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| 1 | Recent advances in carbon nanostructures prepared from carbon dioxide for high-performance supercapacitors显示文摘The burgeoning global economy during the past decades gives rise to the continuous increase in fossil fuels consumption and rapid growth of CO_(2) emission,which demands an urgent exploration into green and sustainable devices for energy storage and power management.Supercapacitors based on activated carbon electrodes are promising systems for highly efficient energy harvesting and power supply,but their promotion is hindered by the moderate energy density compared with batteries.Therefore,scalable conversion of CO_(2) into novel carbon nanostructures offers a powerful alternative to tackle both issues:mitigating the greenhouse effect caused by redundant atmospheric CO_(2) and providing carbon materials with enhanced electrochemical performances.In this tutorial review,the techniques,opportunities and barriers in the design and fabrication of advanced carbon materials using CO_(2) as feedstock as well as their impact on the energy-storage performances of supercapacitors are critically examined.In particular,the chemical aspects of various Cv2 conversion reactions are highlighted to establish a detailed understanding for the science and technology involved in the microstructural evolution,surface engineering and porosity control of CO_(2)-converted carbon nanostructures.Finally,the prospects and challenges associated with the industrialization of CO_(2) conversion and their practical application in supercapacitors are also discussed. | Chen Li Xiong Zhang Kai Wang Fangyuan Su Cheng-Meng Chen Fangyan Liu Zhong-Shuai Wu Yanwei Ma | 2021 | Journal of Energy Chemistry2021，30，3： | 4 |
| 2 | A safe,low-cost and high-efficiency presodiation strategy for pouch-type sodium-ion capacitors with high energy density显示文摘Sodium-ion capacitors(SICs)have attracted appreciable attention in virtue of the higher energy and power densities compared with their rivals,supercapacitors and sodium-ion batteries.Due to the lack of sodium resources in cathode,presodiation is critical for SICs to further augment performances.However,current presodiation strategy utilizes metallic sodium as the presodiation material.In this strategy,assembling/disassembling of half-cells is required,which is dangerous and in creases the time and cost of SIC leading to the restriction of their industrialization and commercialization.Herein we present a safe,low-cost and high-efficiency presodiation strategy by first employing Na_(2)C_(2)O_(4) as the sacrificial salt applied in SICs.Na_(2)C_(2)O_(4) is environmentally friendly and possesses considerably low expenditure.No additional residues remain after sodium extraction ascribed to its'zero dead mass'property.When paired with commercial activated carb on as the cathode and commercial hard carbon as the ano de,the constructed pouch-type SICs exhibit high energy and power densities of 91.7 Wh/kg and 13.1 kW/kg,respectively.This work shows a prospect of realizing the safe and low-cost manufacturing for high-performance SICs commercially. | Congkai Sun Xiong Zhang Chen Li Kai Wang Xianzhong Sun Fangyan Liu Zhong-Shuai Wu Yanwei Ma | 2022 | Journal of Energy Chemistry2022，31，1： | 3 |
| 3 | Biophotonic Activity and Transmission Mediated by Mutual Actions of Neurotransmitters are Involved in the Origin and Altered States of Consciousness显示文摘Dear Editor Despite remarkable advances in our understanding of brain functions,the neural substrates and correlates of consciousness remain unclear[1].It has been argued that classical physics is intrinsically incapable of explaining the holistic aspects of consciousness,especially its | Weitai Chai Zhengrong Han Zhuo Wang Zehua Li Fangyan Xiao Yan Sun Yanfeng Dai Rendong Tang Jiapei Dai | 2018 | Neuroscience Bulletin2018，34，3： | 2 |
| 4 | Three dimensional electrochemical ox- idation depth dop wastewater treatment 显示文摘 | CHEN Fangyan WANG Chunling CHEN Cunjian | 2012 | Environmental engineering2012，6，2： | 1 |
| 5 | Optimization and field experiment of an adjustable device for sugar beet digger显示文摘The harvesting operation,which affects the energy consumption and application performance,usually determines the harvesting effect and production quality of the crop.An adjustable sugar beet excavation device was designed to put the excavation equipment into practice by reducing harvest loss.The device is composed of an excavation disc,hub,pedestal,threaded rod,adjustable nut,boom,mounting seat,leak proof disc,etc.Through theoretical analysis,it was found that the excavation disc and the adjustment mechanism,which determine the excavation space and loading condition of the device,are important to the excavation device.Key parameters of the excavation disc were selected according to the growth status of sugar beet and the requirements of excavation space,with 340 mm as the radius of the excavation disc and 7.5°as the edge angleθ.The adjustment mechanism parameters were selected to change the operating parameters(inclination angleβand deflection angleγ)easily.Through the theoretical and experimental preliminary research,the key components structure and parameters of the excavation device were determined.By Central Composite Design(CCD)method,the regression equation was established,with rotation angleα,opening angleεand excavation depth h as factors,and break rate,loss rate and excavation resistance as performance indexes.The influence of factors on performance indexes was estimated.The optimized parameter combination is:35.37°of rotation angle,15.08°of opening angle and 135.20 mm of the excavation depth.Experiments verified that the adjustable excavation device worked stably and achieved smooth excavation without congestion.The test indexes improved,with 0.6%of break rate,1.1%of loss rate and 2312.8 N of the excavation resistance.This satisfied the requirement for beet harvest quality,and is roughly consistent with the optimization result.The research results can provide reference for the research on mechanized harvesting technology and equipment of sugar beet. | Fangyan Wang | 2021 | International Journal of Agricultural and Biological Engineering2021，14，6： | 1 |
| 6 | Characterizing the effects of climate change on short-term post-disturbance forest recovery in southern China from Landsat time-series observations(1988-2016)显示文摘Climate change,a recognized critical environmental issue,plays an important role in regulating the structure and function of forest ecosystems by altering forest disturbance and recovery regimes.This research focused on exploring the statistical relationships between meteorological and topographic variables and the recovery characteristics following disturbance of plantation forests in southern China.We used long-term Landsat images and the vegetation change tracker algorithm to map forest disturbance and recovery events in the study area from 1988 to 2016.Stepwise multiple linear regression(MLR),random forest(RF)regression,and support vector machine(SVM)regression were used in conjunction with climate variables and topographic factors to model short-term forest recovery using the normalized difference vegetation index(NDVI).The results demonstrated that the regenerating forests were sensitive to the variation in temperature.The fitted results suggested that the relationship between the NDVI values of the forest areas and the post-disturbance climatic and topographic factors differed in regression algorithms.The RF regression yielded the best performance with an R2 value of 0.7348 for the validation accuracy.This indicated that slope and temperature,especially high temperatures,had substantial effects on post-disturbance vegetation recovery in southern China.For other mid-subtropical monsoon regions with intense light and heat and abundant rainfall,the information will also contribute to appropriate decisions for forest managers on forest recovery measures.Additionally,it is essential to explore the relationships between forest recovery and climate change of different vegetation types or species for more accurate and targeted forest recovery strategies. | Fangyan Zhu Heng Wang Mingshi Li Jiaojiao Diao Wenjuan Shen Yali Zhang Hongji Wu | 2020 | Frontiers of Earth Science2020，14，4： | 1 |
| 7 | Optimized design of the 4TSQ-2 sugar beet top cutting machine显示文摘To solve the problems faced by 4TSQ-2 sugar beet top cutting machine,i.e.large structure,high power consumption and high manufacturing cost,the multi-roller mechanism for leaves removal and fixed-thickness cutting method was studied.Using five-factor and two-level tests,the structure configuration of the leaf removal device was optimized,and the scheme of two roller shafts defoliation,the roller shaft rotation speed of 800 r/min and the forward speed of 0.8 m/s were determined.Through the working process and mechanical analysis of the top cutting device,the cutting device with the slant profiling plate structure characterized by a profiling angle of 25°-45°for the profiling plate and a cutting angle of 20°-40°was studied.With the two-factor and three-level experiments,the profiling angle of profiling plate of the top cutting device was 35°,and the cutting angle was 30°.Compared with the 4TSQ-2 sugar beet top cutting machine before optimization,the structure size of the machine was reduced by 30%,the weight was reduced by 15%,the cost was reduced by 25%,the qualified rate of top cutting wad was increased by 2.6%,and the push over rate of sugar beet was reduced by 0.5%.Besides,each index met the index requirements of beet top cutting harvest. | Fangyan Wang Zhenyu Zhang Yongfei Pan Yuliang Yun Dongwei Wang | 2022 | International Journal of Agricultural and Biological Engineering2022，15，2： | 1 |
| 8 | Protein Phosphatase 4 Cooperates with Smads to Promote BMP Signaling in Dorsoventral Patterning of Zebrafish Embryos显示文摘 | Shunji Jia Fangyan Dai Di Wu Xia Lin Cencan Xing Yu Xue Ying Wang Mu Xiao Wei Wu Xin-Hua Feng Anming Meng | 2012 | Developmental Cell2012，，5： | 1 |
| 9 | Two-dimensional extension of variance-based thresholding for image segmentation 显示文摘 | Nie Fangyan Wang Yonglin Pan Meisen | 2013 | Multidimensional Systems and Signal Processing2013，24，3： | 1 |
| 10 | A novel long-term intravenous combined with local treatment with human amnion-derived mesenchymal stem cells for a multidisciplinary rescued uremic calciphylaxis patient and the underlying mechanism显示文摘Calciphylaxis is a rare disease characterized histologically by microvessel calcification and microthrombosis,with high mortality and no proven therapy.Here,we reported a severe uremic calciphylaxis patient with progressive skin ischemia,large areas of painful malodorous ulcers,and mummified legs.Because of the worsening symptoms and signs refractory to conventional therapies,treatment with human amnion-derived mesenchymal stem cells(hAMSCs)was approved.Preclinical release inspections of hAMSCs,efficacy,and safety assessment,including cytokine secretory ability,immunocompetence,tumorigenicity,and genetics analysis in vitro,were introduced.We further performed acute and long-term hAMSC toxicity evaluations in C57BL/6 mice and rats,abnormal immune response tests in C57BL/6 mice,and tumorigenicity tests in neonatal Balbc-nu nude mice.After the preclinical research,the patient was treated with hAMSCs by intravenous and local intramuscular injection and external supernatant application to the ulcers.When followed up to 15 months,the blood-based markers of bone and mineral metabolism improved,with skin soft tissue regeneration and a more favorable profile of peripheral blood mononuclear cells.Skin biopsy after 1-month treatment showed vascular regeneration with mature noncalcified vessels within the dermis,and 20 months later,the re-epithelialization restored the integrity of the damaged site.No infusion or local treatment-related adverse events occurred.Thus,this novel long-term intravenous combined with local treatment with hAMSCs warrants further investigation as a potential regenerative treatment for uremic calciphylaxis due to effects of inhibiting vascular calcification,stimulating angiogenesis and myogenesis,anti-inflammatory and immune modulation,multidifferentiation,re-epithelialization,and restoration of integrity. | Lianju Qin Jing Zhang Yujie Xiao Kang Liu Yugui Cui Fangyan Xu Wenkai Ren Yanggang Yuan Chunyan Jiang Song Ning Xiaoxue Ye Ming Zeng Hanyang Qian Anning Bian Fan Li Guang Yang Shaowen Tang Zhihong Zhang Juncheng Dai Jing Guo Qiang Wang Bin Sun Yifei Ge Chun Ouyang Xueqiang Xu Jing Wang Yaoyu Huang Hongqing Cui Jing Zhou Meilian Wang Zhonglan Su Yan Lu Di Wu Jingping Shi Wei Liu Li Dong Yinbing Pan Baiqiao Zhao Ying Cui Xueyan Gao Zhanhui Gao Xiang Ma Aiqin Chen Jie Wang Meng Cao Qian Cui Li Chen Feng Chen Youjia Yu Qiang Ji Zhiwei Zhang Mufeng Gu Xiaojun Zhuang Xiaolin Lv Hui Wang Yanyan Pan Ling Wang Xianrong Xu Jing Zhao Xiuqin Wang Cuiping Liu Ningxia Liang Changying Xing Jiayin Liu Ningning Wang | 2022 | Journal of Molecular Cell Biology2022，14，2： | 1 |
| 11 | CD36 promotes tubular ferroptosis by regulating the ubiquitination of FSP1 in acute kidney injury显示文摘Reactive oxidative species(ROos)production-driven ferroptosis plays a role in acute kidney injury(Akl).However,its exact molecular mechanism is poorly understood.Scavenger receptor CD36 has important roles in oxidizing lipids,lipid accumulation,metabolic syndrome,and insulin resistance in chronic kidney disease,but its roles remain unexplored in AKl.The present study investigated the role and mechanism of CD36 in regulating proximal tubular cell ferroptosis and AKl.The expression of CD36 was found to be significantly up-regulated in AKI renal tissues and correlated with renal function,which might serve as an independent biomarker for AKl patients.Moreover,in adult mice subjected to AKl,deletion of CD36(CD36-/-)induced tubular cell Ros accumulation,ferroptosis activation,and renal injury.Mechanistically,combining LC-MS/MS,co-IP,and ubiquitination analyses revealed that CD36 could specifically bind to ferroptosis suppressor protein 1(FSP1)and regulate its ubiquitination at sites K16 and K24,leading to FSP1 degradation and progression of ferroptosis in AKl.The present results emphasize a novel mechanism of CD36 in cisplatin-induced AKl.The discovery of the special CD36 roles in promoting ferroptosis and AKI development by regulating the ubiquitination of FSP1 in proximal tubular cells may be potential therapeutic targets for AKl.Moreover,CD36 may play a key role in the progression of AKl.Therefore,targeting CD36 may provide a promising treatment option for AKI. | Yixin Ma Lili Huang Zheng Zhang Pengfei Yang Qingsong Chen Xujia Zeng Fangyan Tan Chunxia Wang Xiongzhong Ruan Xiaohui Liao | 2024 | Genes & Diseases2024，11，1： | 0 |
| 12 | Structural regulation chemistry of lithium-ion solvation in nonflammable phosphate-based electrolytes for high interfacial compatibility with graphite anode显示文摘With the booming development of lithium-ion batteries,safety has become one of the most primary focuses of current researches.Although there are various approaches to enhance the safety of lithiumion batteries,phosphate-based electrolyte holds the greatest potential for practical application due to their non-flammability.Nonetheless,its compatibility issue with the graphite anode remains a significant obstacle to its widespread use.Herein,an effective method is proposed to improve the compatibility of electrolyte with graphite(Gr)anode by rationally adjusting the proportion of lithium salt and solvent components to optimize the Li^(+)solvation structure.By slightly increasing the Li^(+)/triethyl phosphate(TEP)ratio,TEP alone cannot fully occupy the inner solvation sheath and therefore less polar ethylene carbonate(EC)has to be recruited,and the solvation structure gradually changes from Li^(+)–[TEP]_(4)to Li^(+)–[TEP]_(3)[EC]with the coexistence of EC and TEP.Simultaneously,EC molecules in the Li^(+)–[TEP]_(3)[EC]could be preferentially reduced on graphite compared to the TEP molecules,resulting in the formation of a uniform and durable solid-electrolyte interphase(SEI)layer.Benefiting from the optimized phosphate-based electrolyte,the Gr|Li battery exhibits a capacity retention rate of 96.8%after stable cycling at 0.5 C for 470 cycles which shows a longer cycle life than the battery with carbonate electrolyte(cycling at 0.5 C for 450 cycles).Therefore,this work provides the guidance for designing a non-flammable phosphate-based electrolyte for high-safety and long cycling-life lithium-ion batteries. | Chenyang Shi Xinjing Huang Jiahao Gu Zeyu Huang Fangyan Liu Mengran Wang Qiyu Wang Bo Hong Zhian Zhang Jie Li Yanqing Lai | 2023 | Journal of Energy Chemistry2023，，12： | 0 |
| 13 | Seed guide path planning and parameter optimization for air-suction carrot seed-metering device显示文摘To meet the requirement of“zero speed”for precision sowing,the instantaneous speed of seed falling into the seed bed should be equal to the opposite direction of the forward speed of the machine.Through analyzing the principle of seed guiding process,the main influencing factors affecting the contour curve of the seed tube were determined to plan the seed guiding path and realize zero speed seed delivery.With the help of EDEM simulation software,taking the inclination angle of seed tube end,operating speed of the metering disc,and machine’s forward speed as the experimental factors,a single-factor simulation test was conducted with the pass rate,replay rate,and missing seeding rate as experimental indexes.The results of the simulation test showed that the range of inclination angle of the seed tube end was 23°-40°,the range of machine forward speed was 5-9 km/h,and the range of operating speed of the metering disc was 15-40 r/min.The quadratic orthogonal rotation combination test method was carried out using the bench test,and a mathematical regression model was established between experimental factors and experimental indexes to determine the priority order of factors,and the best combination of factors.The test results showed that the pass rate was 93.25%,the replay rate was 2.97%and the missing seeding rate was 3.78%under the condition with the inclination angle of seed tube end of 32.28°,the forward speed of the machine of 6.89 km/h and the operating speed of the metering disc of 28.67 r/min,which can meet the requirements of relevant national standards. | Fangyan Wang Wenxin Zhang Jingtao Jiang | 2023 | International Journal of Agricultural and Biological Engineering2023，16，5： | 0 |
| 14 | A bHLH transcription factor,CsSPT,regulates high-temperature resistance in cucumber显示文摘High-temperature stress threatens the growth and yield of crops. Basic helix-loop-helix(bHLH) transcription factors(TFs) have been shown to play important roles in regulating high-temperature resistance in plants. However, the bHLH TFs responsible for high-temperature tolerance in cucumbers have not been identified. We used transcriptome profiling to screen the high temperature-responsive candidate bHLH TFs in cucumber. Here, we found that the expression of 75 CsbHLH genes was altered under high-temperature stress. The expression of the CsSPT gene was induced by high temperatures in TT(Thermotolerant) cucumber plants. However, the Csspt mutant plants obtained by the CRISPR-Cas9 system showed severe thermosensitive symptoms, including wilted leaves with brown margins and reduced root density and cell activity.The Csspt mutant plants also exhibited elevated H_(2)O_(2) levels and down-regulated photosystem-related genes under normal conditions.Furthermore, there were high relative electrolytic leakage(REC), malondialdehyde(MDA), glutathione(GSH), and superoxide radical(O_(2)^(·-)) levels in the Csspt mutant plants, with decreased Proline content after the high-temperature treatment. Transcriptome analysis showed that the photosystem and chloroplast activities in Csspt mutant plants were extremely disrupted by the high-temperature stress compared with wildtype(WT) plants. Moreover, the plant hormone signal transduction, as well as MAPK and calcium signaling pathways were activated in Csspt mutant plants under high-temperature stress. The HSF and HSP family genes shared the same upregulated expression patterns in Csspt and WT plants under high-temperature conditions. However, most bHLH, NAC, and bZIP family genes were significantly down-regulated by heat in Csspt mutant plants. Thus, these results demonstrated that CsSPT regulated the high-temperature response by recruiting photosynthesis components, signaling pathway molecules, and transcription factors. Our results provide important insights into the heat response mechanism of CsSPT in cucumber and its potential as a target for breeding heat-resistant crops. | Yonggui Liang Chenyu Yang Fangyan Ming Bingwei Yu Zhihua Cheng Yixi Wang Zhengkun Qiu Xiaolan Zhang Bihao Cao Shuangshuang Yan | 2024 | Horticultural Plant Journal2024，10，2： | 0 |
| 15 | DEM-based parameter optimization and tests of digging green onions显示文摘In view of the problems of easy damage and high digging resistance in the process of green onion harvesting,a mechanical model of digging green onions was established by taking the moment of digging and drawing green onions as the research object,and the main factors affecting the digging and harvesting effect were determined as the angle of digging,the dip angle of clamping carrier and the length of shovel.Thus,a complex simulation model of soil-green onion-digging mechanism system reflecting the state of harvesting was established,and the model was verified by testing soil compactness.The simulation tests were carried out by means of the complex simulation model of soil-green onion-digging mechanism system,making it clear that digging angle and the length of shovel have a extremely significant impact on the digging resistance,and the dip angle of the clamping carrier had a significant impact on the digging resistance.Through target optimization,the optimal combination of digging parameters was obtained,namely,the digging angle of 20°,the dip angle of clamping carrier of 25°and the shovel length of 70 mm,with the digging resistance of 1394 N at this moment.The field digging resistance test has showed that the average digging resistance is 1543 N with the average clamping damage rate of 1.27%and the average clamping loss rate of 0.44%,which can meet the requirements of green onion harvesting. | Fangyan Wang Zhuchuan Qiu Yongfei Pan Guangquan Sun | 2023 | International Journal of Agricultural and Biological Engineering2023，16，4： | 0 |
| 16 | Robust route to H_(2)O_(2)and H_(2)via intermediate water splitting enabled by capitalizing on minimum vanadium-doped piezocatalysts显示文摘H_(2)O_(2)is an environmentally friendly chemical for a wide range of water treatments.The industrial production of H_(2)O_(2)is an anthraquinone oxidation process,which,however,consumes extensive energy and produces pollution.Here we report a green and sustainable piezocatalytic intermediate water splitting process to simultaneously obtain H_(2)O_(2)and H_(2)using single crystal vanadium(V)-doped NaNbO_(3)(V-NaNbO_(3))nanocubes as catalysts.The introduction of V improves the specific surface area and active sites of NaNbO_(3).Notably,V-NaNbO_(3)piezocatalysts of 10 mg exhibit 3.1-fold higher piezocatalytic efficiency than the same catalysts of 50 mg,as more piezocatalysts lead to higher probability of aggregation.The aggregation causes reducing active sites and decreased built-in electric field due to the neutralization between different nano-catalysts.Remarkably,piezocatalytic H_(2)O_(2)and H_(2)production rates of V-NaNbO_(3)(10 mol%)nanocubes(102.6 and 346.2μmol·g^(−1)·h^(−1),respectively)are increased by 2.2 and 4.6 times compared to the as-prepared pristine NaNbO_(3)counterparts,respectively.This improved catalytic efficiency is attributed to the promoted piezo-response and more active sites of NaNbO_(3)catalysts after V doping,as uncovered by piezoresponse force microscopy(PFM)and density functional theory(DFT)simulation.More importantly,our DFT results illustrate that inducing V could reduce the dynamic barrier of water dissociation over NaNbO_(3),thus enhancing the yield of H_(2)O_(2)and H_(2).This facile yet robust piezocatalytic route using minimal amounts of catalysts to obtain H_(2)O_(2)and H_(2)may stand out as a promising candidate for environmental applications and water splitting. | Yuekun Li Li Li Fangyan Liu Biao Wang Feng Gao Chuan Liu Jingyun Fang Feng Huang Zhang Lin Mengye Wang | 2022 | Nano Research2022，15，9： | 0 |
| 17 | Microenvironment components and spatially resolved single-cell transcriptome atlas of breast cancer metastatic axillary lymph nodes显示文摘As an indicator of clinical prognosis,lymph node metastasis of breast cancer has drawn great attention.Many reports have revealed the characteristics of metastatic breast cancer cells,however,the effect of breast cancer cells on the microenvironment components of lymph nodes and spatial transcriptome atlas remains unclear.In this study,by integrating single-cell RNA sequencing(scRNA-seq)and spatial transcriptomics,we investigate the transcriptional profiling of six surgically excised lymph node samples and the spatial organization of one positive lymph node.We identify the existence of osteoclast-like giant cells(OGC)which have high expressions of CD68 and CD163,the biomarkers of tumor-associated macrophages(TAMs).Through a spatially resolved transcriptomic method,we find that OGCs are scattered among metastatic breast cancer cells.In the lymph node microenvironment with breast cancer cell infiltration,TAMs are enriched in protumoral pathways including NF-kB signaling pathways and NoD-like receptor signaling pathways.Further subclustering demonstrates the potential differentiation trajectory in which macrophages develop from a state of active chemokine production to a state of active lymphocyte activation.This study is the first to integrate scRNA-seq and spatial transcriptomics in the tumor microenvironment of axillary lymph nodes,offering a systematic approach to delve into breast cancer lymph node metastasis. | Kun Xu Runtian Wang Qin Chen Yiqiu Liu Xintong Li Ling Mao Cenzhu Wang Fangyan Gao Longfei Hu Hui Xie Cong Wang Guohua Zhou Xiaoxiang Guan | 2022 | Acta Biochimica et Biophysica Sinica2022，54，9： | 0 |
| 18 | The effect of noise barriers on viaducts on pollutant dispersion in complex street canyons显示文摘The noise reduction effect of noise barriers has been extensively studied,but the effect on pollutant dispersion remains unclear.A computational fluid dynamics(CFD)simulation is conducted to investigate the effects of different heights,lengths,and types of noise barriers and different wind speeds on pollutant dispersion in street canyons with viaducts.The field synergy theory of the convective mass transfer process is used for quantitative analysis of pollutant dispersion in street canyons.The results show that as the height and length of the noise barrier increase,the pollutant dispersion capacity decreases.As the wind speed increases,the rate of decrease in the average CO concentration declines.The effect of the wind speed on the synergistic improvement of the speed and concentration gradient vectors differs for different types of noise barriers.The performance follows the order:fully-closed noise barrier>left noise barrier>right noise barrier>semi-closed noise barrier.The different noise barrier types significantly impact the flow field and pollutant dispersion and reduce the CO concentration to varying degrees,except for the fully-closed type.The average CO concentration in the pedestrian breathing zone is reduced by a maximum of 55.85%on the leeward side and by 53%on the windward side,indicating that an appropriate noise barrier on the viaduct reduces noise pollution and improves the air quality in street canyons,especially in the pedestrian breathing zone. | Tingzhen Ming Fangyan He Yongjia Wu Tianhao Shi Changrong Su Caixia Wang Zhengtong Li Wei Chen Renaud de Richter | 2023 | Energy and Built Environment2023，4，5： | 0 |
| 19 | Ultrasound-responsive spherical nucleic acid against c-Myc/PD-L1 to enhance anti-tumoral macrophages in triple-negative breast cancer progression显示文摘Triple-negative breast cancer(TNBC)is the most challenging breast cancer subtype because of its aggressive behavior and limited therapeutic targets.c-Myc is hyperactivated in the majority of TNBC tissues,however,it has been considered an“undruggable”target due to its disordered structure.Herein,we developed an ultrasound-responsive spherical nucleic acid(SNA)against c-Myc and PD-L1 in TNBC.It is a self-assembled and carrier-free system composed of a hydrophilic small-interfering RNA(si RNA)shell and a hydrophobic core made of a peptide nucleic acid(PNA)-based antisense oligonucleotide(ASO)and a sonosensitizer.We accomplished significant enrichment in the tumor by enhanced permeability and retention(EPR)effect,the controllable release of effective elements by ultrasound activation,and the combination of targeted therapy,immunotherapy and physiotherapy.Our study demonstrated significant anti-tumoral effects in vitro and in vivo.Mass cytometry showed an invigorated tumor microenvironment(TME)characterized by a significant alteration in the composition of tumor-associated macrophages(TAM)and decreased proportion of PD-1-positive(PD-1+)T effector cells after appropriate treatment of the ultrasound-responsive SNA(USNA).Further experiments verified that tumor-conditioned macrophages residing in the TME were transformed into the anti-tumoral population.Our finding offers a novel therapeutic strategy against the“undruggable”c-Myc,develops a new targeted therapy for c-Myc/PD-L1 and provides a treatment option for the TNBC. | Runtian Wang Gaigai Li Fangyan Gao Feng Xu Xintong Li Jian Zhang Jinbo Li Xiaoxiang Guan | 2024 | Science China(Life Sciences)2024，67，4： | 0 |
| 20 | Inhibition of MYC suppresses programmed cell death ligand-1 expression and enhances immunotherapy in triple-negative breast cancer显示文摘Background:Cancer immunotherapy has emerged as a promising strategy against triple-negative breast cancer(TNBC).One of the immunosuppressive pathways involves programmed cell death-1(PD-1)and programmed cell death ligand-1(PD-L1),but many patients derived little benefit from PD-1/PD-L1 checkpoint blockades treatment.Prior research has shown that MYC,a master transcription amplifier highly expressed in TNBC cells,can regulate the tumor immune microenvironment and constrain the efficacy of immunotherapy.This study aims to investigate the regulatory relationship between MYC and PD-L1,and whether a cyclin-dependent kinase(CDK)inhibitor that inhibits MYC expression in combination with anti-PD-L1 antibodies can enhance the response to immunotherapy.Methods:Public databases and TNBC tissue microarrays were used to study the correlation between MYC and PD-L1.The expression of MYC and PD-L1 in TNBCs was examined by quantitative real-time polymerase chain reaction and Western blotting.A patient-derived tumor xenograft(PDTX)model was used to evaluate the influence of a CDK7 inhibitor THZ1 on PD-L1 expression.Cell proliferation and migration were detected by 5-ethynyl-2′-deoxyuridine(EdU)cell proliferation and cell migration assays.Tumor xenograft models were established for in vivo verification.Results:A high MYC expression level was associated with a poor prognosis and could alter the proportion of tumor-infiltrating immune cells(TIICs).The positive correlation between MYC and PD-L1 was confirmed by immunostaining samples from 165 TNBC patients.Suppression of MYC in TNBC caused a reduction in the levels of both PD-L1 messenger RNA and protein.In addition,antitumor immune response was enhanced in the TNBC cancer xenograft mouse model with suppression of MYC by CDK7 inhibitor THZ1.Conclusions:The combined therapy of CDK7 inhibitor THZ1 and anti-PD-L1 antibody appeared to have a synergistic effect,which might offer new insight for enhancing immunotherapy in TNBC. | Xintong Li Lin Tang Qin Chen Xumin Cheng Yiqiu Liu Cenzhu Wang Chengjun Zhu Kun Xu Fangyan Gao Jinyi Huang Runtian Wang Xiaoxiang Guan | 2022 | Chinese Medical Journal2022，135，20： | 0 |
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