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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI显示文摘 | Chin C L Tovcimak A E Hradil V P Seifert T R Hollingsworth P R Chandran P Zhu C Z Gauvin D Pai M Wetter J Hsieh G C Honore P Frost J M Dart M J Meyer M D Yao B B Cox B F Fox G B | | 0，，02： | 1 |
| 3 | Spontaneous deletion of the methicillin resistance determinant,mecA,partially compensates for the fitness cost associated with high-level vancomycin resistance in Staphylococcus aureus显示文摘 | Noto M J Fox P M Archer G L | 2008 | Anti micro Agents Chemother2008，52，4： | 1 |
| 4 | A combined approach to improving large-scale production of tobacco etch virus protease显示文摘 | Blommel P G Fox B G | 2007 | Protein Expr Purif2007，55，1： | 1 |
| 5 | Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL) : a randomised, double-blind, placebo-cantrolled trial显示文摘 | FOX K FORD I STEG P G | 2008 | Lancet2008，372，9641： | 1 |
| 6 | Prediction of ruminal volatile fatty acids and pH within thd net carbohydrate and protein system显示文摘 | Pitt R E Van Kessel J S Fox D G Pell A N Barry M C Van Soest P J | 1996 | Journal of Animal Science1996，74，： | 1 |
| 7 | Anaerobic treatment applications and fundamentals: substrate specificity during phase separation 显示文摘 | Fox P Pohland F G | 1994 | Water Environment Research1994，66，5： | 1 |
| 8 | lvabradine for patients with stable coronary artery disease and left - ventricular systolic dysfunction (BEAUTIFUL) : a randomised, double - blind, placebo - controlled trial显示文摘 | Fox K Ford I Steg P G | 2008 | The Lancet2008，372，9641： | 1 |
| 9 | Genetic and environ- mental variation in the Diastatic power of Australian barley 显示文摘 | Arends A M Fox G P Henry R J etal | 1995 | Journal of Cereal Seienee1995，21，： | 1 |
| 10 | High-resolution manometry predicts the success of oesophageal bolus transport and identifies clinically important abnormalities not detected by conventional manometry显示文摘 | Fox M Hebbard G Janiak P | | 0，，： | 1 |
| 11 | Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans显示文摘 | Rhee Eugene P Cheng Susan Larson Martin G Walford Geoffrey A Lewis Gregory D McCabe Elizabeth Yang Elaine Farrell Laurie Fox Caroline S O’Donnell Christopher J Carr Steven A Vasan Ramachandran S Florez Jose C Clish Clary B Wang Thomas J Ger | 2011 | Journal of Clinical Investigation2011，，4： | 1 |
| 12 | The role of glutamate dehydrogenase in plant nitrogen metabolism 显示文摘 | Robinson S A Slade A P Fox G G | 1991 | Plant Physiol1991，95，2： | 1 |
| 13 | Identification of crop and weed host of Ralstonia solanacearum biovar 2 in the hills of Nepal 显示文摘 | Pradhanang P M Elphinstone J G Fox R T V | 2002 | Plant Pathology2002，49，4： | 1 |
| 14 | Predictors of major bleeding in acute coronary syndromes: the Global Registry of Acute Coronary Events (GRACE)显示文摘 | Moscucci M Fox K A Cannon C P Klein W López-Sendón J Montalescot G | 2003 | Eur Heart J2003，24，： | 1 |
| 15 | Absenceof effects of short-term fasting on plasma ghrelin andbrain expression of ghrelin receptors in the tilapia,Oreochromis mossambicus 显示文摘 | RILEY L G FOX B K BREVES J P | 2008 | Zoological Science2008，25，8： | 1 |
| 16 | Household peanut con- sumption as a risk factor for the development of peanut al- lergy显示文摘 | Fox AT Sasieni P du Toit G | 2009 | J Allergy Clin Immunol2009，123，： | 1 |
| 17 | Inactivation of Aspergillus flavus spores by curcumin-mediated photosensitization显示文摘 | TEMBA B A FLETCHER MARY T FOX G P | 2016 | Food control2016，59，： | 1 |
| 18 | Predicting net energy and protein requirements for growth of im- planted and nonimplanted heifers and steers and non- implanted bulls varying in body size 显示文摘 | TYLUTKI T P FOX D G ANRIQUE R G | 1994 | Journal of Animal Science1994，72，： | 1 |
| 19 | Internal shear strength of three geosynthetic clay liners显示文摘 | FOX P J ROWLAND M G SCHEITHE J R | 1998 | J Geotech Geoenviron Eng ASCE1998，124，10： | 1 |
| 20 | Evaluation of the tabular feed energy and protein undegradability values of the National Research Council nutrient re- quirements of beef cattle 显示文摘 | TEDESCHI L O FOX D G DOANE P H | 2005 | The Professional Animal Scientist2005，21，： | 1 |
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