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| 1 | Phased,chromosome-scale genome assemblies of tetraploid potato reveal a complex genome,transcriptome,and predicted proteome landscape underpinning genetic diversity显示文摘Cultivated potato is a clonally propagated autotetraploid species with a highly heterogeneous genome.Phased assemblies of six cultivars including two chromosome-scale phased genome assemblies revealed extensive allelic diversity,including altered coding and transcript sequences,preferential allele expression,and structural variation that collectively result in a highly complex transcriptome and predicted proteome,which are distributed across the homologous chromosomes.Wild species contribute to the extensive allelic diversity in tetraploid cultivars,demonstrating ancestral introgressions predating modern breeding efforts.As a clonally propagated autotetraploid that undergoes limited meiosis,dysfunctional and deleterious alleles are not purged in tetraploid potato.Nearly a quarter of the loci bore mutations are predicted to have a high negative impact on protein function,complicating breeder’s efforts to reduce genetic load.The StCDF1 locus controls maturity,and analysis of six tetraploid genomes revealed that 12 allelic variants of StCDF1 are correlated with maturity in a dosage-dependent manner.Knowledge of the complexity of the tetraploid potato genome with its rampant structural variation and embedded deleterious and dysfunctional alleles will be key not only to implementing precision breeding of tetraploid cultivars but also to the construction of homozygous,diploid potato germplasm containing favorable alleles to capitalize on heterosis in F1 hybrids. | Genevieve Hoopes Xiaoxi Meng John P.Hamilton Sai Reddy Achakkagari Fernanda de Alves Freitas Guesdes Marie E.Bolger Joseph J.Coombs Danny Esselink Natalie R.Kaiser Linda Kodde Maria Kyriakidou Brian Lavrijssen Natascha van Lieshout Rachel Shereda Heather K.Tuttle Brieanne Vaillancourt Joshua C.Wood Jan Mde Boer Nolan Bornowski Peter Bourke David Douches Herman Jvan Eck Dave Ellis Max J.Feldman Kyle M.Gardner Johannes C.P.Hopman Jiming Jiang Walter S.De Jong Joseph C.Kuhl Richard G.Novy Stan Oome Vidyasagar Sathuvalli Ek Han Tan Remco A.Ursum M.Isabel Vales Kelly Vining Richard G.F.Visser Jack Vossen G.Craig Yencho Noelle L.Anglin Christian W.B.Bachem Jeffrey B.Endelman Laura M.Shannon Martina V.Stromvik Helen H.Tai Bjorn Usadel C.Robin Buell Richard Finkers | 2022 | Molecular Plant2022，15，3： | 4 |
| 2 | Structure and function of epididymal protein cysteine-rich secretory protein-1显示文摘充满半胱氨酸的能分泌的 protein-1 (CRISP-1 ) 是 theepididymal 上皮分泌的糖蛋白。它是二个保存领域和一套 16 保存半胱氨酸残余描绘的蛋白质的一个大家庭的一个成员。在哺乳动物, CRISP-1 禁止精子鸡蛋熔化和罐头压制精子 capacitation。未知的哺乳动物的 CRISPproteins 遗体的行动的分子的机制,而是某些非哺乳动物的松脆的蛋白质能堵住离子隧道。在 ther 在, CRISP-1 包括叫作蛋白质 D 和 E 的二种形式。在我们的实验室的最近的工作证明 CRISP-1 的 D 形式与精子表面短暂地联系,而 Eform 紧绑。当精子被洗时,在所有 D 形式分裂了以后, CRISP-1 的 E 形式在精子表面上坚持。Cross-linking 研究为 D 和 E 表明 differentprotein 蛋白质相互作用模式,尽管为任何一个蛋白质的有约束力的搭挡还都没被识别。集体度谱的分析在不是 D 形式上的现在的 E 形式上揭示了潜在的 post-translationalmodification。这是蛋白质 D 和 E 之间的唯一的可辨别的差别,并且大概为在老鼠 CRISP-1 的这二种形式的行为的差别负责。这些研究证明更丰富的 D 形式短暂地与精子交往,可能与精子上的特定的受体出现,与 压制capacitation 功能一致在在附睾的精子运输和存储期间,并且也证实一紧绑能在女繁殖的道行动的 E 形式的人口。 | Kenneth P. Roberts Daniel S. Johnston Michael A. Nolan Joseph L. Wooters Nicole C. Waxmonsky Laura B. Piehl Kathy M. Ensrud-Bowlin David W. Hamilton | 2007 | Asian Journal of Andrology2007，9，4： | 4 |
| 3 | Impact of nutritional support on clinical outcome in patients at nutritional risk: A multicenter, prospective cohort study in Baltimore and Beijing teaching hospitals显示文摘 | Bin Jie Zhu-Ming Jiang Marie T. Nolan David T. Efron Shai-Nan Zhu Kang Yu Jens Kondrup | 2010 | Nutrition2010，，11： | 2 |
| 4 | Application of high-resolution DNA melting for genotyping and variant scanning of diploid and autotetraploid potato显示文摘 | David De Koeyer Katheryn Douglass Agnes Murphy Sean Whitney Lana Nolan Yong Song Walter De Jong | 2010 | Molecular Breeding2010，，1： | 2 |
| 5 | Chronic hyperlactatemia in HIV-infected patients taking antiretroviral therapy显示文摘 | Mina John Corey B. Moore Ian R. James David Nolan Richard P. Upton Elizabeth J. McKinnon Simon A. Mallal | 2001 | AIDS2001，，6： | 1 |
| 6 | Mitigation of Sensitation Effects in Unstabilised 12%Cr Ferritic Stainless Steel Welds显示文摘 | Van Warmelo Martin Nolan David John Norrish | 2007 | Mater Sei Eng A2007，464，： | 1 |
| 7 | Combined optical and atropine penalization for the treatment of strabismic and anisometropic amblyopia显示文摘 | Stephen B. Kaye Sean I. Chen Gary Price Lesley C. Kaye Carmel Noonan Ajay Tripathi Pammal Ashwin Nolan Cota David Clark Jeremy Butcher | 2002 | Journal of AAPOS2002，，5： | 1 |
| 8 | Genomic characterization of human adenovirus 36, a putative obesity agent显示文摘 | John Arnold Máté Jánoska Adriana E. Kajon David Metzgar Nolan Ryan Hudson Sarah Torres Balázs Harrach Donald Seto James Chodosh Morris S. Jones | 2010 | Virus Research2010，，2： | 1 |
| 9 | Determinants of short- and long-term survival from colorectal cancer in very elderly patients显示文摘 | Juliette Sheridan Paul Walsh David Kevans Therese Cooney Shane O’Hanlon Blathnaid Nolan Anne White Edel McDermott Kieran Sheahan Diarmuid O’Shea John Hyland Diarmuid O’Donoghue Jacintha O’Sullivan Hugh Mulcahy Glen Doherty | 2014 | Journal of Geriatric Oncology2014，，： | 1 |
| 10 | European Spas显示文摘 | Farabaugh Patrick Farley David Irving Cindy Le Bor Adam Mycek Shaft Nolan Mariana | 2005 | Conde Nast Traveler2005，，6： | 1 |
| 11 | Testosterone and mate choice in the Dark-eye Junco显示文摘 | Ellem K Nolan P | 1997 | Animal Behaviour1997，54，： | 1 |
| 12 | Single-Cell Trajectory Detection Uncovers Progression and Regulatory Coordination in Human B Cell Development显示文摘 | Sean C. Bendall Kara L. Davis El-ad David Amir Michelle D. Tadmor Erin F. Simonds Tiffany J. Chen Daniel K. Shenfeld Garry P. Nolan Dana Pe’er | 2014 | Cell2014，，3： | 1 |
| 13 | Mitigation of sensitisation effects in unstabilised 12% Cr ferrltic stainless steel welds 显示文摘 | Martin van Warmelo David Nolan John Norrish | 2007 | Materials Science and Engineering A2007，464，： | 1 |
| 14 | Mitigation of sensitation effects in unstabilised 12% Cr ferritic stainless steel welds 显示文摘 | van Warmelo Martin Nolan David and John Norrish | 2007 | Mater Sci Eng A2007，464，： | 1 |
| 15 | Elevated Intra-abdominal Pressure and Renal Function显示文摘 | P. KENT HARMAN IRVING L. KRON H. DAVID McLACHLAN ARTHUR E. FREEDLENDER STANTON P. NOLAN | 1982 | Annals of Surgery1982，，5： | 1 |
| 16 | Hematomas and Limb Skeletal Malformations in Chicken Embryos Following Exposure to 5-Fluoro-2'-Deoxyuridine显示文摘Vascular injury or interruption may play a role in vertebrate limb teratogenesis. Since 5fluoro- 2’- deoxyuridine (FdU) can cause vascular injury in the murine limb and skull prior to the appearance of skeletal malformations in these structures, we studied the effects of this chemical on skeletal development in the chick embryo and noted any vascular injury. The yolk sacs of day three ehick embryos (Hamburger and Hamilton states 17-19) were injected with solutions of vary concentrations of FdU in saline. The embryos developed until the 10th day of incubation when they were fixed for study. Uninjected, saline injected, and sham injected control embryo were similarly fixed. Upon gross inspection, frequent diffuse and saccular hernatomas, as well as fluid-filled blisters, were noted in the limbs of embryos treated with FdU. After the embryos were fixed and cleared, and the skeletons stained, significant skeletal malformations were observed in these limbs. Bony elements of both the upper and lower limbs were affected in at least some of the embryos. The combination of FdU-induced hematomas and blisters with associated skeletal malformations in the same regions of some embryos suggests a relationship between these phenomena. | ROBERT S. NOLAN GARRY SCHWARTZ SEAN FARQUHARSON DAVID R.HOOTNICK E. MARK LEVINSOHN MARY MILLER LISA A. MANZ AND DAVID S. PACKARD, JR (Departments of Anatomy and Cell Biology, Orthopedic Surgery,and Pediatrics, State University of New York Health | 1998 | Biomedical and Environmental Sciences1998，11，1： | 0 |
| 17 | Embryonic Hypertension Following Exposure to Teratogenic Doses of 5-Fluoro-2'-Deoxyuridine显示文摘The teratogenicity of 5-fluoro-2’-deoxyuridine (FdU) is well established. Previously, we have demonstrated that teratogenic doses of FdU produce hematomas and suggested that those hematomas produced skeletal malformations in chicken embryos. In this study, the cardiovascular effects of teratogenic doses of FdU in chicken embryos were studied. A dose of either 0.026 μg FdU or 0.030 μg FdU was injected into the yolk sacs of fertile chicken eggs containing embryos at Hamburger and Hamilton stages 17-19 of development. The embryos were then returned to the incubator. Aortic systolic and diastolic blood pressure,blood velocity and heart rate were measured at stages 21, 24 or 27 using a servonull system and Doppler ultrasound. In addition, mean arterial blood pressure, blood flow, and stroke volume were calculated from these data. Similar data were also recorded from uninjected and saline injected control embryos. Systolic and mean arterial blood pressures were significantly increased in FdU-treated embryos at stage 27. The other parameters measured or calculated were not significantly different from control embryos. Our study suggests that elevated systolic blood pressure in chicken embryos treated with FdU may lead to hematoma formation and subsequent birth | VINU D. PATEL ROBERT S. NOLAN NORMAN HU EDWARD B. CLARKA DAVID R. HOOTNICK E. MARK LEVINSOHN AND DAVID S. PACKARD, JR.(Departments of Obstetrics and Gynecology, Anatomy and Cell Biotogy, and Pediatrics, Stale University of New York Health Science C | 1996 | Biomedical and Environmental Sciences1996，9，4： | 0 |
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