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| 1 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 2 | Proteomic analysis of human ovaries from normal and polycystic ovarian syndrome显示文摘 | Ma,X Fan,L Meng,Y Hou,Z Mao,YDL Wang,W Ding,W Liu,JY | 2007 | 南京医科大学学报(自然科学版)2007，27，11： | 20 |
| 3 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 4 | JWA regulates melanoma metastasis by integrin alpha(V)beta(3) signaling(摘要)显示文摘 | Bai, J Zhang, J Wu, J Shen, L Zeng, J Ding, J Wu, Y Gong, Z Li, A Xu, S Zhou, J Li, G | 2010 | 南京医科大学学报(自然科学版)2010，30，8： | 4 |
| 5 | Inducing embryonic stem cells to differentiate into pancreatic beta cells by a novel three-step approach with activin A and all-trans retinoic acid显示文摘 | Shi Y Hou L Tang F Jiang W Wang P Ding M Deng H | 2006 | 中国生物学文摘2006，20，7： | 4 |
| 6 | Molecular dynamics simulation and continuum modelling of granular surface flow in rotating drums显示文摘Numerical simulations of granular flows in rotating drums operated at medium to high rates (Fr=0.1― 0.2) have been carried out by using a Molecular Dynamics (MD) algorithm that incorporates inelastic particle interactions, sliding friction and rolling friction. The results indicate that the behavior of granular flow in rotating drums can be classified into two distinct zones: a shear active layer at the bed surface and a quasi-static plug flow region adjacent to the wall. The residence time of a tracer particle in the active layer is approximately a third or a half of that in the plug flow region. The thickness of the active layer at mid-chord is about 0.57―0.61 times that of the plug flow region. It is found that all cases simulated in this work are in the rolling-cascading intermediate regime instead of the pure rolling re-gime. The simulated tangential velocity at the mid-chord is also compared with experimental results reported in the literature and good agreement has been obtained. Based on the MD simulations and experimental results, a continuum approach has also been developed. It is shown that the behavior of granular solids in the plug flow region experiences plastic deformation along the radial direction from the wall with the velocity profiles well described by an exponential function, whereas the active layer velocity follows a simple expression for the Couette shear flow. Discussion has also been made on the granular temperature and concentration profiles. | LI ShuiQing YAO Qiang CHEN Bing ZHANG Xuan DING Y L | 2007 | Chinese Science Bulletin2007，52，5： | 3 |
| 7 | In vivo chondrogenesis of adult bone-marrow-derived autologous mesenchymal stem cells显示文摘 | Chen J Wang C Lu S Wu J Guo X Duan C Dong L Song Y Zhang J Jing D Wu L Ding J Li D | 2006 | 中国生物学文摘2006，20，5： | 2 |
| 8 | 氨氯地平和左旋氨氯地平对高血压患者血管内皮功能的影响显示文摘已证明氨氯地平可改善高血压患者的血管内皮功能,但左旋氨氯地平是否具有类似作用仍存在争议。该研究比较氨氯地平和左旋氨氯地平对高血压患者血管内皮功能的影响,应用体外细胞培养研究其相关作用机制。方法:该研究为一项随机、交叉试验。选取原发性高血压患者24例服用氨氯地平和左旋氨氯地平各6周, | He Y Si D Yang C Ni L Li B Ding M Yang P 罗冬梅 叶鹏 | 2014 | 中华高血压杂志2014，22，4： | 2 |
| 9 | Cyclic voltammetry response of coprecipitated Ni (OH)2 electrode in 5M KOH solution显示文摘 | Ding Y C Yuan J L Chang Z R | 1997 | Journal of Power Sources1997，69，： | 1 |
| 10 | Converting ceria polyhedral nanoparticles into single-crystal nanospheres 显示文摘 | Feng X D Sayle D C Wang Z L Paras M S Santora B Sutorik A C Sayle T X T Yang Y Ding Y Wang X D Her Y S | 2006 | Science2006，312，5779： | 1 |
| 11 | On the Marcinkiewicz integral with variable kernels显示文摘 | DING Y LIN C C SHAO S L | 2004 | Indiana Univ Math J2004，53，： | 1 |
| 12 | Parametric studies on fire resistance of fire-resistant steel members显示文摘 | Ding J L Sakumoto G Q Y | 2004 | Journal of Constructional Steel Research2004，60，7： | 1 |
| 13 | Temperature-Dependent Photoluminescence of ZnO Nanorods Prepared by a Simple Solution Route显示文摘 | Lv Y Z Zhang Y H Li C P Ren L R Guo L Xu H B Ding L Yang C L Ge W K and Yang S H | 2007 | Luminescence2007，，： | 1 |
| 14 | Defective intracellular Ca2+ homeostasis contributes to myocyte dysfunction during ventricular remodelling induced by chronic volume overload in rats 显示文摘 | Ding Y F Brower G L Zhong Q | 2008 | Clin Exp Pharmacol Physiol2008，35，7： | 1 |
| 15 | An investigation of the corrosion behavior of A1203-based ceramic composite coating in dilute HCL solution 显示文摘 | YAN D HE J LI X Z LIU Y ZHANG J X DING H L | 2001 | Surf Coat Technol2001，141，： | 1 |
| 16 | Hydrotreating of light cycle oil using WNi catalysts containing hydrothermally and chemically treated zeolite Y 显示文摘 | DING L H ZHENG Y ZHANG Z S | 2007 | Catal Today2007，125，3： | 1 |
| 17 | Radical-scavenging proanthocyanidins from sea buckthorn seed显示文摘 | Fan J L Ding X L Gu W Y | 2007 | Food Chemistry2007，102，： | 1 |
| 18 | A highly sensitive method for determination of paracetamol by adsorptive stripping voltammetry rising a carbon paste electrode modified with nanogold and glutamic acid显示文摘 | Zhang Y Luo L Ding Y | 2010 | Microchim Acta2010，171，： | 1 |
| 19 | Channel allocation in multichannel wireless mesh networks 显示文摘 | DING Y XIAO L | 2011 | Computer Communications2011，34，7： | 1 |
| 20 | 显示文摘 | Zhang H L Ding J C’Qiu Y L | 2012 | Bioresourse Technolo-gy2012，112，： | 1 |
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