|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Migration of bone marrow progenitor cells in the adult brain of rats and rabbits显示文摘Neurogenesis takes place in the adult mammalian brain in three areas:Subgranular zone of the dentate gyrus(DG);subventricular zone of the lateral ventricle;olfactory bulb.Different molecular markers can be used to characterizethe cells involved in adult neurogenesis.It has been recently suggested that a population of bone marrow(BM)progenitor cells may migrate to the brain and differentiate into neuronal lineage.To explore this hypothesis,we injected recombinant SV40-derived vectors into the BM and followed the potential migration of the transduced cells.Long-term BM-directed gene transfer using recombinant SV40-derived vectors leads to expression of the genes delivered to the BM firstly in circulating cells,then after several months in mature neurons and microglial cells,and thus without central nervous system(CNS)lesion.Most of transgene-expressing cells expressed NeuN,a marker of mature neurons.Thus,BM-derived cells may function as progenitors of CNS cells in adult animals.The mechanism by which the cells from the BM come to be neurons remains to be determined.Although the observed gradual increase in transgene-expressing neurons over 16mo suggests that the pathway involved differentiation of BM-resident cells into neurons,cell fusion as the principal route cannot be totally ruled out.Additional studies using similar viral vectors showed that BM-derived progenitor cells migrating in the CNS express markers of neuronal precursors or immature neurons.Transgene-positive cells were found in the subgranular zone of the DG of the hippocampus 16 mo after intramarrow injection of the vector.In addition to cells expressing markers of mature neurons,transgene-positive cells were also positive for nestin and doublecortin,molecules expressed by developing neuronal cells.These cells were actively proliferating,as shown by short term BrdU incorporation studies.Inducing seizures by using kainic acid increased the number of BM progenitor cells transduced by SV40vectors migrating to the hippocampus,and these cells were seen at earlier time points in the DG.We show that the cell membrane chemokine receptor,CCR5,and its ligands,enhance CNS inflammation and seizure activity in a model of neuronal excitotoxicity.SV40-based gene delivery of RNAi targeting CCR5 to the BM results in downregulating CCR5 in circulating cells,suggesting that CCR5 plays an important role in regulating traffic of BM-derived cells into the CNS,both in the basal state and in response to injury.Furthermore,reduction in CCR5 expression incirculating cells provides profound neuroprotection from excitotoxic neuronal injury,reduces neuroinflammation,and increases neuronal regeneration following this type of insult.These results suggest that BM-derived,transgeneexpressing,cells can migrate to the brain and that they become neurons,at least in part,by differentiating into neuron precursors and subsequently developing into mature neurons. | Donnahue Dennie Jean-Pierre Louboutin David S Strayer | 2016 | World Journal of Stem Cells2016，8，4： | 9 |
| 2 | Mollusks as ecosystem engineers: the role of shell production in aquatic habitats显示文摘 | Jorge L. Gutiérrez Clive G. Jones David L. Strayer Oscar O. Iribarne | 2003 | Oikos2003，，1： | 1 |
| 3 | Gene therapy for human α 1 -antitrypsin deficiency in an animal model using SV40-Derived vectors显示文摘 | Yu–You Duan Jian Wu Jian–Liang Zhu Shu–Ling Liu Iwata Ozaki David S. Strayer Mark A. Zern | 2004 | Gastroenterology2004，，4： | 1 |
| 4 | The Function of Marine Critical Transition Zones and the Importance of Sediment Biodiversity显示文摘 | Lisa A. Levin Donald F. Boesch Alan Covich Cliff Dahm Christer Erséus Katherine C. Ewel Ronald T. Kneib Andy Moldenke Margaret A. Palmer Paul Snelgrove David Strayer Jan Marcin Weslawski | 2001 | Ecosystems2001，，5： | 1 |
| 5 | Lymphocyte adhesion to CCR5 ligands is reduced by anti-CCR5 gene delivery显示文摘 | Elena Marusich Jean-Pierre Louboutin Alena A. Chekmasova David S. Strayer | 2011 | Journal of the Neurological Sciences2011，，1： | 1 |
| 6 | 淡水沉积物中的生物多样性和生态系统过程显示文摘所有的淡水在穿过或经过沉积物生境后最终流入海洋或进入大气圈。在这些淡水沉积物带中含有大量制造和加工有机碳化合物的生物种。有的物种担负着特定的功能,如氮的固定和循环,其它物种则分解污染物或将沉积物混匀以改变生态系统过程的速率。现在已描述了大约175000个物种,但新的物种仍不断被发现。它们的多样性及分布随深度梯度、溶解氧、所在纬度和湿地、湖泊、河流及地下水高度的不同而不同。独特的特有种,特别是那些分散能力有限的物种,多分布在深度大且隔离的生境。应该在全球范围培养合格的科学家,以促进物种丰富的生物群和生态系统基本关系方面的研究。 | Margaret A.Palmer Alan P.Covich Bland J.Finlay Janine Gibert Kevin D.Hyde Richard K.Johnson Timo Kairesalo Sam Lake Charles R.Lovell Robert J.Naiman Claudia Ricci Francese Sabater David Strayer 习晓环 | 1997 | 人类环境杂志1997，26，8： | 1 |
| 7 | Current Status of gene therapy strategies to treat HIV/AIDS显示文摘 | David S Strayer Ramesh Akkina Bruce A | 2005 | Molecular therapy2005，11，6： | 1 |
| 8 | Effective Discharge Analysis of Ecological Proces- ses in Streams显示文摘 | DOYLE Martin W STANLEY Emily H STRAYER David L | 2005 | Water Resources Research2005，41，11： | 1 |
| 9 | Ethanol protects from injury due to ischemia and reperfusion by increasing vascularity via vascular endothelial growth factor显示文摘 | Jean-Pierre Louboutin Elena Marusich Ehre Gao Lokesh Agrawal Walter J. Koch David S. Strayer | 2012 | Alcohol2012，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员