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| 1 | Preparation of folate-conjugated starch nanoparticles and its application to tumor-targeted drug delivery vector显示文摘Anion starch nanoparticles (StNP) were prepared in water-in-oil microemulsion. Folate modi-fied with PEG was conjugated to the surface of StNP to obtain the folate-conjugated starch nanoparticles (FA-PEG/StNP). The average diameter of FA-PEG/ StNP determined by AFM and Zeta-Sizer apparatus was about 130 nm. Doxorubicin (DOX)-loaded FA- PEG/StNP was obtained via infiltrating combination. The result of UV spectrophotometer showed that the saturation concentration of DOX-loaded FA-PEG/ StNP was 28 μg/mg, which was effective for the con-trolled release of anticancer drug DOX. The cell ex-periments showed that the Lc50 of DOX-loaded FA-PEG/StNP and DOX-loaded StNP was higher than that of DOX, which indicates that FA-PEG/StNP and StNP can decrease the toxicity of DOX; while the lethal rate of DOX-loaded FA-PEG/StNP was 3 times that of DOX-loaded StNP with the same quantity of DOX, which indicates that FA in FA-PEG/StNP is ef-fective for improving the targeting function of nanoparticles, thus enhancing the inhibition effect of anticancer drug to cancer cell. This work demon-strates that the FA-PEG/StNP system is a potentially useful system for the targeted delivery of anticancer drug DOX. | XlAO Suyao TONG Chunyi LIU Xuanming YU Danmi LIU Qiaoling XUE Changgang TANG Dongyin ZHAO Lijian | 2006 | Chinese Science Bulletin2006，51，14： | 12 |
| 2 | Research on the control method for voltage-current source hybrid-HVDC system显示文摘The hybrid-HVDC topology,which consists of line-commutated-converter(LCC)and voltage source converter(VSC)and combines their advantages,has extensive application prospects.A hybrid-HVDC system,adopting VSC on rectifier side and LCC on inverter side,is investigated,and its mathematic model is deduced.The commutation failure issue of the LCC converter in the hybrid-HVDC system is considered,and a novel coordinated control method is proposed to enhance the system commutation failure immunity.A voltage dependent voltage order limiter(VDVOL)is designed based on the constant DC voltage control on the rectifier side,and constant extinction angle backup control is introduced based on the constant DC current control with voltage dependent current order limiter(VDCOL)on the inverter side.The hybrid-HVDC system performances under normal operation state and fault state are simulated in the PSCAD/EMTDC.Then,system transient state performances with or without the proposed control methods under fault condition are further compared and analyzed.It is concluded that the proposed control method has the ability to effectively reduce the probability of commutation failure and improve the fault recovery performance of the hybrid-HVDC system. | GUO ChunYi LIU WenJing ZHAO ChengYong | 2013 | Science China(Technological Sciences)2013，56，11： | 12 |
| 3 | A high-surface-area silicoaluminophosphate material rich in Brnsted acid sites as a matrix in catalytic cracking显示文摘A transparent gel-like mesoporous silicoaluminophosphate material (SAP) with a Si/Al molar ratio of 20 was synthesized by hydrothermal method. The physicochemical features of SAP were characterized by XRD, XRF, BET, SEM and FT-IR spectroscopy of pyridine adsorption techniques. The results indicated that incorporation of phosphorus (P) into aluminasilica system altered the basic textural characteristics of aluminasilica. Especially after hydrothermal treatment, the material with large special surface area (up to 492 m 2 /g) exhibited a good performance on hydrothermal stability. Moreover, the phosphorus modifier can not only increase the amount of Bro¨nsted acidic sites (up to 48.44 μmol/g) and the percentage of weak acidic sites in total acidic sites, but also regulate the acid type, such as the ratio of B/L (Bro¨nsted acid/Lewis acid) increases to 1.15. The performances of samples as matrices for the catalytic cracking of heavy vacuum gas oil (VGO) were investigated. At 520 C, the catalysts showed much higher gasoline and diesel oil yields achieving to 45.59 wt% and 19.20 wt%, respectively, and lower coke selectivity (2.86%) than conventional FCC matrices, such as kaolin and amorphous silica-alumina. | Shaoiun Xu Qiang Zhang Zhaoxuan Feng Xiaojing Meng Tongyu Zhao Chunyi Li Chaohe Yang Honghong Shan | 2012 | Journal of Natural Gas Chemistry2012，21，6： | 8 |
| 4 | Changes of Accumulated Temperature, Growing Season and Precipitation in the North China Plain from 1961 to 2009显示文摘Using the high-quality observed meteorological data, changes of the thermal conditions and precipitation over the North China Plain from 1961 to 2009 were examined. Trends of accumulated temperature and negative temperature, growing season duration, as well as seasonal and annual rainfalls at 48 stations were analyzed. The results show that the accumulated temperature increased significantly by 348.5℃ day due to global warming during 1961-2009 while the absolute accumulated negative temperature decreased apparently by 175.3℃ day. The start of growing season displayed a significant negative trend of -14.3 days during 1961- 2009, but the end of growing season delayed insignificantly by 6.7 days. As a result, the length of growing season increased by 21.0 days. The annual and autumn rainfalls decreased slightly while summer rainfall and summer rainy days decreased significantly. In contrast, spring rainfall increased slightly without significant trends. All the results indicate that the thermal conditions were improved to benefit the crop growth over the North China Plain during 1961-2009, and the decreasing annual and summer rainfalls had no direct negative impact on the crop growth. But the decreasing summer rainfall was likely to influence the water resources in North China, especially the underground water, reservoir water, as well as river runoff, which would have influenced the irrigation of agriculture. | SONG Yanling ZHAO Yanxia WANG Chunyi | 2011 | Acta meteorologica Sinica2011，25，4： | 8 |
| 5 | Nested-loop Mechanism Based Modular Multilevel Converter Topology and Optimal Design显示文摘普通模块化多电平换流器(modular multilevelconverter,MMC)拓扑中,因子模块数量较多,系统需采集和处理的信息量大,导致控制系统硬件构成复杂。提出一种基于循环嵌套机理的MMC拓扑,其电平输出能力得到显著提升。通过上下两组子模块的协调投切,相对于普通MMC拓扑,新型拓扑输出相同电平数所需的子模块及控制设备数量大幅减少。阐述该新型拓扑的构成方式及基本参数选取原则;针对循环嵌套结构,设计相应的模块协调控制策略;分别以模块用量最小化和换流器运行损耗最小化为目标,优化设计拓扑构成方案。在RTDS中搭建换流器模型,仿真结果表明,新型拓扑具备更强的电平输出能力,并达到大幅减少子模块数量、简化控制系统硬件构成的目标。 | LIU Xinghua ZHAO Chengyong PENG Maolan GUO Chunyi ZHANG Baoshun | 2013 | 中国电机工程学报2013，33，9： | 7 |
| 6 | Dynamics and Small Signal Stability Analysis of PMSG-based Wind Farm with an MMC-HVDC System显示文摘The permanent magnet synchronous generator (PMSG)-based wind farm with a modular multilevel converter (MMC) based HVDC system exhibits various oscillations and can experience dynamic instability due to the interactions between different controllers of the wind farm and MMC stations, which have not been properly examined in the existing literatures. This paper presents a dynamic modeling approach for small signal stability analysis of PMSG-based wind farms with a MMC- HVDC system. The small signal model of the study system is validated by the comprehensive electromagnetic transient (EMT) simulations in PSCAD/EMTDC. Then the eigenvalue approach and participation factors analysis are utilized to comprehensively evaluate the impact of different controllers, system’s parameters and the circulating current suppressing controller (CCSC) on the small signal stability of the entire system. From eigenvalue analysis, it is revealed that as the output active power of the wind farm increases within the rated range, the overall system will exhibit a sub-synchronous oscillation (SSO) instability mode, an extremely weak damping mode, and a low frequency oscillation instability mode. From participation factors analysis, it is observed that the SSO mode and weak damping mode are primarily related to the internal dynamics of the MMC, which can be suppressed or improved by CCSC. It is determined that the low frequency oscillation mode is primarily caused by the interactions between the phase locked loop (PLL) control of the wind farm and the voltage and frequency (V-F) control of the MMC station. The analysis also depicts that the larger proportional gain value of the V-F control of the MMC station and smaller PLL bandwidth of the wind farm can enhance the small signal stability of the entire system. | Yifan Wang Chengyong Zhao Chunyi Guo Atiq Ur Rehman | 2020 | CSEE Journal of Power and Energy Systems2020，6，1： | 7 |
| 7 | Studies of poly-L-lysine-starch nanoparticle preparation and its application as gene carrier显示文摘Anion starch nanoparticle (StNP) with a diameter of 50 nm was prepared in wa- ter-in-oil microemulsion, with soluble starch as raw materials and POCl3 as crosslinking agent. PLL-StNP was prepared by linking poly-L-lysine (PLL) on the surface of StNP. At the same time, the size of PLL-StNP and its stability in aqueous solution were checked by AFM. The analysis of plasmid DNA binding, DNase I enzymatic degradation, toxicity and transfection were done. We discovered that PLL-StNP may be used as non-virus nanoparticle gene carrier. And we devel- oped the method of preparing PLL-StNP gene carrier and used it in cell transfection. As non-virus gene carrier, PLL-StNP has some advantages, such as large load of DNA, high transfection effi- ciency, low cell toxicity and biodegradability. | XIAO Suyao LIU Xuanming TONG Chunyi LIU Jun TANG Dongying ZHAO Lijian | 2005 | Science China Chemistry2005，48，2： | 7 |
| 8 | Isolation and Characterization of a C-repeat Binding Transcription Factor from Maize显示文摘C-repeat binding proteins (CBFs) are a group of transcription factors that have been proven to be important for stress tolerance in plants. Many of these transcription factors transactivate the promoters of cold-regulated genes via binding to low temperature-or dehydration-responsive cis-elements, thus conferring plants cold acclimation. In the present study, we isolated a C-repeat binding transcription factor from maize using the yeast one-hybrid system with the C-repeat motif from the promoter of the Arabidopsis COR15a gene as bait. The isolated transcription factor is highly similar to the Arabidopsis CBF3 in their predicted amino acid sequences, and is therefore designated ZmCBF3. Point mutation analyses of the ZmCBF3-binding cis-element revealed (A/G)(C/T)CGAC as the core binding sequence. Expression analyses showed that ZmCBF3 was upregulated by both abscisic acid and low temperature, and was actively expressed during embryogenesis, suggesting that ZmCBF3 plays a role in stress response in maize. | Lei Wang Yanzhong Luo Lan Zhang Jun Zhao Zhiqiu Hu Yunliu Fan Chunyi Zhang | 2008 | Journal of Integrative Plant Biology2008，50，8： | 6 |
| 9 | A DC Chopper Topology to Mitigate Commutation Failure of Line Commutated Converter Based High Voltage Direct Current Transmission显示文摘To reduce the probability of commutation failure(CF)of a line commutated converter based high-voltage direct current(LCC-HVDC)transmission,a DC chopper topology composed of power consumption sub-modules based on thyristor full-bridge module(TFB-PCSM)is proposed.Firstly,the mechanism of the proposed topology to mitigate CF is analyzed,and the working modes of TFB-PCSM in different operation states are introduced.Secondly,the coordinated control strategy between the proposed DC chopper and LCC-HVDC is designed,and the voltage-current stresses of the TFB-PCSMs are investigated.Finally,the ability to mitigate the CF issues and the fault recovery performance of LCC-HVDC system are studied in PSCAD/EMTDC.The results show that the probability of CF of LCC-HVDC is significantly reduced,and the performances of fault recovery are effectively improved by the proposed DC chopper. | Chunyi Guo Bo Liu Chengyong Zhao | 2020 | Journal of Modern Power Systems and Clean Energy2020，8，2： | 5 |
| 10 | Gene-lndexed Mutations in Maize显示文摘 | Xiaoduo Lu Jisheng Liu Wen Ren Qun Yang Zhenguang Chai Rumei Chen Lei Wang Jun Zhao Zhihong Lang Haiyang Wang Yunliu Fan Jiuran Zhao Chunyi Zhang | 2018 | Molecular Plant2018，11，3： | 4 |
| 11 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 12 | Optimization and Configuration of Control Parameters to Enhance Small-signal Stability of Hybrid LCC-MMC HVDC System显示文摘This paper investigates the small-signal stability of the hybrid high-voltage direct current(HVDC)transmission system.The system is composed of line commutated converter(LCC)as rectifier and modular multi-level converter(MMC)as inverter under weak AC grid condition.Firstly,the impact of short-circuit ratio(SCR)at inverter side on the system stability is investigated by eigen-analysis,and the key control parameters which have major impact on the dominant mode are identified by the participation factor and sensitivity analysis.Then,considering the quadratic index and damping ratio characteristic,an objective function for evaluating the system stability is developed,and an optimization and configuration method for control parameters is presented by the utilization of Monte Carlo method.The eigenvalue results and the electromagnetic transient(EMT)simulation results show that,with the optimized control parameters,the small-signal stability and the dynamic responses of the hybrid system are greatly improved,and the hybrid system can even operate under weak AC grid condition. | Chunyi Guo Peng Cui Chengyong Zhao | 2022 | Journal of Modern Power Systems and Clean Energy2022，10，1： | 3 |
| 13 | Dialdehyde starch nanoparticles as antitumor drug delivery system:An in vitro,in vivo,and immunohistological evaluation显示文摘Sustaining the release of therapeutic nanoparticles in a cell-, tissue-, or disease-specific manner is a potentially powerful technology. A new drug carrier-dialdehyde starch nanoparticle (DASNP) that can sustain the loading and release of 5-fluorouracil (5-Fu) antitumor drug is reported in this study. IR spectrophotometer and 1H NMR confirmed the formation of aldehyde groups, and scan electron microscope determinations showed that the dialdehyde starch nanoparticles obtained had an average diameter of 90 nm. 5-Fu, the model drug, was conjugated into nanoparticles by aldehyde groups. These 5-Fu-binding nanoparticles significantly enhanced breast cancer cell (MCF-7) inhibition in vitro compared with free 5-Fu. After subcutaneous 0 injection in the breast tumor-loaded rats, 5-Fu-DASNP exhibited remarkable tumor-inhibitory efficacy determined by measuring tumor weight in vivo. The tumor inhibition of 5-Fu-DASNP was 61%±6%, whereas that of free 5-Fu was only 42%±4%. Bcl-2/Bax immunohistochem-istry studies indicated that 5-Fu-DASNP remarkably induced tumor tissue necrosis. These results demonstrated that the DASNP prepared in this work is a potentially effective drug carrier. | XIAO SuYao LIU XuanMing TONG ChunYi ZHAO LiChao LIU XiaoJuan ZHOU AiMei CAO Yong | 2012 | Chinese Science Bulletin2012，57，24： | 3 |
| 14 | GM130 regulates pulmonary surfactant protein secretion in alveolar typeⅡcells显示文摘Pulmonary surfactant is a lipid-protein complex secreted by alveolar typeⅡepithelial cells and is essential for the maintenance of the delicate structure of mammalian alveoli to promote efficient gas exchange across the air-liquid barrier.The Golgi apparatus plays an important role in pulmonary surfactant modification and secretory trafficking.However,the physiological function of the Golgi apparatus in the transport of pulmonary surfactants is unclear.In the present study,deletion of GM130,which encodes for a matrix protein of the cis-Golgi cisternae,was shown to induce the disruption of the Golgi structure leading to impaired secretion of lung surfactant proteins and lipids.Specifically,the results of in vitro and in vivo analysis indicated that the loss of GM130 resulted in trapping of Sftpa in the endoplasmic reticulum,Sftpb and Sftpc accumulation in the Golgi apparatus,and an increase in the compensatory secretion of Sftpd.Moreover,global and epithelial-specific GM130 knockout in mice resulted in an enlargement of alveolar airspace and an increase in alveolar epithelial autophagy;however,surfactant repletion partially rescued the enlarged airspace defects in GM130-deficient mice.Therefore,our results demonstrate that GM130 and the mammalian Golgi apparatus play a critical role in the control of surfactant protein secretion in pulmonary epithelial cells. | Qianqian Pang Chunyi Liu Yulong Qiao Jian Zhao Sin Man Lam Mei Mei Guanghou Shui Shilai Bao Qiuling Li | 2022 | Science China(Life Sciences)2022，65，1： | 2 |
| 15 | Supply of an entirely pas- sive AC network through a double-infeed HVDC system显示文摘 | Guo Chunyi Zhao Chengyong | 2010 | IEEE Transactions on Power Electronics2010，25，11： | 1 |
| 16 | Utilization and fairness in spectrum assignment for opportunistic spectrum access显示文摘 | Chunyi Peng Haitao Zheng Ben Y. Zhao | 2006 | Mobile Networks and Applications2006，，4： | 1 |
| 17 | Supply of an entirely passive AC network through a double-infeed HVDC system显示文摘 | Chunyi Guo Chengyong Zhao | 2010 | IEEE Transactions on Power Electronics2010，25，11： | 1 |
| 18 | Identification of herbicide resistance loci using a genome-wide association study and linkage mapping in Chinese common wheat显示文摘Carfentrazone-ethyl and tribenuron-methyl,the two widely used herbicides for weed control in field crops,frequently cause phytotoxicity to wheat seedlings in the field.In this study,a total of 697 wheat accessions containing three panels were scanned using wheat90 K and 660 K SNP arrays to identify important herbicide resistance loci.Genome-wide association study(GWAS)revealed 329 significant single-nucleotide polymorphisms(SNPs)with phenotypic variance explained(PVE)of 11.3%to 27.6%.Among these SNPs,15 were detected in multiple environments and they were mainly distributed on chromosomes 1 B,2 D,5 B,5 D,6 D,and 7 D.Further analysis indicated that g HR-5 B(467–587 Mb),g HR-7 D(46–52 Mb),and g HR-1 B(517–580 Mb)were important herbicide resistance loci in wheat.Linkage mapping in a bi-parental population detected one QTL(q HR-1 B)with PVE of 7.44%to8.28%.This is reliable locus because its physical position(554–566 Mb)overlapped with g HR-1 B by GWAS in the genome of Chinese Spring.This study provided some herbicide-resistant germplasm and important genetic loci for identifying genes of common wheat. | Chaonan Shi Yueting Zheng Junyou Geng Chunyi Liu He Pei Yan Ren Zhongdong Dong Lei Zhao Ning Zhang Feng Chen | 2020 | The Crop Journal2020，8，4： | 1 |
| 19 | Utilization and fairness in spectrum assignment for opportunistic spectrum access显示文摘 | Peng Chunyi Zheng Haitao Zhao B Y | 2006 | Mobile Networks and Applications2006，11，： | 1 |
| 20 | Utilization and fairness in spectrum assignment for opportunistic spectrum access 显示文摘 | PENG Chunyi ZHENG Haitao ZHAO B Y | 2006 | Mobile Networks and Applications2006，11，4： | 1 |
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