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| 1 | Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells显示文摘人的导致的 pluripotent 茎(iPS ) 房间类似于胚胎的茎(ES ) 房间,和罐头强烈地增殖并且区分进许多房间类型。然而,人的 iPS 房间的肝的区别还没被报导了。在这份报告,人的 iPS 房间被导致由一个逐步的协议区分进肝的房间。肝房间标记的表达式和人的 iPS 的肝相关的函数导出房间的房间被监视并且与区分的人的 ES 房间和主要人的 hepatocytes 的相比。在白天 7 点的约 60% 区分的人的 iPS 房间表示了肝的标记 alpha fetoprotein 和白长袍的。在白天 21 点的区分的房间包括白朊 Asecretion,肝糖合成,脲生产和可诱导的细胞色素 P450 活动展出了肝房间功能。肝的标记的表示和 iPS 的肝相关的功能导出房间的肝的房间比得上人的 ES 导出房间的肝的房间的。这些结果证明人的 iPS 房间,类似于人的 ES 房间,能高效地被导致区分房间进象 hepatocyte 一样。 | Zhihua Song Jun Cai Yanxia Liu Dongxin Zhao Jun Yong Shuguang Duo Xijun Song Yushan Guo Yang Zhao Han Qin Xiaolei Yin Chen Wu Jie Che Shichun Lu Mingxiao Ding Hongkui Deng | 2009 | Cell Research2009，19，11： | 63 |
| 2 | Recent advances in energy storage mechanism of aqueous zinc-ion batteries显示文摘Aqueous rechargeable zinc-ion batteries(ZIBs)have recently attracted increasing research interest due to their unparalleled safety,fantastic cost competitiveness and promising capacity advantages compared with the commercial lithium ion batteries.However,the disputed energy storage mechanism has been a confusing issue restraining the development of ZIBs.Although a lot of efforts have been dedicated to the exploration in battery chemistry,a comprehensive review that focuses on summarizing the energy storage mechanisms of ZIBs is needed.Herein,the energy storage mechanisms of aqueous rechargeable ZIBs are systematically reviewed in detail and summarized as four types,which are traditional Zn^(2+)insertion chemistry,dual ions co-insertion,chemical conversion reaction and coordination reaction of Zn^(2+)with organic cathodes.Furthermore,the promising exploration directions and rational prospects are also proposed in this review. | Duo Chen Mengjie Lu Dong Cai Hang Yang Wei Han | 2021 | Journal of Energy Chemistry2021，30，3： | 12 |
| 3 | Stabilizing nickel sulfide nanoparticles with an ultrathin carbon layer for improved cycling performance in sodium ion batteries显示文摘Nanostructured 金属硫化物是为钠离子电池的潜在的电极材料;然而,他们典型地由于大体积变化和分泌物产品的溶解受不了很差的骑车的稳定性。此处,我们建议合理材料设计策略让基于硫化物的材料处理这些问题。拿镍硫化物(是的 NiS x ) 一个例子,我们证明它的电气化学的性能能被限制 NiS 在滤的 x nanoparticles 传导性的碳 nanotube 网络,并且与 ultrathin 碳涂层层稳定他们。碳层用作一个物理障碍减轻体积变化和活跃材料的溶解的效果。混合材料展出了一个大可逆特定的能力 > 超过 200 的 500 mAh/g 和优秀骑车稳定性骑车。作为电池阳极材料给 NiS x 的传统地有问题的性质,我们相信这里报导的观察高效反映我们的材料设计策略的有效性。 | Feipeng Zhao Qiufang Gong Brian Traynor Duo Zhang Jiaojiao Li Hualin Ye Fengjiao Chen Na Han Yeyun Wang Xuhui Sun Yanguang Li | 2016 | Nano Research2016，9，10： | 6 |
| 4 | Solvent-free nanocasting toward universal synthesis of ordered mesoporous transition metal sulfide@N-doped carbon composites for electrochemical applications显示文摘Transition metal sulfides (TMSs) have a wide range of applications owing to their intriguing properties.Significant efforts have been devoted to nanostructuring TMSs to enhance their properties and performance,still there is a high need in general synthesis of TMS nanostructures.Herein,for the first time,a simple solvent free reactive nanocasting approach that integrates solid precursor loading,in-situ sulfuration and carbonization into a single heating step is developed for the universal synthesis of ordered mesoporous TMS@N-doped carbon composites (denoted as OM-TMS@NCs) with methionine (Met) and metal chlorides as the precursors and the mesoporous silica (SBA-15) as the hard template.A series of OM-TMS@NCs with a hexagonal mesostructure,ultra-high surface areas (430-754 m2·g-1),large pore volumes (0.85-1.32 cm3·g-1),and unique TMS stoichiometries,including MoS2,Fe7S8,Co9S8,NiS,Cu7S4 and ZnS,are obtained.Two distinct structure configurations,namely,highly dispersed ultrathin TMS nanosheets within NCs and TMS@NC co-nanowire arrays,can be obtained depending on different metals.The structure evolution of the OM-TMS@NCs over the solvent-free nanocasting process is studied in detail for a deep understanding of the synthesis.As demonstrations,these materials are promising for electrocatalytic hydrogen evolution reaction and lithium ion storage with high performances. | Jiahui Zhu Zhi Chen Lin Jia Yuqi Lu Xiangru Wei Xiaoning Wang Winston Duo Wu Na Han Yanguang Li Zhangxiong Wu | 2019 | Nano Research2019，12，9： | 5 |
| 5 | Ammonia-treatment assisted fully encapsulation of Fe_2O_3 nanoparticles in mesoporous carbons as stable anodes for lithium ion batteries显示文摘To improve the initial coulombic efficiency and bulk density of ordered mesoporous carbons, active Fe2O3 nanoparticles were introduced into tubular mesopore channels of CMK-5 carbon, which possesses high specific surface area (>1700 m 2 g-1 ) and large pore volume (>1.8 cm 3 g-1 ). Fine Fe2O3 nanoparticles with sizes in the range of 5 7 nm were highly and homogenously encapsulated into CMK-5 matrix through ammonia-treatment and subsequent pyrolysis method. The Fe2O3 loading was carefully tailored and designed to warrant a high Fe2O3 content and adequate buffer space for improving the electrochemical performance. In particular, such Fe2O3 and mesoporous carbon composite with 47 wt% loading exhibits a considerably stable cycle performance (683 mAh g-1 after 100 cycles, 99% capacity retention against that of the second cycle) as well as good rate capability. The fabrication strategy can effectively solve the drawback of single material, and achieve a high-performance lithium electrode material. | Fei Han Wen-Cui Li Duo Li An-Hui Lu | 2013 | Journal of Energy Chemistry2013，22，2： | 4 |
| 6 | A survey on recent progress in control of swarm systems显示文摘It has been witnessed that swarm systems are superior to individual agents in performing complicated tasks. In recent years, new results in some branches of control for swarm systems have developed and investigated with respect to various objectives and scenarios. This survey is to take a glimpse into some newly developed control techniques for swarm systems, especially those presented after 2013. The covered topics include some up-to-date progress in the areas of consensus, formation, flocking, containment, optimal coverage/mission planning, and sensor networks. Contributions and connections of the mentioned references are discussed briefly.Based on the new results in control of swarm systems, some possible new future research topics are suggested. | Bing ZHU Lihua XIE Duo HAN Xiangyu MENG Rodney TEO | 2017 | Science China(Information Sciences)2017，60，7： | 3 |
| 7 | Characterization of insoluble dietary fiber from Pleurotus eryngii and evaluation of its effects on obesity-preventing or relieving effects via modulation of gut microbiota显示文摘The purpose of this study was to evaluate the obesity preventing or relieving effect of insoluble dietary fiber(IDF)from Pleurotus eryngii through its modulations on intestinal microbiota.The IDF was extracted and structurally characterized through FTIR,X-Ray and thermogravimetric(TG)analysis.The mice for in vivo experiments were divided into obesity preventing group(feeding high-fat diet while gavage IDF simultaneously)and obesity relieving group(IDF intervention after the establishment of the obese model)to evaluate its hypolipidemic effect.Results:The yield of P.eryngii IDF extracts was 56.49%(on P.eryngii dry weight base)with IDF content of 85.15%in the extracts.The in vivo results showed that the body weight of the obesity-preventing groups was still increasing after intervention with IDF,but the growth rate was lowered,and the abnormal lipid metabolism and inflammation syndromes were alleviated;the acetic acid content of the medium and low dose dietary fiber intervention groups was significantly higher than that of the normal group,and the structure of the intestinal flora was improved.The mice weight from the obesity-relieving group decreased significantly.The abnormal lipid metabolism and inflammation were alleviated.In conclusion,The IDF intervention decreased the abnormal lipid metabolism and inflammation in both obesity-preventing and relieving experiments.The intestinal flora structure was obviously improved.P.eryngii IDF is a good candidate as hypolipidemic agent. | Xiaoyun Han Duo Yang Song Zhang Xiaoli Liu Yuelong Zhao Chunyue Song Qingshen Sun | 2023 | Journal of Future Foods2023，3，1： | 2 |
| 8 | ~1H NMR analysis of the tolylene-2,4-diisocyanate-methanol reaction显示文摘Tolylene-2,4-diisocyanate(2,4-TDI) 1 reacts with methanol through two simultaneous paths in the polyurethane reaction,which involve two different intermediates-tolylene-4-carbamatic-2-isocyanate 2 and tolylene-2-carbamatic-4-isocyanate 3,and the final product is tolylene-2,4-dicarbamate 4.The-CH_3 chemical shifts in benzene ring in compounds 1,2,3 and 4 can be easily tested and well distinguished,through which those four compounds are quantified and their kinetics are investigated.It shows that four rate constants for the tolylene-2,4-diisocyanate-methanol reaction in CCl_4 at 50℃are k_1=9.6×10^(-2)h^(-2)mol^(-2)min^(-1), k_2=1.4×10^(-2)h^(-2)mol^(-2)min^(-1),k_3=4.0×10^(-3)h^(-2)mol^(-2)min^(-1),k_4=1.4×10^(-3)h^(-2)mol^(-2)min^(-1).(k_1 is the reaction rate constant from compounds 1 to 2;k_2 is the reaction rate constant from compounds 1 to 3;k_3 is the reaction rate constant from compounds 3 to 4;k_4 is the reaction rate constant from compounds 2 to 4). | Peng Fei Yang Yong De Han Tian Duo Li Jun Ying Li | 2010 | Chinese Chemical Letters2010，21，7： | 2 |
| 9 | Correlates of HIV infection among transgender women in two Chinese cities显示文摘Background:In an era when HIV transmission has been on the rise among men who have sex with men(MSM),transgender women may play a considerable role in China’s current HIV epidemic as a potential“bridge”of HIV transmission between homosexual and heterosexual populations.We sought to understand the risk behaviours and factors associated with HIV infection among transgender women in two cities in China.Methods:From January to December 2016,we recruited transgender women with the help of community-based organizations(CBOs)through a wide range of methods,including snowball sampling.After recruitment,we asked participants to fill out a structured questionnaire including questions about socio-demographics,sexual behaviours,condom use,substance use and uptake of health care services.HIV infection status was determined by using two different rapid testing reagents.Results:Among 498 subjects enrolled in this study,233 were from Shanghai and 265 were from Tianjin.The median age was 30 years(range:18-68;IQR:24-33).Of them,337(67.7%)preferred feminine dress,13(2.6%)had undergone transsexual operation and 68(13.7%)had used hormones for transition purposes.Nearly half(45.6%)reported having regular partners,and 351(70.5%)had casual partners.Regarding condom use,81.5%reported not always using condoms with stable partners,and 70.9%reported not using condoms with casual partners.Twentyfive(5.0%)had a history of buying sex and fifty-one(10.2%)had a history of selling sex in the past three months.A total of 200(40.2%)participants had used at least one kind of controlled substance in the past six months.The most commonly used substances were amyl nitrates(rush popper)(99.5%)and 5-MeO-DiPT(20.0%).Among rush popper users,170(85.4%)reported always having sex while on the drug,and 177(88.9%)reported increased sexual pleasure after using the drug.The HIV infection risk factors identified in our study were being located in Shanghai(aOR=9.35,95%CI=3.89-22.49),selling sex in the past three months(aOR=3.44,95%CI=1.31-9.01),and substance use in the past six months(aOR=5.71,95%CI=2.63-12.41).Conclusions:Transgender women bear a high HIV burden in the two Chinese cities.Those involved in commercial sex tended to have inconsistent condom use,leading to high risk of HIV infection.Substance use was an independent risk factor of HIV infection by increasing sexual activities and unprotected sex,which indicated an aggravated and complex situation with possible interacting syndemic factors that could cumulatively facilitate sexual risk behaviours and HIV infection in transgender women.There is an urgent need for innovative and appropriate HIV prevention programmes targeting this unique population.Efforts should be made to provide them with tailored services including persuasive communication on consistent condom use,substance use counselling and related referral services,all with the goal of reducing HIV epidemic among transgender women. | Duo Shan Mao-He Yu Jie Yang Ming-Hua Zhuang Zhen Ning Hui Liu Lu Liu Meng-Jie Han Da-Peng Zhang | 2018 | Infectious Diseases of Poverty2018，7，1： | 1 |
| 10 | Mesophilic bio-liquefaction of lincomycin manufacturing biowaste: The influence of total solid content and inoculum to substrate ratio显示文摘 | Duo Wu Fan Lü Han Gao Liming Shao Pinjing He | 2011 | Bioresource Technology2011，，10： | 1 |
| 11 | A novel xeno-free culture system for human retinal pigment epithelium cells显示文摘AIM: To find out an animal-free, xeno-free culture method for human fetal retinal pigment epithelium(fRPE) cells aiming for cell-replacement therapy. METHODS: Human AB serum, knock-out serum replacement(KSR) and B27 were supplemented as a substitute of fetal bovine serum(FBS) in culture medium of human fRPE cells. Cell morphology was examined by light microscope and transmission electron microscope. Proliferation ability was detected by cell cycle analysis and examination of KI67 expression. Apoptosis was analyzed using FACS. The expression ofRPE-specific markers was demonstrated by quantitative real-time polymerase chain reaction(qPCR), Western blot(WB) and immunocytochemistry. Paracrine function was determined using enzyme-linked immunosorbent assay method.RESULTS: Our results indicated that the optimum concentration of KSR was 15%, the optimum concentration of B27 was 2%, and the optimum concentration of human AB serum was 10%. fRPE cells cultured in 15% KSR and 2% B27 media showed repressed propagation and differentiation ability, and gradually lost epithelial morphology and RPE function. While fRPE cells cultured in 10% human AB serum media showed a typical cobblestone morphology with pigmentation, elevated proliferation ability, satisfying paracrine function and expressed RPE-specific markers. CONCLUSION: Our study indicates that culturing fRPE cells in 10% human AB serum-supplemented medium is more favorable compared with KSR, B27 and traditional FBS-supplemented mediums when fRPE cells are to be applied in cell-based therapy. | Han Shen Min Wang Duo Li Song-Tao Yuan Qing-Huai Liu | 2019 | International Journal of Ophthalmology(English edition)2019，12，4： | 1 |
| 12 | Review on HVDC cable terminations显示文摘With modern power utilities going green by utilising renewable energy technologies and the development of the smart power grid,high-voltage direct current(HVDC)technologies become more and more important in the energy transmission.In particular,HVDC cable systems play a prominent role in undersea power transmission and offshore renewable energy integration.As an essential part of a complete HVDC cable system,the cable termination is one of the most critical components.The mathematical and physical background of HVDC cable systems is discussed and the development of various types of HVDC cable terminations is reviewed.Regarding the non-uniform field distribution,the influence of temperature on the non-linear conductivity is briefly discussed.Furthermore,faults of terminations caused by inappropriate installation and testing of cable systems are discussed. | Hanyu Ye Tobias Fechner Xianzhang Lei Yi Luo Mingyu Zhou Zhengyi Han Haitian Wang Qikai Zhuang Ruoyu Xu Duo Li | 2018 | High Voltage2018，3，2： | 1 |
| 13 | Nanoengineered Polypyrrole‐Coated Fe2O3@C Multifunctional Composites with an Improved Cycle Stability as Lithium‐Ion Anodes显示文摘 | Fei Han Duo Li Wen‐Cui Li Cheng Lei Qiang Sun An‐Hui Lu | 2012 | Mater2012，，13： | 1 |
| 14 | DSCR9/miR-21-5p axis inhibits pancreatic cancer proliferation and resistance to gemcitabine via BTG2 signaling显示文摘The outcome of pancreatic adenocarcinoma(PAAD)patients is poor,given resistance to gemcitabine.Long noncoding RNA(lncRNA)has been implicated in the carcinogenesis of pancreatic cancer;however,its function and mechanism in PAAD resistance to gemcitabine(GEM)are yet unknown.Herein,we demonstrate that lncRNA DSCR9 is significantly reduced in PAAD in vitro and in vivo.CCK-8,BrdU and flow cytometry assays show that overexpression of DSCR9 markedly suppresses pancreatic cancer cell proliferation and invasion,and promotes apoptosis under gemcitabine treatment.BTG2 acts as a tumor suppressor by reducing the proliferation and invasion of pancreatic cancer cells and increasing gemcitabine-induced apoptosis.Immunofluorescence(IF)staining combined with fluorescence in situ hybridization(FISH)of pancreatic cancer tissues shows that DSCR9 and BTG2 are both increased in pancreatic cancer tissues.Luciferase assay shows that miR-21-5p simultaneously binds to DSCR9 and 3′UTR of BTG2;DSCR9 relieves miR-21-5p-induced inhibition of BTG2 by competing with BTG2 for miR-21-5p binding.Overexpression of miR-21-5p enhances the invasiveness of pancreatic cancer cells by promoting cancer cell proliferation and invasion and attenuating gemcitabine-induced apoptosis.Overexpression of miR-21-5p attenuates the effect of DSCR9 overexpression on BTG2 expression and invasiveness of pancreatic cancer cells.Finally,miR-21-5p expression is increased,while BTG2 expression is decreased in pancreatic cancer tissues.miR-21-5p is negatively correlated with DSCR9 and BTG2.In conclusion,the DSCR9/miR-21-5p/BTG2 axis modulates pancreatic cancer proliferation,invasion,and gemcitabine resistance. | Hui Huang Xia Li Xianlin Zhang Zhiqiang Li Duo Han Wenzhe Gao Ling Liu Cheng Peng Hongwei Zhu Xiao Yu | 2022 | Acta Biochimica et Biophysica Sinica2022，54，12： | 1 |
| 15 | Primary Malignant Melanoma of the Vagina A Retrospective Clinicopathologic Study of 44 Cases显示文摘 | Lingfang Xia Duo Han Wentao Yang | 2014 | Int J Gynecol Cancer2014，24，1： | 1 |
| 16 | Corrosion Resistance and Semiconducting Properties of Passive Films Formed on 00Cr13Ni5Mo2 Supermartensitic Stainless Steel in Cl^- Environment显示文摘The semiconducting properties of passive films grown on 00Cr13Ni5Mo2 supermartensitic stainless steel were investigated in comparison with conventional 2Cr13 martensitic stainless steel.Cyclic voltammetry and electrochemical impedance spectroscopy(EIS)were used for the studies.00Cr13Ni5Mo2 steel exhibited a good corrosion resistance performance,attributing to its passive capability.The results of Mott-Schottky analysis demonstrated ntype semiconductors for the passive films with doping densities of about 1020-1021 cm-3,and the thickness of spacecharge layers was also calculated.The experimental results confirmed that Mo plays an important role in improving the corrosion resistance of 00Cr13Ni5Mo2 steel due to its impact on the doping density. | De-ning ZOU Rong LIU Jiao LI Wei ZHANG Duo WANG Ying HAN | 2014 | Journal of Iron and Steel Research(International)2014，21，6： | 0 |
| 17 | Control Aggregation of P3HT in Solution for High Efficiency Doping:Ensuring Structural Order and the Distribution of Dopants显示文摘Molecular doping is one of the most important tools to manipulate the electrical properties of conjugated polymers for application in organic optoelectronics.The polymer crystallinity and distribution position of the dopant crucially determine electrical conductivity of the doped polymer.However,in solution-mixed doping,the interplay between polymer and dopant leads to highly structural disorder of polymer and random arrangement of dopant.Here,we propose a strategy to ensure the dopant induced polarons have high charge dissociation and transport by letting the conjugated polymers aggregate in the marginal solvent solution by cooling it from higher temperature to room temperature.We select poly(3-hexylthiophene-2,5-diyl)(P3HT)solution doped by 2,3,5,6-tetrafluoro-7,7,8,8-tetracyanoquinodimethane(F4TCNQ)as a model system.P3HT crystallizes in the marginal solvent,such as 1,1,2-trichloroethane(TCE)driven by the favorπ-πinteraction between planar polymer backbone.The dopant F4TCNQ enters the alkyl side chain region not theπ-πstacking region and thus guarantees high crystallinity and theπ-πinteraction of P3HT.This distribution of F4TCNQ which away from the polymer backbone to ensure higher charge dissociation and transport.Finally,we obtained a high conductivity value of 23 S/cm by doping P3HT with 20%F4TCNQ by using the marginal solvent,which is higher than doping P3HT with a disordered coil conformation in chlorobenzene(CB)of 7 S/cm,which the dopants enter both the alkyl side chain region and theπ-πstacking region. | Duo Liu Jun-Hang Li Si-Chun Wang Lu Zhang Xin-Yu Liu Qiang Zhang Yan-Chun Han | 2023 | Chinese Journal of Polymer Science2023，41，5： | 0 |
| 18 | A novel selective ERK1/2 inhibitor,Laxiflorin B,targets EGFR mutation subtypes in non-small-cell lung cancer显示文摘Extracellular regulated protein kinases 1/2(ERK1/2)are key members of multiple signaling pathways,including the ErbB axis.Ectopic ERK1/2 activation contributes to various types of cancer,especially drug resistance to inhibitors of RTK,RAF and MEK,and specific ERK1/2 inhibitors are scarce.In this study,we identified a potential novel covalent ERK inhibitor,Laxiflorin B,which is a herbal compound with anticancer activity.However,Laxiflorin B is present at low levels in herbs;therefore,we adopted a semi-synthetic process for the efficient production of Laxiflorin B to improve the yield.Laxiflorin B induced mitochondria-mediated apoptosis via BAD activation in non-small-cell lung cancer(NSCLC)cells,especially in EGFR mutant subtypes.Transcriptomic analysis suggested that Laxiflorin B inhibits amphiregulin(AREG)and epiregulin(EREG)expression through ERK inhibition,and suppressed the activation of their receptors,ErbBs,via a positive feedback loop.Moreover,mass spectrometry analysis combined with computer simulation revealed that Laxiflorin B binds covalently to Cys-183 in the ATP-binding pocket of ERK1 via the D-ring,and Cys-178 of ERK1 through non-inhibitory binding of the A-ring.In a NSCLC tumor xenograft model in nude mice,Laxiflorin B also exhibited strong tumor suppressive effects with low toxicity and AREG and EREG were identified as biomarkers of Laxiflorin B efficacy.Finally,Laxiflorin B-4,a C-6 analog of Laxiflorin B,exhibited higher binding affinity for ERK1/2 and stronger tumor suppression.These findings provide a new approach to tumor inhibition using natural anticancer compounds. | Cheng-Yao Chiang Min Zhang Junrong Huang Juan Zeng Chunlan Chen Dongmei Pan Heng Yang Tiantian Zhang Min Yang Qiangqiang Han Zou Wang Tian Xiao Yangchao Chen Yongdong Zou Feng Yin Zigang Li Lizhi Zhu Duo Zheng | 2024 | Acta Pharmacologica Sinica2024，45，2： | 0 |
| 19 | HIV incidenee and risk factors among transgender women and cisgender men who have sex with men in two cities of China:a prospective cohort study显示文摘Background:HIV epidemic among men who have sex with men(MSM)remains a major public health concern in China.Despite a growing body of research on transgender women worldwide,little is known about Chinese transgender women within MSM.We sought to estimate HIV incidence and distinguish risk factors of HIV acquisition among them from that among cisgener(non-transgender)MSM(cis-MSM).Methods:We conducted an open cohort study among Chinese MSM,including those who were identifed as transgender in Shanghai and Tianjin.Participants were initially recruited by local community-based organizations from January to June,2016,and were followed up approximately every 6 months until June 2018.At each visit,a structured questionnaire was used to gather information on demographics,sexual risk behaviors,and HIV status.HIV incidence was calculated as the number of seroconversions divided by total number of person-years of follow-up among HIV-negatives at baseline.Risk factors of HIV acquisition were assessed by univariate and multivariate Cox regression models with time-dependent variables.Results:A total of 1056 participants contributed 1260.53 person-years(PYs)of follow-up,33 HIV seroconversions occurred during the follow-up period,yielding an estimated HIV incidence of 2.62(95%CI 1.80–3.68)per 100 PYs.HIV incidence among transgender women was 4.42 per 100 PYs,which was signifcantly higher than that of 1.35 per 100 PYs among cis-MSM,demonstrating a threefold higher odds of HIV infection than cis-MSM.For transgender women,those lived locally≤2 years(adjusted hazard ratio[aHR]=1.76,95%CI 1.13–2.76)and unprotected anal sex last time(aHR=4.22,95%CI 1.82–9.79)were more likely to acquire HIV.For cis-MSM,factors associated with HIV acquisition were frequency of anal sex≥3 times in past one month(aHR=4.19,95%CI 1.06–16.47)and unprotected anal sex last time(aHR=5.33,95%CI 1.52–18.73).Conclusions:Compared to cis-MSM,transgender women were at higher risk of HIV acquisition,highlighting an urgent need of tailored prevention.Future HIV program should consider to include them to ensure that this population in China are not left behind. | Duo Shan Zhen Ning Maohe Yu Huang Zheng Jie Yang Hui Gong Jian Li Hui Liu Lu Liu Vania Wang Xiong Ran Mengjie Han Dapeng Zhang | 2022 | Infectious Diseases of Poverty2022，11，2： | 0 |
| 20 | Systemic delivery of microRNA for treatment of brain ischemia显示文摘Brain ischemia is the second leading cause of death and the third leading cause of disability in the world.Systemic delivery of microRNA,a class of molecules that regulate the expression of cellular proteins associated with angiogenesis,cell growth,proliferation and differentiation,holds great promise for the treatment of brain ischemia.However,their therapeutic efficacy has been hampered by poor delivery efficiency of microRNA.We report herein a platform technology based on microRNA nanocapsules,which enables their effective delivery to the disease sites in the brain.Exemplified by microRNA-21,intravenous injection of the nanocapsules into a rat model of cerebral ischemia could effectively ameliorate the infarct volume,neurological deficit and histopathological severity. | Chaoyong Liu Jing Wen Dai Li Hongzhao Qi Lina Nih Jialin Zhu Duo Xu Yu Ren Shanshan Zhang Donglin Han Huanhuan Jia Junhu Zhou Meng Qin Jialing Wu Xubo Yuan Ji Liu Jin Zhao Chunsheng Kang Yunfeng Lu | 2021 | Nano Research2021，14，9： | 0 |
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