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| 1 | Efficacy and safety evaluation of intravenous infusion of cervus and cucumis polypeptides for treatment of avascular necrosis of the femoral head: a randomized clinical trial显示文摘OBJECTIVE: To investigate the efficacy and safety of intravenous cervus and cucumis polypeptides for treating avascular necrosis of the femoral head(ANFH) in regard to pain and hip function in a randomized clinical trial.METHODS: A total of 96 subjects with ANFH who were recruited at the Orthopaedic Hospital Affiliated with Hebei United University and Qian Hai Femoral Head Hospital of Beijing were assigned by lottery to an intervention group(n = 48) or a control group(n = 48). All subjects underwent physical therapy and rehabilitation exercises. In addition,subjects in the intervention group were given intravenous infusions of cervus and cucumis polypeptides. Visual analogue scale(VAS), Harris hip score,and radiography or magnetic resonance imaging were applied to assess all subjects at the beginning of treatment and 3, 6, and 9 months afterward. All the subjects were followed up for 2 years.RESULTS: At the beginning of treatment, there were no statistically significant differences between the two groups in terms of the general condition of patients or the VAS and Harris hip scores(all P > 0.05). At 3, 6, and 9 months after treatment,however, the VAS score decreased and the Harris hip score increased in all patients, with the improvement of intervention group significantly greater than that of the control group(P < 0.05).The total effectiveness rates for the intervention and control groups were 89.58% and 70.83%, respectively, with the difference being statistically significant(P < 0.05). There was no statistically significant difference between the two groups in terms of the safety of the injections(P > 0.05).CONCLUSION: Intravenous infusion of cervus and cucumis polypeptides relieved pain and improved hip function of subjects with ANFH.Thus, the intravenous infusion of cervus and cucumis polypeptides was a safe, effective treatment for ANFH. | Wei Liyou Zhang Hongwei Li Xinmin Yang Chunyan Wang Guoqiang Zhang Lifeng Cui Mingwu Han Lijun | 2016 | Journal of Traditional Chinese Medicine2016，36，1： | 15 |
| 2 | Ground Surface Ruptures and Near-Fault,Large-Scale Displacements Caused by the Wenchuan Ms8.0 Earthquake Derived from Pixel Offset Tracking on Synthetic Aperture Radar Images显示文摘The 12 May 2008 Wenchuan Ms8.0 earthquake produced surface displacements along the causative fault,the Yingxiu-Beichuan Fault,which are up to several meters near the fault.Because of the large gradient,satellite synthetic aperture radar(SAR) interferometric data are strongly incoherent;the usual SAR interferometry method does not allow such displacements to be measured.In the present study,we employed another approach,the technique based on pixel offset tracking,to solve this problem.The used image data of six tracks are from the Advanced Land Observing Satellite,Phased Array type L-band Synthetic Aperture Radar(ALOS/PALSAR) dataset of Japan.The results show that the entire surface rupture belt is 238 km long,extending almost linearly in a direction of 42° north-east.It is offset left laterally by a north-west-striking fault at Xiaoyudong,and turns at Gaochuan,where the rupture belt shifts toward the south by 5 km,largely keeping the original trend.In terms of the features of the rupture traces,the rupture belt can be divided into five sections and three types.Among them,the Beichuan-Chaping and Hongkou-Yingxiu sections are relatively complex,with large widths and variable traces along the trend.The Pingtong-Nanba and Qingping-Jingtang sections appear uniform,characterized by straight traces and small widths.West of Yingxiu,the rupture traces are not clear.North of the rupture belt,surface displacements are 2.95 m on average,mostly 2-3.5 m,with 7-9 m the maximum near Beichuan.South of the rupture belt,the average displacement is 1.75 m,dominated by 1-2 m,with 3-4 m at a few sites.In the north,the displacements in the radar line of sight are of subsidence,and in the south,they are uplifted,in accordance with a right-slip motion that moves the northern wall of the fault to the east,and the southern wall to the west,respectively.Along the Guanxian-Jiangyou Fault,there is a uplift zone in the radar line of sight,which is 66 km long,1.5-6 km wide,and has vertical displacements of approximately 2 m,but no observable rupture traces. | QU Chunyan SHAN Xinjian LIU Yunhua ZHANG Guohong SONG Xiaogang ZHANG Guifang GUO Liming HAN Yufei | 2012 | Acta Geologica Sinica(English Edition)2012，86，2： | 10 |
| 3 | IL-17A-dependent gut microbiota is essential for regulating diet-induced disorders in mice显示文摘The gut microbiota plays a key role in obesity and related metabolic disorders, and multiple factors including diet, host genotype, and age regulate it. Many studies have examined the contribution of extrinsic factors to the regulation of the gut microbiota, but the importance of the host genetic constitution cannot be ignored. Interleukin 17A(IL-17A), a pro-inflammatory cytokine, is important in the defense against infection and diseases. Here, we investigated the association among IL-17, a high-fat diet(HFD), and the gut microbiota. Mice deficient in IL-17A were resistant to diet-induced obesity and related diseases. Compared with the Ⅱ-17^(-/-)mice, wild-type(WT) mice challenged with HFD showed obvious weight fluctuations, such as those seen in type 2 diabetes, and hematological changes similar to those associated with metabolic syndrome. However, housing WT mice and Ⅱ-17a^(-/-)mice together significantly alleviated these symptoms in the WT mice. A metagenomic analysis of the mouse feces indicated that the microbial community compositions of these two groups differed before HFD feeding. The HFD mediated shifts in the gut microbial compositions, which were associated with the mouse phenotypes.We also identified potentially beneficial and harmful species present during this period, and drew networks of the most abundant species. A functional analysis indicated pathway changes in the WT and Ⅱ-17a^(-/-)mice when fed the HFD. Collectively, these data underscore the importance of the host factor IL-17 A in shaping and regulating the gut microbiota, which conversely, influences the host health. | Yujing Bi Chunxiao Li Lin Liu Jiyuan Zhou Zhengchao Li Huimin Deng Chunyan Wu Yanping Han Yajun Song Yafang Tan Xiaoyi Wang Zongmin Du Yujun Cui Yanfeng Yan Fachao Zhi Guangwei Liu Nan Qin Heping Zhang Ruifu Yang | 2017 | Science Bulletin2017，62，15： | 5 |
| 4 | Influence of phenol on ammonia removal in an intermittent aeration bioreactor treating biologically pretreated coal gasification wastewater显示文摘A laboratory-scale intermittent aeration bioreactor was investigated to treat biologically pretreated coal gasification wastewater that was mainly composed of NH_3-N and phenol.The results showed that increasing phenol loading had an adverse effect on NH_3-N removal;the concentration in effluent at phenol loading of 40 mg phenol/(L·day) was 7.3 mg/L, 36.3%of that at 200 mg phenol/(L·day). The enzyme ammonia monooxygenase showed more sensitivity than hydroxylamine oxidoreductase to the inhibitory effect of phenol, with32.2% and 10.5% activity inhibition, respectively at 200 mg phenol/(L·day). Owing to intermittent aeration conditions, nitritation-type nitrification and simultaneous nitrification and denitrification(SND) were observed, giving a maximum SND efficiency of 30.5%.Additionally, ammonia oxidizing bacteria(AOB) and denitrifying bacteria were the main group identified by fluorescent in situ hybridization. However, their relative abundance represented opposite variations as phenol loading increased, ranging from 30.1% to 17.5%and 7.6% to 18.2% for AOB and denitrifying bacteria, respectively. | Chunyan Xu Hongjun Han Shengyong Jia Qian Zhao | 2016 | Journal of Environmental Sciences2016，28，5： | 5 |
| 5 | Micelle or polymersome formation by PCL-PEG-PCL copolymers as drug delivery systems显示文摘Polye-caprolactone)-b-poly(ethylene glycol)-b-poly(e-caprolactone)(PCL-b-PEG-b-PCL,PCEC) triblock copolymers have been widely investigated in last several decades.Here,by altering the weight ratio of monomers in ring-opening polymerization,a series of PCEC triblock copolymers with varying hydrophobicity were synthesized,which were characterized by FTIR,1 H NMR,GPC and DSC.When PCEC copolymers with different weight ratios of PCL/PEG were dispersed in different aqueous solutions,they could self-assemble and form two distinctive nanoparticular structures:micelles or polymersomes.We then chose paclitaxel(PTX) as the model drug and encapsulate PTX into PCEC polymeric micelles and polymersomes.The physicochemical characterizations of the nanoparticles such as morphology,the size and distribution,zeta potential,drug loading content,and encapsulation efficiency were also performed.Our results showed that polymeric micelles or polymersomes from PCEC both displayed narrow size distributions and could achieve high drug loading efficiencies.In vitro cellular uptake results suggested that Nile Red loaded polymeric micelles or polymersomes displayed more internalization after 24 h incubation than those after 4 h incubation.These findings suggest that polymeric micelles and polymersomes based on PCL-b-PEG-b-PCL copolymers have great potential to effectively delivery hydrophobic drugs. | Chunyan Hu Zhuo Chen Shengjie Wu Yanfeng Han Hai Wang Hongfan Sun Deling Kong Xigang Leng Chun Wang Linhua Zhang Dunwan Zhu | 2017 | Chinese Chemical Letters2017，28，9： | 4 |
| 6 | Robust model predictive control for continuous uncertain systems with state delay显示文摘This paper is concerned with robust model predictive control for linear continuous uncertain systems with state delay and control constraints. A piecewise constant control sequence is calculated by minimizing the upper-bound of the infinite horizon quadratic cost function. At each sampling time, the sufficient conditions for the existence of the model predictive control are derived, and expressed as a set of linear matrix inequalities. The robust stability of the closed-loop systems is guaranteed by the proposed design method. A numerical example is given to illustrate the main results. | Chunyan HAN Xiaohua LIU Huanshui ZHANG | 2008 | 控制理论与应用(英文版)2008，6，2： | 4 |
| 7 | Receding Horizon Estimation for Linear Discrete-time Systems with Multi-channel Observation Delays显示文摘This paper investigates the receding horizon state estimation for the linear discrete-time system with multi-channel observation delays. The receding horizon estimation is designed by the reorganized observation technique and the linear unbiased estimation method. The estimation gains are developed by solving a set of Riccati equations, and a stability result about the state estimation is shown. Finally, an example is given to illustrate the efficiency of the receding horizon state estimation. | Chunyan Han Chaochao Li Fang He Yue Liu | 2019 | IEEE/CAA Journal of Automatica Sinica2019，6，2： | 2 |
| 8 | Micro RNA ‐212 inhibits proliferation of gastric cancer by directly repressing retinoblastoma binding protein 2显示文摘 | Zeng Jiping Fang Ming Wang Lixiang Liang Xiuming Shen Yuqun Yu Han Liu Zhifang Sun Yundong Liu Shili Chen Chunyan Jia Jihui | 2013 | J Cell Biochem2013，，12： | 2 |
| 9 | A Superhydrophobic/Electrothermal/Photothermal Synergistically Anti-icing Strategy with Excellent Self-healable and Anti-abrasion Property显示文摘Unexpected ice accumulation tends to cause many problems or even disasters in our daily life.Based on the superior electrothermal and photothermal function of the carbon nanotubes,we introduced a superhydrophobic/electrothermal/photothermal synergistically anti-icing strategy.When a voltage of 15 V was applied to the superhydrophobic sample,the surface could rapidly melt the ice layer(~3 mm thickness)within 530 s at the environmental temperature of-25℃.When the near-infrared light(808 nm)irradiates on the superhydrophobic sample,the ice could be rapidly removed after 460 s.It was found that the superhydrophobicity helps the melted water to roll off immediately,and then solves the re-freeze problem the traditional surfaces facing.Moreover,the ice can be completely melted with 120 s when the superhydrophobic/electrothermal/photothermal synergistically anti-icing strategy was utilized.To improve the mechanical robustness for practical application,both nanoscale carbon nanotubes and microscale carbon powders were utilized to construct hierarchical structure.Then these dual-scale fillers were sprinkled onto the semi-cured elastomer substrate to prepare partially embedded structure.Both hierarchical structure and partially embedded structure were obtained after completely curing the substrate,which imparts excellent abrasion resistance(12.50 kPa,16.00 m)to the prepared sample.Moreover,self-healable poly(urea–urethane)elastomer was introduced as the substrate.Thus,the cutted superhydrophobic sample can be mended by simply contacting at room temperature. | Peng Wang Jian Wang Wei Duan Chunyan Li Huilong Han Qing Xie | 2021 | Journal of Bionic Engineering2021，18，5： | 2 |
| 10 | Optimal linear estimator for discrete-time systems with random delays显示文摘In this paper, optimal estimation for discrete-time linear time-varying systems with randomly state and measurement delays is considered. By introducing a set of binary random variables, the system is converted into the one with both multiplicative noises and constant delays. Then, an estimator which includes the cases of smoothing and filtering, is derived via the projection formula, and the solution is given in terms of a partial difference Riccati equation with boundary conditions. A predictor for such systems is also presented based on the proposed filter and smoother. The obtained estimators have the same dimension as the original state. Conditions for existence, uniqueness, and stability of the steady-state optimal estimators are studied for time-invariant cases. In this case, the obtained estimators are very easy to implement and all calculations can be performed off line, leading to a linear time-invariant estimator. | Chunyan HAN Huanshui ZHANG Gang FENG | 2012 | 控制理论与应用(英文版)2012，10，1： | 2 |
| 11 | Nitrous oxide and nitric oxide emissions from an irrigated cotton field in Northern China显示文摘 | Chunyan Liu Xunhua Zheng Zaixing Zhou Shenghui Han Yinghong Wang Kai Wang Wangguo Liang Ming Li Deli Chen Zhiping Yang | 2010 | 2010 (1-2)2010，，1： | 2 |
| 12 | FoxM1 is Overexpressed in Helicobacter pylori–Induced Gastric Carcinogenesis and Is Negatively Regulated by miR-370显示文摘 | Yimin Feng Lixiang Wang Jiping Zeng Li Shen Xiuming Liang Han Yu Shili Liu Zhifang Liu Yundong Sun Wenjuan Li Chunyan Chen Jihui Jia | 2013 | Molecular Cancer Research2013，，8： | 2 |
| 13 | ROBUST MODEL PREDICTIVE CONTROL OF CONTINUOUS UNCERTAIN SYSTEMS显示文摘作者使柔韧的模型担心为有 polytopic 不确定性和输入限制的线性连续系统的预兆的控制。在每采样时间,一片明智的经常的控制顺序被解决一套线性矩阵不平等获得。预兆的控制被给的模型的存在上的足够的条件,和靠近环的系统的柔韧的稳定性被保证。一个模拟例子说明建议方法的效率。 | Xiaohua LIU Chunyan HAN | 2008 | Journal of Systems Science & Complexity2008，21，2： | 2 |
| 14 | Sensitive and specific HBV genomic DNA detection using RCA-based QCM biosensor显示文摘 | Chunyan Yao Yang Xiang Kun Deng Han Xia Weiling Fu | 2013 | Sensors & Actuators: B Chemical2013，，： | 1 |
| 15 | Assembly of layer-by-layer films of superoxide dismutase and gold nanorods:A third generation biosensor for superoxide anion显示文摘Based on the layer-by-layer self-assembly of positively charged cetyltrimethylammonium bromide (CTAB) wrapped gold na- norods (AuNRs) and negatively charged superoxide dismutase (SOD) from their aqueous solutions on cysteine modified gold electrode (Cys/Au), a third generation electrochemical biosensor ((SOD/AuNRs)2/Cys/Au) for superoxide anion (O2·-) was developed. The two layers assembly of SOD/AuNRs can significantly enhance the direct electron transfer between SOD and the electrode. The functional enzymatic activities of the SOD offer an electrochemical approach to the determination of O2·-. In the reductive regions, the proposed sensor exhibits excellent analytical performances, such as wide linear range (200 nM to 0.2 mM O2·-), low detection limit (100 nM O2·-), high sensitivity (22.11 nA cm-2 μM-1), short response time (less than 5 s), good stability and reproducibility, while no obvious interferences are caused by commonly met interfering species including hydrogen peroxide (H2O2), uric acid (UA) and ascorbic acid (AA). | WANG MengDong HAN YiTao LIU XingXing NIE Zhou DENG ChunYan GUO ManLi YAO ShouZhuo | 2011 | Science China Chemistry2011，54，8： | 1 |
| 16 | Preparation and photocatalytic performance ofFe( III) -amidoximated PAN fiber complex for oxidativedegradation of azo dye under visible light irradia-tion 显示文摘 | DONG Yongchun HAN Zhenbang LIU Chunyan etal | 2010 | Science of the Total Environment2010，，408： | 1 |
| 17 | Long-term outcomes of intensity-modulated radiotherapy for 868 patients with nasopharyngeal carcinoma: An analysis of survival and treatment toxicities显示文摘 | Xueming Sun Shengfa Su Chunyan Chen Fei Han Chong Zhao Weiwei Xiao Xiaowu Deng Shaomin Huang Chengguang Lin Taixiang Lu | 2013 | Radiotherapy and Oncology2013，，： | 1 |
| 18 | Analysis on phosphorus removal from domestic wastewater treatment plant by biological aerated filter显示文摘 | Yinsong Liu Hongun Han Chunyan Xu Bing Wang Jianfeng Tan | 2011 | Energy Procedia2011，11，： | 1 |
| 19 | Global well-posedness and scattering for the derivative nonlinear Schr?dinger equation with small rough data显示文摘 | Baoxiang Wang Lijia Han Chunyan Huang | 2009 | Annales de l’Institut Henri Poincare / Analyse non lineaire2009，，6： | 1 |
| 20 | Finite Element Analysis and Vibration Suppression Control of Smart Wind Turbine Blade 显示文摘 | YIN Huqiao JIANG Han ZHANG Chunyan | 2012 | Appl Compos Mater2012，，19： | 1 |
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