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| 1 | 吸烟者肺局部IgA变化及对抗原的免疫应答显示文摘目的 研究吸烟对年轻吸烟者肺局部免疫功能的损害。方法 对 12名健康志愿者 (其中 5名吸烟 )行右肺中叶肺灌洗 (BAL) ,分析肺灌洗 (BALF)中IgA型别、细胞分类计数、白蛋白含量 ,并从左肺舌肺叶内注入钥孔血蓝蛋白抗原 ,观察肺局部抗原免疫后血循环中特异性IgA抗体的免疫应答能力。结果 吸烟者BALF中单体IgA含量、白细胞数、巨噬细胞数显著高于不吸烟者 ,而双体IgA含量未见增加 ;BALF中单体IgA含量与白蛋白含量、白细胞数量呈正相关。肺局部抗原免疫后血清特异性IgA应答表现为抗体出现晚、峰值低、下降早的特点。结论 早期吸烟可引起年轻吸烟者支气管肺泡炎症反应并导致肺局部免疫应答功能损害。 | 黄曙海 黄萍 David N. Weissman | 2000 | 中华预防医学杂志2000，34，5： | 4 |
| 2 | CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis显示文摘 | Siddhartha Jaiswal Catriona H.M. Jamieson Wendy W. Pang Christopher Y. Park Mark P. Chao Ravindra Majeti David Traver Nico van Rooijen Irving L. Weissman | 2009 | Cell2009，，2： | 2 |
| 3 | Randomized, Phase II Trial of Pemetrexed and Carboplatin with or without Enzastaurin versus Docetaxel and Carboplatin as First-Line Treatment of Patients with Stage IIIB/IV Non-small Cell Lung Cancer显示文摘 | Mark A. Socinski Robert N. Raju Thomas Stinchcombe Darren M. Kocs Linda S. Couch David Barrera Steven R. Rousey Janak K. Choksi Robert Jotte Debra A. Patt Phillip O. Periman Howard R. Schlossberg Charles H. Weissman Yunfei Wang Lina Asmar Sharon Pritchard | 2010 | Journal of Thoracic Oncology2010，，： | 1 |
| 4 | STEM AND PROGENITOR CELLS: Origins, Phenotypes, Lineage Commitments, and Transdifferentiations显示文摘 | Irving L. Weissman David J. Anderson Fred Gage | 2001 | Annual Review of Cell and Developmental Biology2001，，： | 1 |
| 5 | Molecular evolution of the vertebrate immune system显示文摘 | Simona Bartl David Baltimore Irving L Weissman | 1994 | Proceedings of the National Academy of Sciences of the United States of America1994，91，10： | 1 |
| 6 | Hematopoietic Stem Cells显示文摘 | David Bryder Derrick J. Rossi Irving L. Weissman | 2006 | The American Journal of Pathology2006，，2： | 1 |
| 7 | Best Cases from the AFIP:Primary Diffuse Large B-Cell Lymphoma of the Epididymis and Testis显示文摘 | Jason M Zicherman David Weissman | 2005 | RadioGraphics2005，25，： | 1 |
| 8 | Textbook of Assisted Reproductive Techniqnes(secondedition)显示文摘 | David K Gardner Ariel Weissman Colin M Howles | 2004 | Taylor&- Francis group2004，，： | 1 |
| 9 | Hematopoietie stem cellaging: mechanism and consequence 显示文摘 | Rossi 19 J David Bryder Weissman I L | 2007 | Exp Gerontol2007，42，5： | 1 |
| 10 | Hematopoietic stem cell aging:Mechanism and consequence显示文摘 | Rossi DJ David B Weissman IL | 2007 | Exp Gerontol2007，42，5： | 1 |
| 11 | The first probabilistic track of the international planning competition显示文摘 | Haakan L S Younes Michael L Littman David Weissman | 2005 | Journal of Artificial Intelligence Research2005，24，： | 1 |
| 12 | Dehydroepiandrosterone supplementation increases baseline follicular phase progesterone levels显示文摘 | Ariel Weissman Eran Horowitz Amir Ravhon Abraham Golan David Levran | 2011 | Gynecological Endocrinology2011，，： | 1 |
| 13 | Interaction between age and gender on survival outcomes in extramedullary multiple myeloma over the past two decades显示文摘BACKGROUND Extramedullary multiple myeloma(MM)(EMM)is a rare and aggressive subentity of MM that can be present at diagnosis or develop anytime during the disease course.There is a paucity of data on the clinical characteristics and overall epidemiology of EMM.Furthermore,there is a scarcity of data on how the interaction of age and gender influences the survival of EMM.AIM To evaluate the clinical characteristics of patients with EMM over the past 2 decades and to identify epidemiologic characteristics that may impact overall prognosis.METHODS A total of 858 patients diagnosed with EMM,between 2000 and 2017,were ultimately enrolled in our study by retrieving the Surveillance,Epidemiology,and End Results database.We analyzed demographics,clinical characteristics,and overall mortality(OM)as well as cancer-specific mortality(CSM)of EMM.Variables with a P value<0.1 in the univariate Cox regression were incorporated into the multivariate Cox model to determine the independent prognostic factors,with a hazard ratio(HR)of greater than 1 representing adverse prognostic factors.RESULTS From a sample of 858 EMM,the male gender(63.25%),age range 60-79 years(51.05%),and non-Hispanic whites(66.78%)were the most represented.Central Nervous System and the vertebral column was the most affected site(33.10%).Crude analysis revealed higher OM in the age group 80+[HR=6.951,95%confidence interval(95%CI):3.299-14.647,P=0],Non-Hispanic Black population(HR=1.339,95%CI:1.02-1.759,P=0.036),Bones not otherwise specified(NOS)(HR=1.74,95%CI:1.043-2.902,P=0.034),and widowed individuals(HR=2.107,95%CI:1.511-2.938,P=0).Skin involvement(HR=0.241,95%CI:0.06-0.974,P=0.046)and a yearly income of$75000+(HR=0.259,95%CI:0.125-0.538,P=0)had the lowest OM in the crude analysis.Crude analysis revealed higher CSM in the age group 80+,Non-Hispanic Black,Bones NOS,and widowed.Multivariate cox proportional hazard regression analyses only revealed higher OM in the age group 80+(HR=9.792,95%CI:4.403-21.774,P=0)and widowed individuals(HR=1.609,95%CI:1.101-2.35,P=0.014).Multivariate cox proportional hazard regression analyses of CSM also revealed higher mortality of the same groups.Eyes,mouth,and ENT involvement had the lowest CSM in the multivariate analysis.There was no interaction between age and gender in the adjusted analysis for OM and CSM.CONCLUSION EMM is a rare entity.To our knowledge,there is a scarcity of data on the clinical characteristics and prognosis factors of patients with extramedullary multiple myeloma.In this retrospective cohort,using a United States-based population,we found that age,marital status,and tumor site were independent prognostic factors.Furthermore,we found that age and gender did not interact to influence the mortality of patients with EMM. | Ayrton I Bangolo Pierre Fwelo Chinmay Trivedi Sowmya Sagireddy Hamed Aljanaahi Auda Auda Maryama Mohamed Sonia Onyeka Miriam Fisher Jyoti Thapa Erwin J Tabucanon Lyuben Georgiev Annetta Wishart Shilpee Kumari Conrad Erikson Mary Bangura Orent Paddy Rashmi Madhukar Eugenio L Gomez Joshua Rathod Mansi Naria Basel Hajal Mohammad Awadhalla David Siegel Harsh Parmar Noa Biran David H Vesole Pooja Phull Simcha Weissman | 2023 | World Journal of Clinical Oncology2023，14，4： | 1 |
| 14 | Phase II Trial of Nanoparticle Albumin-Bound Paclitaxel, Carboplatin, and Bevacizumab in First-line Patients with Advanced Nonsquamous Non-small Cell Lung Cancer显示文摘 | Craig Reynolds David Barrera Robert Jotte Alexander I. Spira Charles Weissman Kristi A. Boehm Sharon Pritchard Lina Asmar | 2009 | Journal of Thoracic Oncology2009，，12： | 1 |
| 15 | The first probabilistic track of the international planning competition显示文摘 | Haakan L S Younes Michael L Littman David Weissman | 2005 | Journal of Artificial Intelligence Research2005，24，： | 1 |
| 16 | Divergently Transcribed Overlapping Genes Expressed in Liver and Kidney and Located in the 11p15.5 Imprinted Domain显示文摘 | Paul R. Cooper Nancy J. Smilinich Colleen D. Day Norma J. Nowak Laura H. Reid R.Scott Pearsall Mark Reece Dirk Prawitt John Landers David E. Housman Andreas Winterpacht Bernhard U. Zabel Jerry Pelletier Bernard E. Weissman Thomas B. Shows Michael J. Higgi | 1998 | Genomics1998，，1： | 1 |
| 17 | Second harmonic generation hotspot on a centrosymmetric smooth silver surface显示文摘Second harmonic generation(SHG)is forbidden for materials with inversion symmetry,such as bulk metals.Symmetry can be broken by morphological or dielectric discontinuities,yet SHG from a smooth continuous metallic surface is negligible.Using non-linear microscopy,we experimentally demonstrate enhanced SHG within an area of smooth silver film surrounded by nanocavities.Nanocavity-assisted SHG is locally enhanced by more than one order of magnitude compared to a neighboring silver surface area.Linear optical measurements and cathodoluminescence(CL)imaging substantiate these observations.We suggest that plasmonic modes launched from the edges of the nanocavities propagate onto the smooth silver film and annihilate,locally generating SHG.In addition,we show that these hotspots can be dynamically controlled in intensity and location by altering the polarization of the incoming field.Our results show that switchable nonlinear hotspots can be generated on smooth metallic films,with important applications in photocatalysis,single-molecule spectroscopy and non-linear surface imaging. | Matan Galanty Omer Shavit Adam Weissman Hannah Aharon David Gachet Elad Segal Adi Salomon | 2018 | Light(Science & Applications)2018，7，1： | 0 |
| 18 | Relationships of hospitalization outcomes and timing to endoscopy in non-variceal upper gastrointestinal bleeding:A nationwide analysis显示文摘BACKGROUND The optimal timing of esophagogastroduodenoscopy(EGD)and the impact of clinico-demographic factors on hospitalization outcomes in non-variceal upper gastrointestinal bleeding(NVUGIB)remains an area of active research.AIM To identify independent predictors of outcomes in patients with NVUGIB,with a particular focus on EGD timing,anticoagulation(AC)status,and demographic features.METHODS A retrospective analysis of adult patients with NVUGIB from 2009 to 2014 was performed using validated ICD-9 codes from the National Inpatient Sample database.Patients were stratified by EGD timing relative to hospital admission(≤24 h,24-48 h,48-72 h,and>72 h)and then by AC status(yes/no).The primary outcome was all-cause inpatient mortality.Secondary outcomes included healthcare usage.RESULTS Of the 1082516 patients admitted for NVUGIB,553186(51.1%)underwent EGD.The mean time to EGD was 52.8 h.Early(<24 h from admission)EGD was associated with significantly decreased mortality,less frequent intensive care unit admission,shorter length of hospital stays,lower hospital costs,and an increased likelihood of discharge to home(all with P<0.001).AC status was not associated with mortality among patients who underwent early EGD(aOR 0.88,P=0.193).Male sex(OR 1.30)and Hispanic(OR 1.10)or Asian(aOR 1.38)race were also independent predictors of adverse hospitalization outcomes in NVUGIB.CONCLUSION Based on this large,nationwide study,early EGD in NVUGIB is associated with lower mortality and decreased healthcare usage,irrespective of AC status.These findings may help guide clinical management and would benefit from prospective validation. | Simcha Weissman Muhammad Aziz Ayrton I Bangolo Dean Ehrlich Arnold Forlemu Anthony Willie Manesh K Gangwani Danish Waqar Hannah Terefe Amritpal Singh Diego MC Gonzalez Jayadev Sajja Fatma L Emiroglu Nicholas Dinko Ahmed Mohamed Mark A Fallorina David Kosoy Ankita Shenoy Anvit Nanavati Joseph D Feuerstein James H Tabibian | 2023 | World Journal of Gastrointestinal Endoscopy2023，15，4： | 0 |
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