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| 1 | Late Triassic sedimentary records in the northern Tethyan Himalaya:Tectonic link with Greater India显示文摘The Upper Triassic flysch sediments(Nieru Formation and Langjiexue Group)exposed in the Eastern Tethyan Himalayan Sequence are crucial for unraveling the controversial paleogeography and paleotectonics of the Himalayan orogen.This work reports new detrital zircon U-Pb ages and whole-rock geochemical data for clastic rocks from flysch strata in the Shannan area.The mineral modal composition data suggest that these units were mainly sourced from recycled orogen provenances.The chemical compositions of the sandstones in the strata are similar to the chemical composition of upper continental crust.These rocks have relatively low Chemical Index of Alteration values(with an average of 62)and Index of Compositional Variability values(0.69),indicating that they experienced weak weathering and were mainly derived from a mature source.The geochemical compositions of the Upper Triassic strata are similar to those of graywackes from continental island arcs and are indicative of an acidicintermediate igneous source.Furthermore,hornblende and feldspar experienced decomposition in the provenance,and the sediment became enriched in zircon and monazite during sediment transport.The detrital zircons in the strata feature two main age peaks at 225-275 Ma and 500-600 Ma,nearly continuous Paleoproterozoic to Neoproterozoic ages,and a broad inconspicuous cluster in the Tonian-Stenian(800-1200 Ma).The detrital zircons from the Upper Triassic sandstones in the study area lack peaks at 300-325 Ma(characteristic of the Lhasa block)and 1150-1200 Ma(characteristic of the Lhasa and West Australia blocks).Therefore,neither the Lhasa block nor the West Australia blocks likely acted as the main provenance of the Upper Triassic strata.Newly discovered Permian-Triassic basalt and mafic dikes in the Himalayas could have provided the 225-275 Ma detrital zircons.Therefore,Indian and Himalayan units were the main provenances of the flysch strata.The Tethyan Himalaya was part of the northern passive margin and was not an exotic terrane separated from India during the Permian to Early Cretaceous.This evidence suggests that the Neo-Tethyan ocean opened prior to the Late Triassic and that the Upper Triassic deposits were derived from continental crustal fragments adjacent to the northern passive continental margin of Greater India. | Huawen Cao Yong Huang Guangming Li Linkui Zhang Jianyang Wu Lei Dong Zuowen Dai Liu Lu | 2018 | Geoscience Frontiers2018，9，1： | 27 |
| 2 | Origin of the Newly Discovered Zhunuo Porphyry Cu-Mo-Au Deposit in the Western Part of the Gangdese Porphyry Copper Belt in the Southern Tibetan Plateau,SW China显示文摘The newly discovered Zhunuo porphyry Cu-Mo-Au deposit is located in the western part of the Gangdese porphyry copper belt in southern Tibet, SW China. The granitoid plutons in the Zhunuo region are composed of quartz diorite porphyry, diorite porphyry, granodiorite porphyry, biotite monzogranite and quartz porphyry. The quartz diorite porphyry yielded zircon U-Pb ages of 51.9±0.7 Ma(Eocene) using LA-ICP-MS, whereas the diorite porphyry, granodiorite porphyry, biotite monzogranite and quartz porphyry yielded ages ranging from 16.2±0.2 to 14.0±0.2 Ma(Miocene). CuMo-Au mineralization is mainly hosted in the Miocene granodiorite porphyry. Samples from all granitoid plutons have geochemical compositions consistent with high-K calc-alkaline series magmatism. The samples display highly fractionated light rare-earth element(REE) distributions and heavy REE distributions with weakly negative Eu anomalies on chondrite-normalized REE patterns. The trace element distributions exhibit positive anomalies for large-ion lithophile elements(Rb, K, U, Th and Pb) and negative anomalies for high-field-strength elements(Nb and Ti) relative to primitive mantlenormalized values. The Eocene quartz diorite porphyry yielded εNd(t) values ranging from-3.6 to-5.2,(^(87)Sr/^(86)Sr)i values in the range 0.7046–0.7063 and initial radiogenic Pb isotopic compositions with ranges of 18.599–18.657 ^(206)Pb/^(204)Pb, 15.642–15.673 ^(207)Pb/^(204)Pb and 38.956–39.199 ^(208)Pb/^(204)Pb. In contrast, the Miocene granitoid plutons yielded ε_(Nd)(t) values ranging from-6.1 to-7.3 and(87Sr/86Sr)i values in the range 0.7071–0.7078 with similar Pb isotopic compositions to the Eocene quart diorite. The Sr-Nd-Pb isotopic compositions of the rocks are consistent with formation from magma containing a component of remelted ancient crust. Zircon grains from the Eocene quartz diorite have ε_(Hf)(t) values ranging from-5.2 to +0.9 and two-stage Hf model ages ranging from 1.07 to 1.46 Ga, while zircon grains from the Miocene granitoid plutons have ε_(Hf)(t) values from-9.9 to +4.2 and two-stage Hf model ages ranging from 1.05–1.73 Ga, indicating that the ancient crustal component likely derives from Paleo- to Mesoproterozoic basement. This source is distinct from that of most porphyry Cu-Mo-Au deposits in the eastern part of the Gangdese porphyry copper belt, which likely originated from juvenile crust. We therefore consider melting of ancient crustal basement to have contributed significantly to the formation Miocene porphyry Cu-Mo-Au deposits in the western part of the Gangdese porphyry copper belt. | HUANG Yong LI Guangming DING Jun DAI Jie YAN Guoqiang DONG Suiliang HUANG Hanxiao | 2017 | Acta Geologica Sinica(English Edition)2017，91，1： | 19 |
| 3 | Characteristics of Pegmatite-Related Fluids and Significance to Ore-Forming Processes in the Zhaxikang Pb-Zn-Sb Polymetallic Deposit,Tibet,China显示文摘The Zhaxikang Pb-Zn-Sb polymetallic deposit is one of the most important deposits in the newly recognized southern Tibet antimony-gold metallogenic belt.Compared to the porphyry deposits in the Gangdese belt,much less researches have addressed these deposits,and the genesis of the Zhaxikang deposit is still controversial.Based on field investigation,petrographic,microthermometric,Laser Raman Microprobe(LRM) and SEM/EDS analyses of fluid,melt-fluid,melt and solid inclusions in quartz and beryl from pegmatite,this paper documents the characteristics and the evolution of primary magmatic fluid which was genetically related to greisenization,pegmatitization,and silification in the area.The results show that the primary magmatic fluids were derived from unmixing between melt and fluid and underwent a phase separation process soon after the exsolution.The primary magmatic fluids are of low salinity,high temperature,and can be approximated by the H_2O-NaCl-CO_2 system.The presence of Mn-Fe carbonate in melt-fluid inclusions and a Zn-bearing mineral(gahnite) trapped in beryl and in inclusions from pegmatite indicates high Mn,Fe,and Zn concentrations in the parent magma and magmatic fluids,and implies a genetic link between pegmatite and Pb-Zn-Sb mineralization.High B and F concentrations in the parent magma largely lower the solidus of the magma and lead to late fluid exsolution,thus the primary magmatic fluids related to pegmatite have much lower temperature than those in most porphyry systems.Boiling of the primary magmatic fluids leads to high-salinity and high-temperature fluids which have high capacity to transport Pb,Zn and Sb.The decrease in temperature and mixing with fluids from other sources may have caused the precipitation of Pb-Zn-Sn(Au) minerals in the distal fault systems surrounding the causative intrusion. | XIE Yuling WANG Bogong LI Yingxu LI Guangming DONG Suiliang GUO Xiang WANG Lei | 2015 | Acta Geologica Sinica(English Edition)2015，89，3： | 6 |
| 4 | Microelectronics-embedded channel bridging and signal regeneration of injured spinal cords显示文摘Due to the dificulty in spinal cord regeneration with biological methods,the microelectronic neural bridge,a new concept based on microelectronic technology,is presented.The microelectronic system has been realized in the forms of hybrid and integrated circuits.The integrated circuits forneural signal detection,stimulation,and regeneration are realized in a CMOS process.In animal experiments with 100 toads,48 rats,and 3 rabbits,nerve signals have been successfully detected from spinal cords and sciatic nerves,and functional electrical stimulation has been carried out for spinal cords and sciatic nerves.When the microelectronic system is bridged between the controlling and stimulated nerve,the relevant motion of legs and nerve signal waveforms,which are stimulated by the evoked or spontaneous nerve signal through such a system,have been observed.Therefore,the feasibility of the presented method was demonstrated. | Zhigong Wang Xiaosong Gu Xiaoying Lǔ Zhenglin Jiang Wenyuan Li Guangming Lǔ Yufeng Wang Xiaoyan Shen Xintai Zhao Huiling Wang Zhenyu Zhang Hongmei Shen Yang Wu Weixing Shen Jingyang Zhang Dong Chen Xiaoyi Mao Huaxiang Shen | 2009 | Progress in Natural Science:Materials International2009，19，10： | 5 |
| 5 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 6 | A mathematical modeling study of the HIV epidemics at two rural townships in the Liangshan Prefecture of the Sichuan Province of China显示文摘Background:As a response to a severe HIV epidemic in the Liangshan Prefecture,one of the worst in China,population based HIV interventions,including two population-wide HIV screening,have been carried out since 2005 at two townships in a remote mountainous region of Liangshan.The objective of our mathematical modeling study is to assess the temporal dynamics of the HIV epidemic in the two townships based on the data collected in the study area during the period 2005e2010.Methods:A mathematical model was set up to describe the population dynamics of HIV transmission in study area.The model was calibrated by fitting it to the HIV testing and treatment data from 2005 to 2008.Validation of the model was done by comparing its predicted value of HIV prevalence in 2010 to the prevalence data obtained in the 2010 population wide HIV testing.The validated model was used to produce estimation of HIV incidence,prevalence and death.Results:Our model estimations show that population-based HIV interventions have significantly slowed down the rise of the HIV epidemic in the two townships.Over the five-year period from 2005 to 2010,the year-over-year rate of increase in HIV incidence,prevalence,and death has declined by 91.5%,28.7%,and 52.3%,respectively.Conclusion:Mathematical models,when integrated with epidemiological and surveillance data,can be an effective tool for predicting the temporal dynamics of HIV and assessing the impacts of HIV interventions. | Zhimin Su Caiting Dong Ping Li Hongxia Deng Yuhan Gong Shiyong Zhong Min Wu Yuhua Ruan Guangming Qin Wen Yang Yiming Shao Michael Li | 2016 | Infectious Disease Modelling2016，1，1： | 2 |
| 7 | Interaction between Cu^(2+) and different types of surface-modified nanoscale zero-valent iron during their transport in porous media显示文摘This study investigated the interaction between Cu^(2+)and nano zero-valent iron(NZVI)coated with three types of stabilizers(i.e., polyacrylic acid [PAA], Tween-20 and starch) by examining the Cu^(2+) uptake, colloidal stability and mobility of surface-modified NZVI(SM-NZVI) in the presence of Cu^(2+). The uptake of Cu^(2+)by SM-NZVI and the colloidal stability of the Cu-bearing SM-NZVI were examined in batch tests. The results showed that NZVI coated with different modifiers exhibited different affinities for Cu^(2+), which resulted in varying colloidal stability of different SM-NZVI in the presence of Cu^(2+). The presence of Cu^(2+)exerted a slight influence on the aggregation and settling of NZVI modified with PAA or Tween-20. However, the presence of Cu^(2+)caused significant aggregation and sedimentation of starch-modified NZVI, which is due to Cu^(2+)complexation with the starch molecules coated on the surface of the particles. Column experiments were conducted to investigate the co-transport of Cu^(2+) in association with SM-NZVI in water-saturated quartz sand. It was presumed that a physical straining mechanism accounted for the retention of Cu-bearing SM-NZVI in the porous media. Moreover, the enhanced aggregation of SM-NZVI in the presence of Cu^(2+)may be contributing to this straining effect. | Haoran Dong Guangming Zeng Chang Zhang Jie Liang Kito Ahmad Piao Xu Xiaoxiao He Mingyong Lai | 2015 | Journal of Environmental Sciences2015，27，6： | 2 |
| 8 | Immune memory clonal selection algorithms for designing stack filters 显示文摘 | Dong Weisheng Shi Guangming Zhang Li | 2007 | Neurocomputing2007，70，： | 1 |
| 9 | Image deblurring and super-resolution by adaptive sparse domain selection and adaptive regularization显示文摘 | DONG Weisheng ZHANG Lei SHI Guangming | 2011 | IEEE Transactions on Image Processing2011，20，7： | 1 |
| 10 | Direct Reprogramming of Fibroblasts into Neural Stem Cells by Defined Factors显示文摘 | Dong Wook Han Natalia Tapia Andreas Hermann Kathrin Hemmer Susanne H?ing Marcos J. Araúzo-Bravo Holm Zaehres Guangming Wu Stefan Frank S?ren Moritz Boris Greber Ji Hun Yang Hoon Taek Lee Jens C. Schwamborn Alexander Storch Hans R. Sch?ler | 2012 | Cell Stem Cell2012，，4： | 1 |
| 11 | Constrained independent component analysis and its application to machine fault diagnosis显示文摘 | WANG Zhiyang CHEN Jin DONG Guangming | 2011 | Mechanical Systems and Signal Processing2011，25，7： | 1 |
| 12 | Immune Memo ry Clonal Selection Algorithms for Designing Stack Filters 显示文摘 | Dong Weisheng Shi Guangming Zhang Li | 2007 | Neurocomputing2007，70，46： | 1 |
| 13 | Nonlocally centralized sparse representation for image restoration显示文摘 | Dong Weisheng Zhang Lei Shi Guangming and Li Xin | 2013 | IEEE Transactions on Image Processing2013，22，4： | 1 |
| 14 | Astrocyte reactivity in related brain regions in a mouse model of MPTP-induced Parkinson's disease显示文摘BACKGROUND:Severe injury to dopaminergic neuronal cell bodies and their axon terminals in the substantia nigra pars compacta(SNC) has been observed in both Parkinson's disease(PD) patients or in 1-methy-4-phenyl-1,2,3,6-tetrahydropyrindine(MPTP)-induced PD animal models, but only slight injury occurs in the adjacent ventral tegmental area(VTA).The mechanisms underlying this selective injury remain poorly understood. OBJECTIVE:To comparatively observe astrocyte reactivity in the SNC,caudate putamen(CPu), VTA,and frontal association cortex(FrA). DESIGN,TIME AND SETTING:A cellular and molecular biology,randomized,controlled experiment was performed at the Institute of Neurobiology,Department of Human Anatomy, Medical School of Nantong University,between December 2006 and September 2008. MATERIALS:A total of 80 healthy adult male C57BL/6 mice were included in this study.MPTP was purchased from Sigma,USA. METHODS:Mice were randomly divided into a model group(n=64) and a sham-operated group (n=16).PD was induced in the mice from the model group by intraperitoneal injection of 20 mg/kg MPTP,once every three hours,for a total of 4 times. MAIN OUTCOME MEASURES:Tyrosine hydroxylase(TH)-immunoreactive neurons and glial fibrillary acidic protein(GFAP)-immunoreactive astrocytes were examined by dual immunofluorescence labeling.GFAP-immunoreactive astrocytes in the CPu and FrA were determined by immunofluorescent staining.GFAP mRNA expression in the SNC,CPu,VTA,and FrA was detected using real-time polymerase chain reaction.TH protein levels in the TH-immunoreactive axon terminals of the CPu and FrA were detected by Western blotting. RESULTS:Numbers of TH-immunoreactive neurons in the SNC,and TH protein level in the CPu, markedly decreased(by approximately 68%) 1 day after MPTP injection,and gradually increased at 3 days.Simultaneously,astrocyte reactivity was strengthened,in particular at 7 days.However, after MPTP injection,decreases in the numbers of TH-immunoreactive neurons in the VTA,and TH protein levels in the FrA,were less apparent(approximately 15%).Also,no obvious astrocyte reactivity was observed. CONCLUSION:In a mouse model of PD,astrocyte reactivity was apparent in the SNC and CPu, but not the VTA or FrA.In addition,astrocyte reactivity was greater in regions where injury to dopaminergic neurons was more severe. | Zhijun Zhang Chunlin Xia Yulin Dong Guangming Lü Juan Liu Lin Ding Hengjian Ni | 2009 | Neural Regeneration Research2009，4，2： | 1 |
| 15 | Nonlocally centralized sparse representation for image restoration显示文摘 | Dong Weisheng Zhang Lei Shi Guangming | 2013 | IEEE Trans on Image Processing2013，22，4： | 1 |
| 16 | Nonlocallycentralized sparse representation for image restoration显示文摘 | Dong Weisheng Zhang Lei Shi Guangming | 2013 | IEEE Transactions on Image Processing2013，22，4： | 1 |
| 17 | Image Deblurring and Super-resolution by Adaptive Sparse Domain Selection and Adaptive Regularization显示文摘 | Dong Weisheng Zhang Lei Shi Guangming | 2011 | IEEE Transactions on Image Processing2011，20，7： | 1 |
| 18 | Nonlocally Centralized Sparse Representation for Image Restoration显示文摘 | Dong Weisheng Zhang Lei Shi Guangming | 2013 | IEEE Transactions on Image Processing2013，22，4： | 1 |
| 19 | Image deblurring and super-resolution by adaptive sparse domain selection and adaptive regularization显示文摘 | Dong Weisheng Zhang Lei Shi Guangming | 2011 | IEEE Trans on Image Processing2011，20，7： | 1 |
| 20 | Image deblurring and super-resolution by adaptive sparse domain selection and adaptive regularization显示文摘 | Dong Weisheng Zhang Lei Shi Guangming | 2011 | IEEE Transactions on Image Processing2011，20，7： | 1 |
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