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| 1 | SPSBl-mediated HnRNP A1 alternative splicing and cell ubiquitylation regulates migration in EGF signaling显示文摘细胞外的信号被显示了影响拼接的其他的 pre-mRNA;然而,分子的机制和导致信号的拼接的规定的生物意义仍然保持大部分未知。这里,我们报导那个表皮的生长因素(EGF ) 通过一个著名拼接管理者的 ubiquitylation 导致拼接的变化, hnRNP A1。EGF 发信号 upregulates 一个 E3 ubiquitin (Ub ) ligase 适配器,敏捷的包含域的 SOCS 盒子蛋白质 1 (SPSB1 ) ,它结合离氨酸 29 连接 polyUb 链到 hnRNP A1 上的成员 Elongin B/C-Cullin 建筑群。重要地, hnRNP A1 的 SPSB1 和 ubiquitylation 在驾驶 EGF 的房间移植有一个关键角色。机械学地,和 SR 蛋白质 kinases (SRPK ) 的激活的 hnRNP A1 的导致 EGF 的 ubiquitylation 导致拼接的 Rac1 的 upregulation isoform, Rac1b,支持房间活动性。这些调查结果解开在蛋白质 ubiquitylation 并且在 EGF/EGF 受体发信号的其他的拼接之间的新奇串音,并且在 modulating 房间移植识别新 EGF/SPSB1/hnRNP A1/Rac1 轴,它可以为癌症治疗有重要含意。 | Feng Wang Xing Fu Peng Chen Ping Wu Xiaojuan Fan Na Li Hong Zhu Ting-Ting Jia Hongbin Ji Zefeng Wang Catherine C L Wong Ronggui Hu Jingyi Hui | 2017 | Cell Research2017，27，4： | 5 |
| 2 | A confidence limit for the empirical mode decomposition and Hilbert spectral analysis显示文摘 | Huang Norden E Wu Man-Li C Long Steven R Shen Samuel S.P Qu Wendong Gloersen Per Fan Kuang L | 2003 | Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences . 2003 (2037)2003，，2037： | 3 |
| 3 | Headspace solid phase microextraction and gas chromatography-olfactometry dilution analysis of young and aged Chinese'Yanghe Daqu'liquors显示文摘 | Fan W L Qian M C | 2005 | Journal of Agricultural and Food Chemistry2005，53，20： | 2 |
| 4 | A confidence limit for the empirical mode decomposition and Hilbert spectral analysis显示文摘 | Huang Norden E Wu Man-Li C Long Steven R Shen Samuel S.P Qu Wendong Gloersen Per Fan Kuang L | 2003 | Proceedings of the Royal Society A: Mathematical Physical and Engineering Sciences2003，，2037： | 2 |
| 5 | Characterization of aroma compounds in apple cider using solvent-assisted flavor evaporation and headspace solid-phase microextraction显示文摘 | XU Y FAN W L QIAN M C | 2007 | J Agric Food Chem2007，55，8： | 1 |
| 6 | Mesotunnels on the silica wall of ordered SBA-15 to generate three-dimensional large-pore mesoporous networks显示文摘 | Yu C Wang L | 2001 | J Am Chem SCc2001，123，12： | 1 |
| 7 | Glibert,Effects of light on nitrogen and carbon uptake during a Prorocentrum minimum bloom显示文摘 | PATRICIA M | 2005 | Harmful Algae2005，，4： | 1 |
| 8 | Time-dependent fundamental solutions for homogeneous diffusion problems显示文摘 | Young D L Tsai C C Murugesan K Fan C M Chen C W | 2004 | Engineering Analysis with Boundary Elements2004，28，： | 1 |
| 9 | Innovative design of a new CMM bridge 显示文摘 | Fan K C Wang W L Chen F | 2004 | Chin J Mech Eng2004，17，2： | 1 |
| 10 | Geochronology and geochemistry of the Hegenshan ophiofitic complex: Implications for late-stage tectonic evolution of the Inner Mongolia-Daxinganling Orogenic Belt, China显示文摘 | Miao L C Fan W M Liu D Y | 2008 | Journal of Asian Each Sciences2008，32，： | 1 |
| 11 | A CDM-based study of fatigue-creep interaction behavior显示文摘 | Fan Z C Chen X D Chen L | 2009 | International Journal of Pressure Vessels and Piping2009，86，9： | 1 |
| 12 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 13 | Process configurations adapted to membrane bioreactors for enhanced biological phosphorus and nit rogen removal 显示文摘 | L ESJ FAN B GNIRSS R ADAM C | 2002 | Desalination2002，149，： | 1 |
| 14 | Urbanization from below:the growth of towns in Jiangsu,China显示文摘 | Ma L J C Fan M | 1994 | Urban Studies1994，31，10： | 1 |
| 15 | Hedging with the Nikkei index futures:the conventional model versus the error correction model显示文摘 | Chou W L Fan K K Lee C F | 1996 | Quarterly Review of Economics and Finance1996，36，： | 1 |
| 16 | Urbanization from Below: The Growth of Towns in Jiangsu, China显示文摘 | Ma L J C Fan M | 1994 | Urban Studies1994，31，10： | 1 |
| 17 | Fertility sparing therapy for ovarian cancer has inherent risks and benefits显示文摘 | Douglas N C Fan L Pothuri B | 2005 | Arch Gynecol Obstet2005，272，4： | 1 |
| 18 | 显示文摘 | Tang X D Gao L C Fan X H | 2007 | J Polym Sci Part A: Polym Chem2007，45，： | 1 |
| 19 | Natural variation in GS5 plays an important role in regulating grain size and yield in rice显示文摘 | Li Y B Fan C C Xing Y Z Jiang Y H Luo L J Sun L Shao D Xu C J Li X H Xiao J H He Y Q Zhang Q F | 2011 | Nature genetics2011，2，43： | 1 |
| 20 | Using LMDI method to analyze the change of China's industrial CO2 emissions from final fuel use:an empirical analysis显示文摘 | Liu L C Fan Y Wu G Wei Y M | | 0，，11： | 1 |
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