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| 1 | Bone marrow mesenchymal stem cells repair spinal cord ischemia/reperfusion injury by promoting axonal growth and anti-autophagy显示文摘Bone marrow mesenchymal stem cells can differentiate into neurons and astrocytes after transplantation in the spinal cord of rats with ischemia/reperfusion injury. Although bone marrow mesenchymal stem cells are known to protect against spinal cord ischemia/reperfusion injury through anti-apoptotic effects, the precise mechanisms remain unclear. In the present study, bone marrow mesenchymal stem cells were cultured and proliferated, then transplanted into rats with ischemia/reperfusion injury via retro-orbital injection. Immunohistochemistry and immunofluorescence with subsequent quantification revealed that the expression of the axonal regeneration marker, growth associated protein-43, and the neuronal marker, microtubule-associated protein 2, significantly increased in rats with bone marrow mesenchymal stem cell transplantation compared with those in rats with spinal cord ischemia/reperfusion injury. Furthermore, the expression of the autophagy marker, microtubule-associated protein light chain 3B, and Beclin 1, was significantly reduced in rats with the bone marrow mesenchymal stem cell transplantation compared with those in rats with spinal cord ischemia/reperfusion injury. Western blot analysis showed that the expression of growth associated protein-43 and neurofilament-H increased but light chain 3B and Beclin 1 decreased in rats with the bone marrow mesenchymal stem cell transplantation. Our results therefore suggest that bone marrow mesenchymal stem cell transplantation promotes neurite growth and regeneration and prevents autophagy. These responses may likely be mechanisms underlying the protective effect of bone marrow mesenchymal stem cells against spinal cord ischemia/reperfusion injury. | Fei Yin Chunyang Meng Rifeng Lu Lei Li Ying Zhang Hao Chen Yonggang Qin Li Guo | 2014 | Neural Regeneration Research2014，9，18： | 16 |
| 2 | Rapid Urban Land Expansion in Earthquake-Prone Areas of China显示文摘A timely understanding of urban expansion in earthquake-prone areas is crucial for earthquake risk assessment and urban planning for earthquake mitigation.However, a comprehensive evaluation of urban expansion in earthquake-prone areas is lacking in China, especially in the context of rapid urbanization. Based on time series urban land data and seismic ground-motion parameter zonation maps, this study analyzed urban expansion in the most seismically hazardous areas(MSHAs) of China from1992 to 2015 on the national, regional, and city scales. The results show that urban land area in the MSHAs expanded by 6767 km^2 from 1992 to 2015, with a gain of 350%.Specifically, the increase in urban land area of small cities in the MSHAs of western China during this period was the fastest, 6.24 times greater than that at the national level. In terms of spatial patterns, the urban land patches in the MSHAs in 2015 were more fragmented than those in 1992 on all scales. The percentage of change in the number of patches and the landscape shape index of the urban land patches of small cities in the MSHAs of western China were the highest across all cities. Therefore, we believe that special attention should be paid to the cities in the MSHAs that exhibit the most rapid increases in both urban land area and fragmentation, especially the small cities in western China. It is imperative to integrate earthquake mitigation into the urban planning of these cities. | Qingxu Huang Shiting Meng Chunyang He Yinyin Dou Qiang Zhang | 2019 | International Journal of Disaster Risk Science2019，10，1： | 3 |
| 3 | Quartz crystal microbalance study of the kinetics of surface initiated polymerization显示文摘Surface initiated polymerization (SIP) is a valuable tool in synthesizing functional polymer brushes,yet the kinetic understanding of SIP lags behind the development of its application. We apply quartz crystal microbalance (QCM) to address two issues that are not fully addressed yet play a central role in the rational design of functional polymer brushes,namely quantitative determination of the kinetics and the initiator efficiency (IE) of SIP. SIP are monitored online using QCM. Two quantitative frequencythickness (f-T) relations make the direct determination and comparison of the rate of polymerization possible even for different monomers. Based on the bi-termination model,the kinetics of SIP is simply described by two variables,which are related to two polymerization constants,namely a = 1/(kp,s,app-[M][R·]0) and b = kt,s,app/(kp,s,app[M]). Factors that could alter the kinetics of SIP are studied,including (i) the molecular weight of monomers,(ii) the solvent used,(iii) the initial density of the initiator,(iv) the concentration of monomer,[M],and (v) the catalyst system (ratio among the ingredients,metal,ligands,and additives). The dynamic nature of IE is also described by these two variables,IE = a/(a + bt). Instead of the molecular weight and the polydispersity,we suggest that film thickness,the two kinetic parameters (a and b),and the initial density of the initiator and IE be the parameters that characterize ultrathin polymer brushes. Besides the kinetics study of SIP,the reported method has many other applications,for example,in the fast screening of catalyst system for SIP and other polymerization systems. | CHEN XinAn ZHANG YaoZhong HE JianAn XIONG ChunYang MENG YongHong JIN Gang MA HongWei | 2009 | Science China Chemistry2009，52，12： | 2 |
| 4 | Fractional Order [Proportional Integral] Controllers Parameters Algorithm Based on the Vector Method显示文摘A new calculation method of fractional order [proportional integral ]( FO [PI ]) controller parameters is proposed. And the systematic design schemes of fractional order [proportional integral ]( FO[PI]) controllers based on vector method are discussed in detail. The FO[PI]controller parameters algorithm based on the vector method can be programmed in MATLAB. According to MATLAB programs of the FO[PI]controller parameters algorithm,the FO[PI] controllers are designed following the different phase margins,different gain crossover frequency and different plants,respectively. From the simulation results,the calculated parameters based on MATLAB program is unique and the designed FO[PI] controllers work efficiently. | Nianchun Cai Chunyang Wang Meng Wu Ruihao Xin | 2015 | Journal of Harbin Institute of Technology(New Series)2015，22，1： | 1 |
| 5 | Injury to the Endothelial Surface Layer Induces Glomerular Hyperfiltration Rats with Early-Stage Diabetes显示文摘 | Chunyang Zhang Yao Meng Qi Liu Miao Xuan Lanyu Zhang Bo Deng Keqin Zhang Zhimin Liu Tao Lei Hiroshi Okamoto | 2014 | Journal of Diabetes Research2014，，： | 1 |
| 6 | Effect of chitosan/type I collagen/gelatin composites in biocompatibility and nerve repair显示文摘Chitosan, collagen I and gelatin were mixed in appropriate quantities to develop a new nerve repair material, with good arrangement and structure, as well as even aperture size. The composite material was sterilized by 60Co irradiation for 24 hours prior to implantation in the right thigh of rats following sciatic nerve damage. Results showed that the material was nontoxic to the kidneys and the liver, and did not induce an inflammatory response in the muscles. The composite material enhanced the recovery of sciatic nerve damage in rats. These experimental findings indicate that the composite material offers good biocompatibility and has a positive effect on injured nerve rehabilitation. | Qing Wang Xiaolei Yang Ming Ren Yulin Hu Qiang Chen Lei Xing Chunyang Meng Tiemei Liu | 2012 | Neural Regeneration Research2012，7，15： | 1 |
| 7 | Facile One-Pot Synthesis of ZSM-5 Aggregates with Interand Intra-Crystalline Mesopores for Methanol to Gasoline Conversion显示文摘ZSM-5 aggregates consisting of superfine and hierarchical nanocrystals(combined with micropores and intra-crystalline mesopores) with an average size of 30 nm were prepared through one-pot synthesis with the assistance of anionic polyacrylamide(APAM). The resultant zeolites(AHN-ZSM-5) were characterized by XRD, ICP-OES, SEM, TEM, BET, NH_3-TPD, Py-IR, and TG analyses and evaluated in the methanol to gasoline(MTG) reaction. Characterization results show that the hierarchical ZSM-5 aggregates possessed two kinds of mesopores, namely inter-and intra-crystalline mesopores. The amount of APAM considerably influenced the mesoporosity and textural properties of AHN-ZSM-5 zeolites. With the addition of APAM in the synthesis, the AHN-ZSM-5 zeolites exhibited large mesopore volume, large external surface area, and appropriate acidity. When applied in the MTG reaction, AHN-ZSM-5 demonstrated a catalytic lifetime that was 1.6 times longer than that of conventional ZSM-5 synthesized in the absence of APAM. | Yaquan Wang Chunyang Fan Hongyao Li Xiao Wang Fanjun Meng Chao Sun Liying Sun | 2019 | Transactions of Tianjin University2019，25，1： | 0 |
| 8 | Sulfanion-initiated open-vessel anionic ring-opening polymerization of N-sulfonyl aziridines显示文摘Anionic ring-opening polymerization(AROP)of N-sulfonyl aziridines is an important synthetic route to linear polyethyleneimine(PEI)and its derivatives.In most cases,inert atmosphere and dry solvent were needed because of the oxygen-and water-sensitive initiators/catalysts used.Therefore,the AROP of N-sulfonyl aziridines that can be entirely operated in air atmosphere is still a challenging task.Herein,we report a series of sulfanions,including xanthates,dithiocarbamates,dithiobenzoates,thioacetates,and thiolates,as the initiators for the AROP of N-sulfonyl aziridines.Due to their good stability,openvessel polymerization was achieved with high livingness,affording a range of well-definedα-,ω-telechelic poly(N-sulfonyl aziridine)homopolymers and block copolymers with narrow dispersities and tunable molecular weights.Theα-end group of these polyaziridines was readily converted to thiol group,which enabled further post-polymerization functionalization with benzyl acrylate and poly(ethylene glycol)via thiol-ene click chemistry.The establishment of open-vessel sulfanion-initiated AROP of N-sulfonyl aziridines thus lays a solid foundation for the bulk preparation and application of poly(N-sulfonyl aziridine)s and PEI derivatives. | Meng Huo Yawen Bian Chunyang Yu Gansheng Tong Chongyin Zhang Xinyuan Zhu | 2021 | Science China Chemistry2021，64，10： | 0 |
| 9 | Mechanical stretching boosts expansion and regeneration of intestinal organoids through fueling stem cell self-renewal显示文摘Intestinal organoids,derived from intestinal stem cell self-organization,recapitulate the tissue structures and behav-iors of the intestinal epithelium,which hold great potential for the study of developmental biology,disease modeling,and regenerative medicine.The intestinal epithelium is exposed to dynamic mechanical forces which exert profound effects on gut development.However,the conventional intestinal organoid culture system neglects the key role of mechanical microenvironments but relies solely on biological factors.Here,we show that adding cyclic stretch to intestinal organoid cultures remarkably up-regulates the signature gene expression and proliferation of intestinal stem cells.Furthermore,mechanical stretching stimulates the expansion of SOX9+progenitors by activating the Wnt/β-Catenin signaling.These data demonstrate that the incorporation of mechanical stretch boosts the stemness of intestinal stem cells,thus benefiting organoid growth.Our findings have provided a way to optimize an organoid generation system through understanding cross-talk between biological and mechanical factors,paving the way for the application of mechanical forces in organoid-based models. | Fanlu Meng Congcong Shen Li Yang Chao Ni Jianyong Huang Kaijun Lin Zanxia Cao Shicai Xu Wanling Cui Xiaoxin Wang Bailing Zhou Chunyang Xiong Jihua Wang Bing Zhao | 2022 | Cell Regeneration2022，11，1： | 0 |
| 10 | Migration mechanism and risk assessment of perand polyfluoroalkyl substances in the Ya'Er Lake oxidation pond area,China显示文摘The migration mechanisms,sources,and environmental risks of 29 legacy and emerging perfluorinated and polyfluoroalkyl species present in an oxidation pond(Ya'Er Lake)were investigated for treating sewage based on the analysis of their occurrence and distribution.The concentration of per-and polyfluoroalkyl substances(PFAS)in pond area was between0.30 and 63.2 ng/g dw(dry weight),with the overall average concentration of 8.00 ng/g dw.Notably,the PFAS concentrations in the surface sediments near the sewage outlet in Pond-1(50.2 ng/g dw)and Pond-5(average 15.1 ng/g dw)were 1–2 orders of magnitude higher than those in other areas.In general,the legacy PFAS,i.e.,perfluorooctane sulfonic acid was considered to be the major pollutant in the polluted area,on average,accounting for 73.0%of the total concentration of PFAS pollutants.By evaluating the regional distribution of different PFAS homologs,the short-chain PFAS pollutants with lower K_(ow)were found to migrate farther in both horizontal and vertical directions.The sewage outlets in Pond-1 and Pond-5are the main pollution sources in polluted area and the emerging PFAS pollutants in Pond-5have replaced the legacy PFAS pollutants as the main pollutants.Based on positive matrix factorization analysis,three main industrial sources of PFAS pollutants in the study area were identified:protective coating,fire-fighting,and food packaging sources.Moreover,the environmental risk assessment results showed that most study areas exhibited medium environmental risk(0.01≤Risk quotient(RQ)<1),indicating that the ecological environment risks in this area need further attention. | Chang Li Huifang Zhong Jing Wu Lingyi Meng Yingjun Wang Chunyang Liao Yawei Wang Yujian He | 2024 | Journal of Environmental Sciences2024，，2： | 0 |
| 11 | Innovations of Agricultural Scientific Research Institutions in Management of Special Materials显示文摘In recent years,the Ministry of Agriculture has increased input in agricultural scientific research projects.As a result,the procurement amount and quantity of special materials are increasing gradually,and the management of special materials becomes more standardized.In order to do well in management of special materials,the authors made exploration and thinking about further strengthening management of special materials in combination with actual conditions,including establishing regulations and systems,enhancing procurement process,strengthening requisition and safekeeping,and reinforcing general ledger management of special materials. | Yonghua LIU Haifang CHEN Lixin CUI Chunyang MENG Ran HUO Minghui HU | 2013 | Asian Agricultural Research2013，5，12： | 0 |
| 12 | Adjacent Pt Nanoparticles and Sub-nanometer WO_(x)Clusters Determine Catalytic Isomerization of C_(7)H_(16)显示文摘Processes for the isomerization of light alkanes have been commercialized;however,the isomerization of paraffins(C_(n)H_(2n+2),n≥7)remains a challenge.On mesoporous tungsten-zirconia catalyst supported Pt catalysts(Pt/WZrOx),initial isomerization productivity of 5249 moli-C7/molPt/h was obtained for n-heptane reforming at 275°C and 5 bar of hydrogen. | Bin Zhang Wei Zhou Jie Zhang Zirui Gao Danyang Cheng Lipeng Tang Xingwu Liu Yueqin Song Chunyang Dong Yao Xu Jie Yan Mi Peng Huizhen Liu Mark Douthwaite Meng Wang Ding Ma | 2022 | CCS Chemistry2022，4，8： | 0 |
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