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| 1 | Lamivudine resistance mutations in patients infected with hepatitis B virus genotype D显示文摘AIM: To determine the distribution of viral genotypes for primary or acquired lamivudine resistance. METHODS: A total of 283 patients with chronic hepatitis B virus (HBV) infection (245 patients with chronic hepatitis B and 38 inactive hepatitis B surface antigen carriers) were included in the study. The HBV geno-type was determined by using quantitative real-time polymerase chain reaction and sequence analysis, and tyrosine-methionine-aspartate-aspartate (YMDD) motif mutations were determined using the reverse transcriptase hybridization method. RESULTS: Lamivudine resistance was determined in a total of 25 (10.7%) chronic hepatitis B patients. Eight subjects (4%) had primary resistance to lamivudine, and 17 (53.1%) had secondary resistance to lamivudine. Genotype D, which was isolated from 267 of the patients with chronic HBV infection, was the dominant genotype in Turkey. CONCLUSION: Identification of YMDD motif mutations should have a positive impact on the selection of proper antiviral medication for patients, even for those who are nucleoside nave. | Orhan Yιldιz Bilgehan Aygen Nese Demirtürk Tuna Demirdal Dilara Inan Taner Yιldιrmak Arzu Kantürk Ediz Tütüncü Hepatitis B Study Group | 2011 | World Journal of Gastroenterology2011，17，45： | 3 |
| 2 | Road vehicle emission factors development: A review显示文摘 | Vicente Franco Marina Kousoulidou Marilena Muntean Leonidas Ntziachristos Stefan Hausberger Panagiota Dilara | 2013 | Atmospheric Environment2013，，： | 2 |
| 3 | In vitro effects of phenytoin and DAPT on MDA-MB-231 breast cancer cells显示文摘电压门钠隧道(VGSC ) 活动提高与转移有关的房间行为,例如活动性,侵略,和 oncogene 表示。新生的选择拼接 Nav1.5 isoform 的形式在变形乳癌被表示。而且,异常槽口发信号小径能导致 oncogenesis 并且可以支持乳癌的前进。在这研究,我们试图分析 nNav1.5 禁止者 phenytoin 和槽口信号禁止者 N- 的效果[经由分别地发信号的 nNav1.5 VGSC 活动和槽口的抑制的三倍的否定乳癌房间线(MDA-MB-231 ) 上的 N-(3,5-difluorophenacetyl )-L-alanyl]-S-phenylglycine-t-butyl 酉旨(DAPT ) 。以便决定这些禁止者的单个、联合的效果, 4-[3-(4-iyodophenyl )-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate (WST-1 ) 测试,创伤愈合试金,和 zymography 被执行检测增长,侧面的活动性,和矩阵 metalloproteinase-9 (MMP9 ) 活动分别地。metalloproteinases-1 (TIMP1 ) 的 nNav1.5, Notch4, MMP9,和织物禁止者的表情被量的即时反向的 transcriptasepolymerase 链反应也检测。当剂量比 10 眠獡 ? ┵高时, DAPT 引起了 antiproliferative 效果吗?? | Canan Cakir Aktas N. Dilara Zeybek A. Kevser Piskin | 2015 | Acta Biochimica et Biophysica Sinica2015，47，9： | 2 |
| 4 | Analysis of glimepiride by using derivative UV spectrophotometric method 显示文摘 | DILARA T | 2001 | Journal of Pharamaceutical and Biomedical Analysis2001，24，3： | 1 |
| 5 | Temperature effect on the surface charge properties ofAl203显示文摘 | Mustafa S Dilara B Neelofer Z | 1998 | J Colloid Interface Sei1998，204，： | 1 |
| 6 | Surface properties of the mixed oxides of iron and silica显示文摘 | MUSTAFA S DILARA B NARGIS K NAEEM A SHAHIDA P | 2002 | Coll Surf A2002，205，： | 1 |
| 7 | Diploid/Polyploid Syntenic Shuttle Mapping and Haplotype-Specific Chromosome Walking Toward a Rust Resistance Gene (Bru1) in Highly Polyploid Sugarcane (2n ~ 12x ~ 115)显示文摘 | Le Cunff Lo?c Garsmeur Olivier Raboin Louis Marie Pauquet Jérome Telismart Hugues Selvi Athiappan Grivet Laurent Philippe Romain Begum Dilara Deu Monique Costet Laurent Wing Rod Glaszmann Jean Christophe D’Hont Angélique | 2008 | Genetics2008，，1： | 1 |
| 8 | Effects of ultrasonic energy on dyeing of polyamide (microfibre)/Lycra blends显示文摘 | Nigar Merdan Mehmet Akalin Dilara Kocak | 2004 | Ultrasonics2004，42，19： | 1 |
| 9 | Effects of ultrasonic energy on the wash fastness of reactive dyes显示文摘 | Mehmet Akalin Nigar Merdan Dilara Kocak | 2004 | Ultrasonics2004，42，19： | 1 |
| 10 | Distribution and antifungal susceptibility of Candida species causing nosocomial candiduria显示文摘 | Betil Ozhak-Baysan Dilara Ogunc Dilek Colak Gozde Ongut Levent Donmez Tumer Vural Filiz Gunseren | 2012 | Medical Mycology2012，，5： | 1 |
| 11 | The impact of pretreatment with bolus dose of enteral glutamine on acute lung injury induced by oleic acid in rats显示文摘 | A. Ebru Salman Fahri Yeti?ir Mehmet K?l?? ?zkan ?nal Ahmet Dostbil Dilara Zeybek Mustafa Aksoy Figen Kaymak Tu?rul ?elik Süheyla ünver | 2014 | Journal of Anesthesia2014，，3： | 1 |
| 12 | Clinical outcome in IL-10– and IL-10 receptor–deficient patients with or without hematopoietic stem cell transplantation显示文摘 | Karin R. Engelhardt Neil Shah Intan Faizura-Yeop Dilara F. Kocacik Uygun Natalie Frede Aleixo M. Muise Eyal Shteyer Serkan Filiz Ronnie Chee Mamoun Elawad Britta Hartmann Peter D. Arkwright Christopher Dvorak Christoph Klein Jennifer M. Puck Bodo Grimbach | 2012 | The Journal of Allergy and Clinical Immunology2012，，： | 1 |
| 13 | Surface properties of the mixed oxides of iron and silica 显示文摘 | MUSTAFA S DILARA B NARGIS K | 2002 | Colloids Surf A2002，205，： | 1 |
| 14 | Standard testing methods for mechanical properties and degradation of low density polyethylene (LDPE) films used as greenhouse covering materials :a criyieal evaluation 显示文摘 | Dilara P A Briassoulis D | 1998 | Polymer Testing1998，17，8： | 1 |
| 15 | Molecular and cellular changes in the post-traumatic spinal cord remodeling after autoinfusion of a genetically-enriched leucoconcentrate in a mini-pig model显示文摘Post-traumatic spinal cord remodeling includes both degenerating and regenerating processes,which affect the potency of the functional recovery after spinal cord injury(SCI).Gene therapy for spinal cord injury is proposed as a promising therapeutic strategy to induce positive changes in remodeling of the affected neural tissue.In our previous studies for delivering the therapeutic genes at the site of spinal cord injury,we developed a new approach using an autologous leucoconcentrate transduced ex vivo with chimeric adenoviruses(Ad5/35)carrying recombinant cDNA.In the present study,the efficacy of the intravenous infusion of an autologous genetically-enriched leucoconcentrate simultaneously producing recombinant vascular endothelial growth factor(VEGF),glial cell line-derived neurotrophic factor(GDNF),and neural cell adhesion molecule(NCAM)was evaluated with regard to the molecular and cellular changes in remodeling of the spinal cord tissue at the site of damage in a model of mini-pigs with moderate spinal cord injury.Experimental animals were randomly divided into two groups of 4 pigs each:the therapeutic(infused with the leucoconcentrate simultaneously transduced with a combination of the three chimeric adenoviral vectors Ad5/35‐VEGF165,Ad5/35‐GDNF,and Ad5/35‐NCAM1)and control groups(infused with intact leucoconcentrate).The morphometric and immunofluorescence analysis of the spinal cord regeneration in the rostral and caudal segments according to the epicenter of the injury in the treated animals compared to the control mini-pigs showed:(1)higher sparing of the grey matter and increased survivability of the spinal cord cells(lower number of Caspase-3-positive cells and decreased expression of Hsp27);(2)recovery of synaptophysin expression;(3)prevention of astrogliosis(lower area of glial fibrillary acidic protein-positive astrocytes and ionized calcium binding adaptor molecule 1-positive microglial cells);(4)higher growth rates of regeneratingβIII-tubulin-positive axons accompanied by a higher number of oligodendrocyte transcription factor 2-positive oligodendroglial cells in the lateral corticospinal tract region.These results revealed the efficacy of intravenous infusion of the autologous genetically-enriched leucoconcentrate producing recombinant VEGF,GDNF,and NCAM in the acute phase of spinal cord injury on the positive changes in the post-traumatic remodeling nervous tissue at the site of direct injury.Our data provide a solid platform for a new ex vivo gene therapy for spinal cord injury and will facilitate further translation of regenerative therapies in clinical neurology. | Maria Aleksandrovna Davleeva Ravil Rasimovich Garifulin Farid Vagizovich Bashirov Andrei Aleksandrovich Izmailov Leniz Faritovich Nurullin Ilnur Ildusovich Salafutdinov Dilara Zilbarovna Gatina Dmitrij Nikolaevich Shcherbinin Andrei Aleksandrovich Lysenko Irina Leonidovna Tutykhina Maksim Mikhailovich Shmarov Rustem Robertovich Islamov | 2023 | Neural Regeneration Research2023，18，7： | 1 |
| 16 | Distribution and antifungal susceptibility of Candida species causing nosocomial candiduria 显示文摘 | BETIL OZHAK-BAYSAN DILARA OGUNC DILEK CO- LAK | 2012 | Med Mycol2012，50，： | 1 |
| 17 | Appendiceal endometriosis: two case reports显示文摘 | Hakan Uncu Dilara Taner | 2008 | Archives of Gynecology and Obstetrics2008，，3： | 1 |
| 18 | Effects of ultrasonic energy on dyeing of polyamide (microfibre)/Lycra blends显示文摘 | Nigar Merdan Mehmet Akalin Dilara Kocak Ismail Usta | 2004 | Ultrasonics2004，，1： | 1 |
| 19 | An integrated approach to asses the PCDD/F emissions of the coal fired stoves combining emission measurements and ambient air levels modelling 显示文摘 | Paradic B Dilara P Horak J | 2008 | Chemosphere2008，73，1： | 1 |
| 20 | Road vehicle emission factors development: A review显示文摘 | Vicente Franco Marina Kousoulidou Marilena Muntean Leonidas Ntziachristos Stefan Hausberger Panagiota Dilara | 2013 | Atmospheric Environment2013，，： | 1 |
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