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| 1 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 2 | High performance top-emitting and transparent white organic light-emitting diodes based on Al/Cu/TcTa transparent electrodes for active matrix displays and lighting applications显示文摘 | Zhensong Zhang Pingrui yan Shouzhen Yue Guohua Xie Yu Chen Qingyang Wu Dalong Qu Yi Zhao Shiyong Liu | 2013 | Organic Electronics2013，，6： | 1 |
| 3 | 人胆囊癌耐砷细胞株的建立及其凋亡相关基因差异表达检测(英文)显示文摘Objective:The aim of the study was to establish an arsenic trioxide(ATO)-resistant cell line of human gallbladder carcinoma,GBC-SD/ATO,and to analyze the differential expressions of its apoptosis-associated genes,so as to investigate a correlation between ATO induced resistance of gallbladder carcinoma and expressions of apoptosis associated genes.Methods:The resistant cell line was obtained in vitro by culture of human gallbladder carcinoma cell line GBC-SD with increasingly stepwise concentrations of ATO.The sensitivities of GBC-SD cells and GBC-SD/ATO cells to ATO were determined by MTT assay respectively.cDNA microarray containing 458 apoptosis-related human genes was used to compare the gene expression profiles of GBC-SD/ATO cells and corresponding sensitive cell line GBC-SD.Results:GBC-SD/ATO cell line was established successfully after 8 months of exposure to increasing concentrations of ATO.Compared with the parental cell line,GBC-SD/ATO was 13.6 times more resistant to ATO.Of the 458 apoptosis-related genes,17 genes were detected having > 2-fold difference of expression between the GBC-SD/ATO and GBC-SD cells,with 6 genes up-regulated and 11 genes down-regulated in GBC-SD/ATO cells.Conclusion:The 17 genes involved in the apoptosis pathway might be relevant to the resistance of GBC-SD/ATO cells to ATO,suggesting that the modulation of expression of apoptosis-related genes may be a main mechanism of acquired resistance in GBC-SD/ATO. | Dalong Wu Xiaowei He Chengwen Zhang | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，2： | 1 |
| 4 | Experimental and numerical study on the shrinkage-deformation of carrot slices during hot air drying显示文摘In order to further understand the mechanism of material volume change in the drying process,numerical simulations(considering or neglecting shrinkage)of heat and mass transfer during convective drying of carrot slices under constant and controlled temperature and relative humidity were carried out.Simulated results were validated with experimental data.The results of the simulation show that the Quadratic model fitted well to the moisture ratio and the material temperature data trend with average relative errors of 5.9%and 8.1%,respectively.Additionally,the results of the simulation considering shrinkage show that the moisture and temperature distributions during drying are closer to the experimental data than the results of the simulation disregarding shrinkage.The material moisture content was significantly related to the shrinkage of dried tissue.Temperature and relative humidity significantly affected the volume shrinkage of carrot slices.The volume shrinkage increased with the rising of the constant temperature and the decline of relative humidity.This model can be used to provide more information on the dynamics of heat and mass transfer during drying and can also be adapted to other products and dryers devices. | Dalong Jiang Congcong Li Zifan Lin Yuntian Wu Hongjuan Pei Magdalena Zielinska Hongwei Xiao | 2023 | International Journal of Agricultural and Biological Engineering2023，16，1： | 0 |
| 5 | 氯喹衍生物CQ11逆转乳腺癌多药耐药细胞株MCF/DOX对多柔比星的耐药性(英文)显示文摘Objective: To investigate the reversal effect of CQ11, a chloroquine derivative, on multidrug resistance (MDR) in doxorubicin (DOX)-resistant human breast carcinoma cell line MCF/DOX. Methods: Cells of a human breast cancer cell line, MCF, and its DOX-resistant variant, MCF/DOX, were cultivated with DOX and /or CQ11. The cytotoxicity of drugs in vitro was assayed by MTT method. The accumulation of DOX in these cells was detected by fluorescence spectrophotometer. Results: MCF/DOX cells were 119 times more resistant to DOX in comparison with MCF cells. After simultaneous treatment with CQ11 at the concentrations of 1.0, 2.5 and 5.0 μmol/L, the IC50 of DOX for MCF/DOX cells decreased from 3.1 ± 0.47 μmol/L to 0.58 ± 0.032, 0.19 ± 0.012 and 0.081 ± 0.015 μmol/L, respectively, thus, increasing the DOX sensitivity by 5.3-fold (P < 0.01), 16- fold (P < 0.01) and 38-fold (P < 0.01), respectively. In the accumulation assay of DOX, simultaneous incubation of MCF/DOX cells with CQ11 significantly increased the DOX accumulation in MCF/DOX cells. No such results were found in parental MCF cells. Conclusion: CQ11 had strong MDR reversal effect by enhancing intracellular DOX accumulation in MCF/DOX cells, indicating that CQ11 may be a promising MDR chemosensitivity. | Dalong Wu Shirong Ma Fengying Sui Chengwen Zhang Lixin Yin Huanzhang Lu | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，11： | 0 |
| 6 | Effects of pulsation ratio on center temperature and drying characteristics of pineapple slices with pulsed vacuum drying显示文摘This research explored the application of pulsed vacuum technology on the drying(PVD)of pineapple slices.Influences of drying temperature and pulsed vacuum ratio(PVR)on drying characteristics and pineapple quality(color,rehydration characteristics,microstructure,and texture)were analyzed.As expected,increasing the drying temperature resulted in a higher drying rate and effective moisture diffusivity.The optimal PVR of 5:5 was beneficial in accelerating the drying rate of pineapple slices and the corresponding effective moisture diffusion coefficient(8.9601×10^(-10))was higher than other PVR conditions based on material center temperature.The material temperature increased during the normal pressure period and decreased rapidly when the pressure dropped to the vacuum condition,which indirectly reflected the moisture transfer that occurred during the vacuum holding period,while moisture diffusion happened during the atmospheric pressure holding period.The optimal pulsed vacuum drying process(PVR of 5:5)could expand air and water vapor and create a looser structure so as to obtain better rehydration performance(rehydration ratio(RR)was 5.43).High drying temperature led to the decrease of L^(*)value,the increase ofΔE value,and even the formation of surface scorch at 80℃.At the same drying temperature,the color quality depended on the drying time,and the color difference increased with the extension of the drying time.The chewiness and hardness of pineapple slices dried by PVD were significantly higher than those of fresh samples,which was conducive to the chewing taste. | Dalong Jiang Congcong Li Zifan Lin Yuntian Wu Hongjuan Pei | 2022 | International Journal of Agricultural and Biological Engineering2022，15，6： | 0 |
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