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| 1 | Leptin-induced vascular smooth muscle cell proliferation via regulating cell cycle, activating ERK1/2 and NF-κB显示文摘Leptin 是首先涉及食物吸入和精力开销的规定的肽荷尔蒙。最近的研究建议了 leptin 是为包括动脉粥样硬化和高血压的心血管的疾病的风险因素之一。脉管的光滑的肌肉房间(VSMC ) 在动脉的内层的变厚并且脉管的改变起一个重要作用。在这研究,我们在 VSMC 房间周期规定和可能的小径上调查了 leptin 的效果。我们发现 leptin 刺激了 VSMC 增长并且增加了房间前进到 S 和 G2/M 阶段。cyclinD1 的表示, phosphorylated 细胞外的调整信号的 kinase 1/2 (ERK1/2 ) ,和原子因素(NF )-Bp65 被增加。有 leptin 对手三元组异种的房间的处理稀释了导致 leptin 的 ERK1/2 和 NF-B 激活。这些结果建议 leptin 由从 G1 把转变提升到 S 阶段和 ERK1/2 和 NF-B 小径刺激了 VSMC 增长可能贡献这行列。 | Fen Huang Xiaofang Xiong Huabin Wang Sha You Hesong Zeng | 2010 | Acta Biochimica et Biophysica Sinica2010，42，5： | 20 |
| 2 | The Influence of Phacoemulsification on Corneal Endothelia Cells at Varying Blood Glucose Levels显示文摘Purpose:To investigate the influence of phacoemulsification on corneal endothelial cells in diabetes patients and normal controls. Methods:Phacoemulsification and intraocular lens implantation were performed on 75 patients with diabetic cataract (126 eyes) who were divided into two groups: Trial group 1 (Glu≤6 mmol/L); Trial group 2 (Glu 6-10 mmol/L) and 65 nondiabetic controls (112 eyes).The density and percentage of hexagonal cells and coefficient of variation of the corneal endothelia were measured before surgery and 1 day,1 month and 3 months postoperatively. Results: There was no statistical difference in the density and percentage of hexagonal cells and coefficient of variation of the corneal endothelia prior to phacoemulsification.(P>0.05) between the three groups.The density and percentage of hexagonal cells of the corneal endothelia decreased significantly after surgery in all three groups(P<0.05),while the Coefficient of variation increased in all groups(P<0.05). The rate of loss of corneal endothelial cells in the diabetic groups was significantly higher than for the control group (P<0.05), the percentage of hexagonal cells in the diabetic groups was significantly lower than for the control group (P<0.05), and the coefficient of variation in the diabetic groups was significantly higher than for the control group (P<0.05) at 1 day, 1 month and 3 months post-operatively. There was no statistical difference between the two diabetic groups in terms of these post-operative measurements. Conclusion:The corneal endothelium of diabetic patients is more prone to damage from phacoemulsification. It is advisable to evaluate the corneal endothelium routinely prior to phacoemulsification, particularly in diabetic persons. | RuiMing Yang Xiangyin Sha Mingbing Zeng Yingqian Tan Yu Zheng Feihong Fan | 2011 | Eye Science2011，26，2： | 14 |
| 3 | A new prognostic histopathologic classification of nasopharyngeal carcinoma显示文摘Background:The current World Health Organization(WHO) classification of nasopharyngeal carcinoma(NPC) con?veys little prognostic information.This study aimed to propose an NPC histopathologic classification that can poten?tially be used to predict prognosis and treatment response.Methods:We initially developed a histopathologic classification based on the morphologic traits and cell differentia?tion of tumors of 2716 NPC patients who were identified at Sun Yat?sen University Cancer Center(SYSUCC)(training cohort).Then,the proposed classification was applied to 1702 patients(retrospective validation cohort) from hospitals outside SYSUCC and 1613 patients(prospective validation cohort) from SYSUCC.The efficacy of radiochemotherapy and radiotherapy modalities was compared between the proposed subtypes.We used Cox proportional hazards models to estimate hazard ratios(HRs) with 95% confidence intervals(CI) for overall survival(OS).Results:The 5?year OS rates for all NPC patients who were diagnosed with epithelial carcinoma(EC;3708 patients),mixed sarcomatoid?epithelial carcinoma(MSEC;1247 patients),sarcomatoid carcinoma(SC;823 patients),and squamous cell carcinoma(SCC;253 patients) were 79.4%,70.5%,59.6%,and 42.6%,respectively(P < 0.001).In mul?tivariate models,patients with MSEC had a shorter OS than patients with EC(HR = 1.44,95% CI = 1.27–1.62),SC(HR = 2.00,95% CI = 1.76–2.28),or SCC(HR = 4.23,95% CI = 3.34–5.38).Radiochemotherapy significantly improved survival compared with radiotherapy alone for patients with EC(HR 49–0.75),and possibly for those with SCC(HR = 0.67,95% CI = 0.56–0.80),MSEC(HR = 0.58,95% CI = 0..74–1.28).= 0.63;95% CI = 0.40–0.98),but not for patients with SC(HR = 0.97,95% CI = 0Conclusions:The proposed classification offers more information for the prediction of NPC prognosis compared with the WHO classification and might be a valuable tool to guide treatment decisions for subtypes that are associ?ated with a poor prognosis. | Hai-Yun Wang Yih-Leong Chang Ka-Fai To Jacqueline S.G.Hwang Hai-Qiang Mai Yan-Fen Feng Ellen T.Chang Chen-Ping Wang Michael Koon Ming Kam Shie-Lee Cheah Ming Lee Li Gao Hui-Zhong Zhang Jie-Hua He Hao Jiang Pei-Qing Ma Xiao-Dong Zhu Liang Zeng Chun-Yan Chen Gang Chen Ma-Yan Huang Sha Fu Qiong Shao An-Jia Han Hai-Gang Li Chun-Kui Shao Pei-Yu Huang Chao-Nan Qian Tai-Xiang Lu Jin-Tian Li Weimin Ye Ingemar Ernberg Ho Keung Ng Joseph T.S.Wee Yi-Xin Zeng Hans-Olov Adami Anthony T.C.Chan Jian-Yong Shao | 2016 | Chinese Journal of Cancer2016，35，6： | 10 |
| 4 | Highly sensitive detection of melamine based on reversed phase liquid chromatography mass spectrometry显示文摘In this work, we developed a highly sensitive method to detect melamine based on reversed phase liquid chromatography mass spectrometry. A mass spectrometry compatible ion pair, heptafluorobu-tyric acid(HFBA), was used to separate melamine by reversed phase liquid chromatography prior to electrospray mass spectrometry. The incorporation of isotope internal standard and multiple reaction monitoring improved the accuracy and linearity of quantification. Based on this strategy, the method limit of quantification was 0.1 ng/g. The limits of quantification were 8 ng/g for liquid milk and 15 ng/g for dry milk powder. This method provided a reproducible and stable approach to sensitive detection and quantification of melamine. | WU QingQing FAN KeXin SHA Wei RUAN HongQiang ZENG Rong SHIEH ChiaHui | 2009 | Chinese Science Bulletin2009，54，5： | 7 |
| 5 | A rare case of Castleman's disease of plasma cell type within kidney显示文摘 | ZHU Yu-chun HUANG Ying YAO Jin LI Xiang ZHAO Sha WEI Qiang ZENG Hao | 2009 | Chinese Medical Journal2009，，19： | 7 |
| 6 | FluxExplorer: A general platform for modeling and analyses of metabolic net-works based on stoichiometry显示文摘Stoichiometry-based analyses of meta- bolic networks have aroused significant interest of systems biology researchers in recent years. It is necessary to develop a more convenient modeling platform on which users can reconstruct their network models using completely graphical operations, and explore them with powerful analyzing modules to get a better understanding of the properties of metabolic systems. Herein, an in silico platform, FluxExplorer, for metabolic modeling and analyses based on stoichiometry has been developed as a publicly available tool for systems biology research. This platform integrates various analytic approaches, in- cluding flux balance analysis, minimization of meta- bolic adjustment, extreme pathways analysis, shadow prices analysis, and singular value decom- position, providing a thorough characterization of the metabolic system. Using a graphic modeling process, metabolic networks can be reconstructed and modi- fied intuitively and conveniently. The inconsistencies of a model with respect to the FBA principles can be proved automatically. In addition, this platform sup- ports systems biology markup language (SBML). FluxExplorer has been applied to rebuild a metabolic network in mammalian mitochondria, producing meaningful results. Generally, it is a powerful and very convenient tool for metabolic network modeling and analysis. | LUO Ruoyu LIAO Sha ZENG Shaoqun LI Yixue LUO Qingming | 2006 | Chinese Science Bulletin2006，51，6： | 6 |
| 7 | In vitro testicular organogenesis from human fetal gonads produces fertilization-competent spermatids显示文摘Unlike most organs that mature during the fetal period,the male reproductive system reaches maturity only at puberty with the commencement of spermatogenesis.Robust modelling of human testicular organogenesis in vitro would facilitate research into mechanisms of and factors affecting human spermatogenic failure and male fertility preservation in prepubertal tumor patients.Here,we report successful recapitulation of human testicular organogenesis in vitro from fetal gonadal ridge.Our model displayed the formation of mature seminiferous epithelium and self-renewing spermatogonia.Remarkably,in vitro-derived haploid spermatids have undergone meiotic recombination,and showed increased genetic diversity as indicated by genetic analysis.Moreover,these spermatids were able to fertilize oocytes and support subsequent blastocyst formation.The in vitro testicular organogenesis system described here will play an important role in elucidating the regulation of human testis development and maintaining male fertility in prepubertal cancer patients. | Yan Yuan Laihua Li Qing Cheng Feiyang Diao Qiao Zeng Xiaoyu Yang Yibo Wu Hao Zhang Mingqian Huang Junqing Chen Quan Zhou Yunfei Zhu Rong Hua Jianyu Tian Xin Wang Zuomin Zhou Jie Hao Jinjin Yu Dong Hua Jiayin Liu Xuejiang Guo Qi Zhou Jiahao Sha | 2020 | Cell Research2020，30，3： | 6 |
| 8 | Roles of G protein-coupled receptors in inflammatory bowel disease显示文摘Inflammatory bowel disease(IBD)is a complex disease with multiple pathogenic factors.Although the pathogenesis of IBD is still unclear,a current hypothesis suggests that genetic susceptibility,environmental factors,a dysfunctional immune system,the microbiome,and the interactions of these factors substantially contribute to the occurrence and development of IBD.Although existing and emerging drugs have been proven to be effective in treating IBD,none can cure IBD permanently.G protein-coupled receptors(GPCRs)are critical signaling molecules implicated in the immune response,cell proliferation,inflammation regulation and intestinal barrier maintenance.Breakthroughs in the understanding of the structures and functions of GPCRs have provided a driving force for exploring the roles of GPCRs in the pathogenesis of diseases,thereby leading to the development of GPCR-targeted medication.To date,a number of GPCRs have been shown to be associated with IBD,significantly advancing the drug discovery process for IBD.The associations between GPCRs and disease activity,disease severity,and disease phenotypes have also paved new avenues for the precise management of patients with IBD.In this review,we mainly focus on the roles of the most studied proton-sensing GPCRs,cannabinoid receptors,and estrogen-related GPCRs in the pathogenesis of IBD and their potential clinical values in IBD and some other diseases. | Zhen Zeng Arjudeb Mukherjee Adwin Pidiyath Varghese Xiao-Li Yang Sha Chen Hu Zhang | 2020 | World Journal of Gastroenterology2020，26，12： | 5 |
| 9 | HSV-1 H129-Derived Anterograde Neural Circuit Tracers:Improvements, Production, and Applications显示文摘Anterograde viral tracers are powerful and essential tools for dissecting the output targets of a brain region of interest. They have been developed from herpes simplex virus 1(HSV-1) strain H129(H129), and have been successfully applied to map diverse neural circuits.Initially, the anterograde polysynaptic tracer H129-G4 was used by many groups. We then developed the first monosynaptic tracer, H129-dTK-tdT, which was highly successful, yet improvements are needed. Now, by inserting another tdTomato expression cassette into the H129-dTK-tdT genome, we have created H129-dTK-T2, an updated version of H129-dTK-tdT that has improved labeling intensity. To help scientists produce and apply our H129-derived viral tracers, here we provide the protocol describing our detailed and standardized procedures. Commonly-encountered technical problems and their solutions are also discussed in detail. Broadly, the dissemination of this protocol will greatly support scientists to apply these viral tracers on a large scale. | Hong Yang Feng Xiong Yi-Ge Song Hai-Fei Jiang Hai-Bin Qin Jing Zhou Sha Lu Steven FGrieco Xiangmin Xu Wen-Bo Zeng Fei Zhao Min-Hua Luo | 2021 | Neuroscience Bulletin2021，37，5： | 4 |
| 10 | A Memory Efficient Belief Propagation Decoder for Polar Codes显示文摘Polar codes have become increasingly popular recently because of their capacity achieving property.In this paper,a memory efficient stage-combined belief propagation(BP) decoder design for polar codes is presented.Firstly,we briefly reviewed the conventional BP decoding algorithm.Then a stage-combined BP decoding algorithm which combines two adjacent stages into one stage and the corresponding belief message updating rules are introduced.Based on this stage-combined decoding algorithm,a memory-efficient polar BP decoder is designed.The demonstrated decoder design achieves 50%memory and decoding latency reduction in the cost of some combinational logic complexity overhead.The proposed decoder is synthesized under TSMC 45 nm Low Power CMOS technology.It achieves 0.96 Gb/s throughput with 14.2mm^2 area when code length N=2^(16)which reduces 51.5%decoder area compared with the conventional decoder design. | SHA Jin LIU Xing WANG Zhongfeng ZENG Xiaoyang | 2015 | China Communications2015，12，5： | 3 |
| 11 | Soluplus micelles for improving the oral bioavailability of scopoletin and their hypouricemic effect in vivo显示文摘Scopoletin 是拥有许多药理学活动的活跃香豆素,包括 anti-hyperuricemic 效果,但是与差的溶解度。改进它的口头的 bioavailability,我们试图包含 scopoletin 进 Soluplus 微粒(基于 Soluplus 的 scopoletin 微粒, Sco 女士) 并且评估了 Sco-Ms.Sco 女士的 hypouricemic 行动用一个薄电影的水和方法被准备。Sco 女士与 59.4 灭敬整祬戠潬正摥 ? 噓木椭摮 ' 讚?的一种平均尺寸显示了近球形的形状 ?? 桰獯桰牯汹瑡潩 ? 猠杵敧瑳湩 ? 桴瑡 ??? ‵捡楴杮甠獰牴慥? 景 ?? 愠摮瀠??偁欠湩獡 | Ying-chun ZENG Sha LI Chang LIU Tao GONG Xun SUN Yao FU Zhi-rong ZHANG | 2017 | Acta Pharmacologica Sinica2017，38，3： | 3 |
| 12 | Quality Assessment of Clinical Practice Guidelines for Integrative Medicine in China:A Systematic Review显示文摘Objective: To assess the quality of integrative medicine clinical practice guidelines(CPGs) published before 2014. Methods: A systematic search of the scientific literature published before 2014 was conducted to select integrative medicine CPGs. Four major Chinese integrated databases and one guideline database were searched: the Chinese Biomedical Literature Database(CBM), the China National Knowledge Infrastructure(CNKI), China Science and Technology Journal Database(VIP), Wanfang Data, and the China Guideline Clearinghouse(CGC). Four reviewers independently assessed the quality of the included guidelines using the Appraisal of Guidelines for Research and Evaluation(AGREE) Ⅱ Instrument. Overall consensus among the reviewers was assessed using the intra-class correlation coefficient(ICC). Results: A total of 41 guidelines published from 2003 to 2014 were included. The overall consensus among the reviewers was good [ICC: 0.928; 95% confidence interval(CI): 0.920 to 0.935]. The scores on the 6 AGREE domains were: 17% for scope and purpose(range: 6% to 32%), 11% for stakeholder involvement(range: 0 to 24%), 10% for rigor of development(range: 3% to 22%), 39% for clarity and presentation(range: 25% to 64%), 11% for applicability(range: 4% to 24%), and 1% for editorial independence(range: 0 to 15%). Conclusions: The quality of integrative medicine CPGs was low, the development of integrative medicine CPGs should be guided by systematic methodology. More emphasis should be placed on multi-disciplinary guideline development groups, quality of evidence, management of funding and conflicts of interest, and guideline updates in the process of developing integrative medicine CPGs in China. | YAO Sha Wei Dang CHEN Yao-long WANG Qi WANG Xiao-qin ZENG Zhao LI Hui | 2017 | Chinese Journal of Integrative Medicine2017，23，5： | 3 |
| 13 | Origins of high ductility exhibited by an extruded magnesium alloy Mg-1.8Zn-0.2Ca:Experiments and crystal plasticity modeling显示文摘Low ductility and strength are major bottlenecks against Mg alloys’wide applications.In this work,we systematically design the composition and fabrication process for a low-alloyed Mg-Zn-Ca alloy,showing that it can be extruded at low temperatures(~250℃)and high speeds(~2 mm/s).After the extrusion,this alloy exhibits a substantially weakened basal texture,relatively small grain size,very high tensile elongation(~30%),and good strength.The origin of the considerably improved ductility was studied using a combination of three-dimensional atom probe tomography(3D-APT),transmission electron microscopy(TEM),electron backscattered diffraction(EBSD)in conjunction with surface slip trace analysis,in-situ synchrotron X-ray diffraction,and elasto-plastic self-consistent(EPSC)modeling.Co-segregation of Zn and Ca atoms at a grain boundary is observed and associated with texture weakening and grain boundary mediated plasticity,both improving the ductility.While basal slip and prismatic slip are identified as the dominant deformation systems in the alloy,the ratio between their slip resistances is substantially reduced relative to pure Mg and most other Mg alloys,significantly contributing to the improved ductility of the alloy.This Mg-Zn-Ca alloy exhibiting excellent mechanical properties and low fabrication cost is a promising candidate for industrial productions. | Jie Wang Gaoming Zhu Leyun Wang Evgenii Vasilev Jun-Sang Park Gang Sha Xiaoqin Zeng Marko Knezevic | 2021 | Journal of Materials Science & Technology2021，，25： | 2 |
| 14 | Simultaneous pancreas-kidney transplantation with modified enteric drainage of exocrine pancreatic secretion显示文摘BACKGROUND: As a valid therapeutic option for patients with type 1 diabetes mellitus (IDDM) and secondary dia- betic nephropathy, simultaneous pancreas-kidney trans- plantation (SPK) remains more undeveloped than other solid organ transplantations due to the restrictions of surgi- cal techniques especially the modes of exocrine pancreatic secretion. The aim of this paper was to summarize our sin- gle-center experience in SPK with modified enteric drai- nage (ED). METHODS: From June 2000 to July 2003, 10 patients with IDDM associated with uremia received SPK. The pancrea- tic allograft exocrine secretion was drained into the proxi- mal jejunum via a side-to-side duodenojejunostomy with- out Roux-en-Y anastomosis. Quadruple immunosuppres- sive regimen consisted of induction of tacrolimus (TAC) / cyclosporine (CsA), mycophenolate mofetil (MMF), ste- roids and antibodies, which included antilymphocyte glo- bulin (ALG) or anti-CD25 monoclonal antibody. RESULTS: ED-SPK without Roux-en-Y anastomosis was successful in all 10 patients without serious complications such as pancreatitis, graft thrombosis and pancreatic fistu- la. The patients regained immediate kidney allograft func- tion and euglycemia with insulin-independence. Four pa- tients survived over one year. Episodes of acute rejection were observed in 4 patients, 3 of whom showed reversion after treatment of OKT3 or insulin. Early postoperative complications included peritoneal infection ( 2 patients ), wound infection (2) and renal hematoma (1). CONCLUSION: ED-SPK without Roux-en-Y anastomosis is safe and preferable to the patients with IDDM associated with uremia. | Bin Liu, Chang-Sheng Ming, Fan-Jun Zeng, Bo Sha, Zhi-Shui Chen, Zhong-Hua Chen and Shi Chen Wuhan, China Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030 , China | 2004 | Hepatobiliary & Pancreatic Diseases International2004，3，2： | 2 |
| 15 | SJES14121200034992显示文摘 | Sha Sha Zeng Taro Yamashita Mitsumasa Kondo Kouki Nio Takehiro Hayashi Yasumasa Hara Yoshimoto Nomura Mariko Yoshida Tomoyuki Hayashi Naoki Oishi Hiroko Ikeda Masao Honda Shuichi Kaneko | 2014 | Journal of Hepatology2014，，1： | 2 |
| 16 | An essential role for PNLDC1 in piRNA 3' end trimming and male fertility in mice显示文摘 | Yue Zhang Rui Guo Yiqiang Cui Zhiping Zhu Yingwen Zhang Hao Wu Bo Zheng Qiuling Yue Shun Bai Wentao Zeng Xuejiang Guo Zuomin Zhou Bin Shen Ke Zheng Mingxi Liu Lan Ye Jiahao Sha | 2017 | Cell Research2017，27，11： | 2 |
| 17 | In-situ emb e dding zeolitic imidazolate framework derived Co–N–C bifunctional catalysts in carbon nanotube networks for flexible Zn–air batteries显示文摘Recently, the development of high-performance bifunctional oxygen catalysts integrated with flexible conductive scaffolds f or rechargeable metal-air batteries has attracted considerable interest, driving by fastgrowing wearable electronics. Herein, we report a flexible bifunctional oxygen catalyst thin film consisting of Co–N–C bifunctional catalysts embedding in carbon nanotube(CNT) networks. The catalyst is readily prepared by pyrolysis of cobalt-based zeolitic imidazolate frameworks(ZIF-67) that are in-situ synthesized in CNT networks. Such catalyst film demonstrates very high catalytic activities for oxygen reduction(onset potential: 0.91 V, and half-wave potential: 0.87 V vs. RHE) and oxygen evolution(10 m Acm^-2 at 1.58 V) reactions, high methanol tolerance property, and long-term stability(97% current retention). Moreover, our integrated catalyst film shows very good structure flexibility and robustness. Based on the obtained film air electrodes, flexible Zn–air batteries demonstrate low charging and discharging overpotentials(0.82 V at 1 m A cm^-1) and excellent structure stability in the bending tests. These results indicate that presently reported catalyst films are potential air electrodes for flexible metal–air batteries. | Bo Lv Sha Zeng Wei Yang Jian Qiao Chao Zhang Chengfeng Zhu Minghai Chen Jiangtao Di Qingwen Li | 2019 | Journal of Energy Chemistry2019，28，11： | 2 |
| 18 | Mutations in DNAH8 contribute to multiple morphological abnormalities of sperm flagella and male infertility显示文摘Asthenoteratospermia is an important cause of male infertility.Here,we report two infertile patients with severe asthenoteratospermia accompanied by new genetic abnormality.Whole-exome sequencing and bioinformatics analysis suggested that compound heterozygous mutations in DNAH8(MIM:603337)may be responsible for multiple morphological abnormalities of the sperm flagella(MMAF).Immunofluorescence assay showed that DNAH8 protein expression was significantly decreased in the sperm tail of the patients,and electron microscopy exhibited an abnormal flagellum ultrastructure,while clinical pregnancy could be achieved by intracytoplasmic sperm injection.Therefore,the compound heterozygous mutations in the DNAH8 gene may be responsible for MMAF. | Mingxiang Weng Yanwei Sha Yu Zeng Ningyu Huang Wensheng Liu Xinzong Zhang Huiliang Zhou | 2021 | Acta Biochimica et Biophysica Sinica2021，53，4： | 2 |
| 19 | Design and evaluation of glomerulus mesangium-targeted PEG-PLGA nanoparticles loaded with dexamethasone acetate显示文摘Mesangial proliferative glomerulonephritis (MsPGN),one of the most common glomerulonephritis pathological types,often leads to end-stage renal disease over a prolonged period.But the current treatment of MsPGN is non-specific and causes serious side effects,thus novel therapeutics and targeting strategies are urgently demanded.By combining the advantages of PEG-PLGA nanoparticles and the size selection mechanism of renal glomerulus,we designed and developed a novel PEG-PLGA nanoparticle delivery system capable of delivering dexamethasone acetate (A-DEX)into glomerular mesangium.We determined that 90 nm was the optimum size to encapsulate A-DEX for glomerular mesangium targeting based on the size-selection mechanism of glomerulus. After intravenous administration in rats,90 nm DiD-loaded NPs were found to accumulate to a greater extent in the kidney and kidneycortex compared with the free DiD solution.The 90 nm A-DEX NPs are also more stable at room temperature and showed a sustained release pattern.In rat glomerular mesangial cells (HBZY-1)in vitro,we found that the uptake of 90 nm A-DEX NPs was both temperature-dependent and energe-dependent,and they were mostly engulfed via clathrin-dependent endocytosis pathways,in summary,we have successfully developed a glomerular mesangium-targeted PEG-PLGA NPs,which is potential for the treatment of MsPGN. | Sha Li Ying-chun Zeng Ke Peng Chang Liu Zhi-rong Zhang Ling Zhang | 2019 | Acta Pharmacologica Sinica2019，40，1： | 2 |
| 20 | A critical role for CHIP in the aggresome pathway显示文摘 | Sha Y Pandit L Zeng S | 2009 | Mol Cell Biol2009，29，1： | 1 |
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