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| 1 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 2 | RETROPERITONEAL LAPAROSCOPIC RADICAL NEPHRECTOMY: THE CLEVELAND CLINIC EXPERIENCE显示文摘 | INDERBIR S. GILL DANA SCHWEIZER MICHAEL G. HOBART GYUNG TAK SUNG ERIC A. KLEIN ANDREW C. NOVICK | 2000 | The Journal of Urology2000，，6： | 2 |
| 3 | Nephrectomy Induced Chronic Renal Insufficiency is Associated With Increased Risk of Cardiovascular Death and Death From Any Cause in Patients With Localized cT1b Renal Masses显示文摘 | Christopher J. Weight Benjamin T. Larson Amr F. Fergany Tianming Gao Brian R. Lane Steven C. Campbell Jihad H. Kaouk Eric A. Klein Andrew C. Novick | 2010 | The Journal of Urology2010，，： | 2 |
| 4 | The Forgotten Indwelling Ureteral Stent: A Urological Dilemma显示文摘 | Manoj Monga Eric Klein Wilfrido R. Castaneda-Zuniga Raju Thomas | 1995 | The Journal of Urology1995，，6： | 1 |
| 5 | Expression of the α -tocopherol transfer protein gene is regulated by oxidative stress and common single-nucleotide polymorphisms显示文摘 | Lynn Ulatowski Cara Dreussi Noa Noy Jill Barnholtz-Sloan Eric Klein Danny Manor | 2012 | Free Radical Biology and Medicine2012，，： | 1 |
| 6 | IT support in manufacturing firms for a knowledge management dynamic capabilities link to performance 显示文摘 | Wang Eric Klein Gary Jiang James J | 2007 | International Journal of Production Research2007，45，： | 1 |
| 7 | Mean values of Dedekind sums显示文摘 | ERIC Fransen ROBERT Klein | 1996 | Journal of Number Theory1996，56，： | 1 |
| 8 | Contemporary Mortality Risk Prediction for Percutaneous Coronary Intervention显示文摘 | Eric D. Peterson David Dai Elizabeth R. DeLong J. Matthew Brennan Mandeep Singh Sunil V. Rao Richard E. Shaw Matthew T. Roe Kalon K.L. Ho Lloyd W. Klein Ronald J. Krone William S. Weintraub Ralph G. Brindis John S. Rumsfeld John A. Spertus | 2010 | Journal of the American College of Cardiology2010，，18： | 1 |
| 9 | A genomic approach to active surveillance: a step toward precision medicine显示文摘 | Eric A Klein | 2013 | Asian Journal of Andrology2013，15，3： | 1 |
| 10 | Vaccinations Given During Pregnancy, 2002–2009 A Descriptive Study显示文摘 | Allison L. Naleway Samantha Kurosky Michelle L. Henninger Rachel Gold James D. Nordin Elyse O. Kharbanda Stephanie Irving T.Craig Cheetham Cynthia Nakasato Jason M. Glanz Simon J. Hambidge Robert L. Davis Nicola P. Klein Natalie L. McCarthy Eric Weintraub | 2013 | American Journal of Preventive Medicine2013，，： | 1 |
| 11 | IT support in manufacturing firms for a knowledge management dynamic capability link to performance显示文摘 | Eric Wang Gary Klein James J. Jiang | 2007 | International Journal of Production Research2007，，11： | 1 |
| 12 | ACC/AHA/ESC Guidelines for the Management of Patients With Atrial Fibrillation: Executive Summary A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee 显示文摘 | Valentin Fuster Lars E. Ryden Richard W. Asinger David S. Cannom Harry J. Crijns Robert L. Frye Jonathan L. Halperin G. Neal Kay Werner W. Klein Samuel Levy Robert L. McNamara Eric N. Prystowsky L. Samuel Wann D. George Wyse Raymond J. Gibbons Elliott M. | 2001 | Circulation: Journal of the American Heart Association2001，，17： | 1 |
| 13 | Room shielding for intensity-modulated radiation therapy treatment facilities 显示文摘 | Sasa Mutic Dantel A Low Eric E Klein | 2001 | Int J Radiation Oncology Biol Phys2001，50，1： | 1 |
| 14 | Peripancreatic tuberculosis mimicking pancreatic neoplasia显示文摘 | Eric S. Weiss M.D. Walter M. Klein M.D. Charles J. Yeo M.D | 2005 | Journal of Gastrointestinal Surgery2005，，2： | 1 |
| 15 | Mean values of dedekind sums显示文摘 | Conrey J B Eric Fransen Robert Klein and Clayton Scott | 1996 | Journal of Number Theory1996，56，： | 1 |
| 16 | IT support in manufacturing firms for a knowledge management dynamic capability link to performance显示文摘 | Eric Wang Gary Klein James J. Jiang | 2007 | International Journal of Production Research2007，，11： | 1 |
| 17 | Impact of Ethnicity and Gender Differences on Angiographic Coronary Artery Disease Prevalence and In-Hospital Mortality in the American College of Cardiology–National Cardiovascular Data Registry显示文摘 | Leslee J. Shaw Richard E. Shaw C Noel Bairey Merz Ralph G. Brindis Lloyd W. Klein Brahmajee Nallamothu Pamela S. Douglas Ronald J. Krone Charles R. McKay Peter C. Block Kathleen Hewitt William S. Weintraub Eric D. Peterson | 2008 | Circulation2008，，14： | 1 |
| 18 | Nephrectomy Induced Chronic Renal Insufficiency is Associated With Increased Risk of Cardiovascular Death and Death From Any Cause in Patients With Localized cT1b Renal Masses显示文摘 | Christopher J. Weight Benjamin T. Larson Amr F. Fergany Tianming Gao Brian R. Lane Steven C. Campbell Jihad H. Kaouk Eric A. Klein Andrew C. Novick | 2010 | The Journal of Urology2010，，4： | 1 |
| 19 | Are Biochemical Recurrence Outcomes Similar After Radical Prostatectomy and Radiation Therapy? Analysis of Prostate Cancer–Specific Mortality by Nomogram-predicted Risks of Biochemical Recurrence显示文摘 | Byron H. Lee Adam S. Kibel Jay P. Ciezki Eric A. Klein Chandana A. Reddy Changhong Yu Michael W. Kattan Andrew J. Stephenson | 2014 | European Urology2014，，： | 1 |
| 20 | Commercial absorption chiller models for evaluation of control strategies显示文摘 | Sanford A Klein John W Mitchell | 1995 | ASHRAE Trans1995，101，1： | 1 |
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