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| 1 | A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV) infected pneumonia(standard version)显示文摘In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province;and then named '2019 novel coronavirus(2019-nCoV)' by the World Health Organization(WHO) on 12 January 2020. For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world’s attention but without treatment and control manual. For the request from frontline clinicians and public health professionals of 2019-nCoV infected pneumonia management, an evidence-based guideline urgently needs to be developed. Therefore, we drafted this guideline according to the rapid advice guidelines methodology and general rules of WHO guideline development;we also added the first-hand management data of Zhongnan Hospital of Wuhan University. This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control(including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. This rapid advice guideline is suitable for the first frontline doctors and nurses, managers of hospitals and healthcare sections, community residents, public health persons, relevant researchers, and all person who are interested in the 2019-nCoV. | Ying-Hui Jin Lin Cai Zhen-Shun Cheng Hong Cheng Tong Deng Yi-Pin Fan Cheng Fang Di Huang Lu-Qi Huang Qiao Huang Yong Han Bo Hu Fen Hu Bing-Hui Li Yi-Rong Li Ke Liang Li-Kai Lin Li-Sha Luo Jing Ma Lin-Lu Ma Zhi-Yong Peng Yun-Bao Pan Zhen-Yu Pan Xue-Qun Ren Hui-Min Sun Ying Wang Yun-Yun Wang Hong Weng Chao-Jie Wei Dong-Fang Wu Jian Xia Yong Xiong Hai-Bo Xu Xiao-Mei Yao Yu-Feng Yuan Tai-Sheng Ye Xiao-Chun Zhang Ying-Wen Zhang Yin-Gao Zhang Hua-Min Zhang Yan Zhao Ming-Juan Zhao Hao Zi Xian-Tao Zeng Yong-Yan Wang Xing-Huan Wang 无 | 2020 | Military Medical Research2020，7，1： | 161 |
| 2 | Relationship between hyperuricemia and metabolic syndrome显示文摘Objective: To investigate the relationship between metabolic syndrome and hyperuricemia. Methods: A total of 2 374 subjects who received health examination in our hospital from Jan. 2004 to Dec. 2006 were enrolled in our study. Hyperuricemia is defined as ≥7 mg/dl (in men) or ≥6.0 mg/dl (in women). Metabolic syndrome was defined using AHA/NHLBI (American Heart Association/National Heart, Lung, and Blood Institute) criteria. Results: (1) The overall prevalence of hyperuricemia was 13.10%. The condition was more common in men than in women (19.07% vs 3.42%). (2) Among men, uric acid concentration is statistically significantly positively correlated with waist circumference, blood pressure, and triglyceride. Uric acid is negatively correlated with serum high-density lipoprotein-cholesterol (HDL-C). Uric acid concentration is most strongly correlated with serum triglyceride (r=0.379) and waist circumference (r=0.297). Among women, statistically significant positive correlations were noted for the serum uric acid concentrations with waist circumference, triglyceride and fasting plasma glucose. Serum triglyceride (r=0.329) and waist circumference (r=0.234) are most strongly correlated with uric acid concentrations. (3) Men with hyperuricemia had a 1.634-fold increased risk of metabolic syndrome as compared with those without hyperuricemia odds ratio (OR)=1.634, P=0.000. Women with hyperuricemia had a 1.626-fold increased risk of metabolic syndrome (OR=1.626, P=0.000) as compared with those without hyperuricemia. Conclusion: Hyperuricemia is prevalent among Chinese population. Additionally, serum uric acid is positively associated with metabolic syndrome. | CHEN Li-ying ZHU Wen-hua CHEN Zhou-wen DAI Hong-lei REN Jing-jing CHEN Jian-hua CHEN Lei-qian FANG Li-zheng | 2007 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2007，8，8： | 54 |
| 3 | Improved Base Editor for Efficiently Inducing Genetic Variations in Rice with CRISPR/Cas9- Guided Hyperactive hAID Mutant显示文摘 | Bin Ren Fang Yan Yongjie Kuang Na Li Dawei Zhang Xueping Zhou Honghui Lin Huanbin Zhou | 2018 | Molecular Plant2018，11，4： | 46 |
| 4 | Change of Inflammatory Factors in Patients with Acute Coronary Syndrome显示文摘 | Cai-Yun Ma Zhen-Ye Xu Shao-Ping Wang Hong-Yu Peng Fang Liu Jing-Hua Liu Feng-Xue Ren | 2018 | Chinese Medical Journal2018，，12： | 47 |
| 5 | Base-Editing-Mediated Artificial Evolution of OsALS1 In Planta to Develop Novel Herbicide-Tolerant Rice Germplasms显示文摘Recently developed CRISPR-mediated base editors,which enable the generation of num erous nucleotide changes in target genomic regions,have been widely adopted for gene correction and generation of crop germ plasms containing im portant gain-of-function genetic variations.How ever,to engineer target genes with unknown functional SNPs remains challenging.To address this issue,we present here abase-e diting-mediated gene evolution(BEMGE)m ethod,employing both Cas9n-based cytosine and adenine base editors as well as a single-guide RNA(sgRNA)library tiling the full-length coding region,for developing novel rice germ plasm swith mutations in any endogenous gene.To this end,OsALS1 was artificially evolved in rice cells using BEMGE through both Agrobacterium-mediated and particle-bom bardment-mediated transform ation.Four different types of amino acid substitutions in the evolved OsALS1,derived from two sites that have never been targeted by natural or human selection during rice dom estication,were identified,conferring varying levels of tolerance to the herbicide bispyribac-sodium.Furtherm ore,the P171F substitution identified in a strong OsALS1 allele was quickly introduced into the commercial rice cultivar Nangeng 46 through precise base editing w ith the corresponding base editor and sgRNA.Collectively,these data indicate great potential of BEMGE in creating important genetic variants of target genes for crop improvement. | Yongjie Kuang Shaofang Li Bin Ren Fang Yan Carl Spetz Xiangju Li Xueping Zhou Huanbin Zhou | 2020 | Molecular Plant2020，13，4： | 37 |
| 6 | Hydrophobicity mechanism of non-smooth pattern on surface of butterfly wing显示文摘Twenty-nine species (24 genera, 6 families) of butterflies typical and common in northeast China were selected to make qualitative and quantitative studies on the pattern, hydrophobicity and hydrophobicity mechanism by means of scanning electron microscopy and contact angle measuring system. The scale surface is composed of submicro-class vertical gibbosities and horizontal links. The distance of scale is 48—91 μm, length 65—150 μm, and width 35—70 μm. The distance of submicro-class vertical gib-bosities on scale is 1.06—2.74 μm, height 200—900 nm, and width 200—840 nm. The better hydropho-bicity on the surface of butterfly wing (static contact angle 136.3°—156.6°) is contributed to the co-effects of micro-class scale and submicro-class vertical gibbosities on the wing surface. The Cassie equation was revised, and new mathematical models and equations were established. | FANG Yan SUN Gang WANG TongQing CONG Qian REN LuQuan | 2007 | Chinese Science Bulletin2007，52，5： | 31 |
| 7 | A CRISPR/Cas9 toolkit for efficient targeted base editing to induce genetic variations in rice显示文摘Dear Editor,Gene-targeting technologies using sequence specific nucleases have been widely adopted to induce genetic modifications in both plant molecular biology research and crop improvement,of which generating targeted point mutation for gain-of-function phenotype is of great value.Although tremendous efforts have been made in developing geneinsertion or replacement approaches by | Bin Ren Fang Yan Yongjie Kuang Na Li Dawei Zhang Honghui Lin Huanbin Zhou | 2017 | Science China(Life Sciences)2017，60，5： | 28 |
| 8 | Highly Efficient A. T to G. C Base Editing by Cas9n- 3uided tRNA Adenosine Deaminase in Rice显示文摘 | Fang Yan Yongjie Kuang Bin Ren Jingwen Wang Dawei Zhang Honghui Lin Bing Yang Xueping Zhou Huanbin Zhou | 2018 | Molecular Plant2018，11，4： | 26 |
| 9 | TANDEM and GMAW Twin Wire Welding of Q690 Steel Used in Hydraulic Support显示文摘Compared with using semi-automatic gas shielded arc welding, using automatic TANDEM twin wire welding and twin wire gas metal arc welding (GMAW) to weld Q690 steel, a low-alloy high-strength structural steel used in the hydraulic support in the fully-mechanized mining face, the welding speed, deposition rate, production environment and welding quality can be obviously improved. Compared with GMAW twin wire welding, a refined microstructure in the weld and heat-affected zone (HAZ), narrow HAZ and improved joint strength were achieved with TANDEM on Q690. Also, due to the push-pull pulsed way in TANDEM welding, the droplet transfer, distribution on heat flow and interaction between two arcs were completely different from those in GMAW twin wire system. The heat input of TANDEM is only about 76.6% of GMAW, and correspondingly, the welding speed and welding seam can be obviously improved. The complete oscillation caused by TANDEM pulsed current occurred in the welding pool, which refined the grains in the microstructure. The results show that TANDEM twin wire welding is very suitable in the welding of Q690 used in the hydraulic support. | FANG Chen-fu MENG Xiao-hui HU Qing-xian WANG Feng-jiang REN He WANG Hai-song GUO Yu MAO Ming | 2012 | Journal of Iron and Steel Research(International)2012，19，5： | 22 |
| 10 | Analysis of emergy-based metabolic efficiency and environmental pressure on the local coupling and telecoupling between urbanization and the eco-environment in the Beijing-Tianjin-Hebei urban agglomeration显示文摘We use emergy-based urban metabolism analysis in this study to investigate the local coupling and telecoupling between urbanization and the eco-environment in the Beijing-Tianjin-Hebei urban agglomeration. Our analysis encompasses the last 35 years spanning the period between 1980 and 2014. In addition, we analyze urban metabolic efficiency and environmental pressure in these couplings. There are three main conclusions of this study. First, we show that the total metabolic emergy value of the Beijing-Tianjin-Hebei urban agglomeration has increased over the last 35 years, and that external elements have replaced internal ones as the leading contributors to urban metabolism in this region. The proportion of metabolic emergy derived from external elements increased from 30.87% in 1980 to 67.43% in 2014. The emergy extroversion ratio has continued to increase over our study period, while the development of this urban agglomeration had become progressively and more heavily reliant on external elements. Second, over the study period, the metabolic emergy intensity of elements of local coupling and telecoupling in the Beijing-Tianjin-Hebei urban agglomeration has declined at an accelerating rate, from 1.15×10^(21) Sej/100 million RMB in1980 to 9.69×10^(19) Sej/100 million RMB in 2014. This reflects a continuous increase in the economic efficiency of this area.Correspondingly, emergy use per capita increased from 7.8×10^(15) Sej/person in 1980 to 5.83×10^(16) Sej/person in 2014, suggesting a gradual rise in the level of social welfare in this urban agglomeration. However, we also observed a consistently elevated environmental loading ratio(ELR) in our analysis in terms of metabolism of local coupling and telecoupling elements. This result indicates that environmental pressure has also increased constantly within the Beijing-Tianjin-Hebei urban agglomeration. Third,our analysis shows that the ELR of metabolic emergy from internal elements increased from 8.30 in 1980 to 43.46 in 2014, while the ratio from external elements increased from 4.15 to 92.03. Thus, we quantitatively investigated the dependency of development within this urban agglomeration on external elements as well as the resultant environmental load. The conclusions of this study provide the basis for quantitative policy-making in the Beijing-Tianjin-Hebei region, optimizing economic structures, improving economic efficiency, controlling environmental pollution, and promoting the coordinated development of this region. | FANG ChuangLin REN YuFei | 2017 | Science China Earth Sciences2017，60，6： | 22 |
| 11 | A novel gene delivery system targeting cells expressing VEGF receptors显示文摘Two ligand oligopeptides GV1 and GV2 were designed according to the putative binding region of VEGF to its receptors. GV1, GV2 and endosome releasing oligopeptide HA20 were conjugated with poly-L-lysine or protamine and the resulting conjugates could interact with DNA in a noncovalent bond to form a complex. Using pSV2-β-galactosidase as a reporter gene, it has been demonstrated that exogenous gene was transferred into bovine aortic arch-derived endothelial cells (ABAE) andhuman malignant melanoma cell lines (A375) in vitro. In vivo experiments, exogenous gene was transferred into tumor vascular endothelial cells and tumor cells of subcutaneously transplanted human colon cancer LOVO, human malignant melanoma A375 and human hepatoma graft in nude mice. This system could also target gene to intrahepatically transplanted human hepatoma injected via portal vein in nude mice. These results are correlated with theGene delivery system targeting VEGF receptors relevant receptors (flt-1, flk-1/KDR) expression on the targeted cells and tissues. | LI JUN MIN JUN SONG HAN YI HUANG PEI KUN TIAN SHU MIN QU MIN YAO HUI QIU JIANG DA FANG WAN JING CHU LUO CHENG XIAO GU JIAN REN GU( National Labomtory for Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai 200032,China)(National Laboratory of | 1999 | Cell Research1999，9，1： | 22 |
| 12 | Climate and litter C/N ratio constrain soil organic carbon accumulation显示文摘Soil organic carbon(SOC) plays critical roles in stabilizing atmospheric CO2 concentration, but the mechanistic controls on the amount and distribution of SOC on global scales are not well understood. In turn, this has hampered the ability to model global C budgets and to find measures to mitigate climate change. Here, based on the data from a large field survey campaign with 2600 plots across China’s forest ecosystems and a global collection of published data from forested land, we find that a low litter carbon-to-nitrogen ratio(C/N) and high wetness index(P/PET, precipitation-to-potentialevapotranspiration ratio) are the two factors that promote SOC accumulation, with only minor contributions of litter quantity and soil texture. The field survey data demonstrated that high plant diversity decreased litter C/N and thus indirectly promoted SOC accumulation by increasing the litter quality. We conclude that any changes in plant-community composition, plant-species richness and environmental factors that can reduce the litter C/N ratio, or climatic changes that increase wetness index, may promote SOC accumulation. The study provides a guideline for modeling the carbon cycle of various ecosystem scales and formulates the principle for land-based actions for mitigating the rising atmospheric CO2 concentration. | Guoyi Zhou Shan Xu Philippe Ciais Stefano Manzoni Jingyun Fang Guirui Yu Xuli Tang Ping Zhou Wantong Wang Junhua Yan Gengxu Wang Keping Ma Shenggong Li Sheng Du Shijie Han Youxin Ma Deqiang Zhang Juxiu Liu Shizhong Liu Guowei Chu Qianmei Zhang Yuelin Li Wenjuan Huang Hai Ren Xiankai Lu Xiuzhi Chen | 2019 | National Science Review2019，6，4： | 21 |
| 13 | Cropland cover change in Northeast China during the past 300 years显示文摘Land use/cover change induced by human activities has emerged as a 'global' phenomenon with Earth system consequences. Northeast China is an area where the largest land cultivation activities by migrants have happened in China during the past 300 years. In this paper, methods including documentary data calibration and multi-sourced data conversion model are used to reconstruct historical cropland cover change in Northeast China during the past 300 years. It is concluded that human beings have remarkably changed the natural landscape of the region by land cultivation in the past 300 years. Cropland area has increased almost exponentially during the past 300 years, especially during the past 100 years when the ratio of cropland cover changed from 10% to 20%. Until the middle of the 19th century, the agricultural area was still mainly restricted in Liaoning Province. From the late 19th century to the early 20th century, dramatic changes took place when the northern boundary of cultivation had extended to the middle of Heilongjiang Province. During the 20th century, three agricultural regions with high ratio of cropland cover were formed after the two phases of spatial expansion of cropland area in 1900s—1930s and 1950s—1980s. Since 1930s—1940s, the expansion of new cultivated area have invaded the forest lands especially in Jilin and Heilongjiang Provinces. | YE Yu FANG XiuQi REN YuYu ZHANG XueZhen CHEN Li | 2009 | Science China Earth Sciences2009，52，8： | 21 |
| 14 | Expression of insulin-like growth factor Ⅱ and its receptor in liver cells of chronic liver diseases显示文摘ExpressionofinsulinlikegrowthfactorⅡanditsreceptorinlivercelsofchronicliverdiseasesYANGDongHua1,XIUChong1,YANGBo1,GUJianR... | YANG Dong Hua 1, XIU Chong 1, YANG Bo 1, GU Jian Ren 2, QIAN Lian Fang 2 and QU Shu Ming 2 | 1997 | World Journal of Gastroenterology1997，3，2： | 21 |
| 15 | High-efficiency breeding of early-maturing rice cultivars via CRISPR/Cas9-mediated genome editing显示文摘Rice is a staple food for more than half of the human population.It has been estimated that by 2030,40%more rice needs to be produced in order to meet the growing demand(Khush,2005).One of the strategies to improve rice productivity is to enlarge rice | Xiufeng Li Wenjia Zhou Yuekun Ren Xiaojie Tian Tianxiao Lv Zhenyu Wang Jun Fang Chengcai Chu Jie Yang Qingyun Bu | 2017 | Journal of Genetics and Genomics2017，44，3： | 20 |
| 16 | Effects of Methanol on Wettability of the Non-Smooth Surface on Butterfly Wing显示文摘The contact angles of distilled water and methanol solution on the wings of butterflies were determined by a visual contact angle measuring system.The scale structures of the wings were observed using scanning electron microscopy,The influence of the scale micro-and ultra-structure on the wettability was investigated.Results show that the contact angle of distilled water on the wing surfaces varies from 134.0° to 159.2°.High hydrophobicity is found in six species with contact angles greater than 150°.The wing surfaces of some species are not only hydrophobic but also resist the wetting by methanol solution with 55% concentration.Only two species in Parnassius can not resist the wetting because the micro-structure(spindle-like shape) and ultra-structure(pinnule-like shape) of the wing scales are remarkably different from that of other species.The concentration of methanol solution for the occurrence of spreading/wetting on the wing surfaces of different species varies from 70% to 95%.After wetting by methanol solution for 10 min,the distilled water contact angle on the wing surface increases by 0.8°-2.1°,showing the promotion of capacity against wetting by distilled water. | Yan Fang Gang Sun Qian Cong Guang-hua Chen Lu-quan Ren | 2008 | Journal of Bionic Engineering2008，5，2： | 19 |
| 17 | Patterns and driving factors of WUE and NUE in natural forest ecosystems along the North-South Transect of Eastern China显示文摘从 2008 年 7 月,到 2008 年 8 月,从 22 种类的 72 件叶样品和在九天赋的 81 件土壤样品,森林生态系统对沿着东方中国(NSTEC ) 的纵贯的横断的南方镇定,从北方。把样品基于这些,我们学习了蔬菜水使用效率(WUE ) 和氮使用效率(NUE ) 的地理分发模式,并且分析了他们与环境因素的关系。蔬菜 WUE 和 NUE 分别地通过叶的 13C 的测量和占优势的种类的 C/N 被计算。结果出现了:(1 ) 蔬菜 WUE,从 2.13 ~ 28.67 mg C g1 H2O ,当蔬菜 NUE 显示出一个相反的趋势时,沿着 NSTEC 在代表性的森林生态系统从南方线性地增加了到北方,从北方增加到南方,从 12.92 ~ 29.60 g C g1 N 。(2 ) 蔬菜 WUE 和 NUE 被气候主导地驾驶并且显著地由土壤营养素因素影响。基于集中为 WUE 的 75.5% 变化正在回答的多重逐步的回归分析,吝啬的年度温度,土壤磷集中,和土壤氮(p < 0.001 ) 。当时,吝啬的年度降水和土壤磷集中能在蔬菜 NUE 解释 65.7% 变化(p < 0.001 ) 。而且,蔬菜 WUE 和 NUE 将被大气的氮免职严重也在氮影响浸透的生态系统。(3 ) 在沿着 NSTEC 的典型森林生态系统在蔬菜 WUE 和 NUE 之间有一种重要交易关系(p < 0.001 ) ,沿着 NSTEC 在自然森林生态系统在资源利用为植被显示平衡策略。这研究建议那个全球变化将影响森林生态系统的资源使用效率。然而,当减少时,植被能由增加缺乏资源的使用效率适应那些变化相对宽大的。但是极端影响例如重氮免职,将打破这交易机制并且把戏剧的骚乱给生态系统 biogeochemical 周期。 | SHENG Wenping REN Shujie YU Guirui FANG Huajun JIANG Chunming ZHANG Mi | 2011 | Journal of Geographical Sciences2011，21，4： | 19 |
| 18 | Coping as a Mechanism Linking Stressful Life Events and Mental Health Problems in Adolescents显示文摘Objective Although stressful life events represent an etiologic factor of mental health problems in adolescents,few studies have been conducted to address mechanisms linking the stress‐psychopathology relation.The present study was designed to examine coping as a mediate factor on the relationship between stressful life events and symptoms of anxiety and depression.Methods The participants were 13 512 students from eight cities of China,who participated in a school‐based survey.Data were collected by a questionnaire comprising coping,stressful life events,anxiety,and depressive symptoms.As a model,a series of regression equations were used to examine whether coping mediated the association between stressful life events and symptoms of anxiety and depression.Results Each dimension of stressful life events showed significant correlation with anxiety,depression and coping (all P<0.001).In the model to analyze mediate effects,all standardized coefficients (β) were significant (all P<0.01),indicating marked mediator effects.Furthermore,negative coping might account for more mediate effects than positive coping on this relationship.Conclusion Coping partially mediated the relationship between stressful life events and mental health during adolescence.This study highlighted an important public health priority for preventive interventions targeting stress‐related psychopathology,and for further promoting adolescents'mental health. | MENG Xiu Hong TAO Fang Biao WAN Yu Hui HU Yan WANG Ren Xi | 2011 | Biomedical and Environmental Sciences2011，24，6： | 16 |
| 19 | The ATF/CREB site is the key element for transcription of the human RNA methyltransferase like 1 (RNMTL1) gene, a newly discovered 17p13.3 gene显示文摘The human RNA methyltransferase like i gene (RNMTL1) is one of thirteen newly discovered geneswithin a 116 Kb segment of the chromosome 17p13.3 that suffers from a high frequent loss of heterozygosityin human hepatocellular carcinoma in China[1-5]. To understand the molecular mechanisms underlyingtranscription control of the RNMTL1 gene in human cancers, we decline using of the conventional approachwhere the cis-elements bound by the known transcription factors are primary targets, and carried out thesystematic analyses to dissect the promoter structure and identify/characterize the key cis-elements thatare responsible for its strong expression in cell. The molecular approaches applied included 1, the primerextension for mapping of the transcription starts; 2, the transient transfection/reporter assays on a largenumber of deletion and site-specific mutants of the promoter segment for defining the minimal promoterand the crucial elements within; and 3, the electrophoresis mobility shift assay with specific antibodies forreconfirming the nature of the transcription factors and their cognate cis-elements. We have shown that theinteraction of an ATF/CREB element (-38 to -31) and its cognate transcription factors play a predominantrole in the promoter activity of the RNMTL1 gene. The secondary DNA structures of the ATF/CREBelement play a more vital role in the protein-DNA interaction. Finally, we reported a novel mechanismunderlying the YY1 mediated transcription repression, namely, the ATF/CREB dependent transcription-repression by YY1 is executed in absence of its own sequence-specific binding. | JIAN XU JING DE ZHU MIN NI DA FANG WAN JIAN REN GU | 2002 | Cell Research2002，12，4： | 14 |
| 20 | STUDIES ON SOLUBILIZATION AND TRANSFORMATION OF SPECIES OF Cu,Pb.Zn AND Cr IN SIMULANT ACID RAIN显示文摘STUDIESONSOLUBILIZATIONANDTRANSFORMATIONOFSPECIESOFCu,Pb.ZnANDCrINSIMULANTACIDRAINGuiHuaHE;LianCunGAO;ShuRenWANG(Ensironmenta... | Gui Hua HE Lian Cun GAO Shu Ren WANG (Ensironmental Science Center Shandong University, Jinan 250100)Su Ping FANG (Experimectal Center, Shandong University) | 1994 | Chinese Chemical Letters1994，5，1： | 13 |
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