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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria显示文摘 | Bruno Dubois Howard H Feldman Claudia Jacova Harald Hampel José Luis Molinuevo Kaj Blennow Steven T DeKosky Serge Gauthier Dennis Selkoe Randall Bateman Stefano Cappa Sebastian Crutch Sebastiaan Engelborghs Giovanni B Frisoni Nick C Fox Douglas Galasko Ma | 2014 | Lancet Neurology2014，，6： | 7 |
| 3 | Developments in on-line,electron-beam emittence measurements using optical-transition radiation techniques显示文摘 | Feldman R B Lumpkin A H | 1990 | Nuclear Instruments and Methods in Physics Research1990，296，： | 2 |
| 4 | Causes of Alzheimer's disease显示文摘 | Feldman H | 2000 | CMAJ2000，162，： | 1 |
| 5 | Coxsackievirus B3 induces T regulatory cells, which inhibit cardiomyopathy in tumor necrosis factor-α transgenic mice显示文摘 | H uber SA Feldman AM Sartini D | 2006 | Circ Res2006，99，10： | 1 |
| 6 | Impotence and its medical and psychosocial correlations: results of the Massachusetts male aging study 显示文摘 | Tenover J Feldman H A Goldstein I | 1994 | J Urol1994，151，1： | 1 |
| 7 | Clinical determination of myocardial vs load effects of OPC-18790,a novel intravenous agent for the treatment of patients with congestive heart failure显示文摘 | Feldman M D Haber H L Wu C C | 1993 | Circulation1993，88，42： | 1 |
| 8 | Parental karyotype andsubsequentlive births in recurrent misearriage显示文摘 | CARP H FELDMAN B OELSNER Q | 2004 | Fertility and Sterifity2004，81，5： | 1 |
| 9 | Competing on standards? Entrepreneurship, intellectual property, and platform technologies 显示文摘 | Simcoe T Graham S J H Feldman M P | 2009 | Journal of Economics & Management Strategy2009，18，： | 1 |
| 10 | Parental karyotype and subsequent live births in recurrent miscarriage 显示文摘 | Carp H Feldman B Oelsner Q | 2004 | Fertil Steril2004，81，5： | 1 |
| 11 | Effects of decreasing sugar-sweetened beverage consumption on body weight in adolescents:a randomized,controlled pilot study显示文摘 | EBBELING C B FELDMAN H A OSGANIAN S K | | 0，，03： | 1 |
| 12 | Hopeful choices: A school counselorg guide to hope theory显示文摘 | Snyder C R Feldman D Shorey H Rand K | 2002 | Journal of Personality2002，5，5： | 1 |
| 13 | A 24-week,randomized double-blind study of donepezil in moderate to severe Alzheimer's disesse显示文摘 | Feldman H Gauthier S Hecker J | 2001 | Neurology2001，57，： | 1 |
| 14 | Characterization of a Calcium/calmodulin-dependent Protein Kinase Homolog from Maiz Roots Showing Light-regulated Gravitropism显示文摘 | Lu Y T Hidaka H Feldman L J | 1996 | Planta1996，199，： | 1 |
| 15 | Antiangiogenic gene therapy of cancer utilizing a recombinant adenovirus to elevate systemic endostatin levels in mice显示文摘 | Feldman A L Restifo N P Alexander H R | 2000 | Cancer Res2000，，60： | 1 |
| 16 | Serum endostatin levels are elevated in patients with soft tissue sarcoma显示文摘 | Feldman AL Pak H Yang JC | 2001 | Cancer2001，91，8： | 1 |
| 17 | Impotencean dits medical and psychosocial correlates:results of the massachusetts male aging study显示文摘 | Feldman H A Goldstein I Hatzichristou D G | 1994 | J Urol1994，151，1： | 1 |
| 18 | Parenteral ketorolac and risk of gastrointestinal and operative side bleeding: a postmarketing survillence study显示文摘 | Strom BL Berlin JA Kinman MA Spitz PW Hennessy S Feldman H | 1996 | JAMA1996，275，： | 1 |
| 19 | Treatment of Alzheimer's disease: current status and new perspectives显示文摘 | SCARPINI E SCHELTENS P FELDMAN H | 2003 | Lancet Neurol2003，2，9： | 1 |
| 20 | Translating research into practice: Transitional care for older adults 显示文摘 | Naylor M D Feldman P H Keating S | 2009 | J Eval Clin Pract2009，15，6： | 1 |
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