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| 1 | Circulating tumor cells:biology and clinical significance显示文摘Circulating tumor cells(CTCs)are tumor cells that have sloughed off the primary tumor and extravasate into and circulate in the blood.Understanding of the metastatic cascade of CTCs has tremendous potential for the identification of targets against cancer metastasis.Detecting these very rare CTCs among the massive blood cells is challenging.However,emerging technologies for CTCs detection have profoundly contributed to deepening investigation into the biology of CTCs and have facilitated their clinical application.Current technologies for the detection of CTCs are summarized herein,together with their advantages and disadvantages.The detection of CTCs is usually dependent on molecular markers,with the epithelial cell adhesion molecule being the most widely used,although molecular markers vary between different types of cancer.Properties associated with epithelial-tomesenchymal transition and stemness have been identified in CTCs,indicating their increased metastatic capacity.Only a small proportion of CTCs can survive and eventually initiate metastases,suggesting that an interaction and modulation between CTCs and the hostile blood microenvironment is essential for CTC metastasis.Single-cell sequencing of CTCs has been extensively investigated,and has enabled researchers to reveal the genome and transcriptome of CTCs.Herein,we also review the clinical applications of CTCs,especially for monitoring response to cancer treatment and in evaluating prognosis.Hence,CTCs have and will continue to contribute to providing significant insights into metastatic processes and will open new avenues for useful clinical applications. | Danfeng Lin Lesang Shen Meng Luo Kun Zhang Jinfan Li Qi Yang Fangfang Zhu Dan Zhou Shu Zheng Yiding Chen Jiaojiao Zhou | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 8 |
| 2 | Morphodynamics of an Artificial Cobble Beach in Tianquan Bay, Xiamen, China显示文摘By tracking and monitoring the profile configuration, topography, and hydrodynamic factors of an artificial cobble beach in Tianquan Bay, Xiamen, China over three consecutive years after its completion, we analyzed the evolution of its profile configura- tion and plane morphology, and its storm response characteristics. The evolution of the profile configuration of the artificial cobble beach in Tianquan Bay can be divided into four stages. The beach was unstable during the initial stage after the beach nourishment the profile configuration changed obviously, and an upper concave composite cobble beach formed gradually, which was character- ized by a steep upper part and a gentle lower part. In the second stage, the cobble beach approached dynamic equilibrium with minor changes in the profile configuration. At the third stage the beach was in a high-energy state under the influence of Typhoon Meranti, and the response of the artificial cobble beach differed significantly from that of the low-tide terrace sandy beach. Within a short time, there was net onshore transport of cobbles in the cross-shore direction. The beach face was eroded, the beach berm was accumulated, and the slope of the beach was steepened considerably. In the alongshore direction, there was notable transport of cobbles on the beach from east to west along the shore, and the total volume of the beach decreased by 4.5×103 m 3, which accounted for 50% of the total amount of beach volume lost within three years. The fourth stage was the restoration stage after the typhoon, characterized by a little gentler profile slope and the increase in width and the decrease in height of beach berm. Because of the action of waves and the wave-driven longshore current caused by the specific terrain and landform conditions along the coast (e.g., coastal headlands, near-shore artificial structures, and reefs), the coastline of the artificial cobble beach gradually evolved from being essentially parallel to the artificial coast upon completion to a slightly curved parabolic shape, and three distinct erosion hotspots were formed on the west side of the cape and the artificial drainpipe, and the reefs. Generally, the adoption of cobbles for beach nourishment on this macro-tidal coast beach with severe erosion has yielded excellent stability and adaptability. | SHU Fangfang CAI Feng QI Hongshuai LIU Jianhui LEI Gang ZHENG Jixiang | 2019 | Journal of Ocean University of China2019，18，4： | 5 |
| 3 | Distribution and controlling factors of phytoplankton assemblages associated with mariculture in an eutrophic enclosed bay in the East China Sea显示文摘The distribution of phytoplankton and its correlation with environmental factors were studied monthly during August 2012 to July 2013 in the Yantian Bay. A total of 147 taxa of phytoplankton were identified, and the average abundance was in the range of 0.57×10~4 to 7.73×10~4 cell/L. A total of 19 species dominated the phytoplankton assemblages, and several species that are widely reported to be responsible for microalgae blooms were the absolutely dominant species, such as Skeletonema costatum, Navicula sp., Thalassionema nitzschioides,Pleurosigma sp., and Licmophora abbreviata. The monthly variabilities in phytoplankton abundance could be explained by water temperature, dissolved oxygen, salinity, dissolved inorganic nitrogen(DIN), and suspended solids. The results of a redundancy analysis showed that p H and nutrients, including DIN and silicate(SiO_4), were the most important environmental factors controlling phytoplankton assemblages in specific months. It was found that nutrients and pH levels that were mainly influenced by mariculture played a vital role in influencing the variation of phytoplankton assemblages in the Yantian Bay. Thus, a reduction of mariculture activities would be an effective way to control microalgae blooms in an enclosed and intensively eutrophic bay. | HUO Yuanzi WEI Zhangliang LIU Qiao YANG Fangfang LONG Lijuan ZHANG Qi BI Hongsheng HE Qing HE Peimin | 2018 | Acta Oceanologica Sinica2018，37，8： | 3 |
| 4 | Compositional and structural study of ash deposits spatially distributed in superheaters of a large biomass-fired CFB boiler显示文摘Recognizing the nature and formation progress of the ash deposits is essential to resolve the deposition problem hindering the wide application of large-scale biomass-fired boilers.Therefore,the ash deposits in the superheaters of a 220 t/h biomass-fired CFB boiler were studied,including the platen(PS),the high-temperature(HTS),the upper and the lower low-temperature superheaters(LTS).The results showed that the deposits in the PSs and HTSs were thin(several millimeters)and compact,consisting of a yellow outer layer and snow-white inner layer near the tube surface.The deposits in the upper LTS appeared to be toughly sintered ceramic,while those in the lower LTS were composed of dispersive coarse ash particles with an unsintered surface.Detailed characterization of the cross-section and the initial layers in the deposits revealed that the dominating compositions in both the PSs and the HTSs were Cl and K(approximately 70%)in the form of KCl.Interestingly,the cross-section of the deposition in the upper LTS exhibited a unique lamellar structure with a major composition of Ca and S.The contents of Ca and Si increased from approximately 10%to approximately 60%in the deposits from the high temperature surfaces to the low temperature ones.It was concluded that the vaporized mineral matter such as KCl played the most important role in the deposition progress in the PS and the HTS.In addition,although the condensation of KCl in the LTSs also happened,the deposition of ash particles played a more important role. | Yishu XU Xiaowei LIU Jiuxin QI Tianpeng ZHANG Minghou XU Fangfang FEI Dingqing LI | 2021 | Frontiers in Energy2021，15，2： | 3 |
| 5 | Trends of Mortality in End-Stage Liver Disease—China,2008–2020显示文摘Introduction:Liver cancer and cirrhosis represent the most prevalent forms of end-stage liver diseases(ESLDs).Notably,in China,deaths attributed to ESLDs contribute significantly to the global mortality rate of these disorders.Enhanced comprehension of the mortality profile associated with ESLDs in China could provide crucial insights into intervention prioritization,which could in turn help reduce the overall global burden of these diseases.Methods:Data were obtained from China’s Disease Surveillance Points system.The presentation includes both crude and age-standardized mortality rates,stratified by sex,residential location,and region.Using Joinpoint Regression,trends in annual mortality rates were estimated from the period of 2008 to 2020 and expressed as the average annual percentage change(AAPC).Results:In 2020,the gross mortality rate of ESLD stood at 30.08 cases per 100,000 individuals.A higher age-standardized ESLD mortality rate was observed in males and rural populations in comparison to their female and urban counterparts,respectively.Noticeably,the highest mortality rates associated with liver cancer and cirrhosis were reported in South and Southwest China,respectively.A positive correlation was noticed between age-specific ESLD mortality rates and advancing age.Interestingly,an annual decrease in the ESLD mortality rate was observed from 2008 to 2020.In urban contexts,the AAPC of cirrhosis was noted to be higher than that of liver cancer.Conclusions:The mortality rate associated with ESLDs in China decreased between 2008 and 2020.Nevertheless,the death burden attributable to ESLD continues to be alarmingly high.Future initiatives should prioritize the reduction of ESLD mortality in particular populations:males,elderly individuals,and those residing in rural regions of South and Southwest China.The emphasis of future interventions should beplaced on antiviral therapy for adults diagnosed with viral hepatitis,and on the prevention of hepatitis B virus(HBV)infection across all demographics. | Xiaoxiao Wang Huixin Liu Jinlei Qi Fangfang Zeng Lijun Wang Peng Yin Feng Liu Hongbo Li Yunning Liu Jiangmei Liu Lai Wei Xiaofeng Liang Yu Wang Huiying Rao Maigeng Zhou | 2023 | China CDC weekly2023，5，30： | 1 |
| 6 | Modeling and simulation of the nons- mooth planar rigid multibody systems with frictional translational joints 显示文摘 | Zhuang Fangfang Wang Qi | 2013 | Multibody System Dynamics2013，29，4： | 1 |
| 7 | A constraint - stabi- lized method for muhibody dynamics with friction - affected translational joints based on HLCP 显示文摘 | Wang Qi Peng Huilian Zhuang Fangfang | 2011 | Discrete and Continuous Dynamical Systems Series B2011，16，2： | 1 |
| 8 | Development AMS Device for 14C Measurement and Its Applications显示文摘Carbon is the main component in the aerosol.In order to study the source of carbon,it isnecessary to analyze the 14C in the particles.Accelerator mass spectrometry(AMS)is the mosteffective analytical instrument for measuring 14C.Therefore,the purpose of this work is to develop an AMS device,so as to analyze the source | PANG Yijun ZHAO Qingzhang ZHANG Yuxuan WANG Fangfang MENG Qi YU Bo WU Shaoyong HE Ming | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 1 |
| 9 | Effect of Momordica grosvenori on oxidative stress pathways in renal mitochondria of normal and alloxan-induced diabetic mice 显示文摘 | Fangfang Song Xiangyang Qi Wenjun Chen | 2007 | European Journal of Nutrition2007，46，2： | 1 |
| 10 | Comparable outcomes but higher risks of prolonged viral RNA shedding duration and secondary infection in cancer survivors with COVID-19: A multi-center, matched retrospective cohort study显示文摘Results Sixty-one cancer survivors and 183 matched non-cancer patients were screened from 2,828 COVID-19 infected patients admitted to 4 hospitals in Wuhan,China.The median ages of the cancer survivor cohort and non-cancer patient cohort were 64.0(55.0–73.0)and 64.0(54.0–73.5),respectively(P=0.909).Cancer survivors reported a higher incidence of symptom onset than non-cancer patients.Fever(80.3%vs.65.0%;P=0.026)was the most prevalent symptom,followed by cough(65.6%vs.37.7%;P<0.001),myalgia,and fatigue(45.9%vs.13.6%;P<0.001).The risks of the development of severe events(adjusted hazard ratio[AHR]=1.25;95%confidence interval[CI]:0.76–2.06;P=0.378)and mortality(relative risk[RR]=0.90,95%CI:0.79–1.04;P=0.416)in the cancer survivor cohort were comparable to those of the matched non-cancer patient cohort.However,the cancer survivor cohort showed a higher incidence of secondary infection(52.5%vs.30.1%;RR=1.47,95%CI:1.11–1.95;P=0.002)and a prolonged viral RNA shedding duration(32 days[IQR 26.0–46.0]vs.24.0 days[IQR 18.0–33.0];AHR=0.54;95%CI:0.38–0.80;P<0.05).Conclusion Compared to non-cancer patients,cancer survivors with COVID-19 exhibited a higher incidence of secondary infection,a prolonged period of viral shedding,but comparable risks of the development of severe events and mortality.It is helpful for clinicians to take tailored measures to treat cancer survivors with COVID-19. | Hui Peng Sheng Wang Qi Mei Yuhong Dai Jian Li Ming Li Kathrin Halfter Xueyan Jiang Qin Huang Lei Wang Wei Wei Ru Liu Zhen cao Motuma Yigezu Daba Fangfang Wang Bingqing Zhou Hong Qiu Xianglin Yuan | 2020 | Oncology and Translational Medicine2020，6，6： | 1 |
| 11 | Research on the relationship among market orientation, customer relation- ship management, customer knowledge management and business performance显示文摘 | Liyun Qi Keyil Wang Wang Xiaoshul Fangfang Zhang | 2008 | Management Science ~ Engineering2008，2，1： | 1 |
| 12 | Detection of adulteration of sesame and peanut oils via volatiles by GC × GC–TOF/MS coupled with principal components analysis and cluster analysis显示文摘 | Fangfang Zhao Jingkun Liu Xiupin Wang Peiwu Li Wen Zhang Qi Zhang | 2012 | Eur J Lipid Sci Technol2012，，3： | 1 |
| 13 | Finger print analysis of Codonopsis radix by HPLC coupled with ehe mometries analysis显示文摘 | CHEN Fangfang QI Huanyang SHI Yanping | 2013 | Chinese Herbal Medicines2013，5，4： | 1 |
| 14 | Measurement Method and Application of 60Fe by Accelerator Mass Spectrometry显示文摘60Fe plays a very important role in nuclear astrophysics,biomedicine,and safety of nuclear facilities.The high sensitive measurement of 60Fe is the basis of realizing the application of 60Fe.The measurement of 60Fe by accelerator mass spectrometry is the only way to achieve high sensitivity measurement of 60Fe.China Institute | WANG Fangfang HE Ming ZHANG Yuxuan ZHAO Qingzhang PANG Yijun MENG Qi YU Bo WU Shaoyong | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 15 | Experimental investigation on weak shock wave mitigation characteristics of flexible polyurethane foam and polyurea显示文摘In recent years,explosion shock wave has been considered as a signature injury of the current military conflicts.Although strong shock wave is lethal to the human body,weak shock wave can cause many more lasting consequences.To investigate the protection ability and characteristics of flexible materials and structures under weak shock wave loading,the blast wave produced by TNT explosive is loaded on the polyurethane foam with the density of 200.0 kg/m3(F-200)and 400.0 kg/m3(F-400),polyurea with the density of 1100.0 kg/m^(3)(P-1100)and structures composed of the two materials,which are intended for individual protection.Experimental results indicate that the shock wave is attenuated to weak pressure disturbance after interacting with the flexible materials which are not damaged.The shock wave protective capability of single-layer materials is dependent on their thickness,density and microscopic characteristics.The overpressure,maximum pressure rise rate and impulse of transmitted wave decrease exponentially with increase in sample thickness.For the same thickness,F-400 provides better protective capability than F-200 while P-1100 shows the best protective capability among the three materials.In this study,as the materials are not destroyed,F-200 with a thickness more than10.0 mm,F-400 with a thickness more than 4.0 mm,and P-1100 with a thickness more than 1.0 mm can attenuate the overpressure amplitude more than 90.0%.Further,multi-layer flexible composites are designed.Different layer layouts of designed structures and layer thickness of the single-layer materials can affect the protective performance.Within the research range,the structure in which polyurea is placed on the impact side shows the optimal shock wave protective performance,and the thicknesses of polyurea and polyurethane foam are 1.0 mm and 4.0 mm respectively.The overpressure attenuation rate reached maximum value of 93.3%and impulse attenuation capacity of this structure are better than those of single-layer polyurea and polyurethane foam with higher areal density. | Shiyu Jia Cheng Wang Wenlong Xu Dong Ma Fangfang Qi | 2024 | Defence Technology(防务技术)2024，31，1： | 0 |
| 16 | Design of Multi Anode Gas Ionization Chamber with Si3N4 Windows for Detection of Low Energy Heavy Ion显示文摘In order to establish accelerator mass spectrometry technology of the detection of low energy heavy ions,gas ionization chambers with thin windows need to be developed.Mylar membranes are generally used for conventional gas | ZHAO Qingzhang HE Ming YU Bo ZHANG Yuxuan PANG Yijun WANG Fangfang MENG Qi WU Shaoyong | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 17 | Study on Method of Measuring 128I(n,γ)Reaction Cross Section by Accelerator Mass Spectrometry显示文摘The thermal neutron cross section of 128I(n,γ)129I is an important parameter in the research of nuclear physics.For the national application data,stellar evolution model,reactor design,waste disposal and other research has important applications.At present,this reaction cross section has no experimental data in the world. | ZHANG Yuxuan YIN Xinyi HE Ming ZHAO Qingzhang WANG Fangfang WU Shaoyong PANG Yijun MENG Qi YU Bo | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 18 | Service behavior of triboelectric nanogenerators:Bridging the gap between prototypes and applications显示文摘The triboelectric nanogenerators(TENGs),suppling power for freely mobile and distributed electronic equipment from Internet of Things,have been considered as“the energy for the new era”.Research on the service behavior has become increasingly important for achieving the reliability evaluation and life prediction of TENGs,as TENGs advance from prototypes to practical applications.Due to the wide selection of materials,the diversity of device structures,and the complexity of working environment,TENGs show unique characteristics in the service behavior.These dilemmas lead to the fact that systematical summary of service behavior for TENGs is still in its infancy.Here,the progresses of the service behavior for TENGs are comprehensively reviewed from the influence of environmental factors on the service performance of TENGs to the impact of TENGs during the service on their surroundings.We summed up the performance evolution of TENGs in the real environment and the reproducibility of TENGs of which the electrical output will be restored after failure.Then,the service adaptability of TENG is systematically discussed,including the biological and environmental compatibility.Finally,the challenges and opportunities that the related research faced are proposed to promote the emerging technology from laboratory to factory. | Fangfang Gao Xiaochen Xun Xuan Zhao Liangxu Xu Qi Li Bin Zhao Tian Ouyang Qingliang Liao Yue Zhang | 2023 | Nano Research2023，16，9： | 0 |
| 19 | Design & Reality of CAD/CAM in Laser Beam Scanning Manufacturing System显示文摘In laser beam scanning manufacturing(LSM)system the PLT file was adopted as design file.The data of de- sign file were processed by CAD software programmed.And the control model was adopted DEA control model.The DEA model was concerned with not only the distance of the two swaying mirrors,the distance between the swaying mirror and convex lens,the mirror swaying angle and the lens focal length but also the lens central height,the lens convex radius and the medium refractive in- dex.It improved the precision and reduced the error in LBM system.The application of CAD/CAM system in LSM improved the LSM manufacturing velocity and manufacturing quality. | SUN Jianjun SUN Huilai ZHAO Fangfang LIN Shuzhong QI Xiangyang School of Mechanical & Electronic Engineering,Tianjin Polytechnic University,TianJin 300160,China, | 2006 | 武汉理工大学学报2006，28，S3： | 0 |
| 20 | Experimental Study of the Elastic Scattering of^(10)Be on^(208)Pb at the Energy around Three Times of the Coulomb Barrier显示文摘Elastic scattering is the simplest nuclear process and has been widely used to investigate the structure of the interacting nuclei[1,2]. | Duan Fangfang Yang Yanyun Pang Danyang Hu Bitao Wang Jiansong Wang Kang Yang Guo Valdir Guimaraes Ma Peng Xu Shiwei Liu Xingquan Ma Junbing Bai Zhen Hu Qiang Shu Jinya Sun Xinxin Yao Jiasheng Qi Hangkai Sun Zhiyu | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
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