全、微型侵略的过程。长期的后续被要求证实 neobladder 功能和 oncological 结果。 | LIN Tian-xin ZHANG Cai-xia XU Ke-wei HUANG Hai JIANG Chun HAN Jin-li YAO You-sheng GUO Zheng-hui XIE Wen-lian YIN Xin-bao HUANG Jian | 2008 | Chinese Medical Journal2008，，10： | 18 |
| 5 | Overexpression of Arabidopsis YUCCA6 in Potato Results in High-Auxin Developmental Phenotypes and Enhanced Resistance to Water Deficit显示文摘Indole-3-acetic 酸(IAA ) ,主要植物植物生长素,在色氨酸依赖者和色氨酸无关的小径被生产。在 Arabidopsis thaliana 的一条主要小径从色氨酸在二反应产生 IAA。步骤一由把国际语音学协会变换成丝兰属植物蛋白质催化的 IAA 的一个限制率的步骤跟随的色氨酸 aminotransferases 把色氨酸变换成 indole-3-pyruvic 酸(国际语音学协会) 。我们识别了推出了氨基酸序列的基因分享的八通常认为的 StYUC (茄属 tuberosum 丝兰属植物) Arabidopsis 丝兰属植物蛋白质的有那些的 50%70% 身份。都包括正规、保存丝兰属植物序列:FATGY 主题, FMO 签名顺序和 NADP 有约束力的序列。另外,五基因与 ~ 被发现 50% 氨基酸顺序身份到 Arabidopsis 色氨酸 aminotransferases。转基因的土豆(茄属 tuberosum cv。Jowon ) 组成地, overexpressing Arabidopsis AtYUC6 显示了象狭窄的向下卷的叶子,增加的高度,直立的身高,和长寿那样的高植物生长素的显型。转基因的土豆植物 overexpressing AtYUC6 基于减少的水损失显示出提高的干旱忍耐。显型在叶子与反应的氧种类的减少的层次被相关。结果在可以被利用改变植物回答到环境的土豆建议植物生长素生合成的一条功能的丝兰属植物小径。 | Jeong Im Kim Dongwon Baek Hyeong Cheol Park Hyun Jin Chun Dong-Ha Oh Min Kyung Lee Joon-Yung Cha Woe-Yeon Kim Min Chul Kim Woo Sik Chung Hans J. Bohner Sang Yeol Lee Ray A. Bressan Shin-Woo Lee Dae-Jin Yun | 2013 | Molecular Plant2013，6，2： | 15 |
| 6 | A Chromosome-Level Genome Assembly of Garlic (Allium sativum) Provides Insights into Genome Evolution and Allicin Biosynthesis显示文摘Garlic,an economically important vegetable,spice,and medicinal crop,produces highly enlarged bulbs and unique organosulfur compounds.Here,we report a chromosome-level genome assembly for garlic,with a total size of approximately 16.24 Gb,as well as the annotation of 57561 predicted protein-coding genes,making garlic the first Allium species with a sequenced genome.Analysis of this garlic genome assembly reveals a recent burst of transposable elements,explaining the substantial expansion of the garlic genome.We examined the evolution of certain genes associated with the biosynthesis of allicin and inulin neoseries-type fructans,and provided new insights into the biosynthesis of these two compounds.Furthermore,a large-scale transcriptome was produced to characterize the expression patterns of garlic genes in different tissues and at various growth stages of enlarged bulbs.The reference genome and large-scale transcriptome data generated in this study provide valuable new resources for research on garlic biology and breeding. | Xiudong Sun Siyuan Zhu Ningyang Li Yi Cheng Jing Zhao Xuguang Qiao Li Lu Shiqi Liu Yanzhou Wang Chan Liu Benping Li Wu Guo Shuang Gao Zemao Yang Fu Li Zheng Zeng Qing Tang Yupeng Pan Mengjiao Guan Jian Zhao Xiaomi ng Lu Huanwe n Meng Zhenlin Han Chun she ng Gao Wenkai Jiang Xing Zhao Shilin Tian Jianguang Su Zhihui Cheng Touming Liu | 2020 | Molecular Plant2020，13，9： | 14 |
| 7 | Clinicopathological significance of altered Notch signaling in extrahepatic cholangiocarcinoma and gallbladder carcinoma显示文摘AIM:To investigate the role and clinicopathological significance of aberrant expression of Notch receptors and Delta-like ligand-4 (DLL4) in extrahepatic cholangiocarcinoma and gallbladder carcinoma.METHODS:One hundred and ten patients had surgically resected extrahepatic cholangiocarcinoma (CC) and gallbladder carcinoma specimens examined by immunohistochemistry of available paraffin blocks.Immunohistochemistry was performed using anti-Notch receptors 1-4 and anti-DLL4 antibodies.We scored the immunopositivity of Notch receptors and DLL4 expression by percentage of positive tumor cells with cytoplasmic expression and intensity of immunostaining.Coexistent nuclear localization was evaluated.Clinicopatho-logical parameters and survival data were compared with the expression of Notch receptors 1-4 and DLL4.RESULTS:Notch receptor proteins showed in the cytoplasm with or without nuclear expression in cancer cells,as well as showing weak cytoplasmic expression in non-neoplastic cells.By semiquantitative evaluation,positive immunostaining of Notch receptor 1 was detected in 96 cases (87.3%),Notch receptor 2 in 97 (88.2%),Notch receptor 3 in 97 (88.2%),Notch receptor 4 in 103 (93.6),and DLL4 in 84 (76.4%).In addition,coex- istent nuclear localization was noted [Notch receptor 1;18 cases (18.8%),Notch receptor 2;40 (41.2%),Notch receptor 3;32 (33.0%),Notch receptor 4;99 (96.1%),DLL4;48 (57.1%)].Notch receptor 1 expression was correlated with advanced tumor,node,metastasis (TNM) stage (P=0.043),Notch receptor 3 with advanced T stage (P=0.017),tendency to express in cases with nodal metastasis (P=0.065) and advanced TNM stage (P=0.052).DLL4 expression tended to be related to less histological differentiation (P=0.095).Coexistent nuclear localization of Notch receptor 3 was related to no nodal metastasis (P=0.027) and Notch receptor 4 with less histological differentiation (P=0.036),while DLL4 tended to be related inversely with T stage (P=0.053).Coexistent nuclear localization of DLL4 was related to poor survival (P=0.002).CONCLUSION:Aberrant expression of Notch receptors 1 and 3 play a role during cancer progression,and cytoplasmic nuclear coexistence of DLL4 expression correlates with poor survival in extrahepatic CC and gallbladder carcinoma. | Hyun Ah Yoon Myung Hwan Noh Byung Geun Kim Ji Sun Han Jin Seok Jang Seok Ryeol Choi Jin Sook Jeong Jin Ho Chun | 2011 | World Journal of Gastroenterology2011，17，35： | 14 |
| 8 | Mass elevation effect and its forcing on timberline altitude显示文摘集体举起效果的概念(massenerhebungseffect, MEE ) 被 A 介绍。de Quervain 大约 100 年以前排队为象树那样的温度相关的参数说明观察趋势并且比在他们的外部边缘上在中央阿尔卑斯山脉发生在更高的举起的 snowline。它广泛地也在世界的另外的区域被观察了,但是没有重要,更不用说量,关于这现象的研究。特别,它完全通常在开发树带界线举起的恰当的模型被忽视了,与仅仅看作影响因素的经度或纬度。这篇论文试着确定到树带界线的 MEE 的贡献举起。认为更多广泛陆地团并且特别越高在陆地质量的内部的山底,越 greater 集体举起效果,这篇论文作为 MEE 的大小拿山底举起(MBE ) 。我们收集树带界线举起的 157 个数据点,并且把他们的纬度,经度和 MBE 用作独立变量在东南的欧亚的大陆为树带界线举起造一个多重线性回归方程。结果生产到树带界线高度活动范围 25.11% , 29.43% ,和 45.46% 的纬度,经度和 MBE 的贡献分别地。北纬度的诺思 | HAN Fang YAO Yonghui DAI Shibao WANG Chun SUN Ranhao XU Juan ZHANG Baiping | 2012 | Journal of Geographical Sciences2012，22，4： | 12 |
| 9 | A 12-year cohort study on the efficacy of plasmaderived hepatitis B vaccine in rural newborns显示文摘AIM To understand the anti-HBs persistenceand the long-term preventive efficacy in ruralnewborns after vaccination with plasma-derivedhepatitis B vaccine.METHODS In the time of expanded program onimmunization(EPI),the newborns werevaccinated with 10μg×3 doses of hepatitis Bvaccine and 762 newborns who were HBsAgnegative after primary immunization wereselected for cohort observation from 1986 to1998.Their serum samples were detectedqualitatively and quantitatively for hepatitis Binfecting markers,including HBsAg,anti-HBsand anti-HBc by SPRIA Kits.The annual HBsAgpositive conversion rate was counted by life-table method.RESULTS①The anti-HBs positive rate was94.44% for the babies born to HBsAg negativemothers and 84.21% for those born to HBsAgpositive mothers in the 1st year afterimmunization,and dropped to 51.31% and52.50% in the 12th year respectively.GMT valuewas dropped from 31.62 to 3.13 and 23.99 to 3.65in the 2nd to the 12th year respectively.Therewas a marked drop in GMT at the 3rd to the 5thyear,and in anti-HBs positive rate at the 9th tothe 10th year.②In the period of 12 yearsobservation,the person-year HBsAg positive conversion rates were 0.12%(5/4150.0)innewborns born to HBsAg negative mothers and0.20%(1/508.0)in those born to HBsAgpositive mothers,and none of the HBsAgpositive converted children became HBsAgchronic carriers.Compared with the baselinebefore immunization,the protective rates were97.19% and 95.32% respectively.CONCLUSION The protective efficacy ofplasma-derived hepatitis B vaccine persisted atleast 12 years,and a booster dose seems notnecessary within at least 12 years after theprimary three-doses immunization to newbornsborn to HBsAg negative mothers. | Hong Bin Liu Zong Da Meng Jing Chen Ma Chang Quan Han Ying Lin Zhang Zhan Chun Xing Yu Wei Zhang Yu Zhong Liu Hui Lin Cao | 2000 | World Journal of Gastroenterology2000，6，3： | 11 |
| 10 | POWER FLOW ANALYSIS FOR A NEW ISOLATION SYSTEM-FLEXIBLE FLOATING RAFT显示文摘POWERFLOWANALYSISFORANEWISOLATIONSYSTEM-FLEXIBLEFLOATINGRAFTPOWERFLOWANALYSISFORANEWISOLATIONSYSTEM-FLEXIBLEFLOATINGRAFTXiong... | Xiong Yeping Song Kongjie Wang Chun Han Yuchang( Shandong University of Technology) | 1996 | Chinese Journal of Mechanical Engineering1996，9，3： | 10 |
| 11 | Combination of mild therapeutic hypothermia and adipose-derived stem cells for ischemic brain injury显示文摘Mild therapeutic hypothermia has been shown to mitigate cerebral ischemia, reduce cerebral edema, and improve the prognosis of patients with cerebral ischemia. Adipose-derived stem cell-based therapy can decrease neuronal death and infiltration of inflammatory cells, exerting a neuroprotective effect. We hypothesized that the combination of mild therapeutic hypothermia and adipose-derived stem cells would be neuroprotective for treatment of stroke. A rat model of transient middle cerebral artery occlusion was established using the nylon monofilament method. Mild therapeutic hypothermia(33°C) was induced after 2 hours of ischemia. Adipose-derived stem cells were administered through the femoral vein during reperfusion. The severity of neurological dysfunction was measured by a modified Neurological Severity Score Scaling System. The area of the infarct lesion was determined by 2,3,5-triphenyltetrazolium chloride staining. Apoptotic neurons were detected by terminal deoxynucleotidyl transferase-mediated d UTP-biotin nick end labeling(TUNEL) staining. The regeneration of microvessels and changes in the glial scar were detected by immunofluorescence staining. The inflammatory responses after ischemic brain injury were evaluated by in situ staining using markers of inflammatory cells. The expression of inflammatory cytokines was measured by reverse transcription-polymerase chain reaction. Compared with mild therapeutic hypothermia or adipose-derived stem cell treatment alone, their combination substantially improved neurological deficits and decreased infarct size. They synergistically reduced the number of TUNEL-positive cells and glial fibrillary acidic protein expression, increased vascular endothelial growth factor levels, effectively reduced inflammatory cell infiltration and down-regulated the m RNA expression of the proinflammatory cytokines interleukin-1β, tumor necrosis factor-α and interleukin-6. Our findings indicate that combined treatment is a better approach for treating stroke compared with mild therapeutic hypothermia or adipose-derived stem cells alone. | Kai Zhao Rui Li Sheng Bi Yu Li Long Liu Yu-Long Jia Peng Han Chang-Cong Gu Xi-Ze Guo Wan-Ping Zhang Chun Wang Chun-Ying Pei Lin-Lu Tian Li-Xian Li | 2018 | Neural Regeneration Research2018，13，10： | 9 |
| 12 | A Novel Thixotropic Phenomenon——Complex Thixotropic Behavior显示文摘ANovelThixotropicPhenomenon——ComplexThixotropicBehavior*Towhomcorrespondenceshouldbeaddresed.HOUWan-guo*,SUNDe-jun,HANShu-hua... | HOU Wan guo, SUN De jun, HAN Shu hua, ZHANG Chun guang and WANG Guo ting (Institute of Colloid and Interface Chemistry, Shandong University , Jinan, 250100) | 1997 | Chemical Research in Chinese Universities1997，13，1： | 8 |
| 13 | Malnutrition and Quality of Life in Chinese Cancer Patients: a Clinical Study of 23,994 Subjects显示文摘Background Malnutrition is common in patients with cancer,and can negatively impact their quality of life(QoL)and even survival.However,there is currently no large data available on the prevalence of malnutrition in Chinese cancer patients.This study evaluated the prevalence of malnutrition and the QoL of Chinese patients with locoregional,recurrent or metastatic cancer.Methods We conducted a nationwide observational,multi-center,hospital-based cross-sectional study within the Chinese Society of Nutritional Oncology(CSNO)Network.All of the patients were diagnosed with one of the following 18 different types of malignant tumors:lung cancer,gastric cancer,liver cancer,colorectal cancer,breast cancer,esophageal cancer,cervical cancer,endometrial cancer,nasopharyngeal carcinoma,malignant lymphoma,leukemia,pancreatic cancer,ovarian cancer,prostate cancer,bladder cancer,brain cancer,biliary tract malignant tumors or gastrointestinal stromal tumors.These patients were enrolled from 72 hospitals located in different regions of China.The patients’nutritional status was evaluated based on the body mass index(BMI),loss of bodyweight,laboratory measurements and patient generated-subjective global assessment(PG-SGA)scores.The cancer patients’physical status and QoL were assessed by the Karnofsky Performance Status(KPS)questionnaire and the European Organization for Research and Treatment of Cancer(EORTC)QLQ-C30 questionnaire,respectively.Results From December 2013 to April 2016,23,994 patients hospitalized for cancer treatment(such as surgery,chemotherapy or radiotherapy)were enrolled in the study.The patients included 12,494(52.9%)males and 11,124(47.1%)females.The mean age was 55.8±13.7 years.The proportions of patients in cancer stagesⅠ,Ⅱ,Ⅲ,Ⅳand uncertain were 11.5%,20.3%,27.5%,30.2%and 10.5%,respectively.Among the 23,994 inpatients,the proportions of patients who were underweight(BMI<18.5 kg/m2),normal(18.5 kg/m2 | Hong Xia Xu Chun Hua Song Zhen Ming Fu Chang Wang Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Jiu Wei Cui Wei Li Han Ping Shi the Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2021 | Journal of Nutritional Oncology2021，6，1： | 8 |
| 14 | The internalization pathway,metabolic fate and biological effect of superparamagnetic iron oxide nanoparticles in the macrophage-like RAW264.7 cell显示文摘The potential applications of superparamagnetic iron oxide nanoparticles (SPIONs) in several nanomedical fields have attracted intense interest based on the cell-nano interaction. However, the mechanisms underlying cell uptake, the intracellular trail, final fate and the biological effects of SPIONs have not yet been clearly elucidated. Here, we showed that multiple endocytic pathways were involved in the internalization process of SPIONs in the RAW264.7 macrophage. The internalized SPIONs were biocompatible and used three different metabolic pathways: The SPIONs were distributed to daughter cells during mitosis; they were degraded in the lysosome and free iron was released into the intracellular iron metabolic pool; and, the intact SPIONs were potentially exocytosed out of the cells. The internalized SPIONs did not induce cell damage but affected iron metabolism, inducing the upregulation of ferritin light chain at both the mRNA and protein levels and ferroportin 1 at the mRNA level. These results may contribute to the development of nanobiology and to the safe use of SPIONs in medicine when administered as a contrast medium or a drug delivery tool. | GU JingLi XU HaiFei HAN YeHua DAI Wei HAO Wei WANG Chun Yu GU Ning XU HaiYan CAO JiMin | 2011 | Science China(Life Sciences)2011，54，9： | 8 |
| 15 | Increased end-stage renal disease risk in patients with inflammatory bowel disease:A nationwide populationbased study显示文摘AIM To estimate the risk of end-stage renal disease(ESRD)in patients with inflammatory bowel disease(IBD).METHODS From January 2010 to December 2013, patients with Crohn's disease(CD) and ulcerative colitis(UC) were identified, based on both the International Classification of Diseases, 10 th revision(ICD-10) and the rare,intractable disease registration program codes from the National Health Insurance(NHI) database in South Korea. We compared 38812 patients with IBD to ageand sex-matched non-IBD controls with a ratio of 1:3.Patients newly diagnosed with ESRD were identified with the ICD-10 code.RESULTS During a mean follow-up of 4.9 years, ESRD was detected in 79(0.2%) patients with IBD and 166(0.1%)controls. The incidence of ESRD in patients with IBD was0.42 per 1000 person-years. Patients with IBD had a significantly higher risk of ESRD than controls [adjusted hazard ratio(HR) = 3.03; 95% confidence interval(CI):1.77-5.20; P < 0.001]. The incidences(per 1000 personyears)of ESRD were 0.51 in patients with CD and 0.13 in controls, respectively(adjusted HR = 6.33; 95%CI:2.75-14.56; P < 0.001). In contrast, the incidence of ESRD was similar between the UC and control groups(0.37 vs 0.37 per 1000 person-years; adjusted HR = 2.01;95%CI: 0.90-4.51; P = 0.089).CONCLUSION The risk of ESRD was elevated in patients with CD, but not UC. Patients with CD should be monitored carefully for signs of renal insufficiency. | Seona Park Jaeyoung Chun Kyung-Do Han Hosim Soh Kookhwan Choi Ji Hye Kim Jooyoung Lee Changhyun Lee Jong Pil Im Joo Sung Kim | 2018 | World Journal of Gastroenterology2018，24，42： | 7 |
| 16 | Non-surgical treatment of post-surgical bile duct injury: Clinical implications and outcomes显示文摘AIM:To investigate the prognostic factors determining the success rate of non-surgical treatment in the management of post-operative bile duct injuries(BDIs).METHODS:The study patients were enrolled from the pancreatobiliary units of a tertiary teaching hospital for the treatment of BDIs after hepatobiliary tract surgeries,excluding operations for liver transplantation andmalignancies,from January 1999 to August 2010.A total of 5167 patients underwent operations,and 77patients had BDIs following surgery.The primary end point was the treatment success rate according to different types of BDIs sustained using endoscopic or percutaneous hepatic approaches.The type of BDI was defined using one of the following diagnostic tools:endoscopic retrograde cholangiography,percutaneous transhepatic cholangiography,computed tomography scan,and magnetic resonance cholangiography.Patients with a final diagnosis of BDI underwent endoscopic and/or percutaneous interventions for the treatment of bile leak and/or stricture if clinically indicated.Patient consent was obtained,and study approval was granted by the Institutional Review Board in accordance with the legal regulations of the Human Clinical Research Center at the Seoul National University Hospital in Seoul,South Korea.RESULTS:A total of 77 patients were enrolled in the study.They were divided into three groups according to type of BDI.Among them,55 patients(71%)underwent cholecystectomy.Thirty-six patients(47%)had bile leak only(type 1),31 patients had biliary stricture only(type 2),and 10 patients had both bile leak and biliary stricture(type 3).Their initial treatment modalities were non-surgical.The success rate of non-surgical treatment in each group was as follows:BDI type 1:94%;type 2:71%;and type 3:30%.Clinical parameters such as demographic factors,primary disease,operation method,type of operation,non-surgical treatment modalities,endoscopic procedure steps,type of BDI,time to diagnosis and treatment duration were evaluated to evaluate the prognostic factors affecting the success rate.The type of BDI was a statistically significant prognostic factor in determining the success rate of non-surgical treatment.In addition,a shorter time to diagnosis of BDI after the operation correlated significantly with higher success rates in the treatment of type 1 BDIs.CONCLUSION:Endoscopic or percutaneous hepatic approaches can be used as an initial treatment in type1 and 2 BDIs.However,surgical intervention is a treatment of choice in type 3 BDI. | Young Ook Eum Joo Kyung Park Jaeyoung Chun Sang-Hyub Lee Ji Kon Ryu Yong-Tae Kim Yong-Bum Yoon Chang Jin Yoon Ho-Seong Han Jin-Hyeok Hwang | 2014 | World Journal of Gastroenterology2014，20，22： | 7 |
| 17 | Validity of the Chinese Version of the Patient-Generated Subjective Global Assessment (PG-SGA) in Lung Cancer Patients显示文摘The prevalence of malnutrition is high among oncology patients in China. Although the Patient- Generated Subjective Global Assessment (PG-SGA) is widely recognized as an important nutritional assessment tool, it has not been validated for Chinese cancer patients. The purpose of this study was to conduct an analysis of nutrition screening and assessment data to validate the Chinese version of the PG-SGA in Chinese patients with lung cancer. This was an observational, cross-sectional study of 2,000 consecutive adult patients with lung cancer treated at several tertiary hospitals in China. Anthropometric and patient descriptive data were collected. The PG-SGA generated a score for the nutritional risk and a global rating for the nutritional status. The internal consistency, external consistency, and construct validity were evaluated, and a known-groups comparison and principal component analyses were conducted to evaluate the reliability and validity of the PG-SGA. The known-groups comparison demonstrated the ability of the PG-SGA to differentiate lung cancer patients of different nutritional and body mass index (BMI) groups. A confirmatory factor analysis supported the original four-factor structure of the PG-SGA. In terms of the internal and external consistency, the PG-SGA demonstrated intra-class correlation coefficients (ICC) up to 0.987. Alternative form validity was also demonstrated between Box 4 of the PG-SGA and the Karnofsky Performance Status score, with excellent external consistency (r = 0.972, P < 0.001). The construct validity was supported, and selected questionnaire dimensions were evident in the principal component analysis. Significant Spearman correlations (P < 0.001) were demonstrated. The Chinese version of the PG-SGA demonstrated significant reliability and sufficient exploratory properties to support its validity. It seems to be a valid tool that can be used to access the nutritional status of Chinese lung cancer patients. The validity of the PG-SGA in Chinese cancer patients warrants further investigation in other cancer types. | Zhen Ming Fu Hong Xia Xu Chun Hua Song Wei Li Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Chang Wang Han Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers (INSCOC) Group | 2016 | Journal of Nutritional Oncology2016，1，1： | 7 |
| 18 | Risk of inflammatory bowel disease in patients with chronic obstructive pulmonary disease: A nationwide, population-based study显示文摘BACKGROUND There is a growing evidence regarding an increased risk of inflammatory bowel disease(IBD)among patients with airway diseases.AIM To investigate the influence of chronic obstructive pulmonary disease(COPD)on the risk of IBD.METHODS A nationwide,population-based study was conducted using data from the National Health Insurance Service database.A total of 1303021 patients with COPD and 6515105 non-COPD controls were identified.The COPD group was divided into the severe and the mild COPD group according to diagnostic criteria.The risk of IBD in patients with COPD compared to controls was analyzed by Cox proportional hazard regression models.The cumulative incidences of IBD were compared between the groups.RESULTS The COPD group had higher incidences of IBD compared to non-COPD controls(incidence rate,9.98 vs 7.18 per 100000 person-years,P<0.001).The risk of IBD in the COPD group was increased by 1.38(adjusted hazard ratio(HR);95%CI:1.25-1.52).The incidence rate of IBD was higher in the severe COPD group than in the mild COPD group(12.39 vs 9.77 per 100000 person-year,P<0.001).The severity of COPD was associated with an increased risk of IBD(adjusted HR 1.70 in severe COPD,95%CI:1.27-2.21 and adjusted HR 1.35 in mild COPD,95%CI:1.22-1.49)CONCLUSION The incidences of IBD were significantly increased in COPD patients in South Korea and the risk of developing IBD also increased as the severity of COPD increased. | Jooyoung Lee Jong Pil Im Kyungdo Han Seona Park Hosim Soh Kukhwan Choi Jihye Kim Jaeyoung Chun Joo Sung Kim | 2019 | World Journal of Gastroenterology2019，25，42： | 7 |
| 19 | Reemergent Cases of COVID-19—Xinfadi Wholesales Market,Beijing Municipality,China,June 11,2020显示文摘No new local coronavirus disease 2019(COVID-19)cases were reported in Beijing for over 56 days before the reemergent COVID-19 cases that were reported on June 11,2020,and more than 200 confirmed cases have been reported as of June 20 in Beijing.All confirmed COVID-19 cases were associated with Xinfadi Wholesale Market.Here,we reported the phylogenetic characteristics of the COVID-19 viruses(also known as severe acute respiratory syndrome coronavirus 2,SARS-CoV-2,and human coronavirus 2019,HCoV-19)sequenced from the clinical specimens of 2 human cases and 1 environmental sample. | Wenjie Tan Peihua Niu Xiang Zhao Yang Pan Yong Zhang Lijuan Chen Li Zhao Yanhai Wang Dayan Wang Jun Han George FGao Chun Huang Wenbo Xu Guizhen Wu | 2020 | China CDC weekly2020，2，27： | 6 |
| 20 | Key details of the duodenal-jejunal bypass in type 2 diabetes mellitus rats显示文摘AIM: To investigate which surgical techniques and perioperative regimens yielded the best survival rates for diabetic rats undergoing gastric bypass. METHODS: We performed Roux-en-Y gastric bypass with reserved gastric volume, a procedure in which gastrointestinal continuity was reestablished while excluding the entire duodenum and proximal jejunal loop. We observed the procedural success rate, long-term survival, and histopathological sequelae associated with a number of technical modifications. These included: use of anatomical markers to precisely identify Treitz's ligament; careful dissection along surgical planes; careful attention to the choice of regional transection sites; reconstruction using full-thickness anastomoses; use of a minimally invasive procedure with prohemostatic pretreatment and hemorrhage control; prevention of hypo-thermic damage; reduction in the length of the procedure; and accelerated surgical recovery using fast-track surgical modalities such as perioperative permissive underfeeding and goal-directed volume therapy. RESULTS: The series of modif ications we adopted reduced operation time from 110.02 ± 12.34 min to 78.39 ± 7.26 min (P < 0.01), and the procedural success rate increased from 43.3% (13/30) to 90% (18/20) (P < 0.01), with a long-term survival of 83.3% (15/18) (P < 0.01). CONCLUSION: Using a number of fast-track and damage control surgical techniques, we have successfully established a stable model of gastric bypass in diabetic rats. | Li-Ou Han Chun Song Chun-Fang Song Li-Hong Zhou Su-Jun Cheng | 2011 | World Journal of Gastroenterology2011，17，45： | 5 |
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