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| 1 | The acidic tumor microenvironment: a target for smart cancer nano-theranostics显示文摘The acidic tumor microenvironment(TME), which mainly results from the high glycolytic rate of tumor cells, has been characterized as a hallmark of solid tumors and found to be a pivotal factor participating in tumor progression. Recently, due to the increasing understanding of the acidic TME, it has been shown that the acidic TME could be utilized as a multifaceted target during the design of various pH-responsive nanoscale theranostic platforms for the precise diagnosis and effective treatment of cancers. In this article,we will give a focused overview on the latest progress in utilizing this characteristic acidic TME as the target of nano-theranostics to enable cancer-specific imaging and therapy. The future perspectives in the development of acidic TME-targeting nanomedicine strategies will be discussed afterwards. | Liangzhu Feng Ziliang Dong Danlei Tao Yicheng Zhang Zhuang Liu | 2018 | National Science Review2018，5，2： | 14 |
| 2 | Two gap-free reference genomes and a global view of the centromere architecture in rice显示文摘Rice(Oryza sativa),a major staple throughout the world and a model system for plant genomics and breeding,was the first crop genome sequenced almost two decades ago.However,reference genomes for all higher organisms to date contain gaps and missing sequences.Here,we report the assembly and analysis of gap-free reference genome sequences for two elite O.sativa xian/indica rice varieties,Zhenshan 97 and Minghui 63,which are being used as a model system for studying heterosis and yield.Gap-free reference genomes provide the opportunity for a global view of the structure and function of centromeres.We show that all rice centromeric regions share conserved centromere-specific satellite motifs with different copy numbers and structures.In addition,the similarity of CentO repeats in the same chromosome is higher than across chromosomes,supporting a model of local expansion and homogenization.Both genomes have over 395 non-TE genes located in centromere regions,of which∼41%are actively transcribed.Two large structural variants at the end of chromosome 11 affect the copy number of resistance genes between the two genomes.The availability of the two gap-free genomes lays a solid foundation for further understanding genome structure and function in plants and breeding climate-resilient varieties. | Jia-Ming Song Wen-Zhao Xie Shuo Wang Yi-Xiong Guo Dal-Hoe Koo Dave Kudrna Chenbo Gong Yicheng Huang Jia-Wu Feng Wenhui Zhang Yong Zhou Andrea Zuccolo Evan Long Seunghee Lee Jayson Talag Run Zhou Xi-Tong Zhu Daojun Yuan Joshua Udall Weibo Xie Rod AWing Qifa Zhang Jesse Poland Jianwei Zhang Ling-Ling Chen | 2021 | Molecular Plant2021，14，10： | 9 |
| 3 | Rat model of cholelithiasis with human gallstones implanted in cholestasis-induced virtual gallbladder显示文摘AIM:To facilitate translational research on cholelithiasis,we have developed a rat model of human gallstones by exploiting the unique biliopancreatic features of this species.METHODS:Under anesthesia,16 adult rats of equal genders underwent two times of abdominal surgery.First,their common bile duct(CBD)was ligated to cause cholestasis by total biliary obstruction(TBO).On day 0,1,3,7,14,21 and 28 after TBO,magnetic resonance imaging(MRI)was conducted to monitor the dilatation of the CBD,and blood was sampled to analyze total serum bilirubin(TSB).Secondly,on day 30,the abdomen was re-opened and gallstone(s)collected from human patients were implanted in the dilated CBD asa virtual gallbladder(VGB),which was closed by suture ligation.This rat cholelithiasis model was examined by MRI,clinical observation,microcholangiography and histology.RESULTS:All rats survived two laparotomies.After ligation,the CBD was dilated to a stable size of 4 to30 mm in diameter on day 21-28,which became a VGB.The rats initially showed signs of jaundice that diminished over time,which paralleled with the evolving TSB levels from 0.6±0.3 mg/d L before ligation,through a peak of 10.9±1.9 mg/dL on day 14,until a nearly normalized value after day 28.The dilated CBD with thickened wall allowed an incision for implantation of human gallstones of 1-10 mm in diameter.The rat cholelithiasis was proven by in vivo MRI and postmortem microcholangiography and histomorphology.CONCLUSION:A rat model cholelithiasis with human gallstones has been established,which proves feasible,safe,reliable,nontoxic and cost-effective.Given the gallstones of human origin,applications of this model may be of help in translational research such as optical detection and lysis of gallstones by systemic drug administration. | Marlein Miranda Cona Yewei Liu Ting Yin Yuanbo Feng Feng Chen Stefaan Mulier Yue Li Jian Zhang Raymond Oyen Yicheng Ni | 2016 | World Journal of Methodology2016，6，2： | 7 |
| 4 | Viral MIPα homologous with human MIP-1α acts on HIV co-receptor CCR5显示文摘The function and usage of vMIPα encoded by K6 gene of herpesvirus 8 (HHV8) which has homology with human macrophage protein (MIP) have not been clearly known. In the present note the K6 gene of HHV8 was cloned and transfected into NIH3T3 cells and E. coli cells. Conditional media from the 3T3-transfected cells and K6 product vMIPa from E. coli. Cells were used to perform the experiments of ligand-receptor binding and cellular adhesion with peripheral blood macrophages. The conditional media and the purified vMIPa from E. coli could compete to bind to CCR5 located on macrophages from peripheral blood with I125-hMIP-1α chemokine of human. Cellular adhesion showed that the conditional media from transfected cells and the purified vMIPa did not induce the adhesion of macrophages from peripheral blood to ICAM-1. In conclusion, vMIPα encoded by K6 gene of HHV8 can bind to CCR5 of peripheral blood macrophage cells and does not induce their adhesion. This suggests that vMIPa enclosed CCR5, also known as HIV | Hanxiao Sun Lixia Feng Yicheng Li Wenfang He | 2001 | Chinese Science Bulletin2001，46，15： | 6 |
| 5 | An Intramolecular Charge Transfer and Aggregation Induced Emission Enhancement Fluorescent Probe Based on 2-Phenyl-1,2,3-triazole for Highly Selective and Sensitive Detection of Homocysteine and Its Application in Living Cells显示文摘Summary of main observation and con elusion In this work,a new simple and readily synthesized turn-on probe 2-(4-anthracene-9-yl-phenyl)-2H-[l,2,3]triazole-4-carbaldehyde(APTC)was legitimately designed towards homocysteine(Hcy).Moreover,APTC has excellent optical properties such as intramolecular charge transfer(ICT)and aggregation induced emission enhancement(AIEE)characteristics,indicating its extensive application potentiality.What's more,APTC displayed rapid,high selectivity and specificity towards homocysteine over cysteine/glutathione.The detection limit of APTC for Hcy was as low as 2.198×10^-8 mol·L^-1,and the response time was only 5 min.APTC has been successfully applied to detect Hcy in silica gel plates and living cells,which indicates that APTC has good stability and biocompatibility as a selective probe for Hcy.Finally,the mechanism was studied using 1H NMR titration experiments and mass spectrometry. | Yicheng Chu Zhengfeng Xie Daijiao Zhuang Yongshuang Yue Yuhua Yue Wei Shi Shun Feng | 2019 | Chinese Journal of Chemistry2019，37，12： | 5 |
| 6 | Pancreatic imaging:Current status of clinical practices and small animal studies显示文摘Different causative factors acting on the pancreas can result in diseases such as pancreatitis, diabetes and pancreatic tumors. The high incidence and mortality of pancreatic diseases have placed diagnostic imaging in a crucial position in daily clinical practice. In this minireview article different pancreatic imaging techniques are discussed, from the standard clinical imaging modalities and state of the art clinical magnetic resonance imaging techniques to current situations in pre-clinical pancreatic imaging studies. In particular, the challenges of pre-clinical rodent pancreatic imaging are addressed, with both the image acquisition techniques and the post-processing methods for rodent pancreatic imaging elaborated. | Ting Yin Yewei Liu Ronald Peeters Yuanbo Feng Yicheng Ni | 2017 | World Journal of Methodology2017，7，3： | 2 |
| 7 | Polarization behavior of microbial fuel cells under stack operation显示文摘The polarization behavior of microbial fuel cells(MFCs)was evaluated under different stack operation modes,including series,parallel,series–parallel,and parallel–series.During the stack operation,voltages of individual MFCs,subunit stacks,and overall stacks were recorded as a function of the current.Meanwhile,the potentials of individual MFCs’anode and cathode were also determined via Ag/AgCl electrodes to study the change in potentials under stack operations.The results demonstrated that the MFCs with relatively low ability to generate current were easier to suffer polarity reversal in the series stack,which was confirmed in the series subunit of the series–parallel stack.MFCs with high electroactivity would be enhanced to generate larger maximum power;however,MFCs with low electroactivity outputted smaller maximum power in a parallel stack.The changes in individual MFCs’behavior under stack operation mode were determined primarily caused by the influences on the behavior of the anode.Results of the present study provide valuable information for optimization of stack operation of MFCs. | Zejie Wang Yicheng Wu Lu Wang Feng Zhao | 2014 | Chinese Science Bulletin2014，59，18： | 2 |
| 8 | A modified rabbit model of reperfused myocardial infarction for cardiac MR imaging research显示文摘 | Yuanbo Feng Yi Xie Huaijun Wang Feng Chen Yuxiang Ye Lixin Jin Guy Marchal Yicheng Ni | 2009 | The International Journal of Cardiovascular Imaging2009，，3： | 1 |
| 9 | A Hybrid Approach for Generating Secure and Discriminating Face Template显示文摘 | FENG Yicheng YUEN P C JAIN A K | 2010 | IEEE Transactions on Information Forensics and Security2010，5，1： | 1 |
| 10 | Everolimus halts hepatic cystogenesis in a rodent model of polycystic-liver-disease显示文摘AIM To develop a MRI-based method for accurate determination of liver volume(LV) and to explore the effect of long-term everolimus(EVR) treatment on LV in PCK rats with hepatomegaly. METHODS Thirty-one female PCK rats(model for polycystic-liverdisease: PCLD) were randomized into 3 groups and treatment was started at 16 wk, at the moment of extensive hepatomegaly(comparable to what is done in the human disease). Animals received: controls(n = 14), lanreotide(LAN: 3 mg/kg per 2 wk)(n = 10) or everolimus(EVR: 1 mg/kg per day)(n = 7). LV was measured at week 16, 24, 28. At week 28, all rats were sacrificed and liver tissue was harvested. Fibrosis was evaluated using quantitative image analysis. In addition, gene(quantitative RT-PCR) and protein expression(by Western blot) of the PI3K/Ak T/m TOR signaling pathway was investigated. RESULTS LV determination by MRI correlated excellent with the ex vivo measurements(r = 0.99, P < 0.001). The relative changes in LV at the end of treatment were:(controls) +31.8%;(LAN) +5.1% and(EVR) +8.8%, indicating a significantly halt of LV progression compared with controls(respectively, P = 0.01 and P = 0.04). Furthermore, EVR significantly reduced the amount of liver fibrosis(P = 0.004) thus might also prevent the development of portal hypertension. There was no difference in phosphorylation of Akt(Threonine 308) between LAN-treated PCK rats control PCK rats, whereas S6 was significantly more phosphorylated in the LAN group. Phosphorylation of Akt was not different between controls and EVR treated rats, however, for S6 there was significantly less phosphorylation in the EVR treated rats. Thus, both drugs interact with the PI3K/Ak T/m TOR signaling cascade but acting at different molecular levels.CONCLUSION Everolimus halts cyst growth comparable to lanreotide and reduces the development of fibrosis. m TORinhibition should be further explored in PCLD patients especially those that need immunosuppression. | Frederik Temmerman Feng Chen Louis Libbrecht Ingrid Vander Elst Petra Windmolders Yuanbo Feng Yicheng Ni Humbert De Smedt Frederik Nevens Jos van Pelt | 2017 | World Journal of Gastroenterology2017，23，30： | 1 |
| 11 | Flux growth and characterization of a new oxyborate crystal Na3La9O3(BO3)8显示文摘 | Zhang Guochun Wu Yicheng Li Yunge Chang Feng Pan Shilie Fu Peizhen Chen Chuangtian | 2005 | Journal of Crystal Growth2005，275，12： | 1 |
| 12 | Effect ofCa and Nd alloying on the microstructure of Mg-6Al-Ca-Nd alloy 显示文摘 | Feng Yicheng Wang Qin Zhao Sicong | 2015 | Advanced Materials Research2015，1095，： | 1 |
| 13 | Microstructure in the Semi-solid State and Mechanical Properties of AZ80 Magnesium Alloy Reheated from the As-cast and Extruded States显示文摘The multi-axial forging(MAF) process was introduced into the strain induced metal activation(SIMA) process to replace conventional forging.Microstructure evolution of MAF formed AZ80 magnesium alloy during partial remelting was investigated.Furthermore,the tensile mechanical properties for AZ80 magnesium alloy thixoextruded from the starting materials treated by MAF were determined.For comparison,as-cast AZ80 magnesium alloy was also thixoextruded.The results show that the SIMA route produced ideal,fine semi-solid microstructure,in which almost completely spheroidal primary solid grains had a little amount of entrapped liquid.The microstructure of the as-cast alloy in the semi-solid state is less spheroidized compared with the MAF alloy under the similar isothermal holding conditions.With prolonged holding time,the size of the solid grain increases and the degree of spheroidization is improved in the MAF formed alloys.However,the solid grain size of the as-cast alloys decreases initially,and then increases with further increasing temperature.The tensile mechanical properties for AZ80 magnesium alloy thixoextruded from the starting material produced by MAF are better than those of AZ80 magnesium alloy thixoextruded from the starting material produced by casting.The ultimate tensile strength,yield strength and elongation of the alloy thixoextruded from the starting material produced by MAF are 314 MPa,238 MPa and 14%,respectively. | Wenyong JIANG Tian CHEN Liping WANG Yicheng FENG Yan ZHU Kaifeng WANG Jiapeng LUO Shouwei ZHANG | 2013 | Acta Metallurgica Sinica(English Letters)2013，26，4： | 1 |
| 14 | Phonon engineering in Yb:La_(2)CaB_(10)O_(19)crystal for extended lasing beyond the fluorescence spectrum显示文摘Since the first invention of the laser in 1960,direct lasing outside the fluorescence spectrum is deemed impossible owing to the“zero-gain”cross-section.However,when electron-phonon coupling meets laser oscillation,an energy modulation by the quantized phonon can tailor the electronic transitions,thus directly creating some unprecedented lasers with extended wavelengths by phonon engineering.Here,we demonstrate a broadband lasing(1000-1280 nm)in a Yb-doped La_(2)CaB_(10)O_(19)(Yb:LCB)crystal,far beyond its spontaneous fluorescence spectrum.Numerical calculations and in situ Raman verify that such a substantial laser emission is devoted to the multiphonon coupling to lattice vibrations of a dangling“quasi-free-oxygen”site,with the increasing phonon numbers step-by-step(n=1–6).This new structural motif provides more alternative candidates with strong-coupling laser materials.Moreover,the quantitative relations between phonon density distribution and laser wavelength extension are discussed.These results give rise to the search for on-demand lasers in the darkness and pave a reliable guideline to study those intriguing electron-phonon-photon coupled systems for integrated photonic applications. | Yanling Cheng Fei Liang Dazhi Lu Jingcheng Feng Guochun Zhang Haohai Yu Huaijin Zhang Yicheng Wu | 2023 | Light(Science & Applications)2023，12，9： | 1 |
| 15 | Tumor models and specific contrast agents for small animal imaging in oncology 显示文摘 | Yicheng Ni Huaijun Wang Feng Chen | 2009 | Methods2009，4，2： | 1 |
| 16 | Morphological, functional and metabolic imaging biomarkers: assessment of vascular-disrupting effect on rodent liver tumours显示文摘 | Huaijun Wang Junjie Li Feng Chen Frederik Keyzer Jie Yu Yuanbo Feng Johan Nuyts Guy Marchal Yicheng Ni | 2010 | European Radiology2010，，8： | 1 |
| 17 | Murine liver implantation of radiation-induced fibrosarcoma: characterization with MR imaging, microangiography and histopathology显示文摘 | Huaijun Wang Marie Putte Feng Chen Frederik Keyzer Lixin Jin Jie Yu Guy Marchal Peter Witte Yicheng Ni | 2008 | European Radiology2008，，7： | 1 |
| 18 | Magnetic Resonance Imaging of Acute Reperfused Myocardial Infarction: Intraindividual Comparison of ECIII-60 and Gd-DTPA in a Swine Model显示文摘 | Jiyang Jin Gaojun Teng Yi Feng Yanping Wu Qindi Jin Yu Wang Zhen Wang Qin Lu Yibo Jiang Shengqi Wang Feng Chen Guy Marchal Yicheng Ni | 2007 | CardioVascular and Interventional Radiology2007，，2： | 1 |
| 19 | First preclinical evaluation of mono-[123I]iodohypericin as a necrosis-avid tracer agent显示文摘 | Yicheng Ni Dieter Huyghe Kristin Verbeke Peter A. Witte Johan Nuyts Luc Mortelmans Feng Chen Guy Marchal Alfons M. Verbruggen Guy M. Bormans | 2006 | European Journal of Nuclear Medicine and Molecular Imaging2006，，5： | 1 |
| 20 | Morphological, functional and metabolic imaging biomarkers: assessment of vascular-disrupting effect on rodent liver tumours显示文摘 | Huaijun Wang Junjie Li Feng Chen Frederik Keyzer Jie Yu Yuanbo Feng Johan Nuyts Guy Marchal Yicheng Ni | 2010 | European Radiology2010，，8： | 1 |
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