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| 1 | Lipoprotein(a) as a Marker for Predicting the Presence and Severity of Coronary Artery Disease in Untreated Chinese Patients Undergoing Coronary Angiography显示文摘Objective Low-density lipoprotein cholesterol(LDL-C) has been well known as the risk factor of coronary artery disease(CAD). However, the role of lipoprotein(a) [Lp(a)] in the development of CAD is of great interest but still controversial. Thus, we aim to explore the effect of Lp(a) on predicting the presence and severity of CAD in Chinese untreated patients, especially in combination with LDL-C. Methods We consecutively recruited 1,980 non-treated patients undergoing coronary angiography, among which 1,162 patients were diagnosed with CAD. Gensini score(GS) was used to assess the severity of CAD. Lp(a) was measured by immunoturbidimetric method. Results Patients with CAD had higher level of LDL-C and Lp(a) compared with non-CAD(P < 0.05). Multivariable logistic regression revealed that Lp(a) > 205 mg/L(highest tertile) predicted 1.437-fold risk for CAD(95% CI: 1.108-1.865, P = 0.006) and 1.480-fold risk for high GS(95% CI: 1.090-2.009, P = 0.012) respectively. Interestingly, concomitant elevated level of Lp(a) and LDL-C conferred the highest risk for both presence [OR = 1.845, 95% CI: 1.339-2.541, P < 0.001] and severity [OR = 1.736, 95% CI: 1.188-2.538, P = 0.004] of CAD. Conclusion Lipoprotein(a) is a useful marker for predicting the presence and severity of CAD, especially combined with LDL-C. | SUN Di ZHAO Xi LI Sha ZHANG Yan WU Na Qiong ZHU Cheng Gang GUO Yuan Lin GAO Ying QING Ping LIU Geng DONG Qian LI Jian Jun | 2018 | Biomedical and Environmental Sciences2018，31，4： | 6 |
| 2 | 冷冻干燥更适合土壤活性氮气体(HONO和NO)排放的研究?显示文摘土壤活性氮气体(HONO和NO)排放是全球氮循环的关键过程,对大气化学具有重要意义。本研究采集了农田,草地和森林三种不同土地利用类型的土壤样品,分别对样品进行了风干,冻干和烘干三种处理,并与未处理的新鲜土壤进行比较研究。结果表明,三种类型土壤的冻干土与新鲜土样品的p H值差异最小。总的来说,三种干燥处理都能提高新鲜土壤NH4+-N, NO3--N和溶解态有机N的含量。与新鲜土壤相比,冻干土壤HONO和NO的最大排放通量及完整干湿交替循环的总排放量没有显著增加,而风干和烘干土壤显著增加。因此,冷冻干燥方法可能更适合涉及土壤活性氮气体排放通量的研究。这一发现的重要启示是,我们需要慎重评价以往基于不同干燥方法得到的有关陆地–大气界面活性氮交换过程和生物地球化学氮循环机制的认识。 | WU Dianming DENG Lingling LIU Yanzhuo XI Di ZOU Huilan WANG Ruhai SHA Zhimin PAN Yuepeng HOU Lijun LIU Min | 2020 | Atmospheric and Oceanic Science Letters2020，13，3： | 3 |
| 3 | Maternal-fetal fluid balance and aquaporins: from molecule to physiology显示文摘母亲胎儿的液体平衡在怀孕期间是批评的,并且羊膜的液体为胎儿的生长和开发是必要的。胎盘作为在母亲和她的胎儿之间的接口在成功的怀孕起一个关键作用。Aquaporins (AQP ) 形式响应渗透 / 静水力学的压力坡度允许水的快速的 transcellular 运动的特定的水隧道。在胎盘和胎儿的膜的 AQP 表示可以处于母亲胎儿的液体平衡起重要作用。 | Xiao-yan SHA Zheng-fang XIONG Hui-shu LIU Xiao-dan DI Tong-hui MA | 2011 | Acta Pharmacologica Sinica2011，32，6： | 3 |
| 4 | Silicone elastomer gel impregnated with 20(S)-protopanaxadiol-loaded nanostructured lipid carriers for ordered diabetic ulcer recovery显示文摘Inefficient diabetic ulcer healing and scar formation remain a challenge worldwide,owing to a series of disordered and dynamic biological events that occur during the process of healing.A functional wound dressing that is capable of promoting ordered diabetic wound recovery is eagerly anticipated.In this study,we designed a silicone elastomer with embedded 20(S)-protopanaxadiol-loaded nanostructured lipid carriers(PPD-NS)to achieve ordered recovery in scarless diabetic ulcer healing.The nanostructured lipid carriers were prepared through an emulsion evaporation-solidification method and then incorporated into a network of silicone elastomer to form a unique nanostructured lipid carrier-enriched gel formulation.Interestingly,the PPD-NS showed excellent in vitro anti-inflammatory and proangiogenic activity.Moreover,in diabetic mice with full-thickness skin excision wound,treatment with PPD-NS significantly promoted in vivo scarless wound healing through suppressing inflammatory infiltration in the inflammatory phase,promoting angiogenesis during the proliferation phase,and regulating collagen deposition in the remodeling phase.Hence,this study demonstrates that the developed PPD-NS could facilitate ordered diabetic wound recovery via multifunctional improvement during different wound-healing phases.This novel approach could be promising for scarless diabetic wound healing. | Di Sun Shi-yan Guo Li Yang Ya-ru Wang Xiao-hui Wei Sha Song Yi-wei Yang Yong Gan Zheng-tao Wang | 2020 | Acta Pharmacologica Sinica2020，41，1： | 3 |
| 5 | Association of assisted reproductive technology, germline de novo mutations and congenital heart defects in a prospective birth cohort study显示文摘Emerging evidence suggests that children conceived through assisted reproductive technology(ART)have a higher risk of congenital heart defects(CHDs)even when there is no family history.De novo mutation(DNM)is a well-known cause of sporadic congenital diseases;however,whether ART procedures increase the number of germline DNM(gDNM)has not yet been well studied.Here,we performed whole-genome sequencing of 1137 individuals from 160 families conceived through ART and 205 families conceived spontaneously.Children conceived via ART carried 4.59 more gDNMs than children conceived spontaneously,including 332 paternal and 1.26 maternal DNMs,after correcting for parental age at conception,cigarette smoking,alcohol drinking,and exercise behaviors.Paternal DNMs in offspring conceived via ART are characterized by C>T substitutions at CpG sites,which potentially affect protein-coding genes and are significantly associated with the increased risk of CHD.In addition,the accumulation of non-coding functional mutations was independently associated with CHD and 87.9% of the mutations were originated from the father.Among ART offspring,infertility of the father was associated with elevated paternal DNMs;usage of both recombinant and urinary follicle-stimulating hormone and high-dosage human chorionic gonadotropin trigger was associated with an increase of maternal DNMs.In sum,the increased gDNMs in offspring conceived by ART were primarily originated from fathers,indicating that ART itself may not be a major reason for the accumulation of gDNMs.Our findings emphasize the importance of evaluating the germline status of the fathers in families with the use of ART. | Cheng Wang Hong Lv Xiufeng Ling Hong Li Feiyang Diao Juncheng Dai Jiangbo Du Ting Chen Qi Xi Yang Zhao Kun Zhou Bo Xu Xiumei Han Xiaoyu Liu Meijuan Peng Congcong Chen Shiyao Tao Lei Huang Cong Liu Mingyang Wen Yangqian Jiang Tao Jiang Chuncheng Lu Wei Wu Di Wu Minjian Chen Yuan Lin Xuejiang Guo Ran Huo Jiayin Liu Hongxia Ma Guangfu Jin Yankai Xia Jiahao Sha Hongbing Shen Zhibin Hu | 2021 | Cell Research2021，31，8： | 2 |
| 6 | The Long Noncoding RNA, Jpx, Is a Molecular Switch for X Chromosome Inactivation显示文摘 | Di Tian Sha Sun Jeannie T. Lee | 2010 | Cell2010，，3： | 2 |
| 7 | In-situ emb e dding zeolitic imidazolate framework derived Co–N–C bifunctional catalysts in carbon nanotube networks for flexible Zn–air batteries显示文摘Recently, the development of high-performance bifunctional oxygen catalysts integrated with flexible conductive scaffolds f or rechargeable metal-air batteries has attracted considerable interest, driving by fastgrowing wearable electronics. Herein, we report a flexible bifunctional oxygen catalyst thin film consisting of Co–N–C bifunctional catalysts embedding in carbon nanotube(CNT) networks. The catalyst is readily prepared by pyrolysis of cobalt-based zeolitic imidazolate frameworks(ZIF-67) that are in-situ synthesized in CNT networks. Such catalyst film demonstrates very high catalytic activities for oxygen reduction(onset potential: 0.91 V, and half-wave potential: 0.87 V vs. RHE) and oxygen evolution(10 m Acm^-2 at 1.58 V) reactions, high methanol tolerance property, and long-term stability(97% current retention). Moreover, our integrated catalyst film shows very good structure flexibility and robustness. Based on the obtained film air electrodes, flexible Zn–air batteries demonstrate low charging and discharging overpotentials(0.82 V at 1 m A cm^-1) and excellent structure stability in the bending tests. These results indicate that presently reported catalyst films are potential air electrodes for flexible metal–air batteries. | Bo Lv Sha Zeng Wei Yang Jian Qiao Chao Zhang Chengfeng Zhu Minghai Chen Jiangtao Di Qingwen Li | 2019 | Journal of Energy Chemistry2019，28，11： | 2 |
| 8 | Geoscience model service integrated workflow for rainstorm waterlogging analysis显示文摘This paper proposed a geoscience model service integrated workflowbased rainstorm waterlogging analysis method to overcome the defects of conventional waterlogging analysis systems.In this research,we studied a general OGC WPS service invoking strategy,an automatic asynchronous invoking mechanism of WPS services in the BPEL workflow,and a distributed waterlogging analysis services integrated workflow to realize the reconstruction of a waterlogging analysis model based on the proposed method.The proposed method can make use of the flexible adjustment capability of the workflow and not only overcomes the inherent defects of conventional geoscience analysis methods but also realizes the integration and calculation of distributed geospatial data,models and computing resources automatically.The method has better construction convenience,execution reliability,extensibility and intelligence potential than a conventional method and has important value for dealing with more natural disasters and environmental challenges. | Xicheng Tan Jingguo Jiao Nengcheng Chen Fang Huang Liping Di Jinchuan Wang Zongyao Sha Jin Liu | 2021 | International Journal of Digital Earth2021，14，7： | 1 |
| 9 | Quality evaluation of Pinelliae Rhizoma using network pharmacology and multi-component quantitative analysis显示文摘Background:Pinelliae Rhizoma(Banxia)is a valuable traditional Chinese medicine,and its quality issues are related to the safety and effectiveness of the medicine.Several pharmacological experiments have shown that Pinelliae Rhizoma has anti-inflammatory activity,but the specific chemical components remain unclear.Methods:In the present study,network pharmacology was used to analyze the potential active ingredients and molecular mechanisms of Pinelliae Rhizoma’s anti-inflammatory activity.A new approach to simultaneously determine eight components using high performance liquid chromatography-photo-diode array was developed to evaluate the quality of Pinelliae Rhizoma and different processed Pinelliae Rhizoma products.Results:Twelve active ingredients were identified from Pinelliae Rhizoma,andβ-sitosterol may have a greater effect than the other active ingredients.Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses revealed the main pathways associated with Pinelliae Rhizoma’s mechanism for treating inflammation.Additionally,theβ-sitosterol content in different processed Pinelliae Rhizoma products decreased significantly,and the level of five nucleosides in Pinelliae Rhizoma was significantly higher than that of the processed Pinelliae Rhizoma products.The 6-gingerol content was detected in eight Pinelliae Rhizoma Praeparatum cum Zingibere et Alumine batches with different origins,and liquiritin and liquiritigenin levels were detected in eight batches of Pinelliae Rhizoma Praeparatum with different origins.Conclusion:Pinelliae Rhizoma quality was affected by different regions and different processing methods,and this research provides a reference for Pinelliae Rhizoma quality evaluation. | Xin-Yang Li Di Liang Xue-Qian Zhang Xiao-Huan Li Miao Sha Xue-Ming Zhang Lan-Ping Guo Wen-Yuan Gao Xia Li | 2022 | Traditional Medicine Research2022，7，4： | 1 |
| 10 | Phosphorylation of Parkin by Parkinson disease-linked kinase PINKI activates Parkin E3 ligase function and NF-KB signaling显示文摘 | Di Sha Lih-shen Chin Lian Li | 2010 | Hum Mol Genet2010，19，2： | 1 |
| 11 | Hofmeister Effect on Thermo-responsive Poly(N-isopropylacrylamide)Hydrogels Grafted on Macroporous Poly(vinyl alcohol) Formaldehyde Sponges显示文摘In this work,the Hofmeister effects of nine kinds of anions at different concentrations on the lower critical solution temperature(LCST)of the macroporous thermo-responsive poly(N-isopropylacrylamide)grafted poly(vinyl alcohol)formaldehyde(PVF-g-PNIPAM)hydrogels are investigated with differential scanning calorimetry(DSC).Four kinds of anions with strong hydration,including CO3^2–,SO4^2–,S2 O3^2–,and F^–,and four kinds of anions with weak hydration,including Br^–,NO3^–,I^–,and ClO4^–,and Cl^–as a medium anion are systematically studied and found to demonstrate the effects of the residual hydroxyl groups and network structure of PVF on the LCST values of PVF-g-PNIPAM hydrogels in comparison with that of neat PNIPAM.On the one hand,the existence of hydroxyl groups on PVF backbone promotes the solubility of grafted PNIPAM due to their hydrophilicity and hydrogen-bond interactions with water.On the other hand,the network structure of as-prepared samples restricts free movements of grafted PNIPAM chains,which results in the increase of LCST values.In addition,the difference of grafting percentage also influences the variation of LCST values of PVF-g-PNIPAM hydrogels under salt concentration. | Kai Shi Di Sha Jiu-Duo Xu Xu Yang Bao-Long Wang Yan-Xiong Pan Xiang-Ling Ji | 2020 | Chinese Journal of Polymer Science2020，38，3： | 1 |
| 12 | Relative Contributions of Spatial and Environmental Processes and Biotic Interactions in a Soil Collembolan Community显示文摘Understanding the underlying processes of how communities are structured remains a central question in community ecology. However, the mechanisms of the soil animal community are still unclear, especially for communities on a small scale. To evaluate the relative roles of biotic interactions and environmental and spatial processes in a soil collembolan community, a field experiment was carried out on a small scale(50 m) in the farmland ecosystem of the Sanjiang Plain, Northeast China. In August and October, 2011, we took 100 samples each month in a 50 m × 50 m plot using a spatially delimited sampling design. Variation partitioning was used to quantify the relative contributions of the spatial and environmental variables. A null model was selected to test for the non-randomness pattern of species co-occurrence and body size in assemblages of collembolans and to test whether the pattern observed was the result of environmental or biotic processes that structured the community on a small scale. The results showed that large variance was accounted for by spatial variables(18.99% in August and 21.83% in October, both were significant). There were relatively lower effects of environmental variation(3.56% in August and 1.45% in October, neither was significant), while the soil water content, soil p H and soybean height explained a significant portion of the variance that was observed in the spatial pattern of the collembolan community. Furthermore, the null model revealed more co-occurrence than expected by chance, suggesting that collembolan communities had a non-random co-occurrence pattern in both August and October. Additionally, environmental niche overlap and the body size ratio of co-occurrence showed that interspecific competition was not influential in collembolan community structuring. Considering all of the results together, the contributions of spatial and environmental processes were stronger than biotic interactions in the small-scale structuring of a soil collembolan community. | SHA Di GAO Meixiang SUN Xin WU Donghui ZHANG Xueping | 2015 | Chinese Geographical Science2015，25，5： | 1 |
| 13 | CoNi nanoparticles anchored inside carbon nanotube networks by transient heating:Low loading and high activity for oxygen reduction and evolution显示文摘Transitional metal alloy and compounds have been developed as the low cost and efficient bifunctional electrocatalysts for oxygen reduction reaction(ORR)and oxygen evolution reaction(OER).However,a high mass loading of these catalysts is commonly needed to achieve acceptable catalytic performance,which could cause such problems as battery weight gain,mass transport blocking,and catalyst loss.We report herein the preparation of fine CoNi nanoparticles(5-6 nm)anchored inside a nitrogendoped defective carbon nanotube network(CoNi@N-DCNT)by a transient Joule heating method.When utilized as an electrocatalyst for oxygen reduction and evolution in alkaline media,the CoNi@N-DCNT film catalyst with a very low mass loading of 0.06 mg cm^(-2) showed excellent bifunctional catalytic performance.For ORR,the onset potential(Eonset)and the half-wave potential(E_(1/2))were 0.92 V versus reversible hydrogen electrode(vs.RHE)and 0.83 V(vs.RHE),respectively.For OER,the potential at the current density(J)of 10 mA cm^(-2)(E_(10))was 1.53 V,resulting in an overpotential of 300 mV much lower than that of the commercial RuO_(2) catalyst(320 mV).The potential gap between E_(1/2) and E_(10) was as small as 0.7 V.Considering the low mass loading,the mass activity at E_(10) reached at 123.2 A g^(-1),much larger than that of the RuO_(2) catalyst and literature results of transitional metal-based bifunctional catalysts.Moreover,the CoNi@N-DCNT film catalyst showed very good long-term stability during the ORR and OER test.The excellent bifunctional catalytic performance could be attributed to the synergistic effect of the bimetal alloy. | Chengfeng Zhu Wei Yang Jiangtao Di Sha Zeng Jian Qiao Xiaona Wang Bo Lv Qingwen Li | 2021 | Journal of Energy Chemistry2021，30，3： | 0 |
| 14 | Relationship Between Climate Change and Marmot Plague of Marmota himalayana Plague Focus—the Altun Mountains of the Qinghai-Xizang Plateau,China,2000–2022显示文摘Introduction:Plague is a zoonotic disease that occurs naturally in specific geographic areas.Climate change can influence the populations of the plague host or vector,leading to variations in the occurrence and epidemiology of plague in animals.Methods:In this study,we collected meteorological and plague epidemiological data from the Marmota himalayana plague focus in the Altun Mountains of the Qinghai-Xizang Plateau.The data spanned from 2000 to 2022.We describe the climatic factors and plague epidemic conditions and we describe their analysis by Pearson’s correlation.Results:During the period from 2000 to 2022,the isolation rates of Yersinia pestis(Y.pestis)from marmots and fleas were 9.27%(451/4,864)and 7.17%(118/1,646),respectively.Additionally,we observed a positive rate of F1 antibody of 11.25%(443/3,937)in marmots and 18.16%(142/782)in dogs.With regards to climate,there was little variation,and a decreasing trend in blowing-sand days was observed.The temperature in the previous year showed a negative correlation with the Y.pestis isolation rate in marmots(r=−0.555,P=0.011)and the positive rate of F1 antibody in marmots(r=−0.552,P=0.012)in the current year.The average annual precipitation in the previous two years showed a positive correlation with marmot density(r=0.514,P=0.024),while blowingsand days showed a negative correlation with marmot density(r=−0.701,P=0.001).Furthermore,the average annual precipitation in the previous three years showed a positive correlation with the isolation rate of Y.pestis from marmots(r=0.666,P=0.003),and blowing-sand days showed a negative correlation with marmot density(r=−0.597,P=0.009).Conclusions:The findings of this study indicate that there is a hysteresis effect of climate change on the prevalence of plague.Therefore,monitoring climate conditions can offer significant insights for implementing timely preventive and control measures to combat plague epidemics. | Qun Duan Xiaojin Zheng Zhiqiang Gan Dongyue Lyu Hanyu Sha Xinmin Lu Xiaoling Zhao Asaiti Bukai Ran Duan Shuai Qin Li Wang Jinxiao Xi Di Wu Peng Zhang Deming Tang Zhaokai He Huaiqi Jing Biao Kan Xin Wang | 2024 | China CDC weekly2024，6，4： | 0 |
| 15 | Comprehensive reutilization of herbal waste:Coproduction of magnolol,honokiol,and β-amyrin from Magnolia officinalis residue显示文摘Herbal extraction residues(HERs)cause serious environmental pollution and resource waste.In this study,a novel green route was designed for the comprehensive reutilization of all components in HERs,taking Magnolia officinalis residues(MOR)as an example.The reluctant structure of MOR was first destroyed by alkali pretreatment to release the functional ingredients(magnolol and honokiol)originally remaining in MOR and to make MOR more accessible for hydrolysis.A metal–organic frame material MIL-101(Cr)with a maximum absorption capacity of 255.64 mg g^(-1)was synthesized to absorb the released honokiol and magnolol from the pretreated MOR solutions,and 40 g L^(-1)reducing sugars were obtained with 81.8%enzymatic hydrolysis rate at 10%MOR solid loading.Finally,382 mg L-1β-amyrin was produced from MOR hydrolysates by an engineered yeast strain.In total,1 kg honokiol,8 kg magnolol,and 7.64 kg β-amyrin could produce from 1 ton MOR by this cleaner process with a total economic output of 170,700 RMB. | Lukun Xiao Anyi Zhao Jie Qiu An Liu Sha Chen Jinzhu Jiang Jun Zhang Cong Guo Jipeng Di Jintang Cheng Chang Chen Kangxin Hou Aiping Zhang Yan Liu Caixia Wang | 2024 | Green Energy & Environment2024，9，2： | 0 |
| 16 | Fractional Fourier transform based transmitted reference scheme for UWB communications显示文摘In this paper,we propose a receiving system for impulse radio ultra-wideband (IR-UWB) communications,in which the data and reference pulses are combined as one signal to transmit,and the received signal can be divided into the data and reference pulses in the receiver end using the energy concentration property of Chirp pulses in fractional Fourier transform (FrFT) domain.A detailed theoretical analysis of the proposed system is given,and the formulation of bit error rate (BER) is obtained.Then according to the BER formulation,system performance of the proposed receiving system is compared with existing STR,DTR and ATR systems,considering timing-variance of IR-UWB channels as well as timing jitter at the transmitter.Results show that the proposed receiving system outperforms existing systems in most situations. | LIN Di WU XuanLi SHA XueJun | 2011 | Science China(Information Sciences)2011，54，8： | 0 |
| 17 | Farmers'Ideological and Political Education under the Background of Rural Revitalization Strategy显示文摘As a new way to solve the issues of agriculture,rural areas and farmers in China,the strategy of rural revitalization puts forward new requirements for the ideological and political education of farmers.However,in the present stage,the ideological and political education of Chinese farmers is often compromised in the process of rural traditional culture,and there is also pride and prejudice in the cadres for'agriculture,rural areas and farmers'.For the ideological and political education of Chinese farmers,it is necessary to pay more attention to the social orientation of farmers and the value orientation contained in the construction of farmers'ideological and political construction,and reconstruct the system of Chinese farmers'ideological and political education based on this orientation and value selection. | Di SHA Weiguang PAN | 2021 | Asian Agricultural Research2021，13，8： | 0 |
| 18 | Characteristics and Containment of 74 Imported COVID-19 Outbreaks: Experiences, Lessons, and Implications — China, 2020–2021显示文摘What is already known about this topic?After the initial coronavirus disease 2019(COVID-19)outbreak in Wuhan,China,the outbreaks during the dynamic-zero policy period in the mainland of China have not been systematically documented.What is added by this report?We summarized the characteristics of 74 imported COVID-19 outbreaks between March 19,2020 and December 31,2021.All outbreaks of early severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variants were successfully contained with the aid of nucleic acid testing,modern communication technologies,and non-pharmacological interventions.What are the implications for public health practice?These findings provide us with confidence for the containment of future emerging infectious diseases alike at early stages to prevent pandemics or to win time to gain experience,develop vaccines and drugs,vaccinate people,and wait for the possible lessening of the virus’pathogenicity. | Fuxiao Li Chang Wei Bingli Li Tengfei Lin Yiwen Jiang Di Liu Zhirong Yang Zuyao Yang Feng Sha Jinling Tang | 2022 | China CDC weekly2022，4，50： | 0 |
| 19 | Hospital Strain and COVID-19 Fatality—England,April 2020–March 2022显示文摘Summary What is already known about this topic?During the coronavirus disease 2019(COVID-19)pandemic,tremendous efforts have been made in countries to suppress epidemic peaks and strengthen hospital services to avoid hospital strain and ultimately reduce the risk of death from COVID-19.However,there is limited empirical evidence that hospital strain increases COVID-19 deaths. | Tengfei Lin Ziyi Zhao Zhirong Yang Bingli Li Chang Wei Fuxiao Li Yiwen Jiang Di Liu Zuyao Yang Feng Sha Jinling Tang | 2022 | China CDC weekly2022，4，52： | 0 |
| 20 | Germinated brown rice relieves hyperlipidemia by alleviating gut microbiota dysbiosis显示文摘Hyperlipidemia is a frequent metabolic disorder that is closely associated with diet. It is believed that brown rice, containing the outer bran layer and germ, is beneficial for the remission of hyperlipidemia. This study established a rat model of hyperlipidemia by feeding a high-fat diet. The hypolipidemic potential of germinated brown rice(Gbrown) and germinated black rice(a germinated black-pigmented brown rice, Gblack) were explored in the model rats, mainly in the aspects of blood lipids, lipases, apolipoproteins, and inflammation. The gut microbiota in hyperlipidemic rats receiving diverse dietary interventions was determined by 16S rDNA sequencing. The results showed that the intervention of Gbrown/Gblack alleviated the hyperlipidemia in rats, evidenced by decreased TC, TG, LDL-C, and apolipoprotein B, and increased HDL-C, HL, LPL, LCAT, and apolipoprotein A1. Gbrown/Gblack also weakened the inflammation in hyperlipidemia rats, evidenced by decreased TNF-α, IL-6, and ET-1. In addition, 16S rDNA sequencing revealed that the diet of Gbrown/Gblack elevated the abundance and diversity of gut microbiota in hyperlipidemia rats. At the phylum level, Gbrown/Gblack decreased Firmicutes, increased Bacteroidetes, and decreased the F/B ratio in hyperlipidemia rats. At the genus level, Gbrown/Gblack decreased Streptococcus and increased Ruminococcus and Allobaculum in hyperlipidemia rats. Some differential microbial genera relating to lipid metabolism were also determined, such as the Lachnospira and Ruminococcus in the Gblack group, and the Phascolarctobacterium, Dorea, Turicibacter, and Escherichia-Shigella in the Gbrown group. Notably, the beneficial effect of Gblack was stronger than Gbrown. To sum up, the dietary interventions of Gbrown/Gblack contributed to the remission of hyperlipidemia by alleviating the dysbiosis of gut microbiota. | REN Chuan-ying ZHANG Shan HONG Bin GUAN Li-jun HUANG Wen-gong FENG Jun-ran SHA Di-xin YUAN Di LI Bo JI Ni-na LIU Wei LU Shu-wen | 2023 | Journal of Integrative Agriculture2023，22，3： | 0 |
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