|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Response of the northwestern Pacific upper water δ^(13)C to the last deglacial ventilation of the deep Southern Ocean显示文摘The deglacial δ~13C minimum events that originated from the ventilation of the deep Southern Ocean around Antarctica, have been recorded in a range of marine sediments from the southern to tropical oceans in late Pleistocene. However, the broad δ~13C minimum event was also reported as far as to the northern middle latitudes, in northwestern Pacific marginal sea areas, during the last deglaciation. In the northwestern Pacific, forcing from the northern high latitudes is strongly expressed, while the records of in- fluence from the southern high latitudes are few. The Kuroshio Source Region (KSR) forms a boundary between the northwestern Pacific and the southern, tropical Pacific. So, high-resolution planktonic foraminiferal records in core MD06-3054 from the KSR are well positioned to identify signals from the southern hemisphere in the northwestern Pacific. Planktonic foraminiferal tests from the upper 1030 cm of the core were subject to AMS14C, carbon and oxygen isotopic measurements. A negative excursion was found to occur from about 20.0-6.0 ka BP in δ~13C records of both surface (Globigerinoides ruber) and subsurface (Pulleni- atina obliquiloculata) dwellers, but the overall trends of the two curves have reversed since 26.5 ka BP. Moreover, the δ~13C rec- ord of G. ruber (the surface dweller) shows a robust link to the record of atmospheric CO2, and its changes precede the records of P. obliquiloculata (the subsurface dweller). According to the hydrologic conditions, the broad δ~13C minimum event recorded in the KSR is also a response to the increasing ventilation of the deep Southern Ocean around Antarctica during the last deglaciation. The inconsistency between the records of the surface and subsurface dwellers was possibly caused by the ways that the low δ~13C signal was transmitted. Subsurface water primarily received the low δ~13C signal from the Antarctic Intermediate Water (AAIW), whereas the surface water was probably mainly impacted by atmospheric CO2 in the KSR. The records from the KSR confirm the deduction that the broad δ~13C minimum event in the Okinawa Trough was due to the impact of tropical Pacific surface water dur- ing the last deglaciation, and suggest that signals from the southern high latitudes also can be delivered to the northern middle latitudes. | CHEN ShuangXi LI TieGang TANG Zheng QIU XiaoHua XIONG ZhiFang NAN QingYun XU ZhaoKai CHANG FengMing | 2011 | Chinese Science Bulletin2011，56，24： | 5 |
| 2 | Calcareous nannofossil bioevents and microtektite stratigraphy in the Western Philippine Sea during the Quaternary显示文摘Two sediment cores, MD06-3050 and MD06-3047, were analyzed to study the Quaternary calcareous nannofossil and microtektite records. We dated bioevents and the microtektite impact event by calibrating with oxygen isotope stratigraphy. Seven calcareous nannofossil bioevents were identified over the past 2.36 Ma including the last appearance of data for Discoaster brouweri, Calcidiscus macintyrei, large Gephyrocapsa and Pseudoemiliania lacunosa, the first appearance of data for large Gephyrocapsa and Emiliania huxleyi, and the abrupt increase in the abundance of Gephyrocapsa caribbeanica. In addition, we fortunately observed that Australasian microtektites were distributed in core MD06-3050 from 1340 to 1374 cm. | SUN HanJie LI TieGang SUN RongTao YU XinKe CHANG FengMing TANG Zheng | 2011 | Chinese Science Bulletin2011，56，25： | 3 |
| 3 | A comprehensive analysis of the Bencao(herbal)small RNA Atlas reveals novel RNA therapeutics for treating human diseases显示文摘Cross-kingdom herbal mi RNA was first reported in 2012.Using a modified herbal extraction protocol,we obtained 73,677,287sequences by RNA-seq from 245 traditional Chinese Medicine(TCM),of which 20,758,257 were unique sequences.We constructed a Bencao(herbal)small RNA(s RNA)Atlas(http://gffzz4a3adbfa122d4a47h66u9bncnp5xc6nuu.ffgz.tsg.suse.edu.cn),annotated the sequences by sequence-based clustering,and created a nomenclature system for Bencao s RNAs.The profiles of 21,757 mi RNAs in the Atlas were highly consistent with those of plant mi RNAs in mi RBase.Using software tools,our results demonstrated that all human genes might be regulated by s RNAs from the Bencao s RNA Atlas,part of the predicted human target genes were experimentally validated,suggesting that Bencao s RNAs might be one of the main bioactive components of herbal medicines.We established roadmaps for oligonucleotide drugs development and optimization of TCM prescriptions.Moreover,the decoctosome,a lipo-nano particle consisting of 0.5%–2.5%of the decoction,demonstrated potent medical effects.We propose a Bencao(herbal)Index,including small-molecule compounds(SM),protein peptides(P),nucleic acid(N),non-nucleic and non-proteinogenic large-molecule compounds(LM)and elements from Mendeleev's periodic table(E),to quantitatively measure the medical effects of botanic medicine.The Bencao s RNA Atlas is a resource for developing gene-targeting oligonucleotide drugs and optimizing botanical medicine,and may provide potential remedies for the theory and practice of one medicine. | Yinghao Cao Yexuan Lin Na Sun Xinyi Du Yixin Dong Song Mei Xingyu Deng Xiaobei Li Shaoting Guo Kegong Tang Jiaqi Liu Xiangyu Qiao Dandan Zhao Yuhao Qin Cong Zhang Tianyi Xin Xiaohu Shi Congzhao Zhou Tao Dong De-an Guo Benedikt MKessler Dong Xu Jingyuan Song Fengming Huang Xiaoyue Wang Chengyu Jiang | 2023 | Science China(Life Sciences)2023，66，10： | 2 |
| 4 | Vibration control of the finite L-shaped beam structures based on the active and reactive power flow显示文摘This paper analyzes the physical meaning of the active and reactive power flow in the finite L-shaped beams and studies the active vibration control of the structures based on the active and reactive power flow.The traveling wave approach is used to calculate the structural dynamic responses.Because the error of control force is inevitable in practical applications,the effects of the error of control force on the control results are studied.The study indicates that the error of control force has pronounced influence on the control results of the acceleration and reactive power flow.It is obvious that the reactive power flow can represent the vibration strength component of the complex intensity,and the active power flow strongly depends on the structural damping of the finite beams. | LIU ChunChuan LI FengMing TANG Liang HUANG WenHu | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，2： | 2 |
| 5 | Grinding Wheel Condition Monitoring with Boosted Minimumdistance Classifiers 显示文摘 | T Warren Liao Fengming Tang J Qu | 2008 | Mechanical Systems and Signal Processing2008，22，： | 1 |
| 6 | Orally administered BZL-s RNA-20 oligonucleotide targeting TLR4 effectively ameliorates acute lung injury in mice显示文摘The global COVID-19 pandemic emerged at the end of December 2019.Acute respiratory distress syndrome(ARDS)and acute lung injury(ALI)are common lethal outcomes of bacterial lipopolysaccharide(LPS),avian influenza virus,and SARS-Co V-2.Toll-like receptor 4(TLR4)is a key target in the pathological pathway of ARDS and ALI.Previous studies have reported that herbal small RNAs(s RNAs)are a functional medical component.BZL-s RNA-20(Accession number:B59471456;Family ID:F2201.Q001979.B11)is a potent inhibitor of Toll-like receptor 4(TLR4)and pro-inflammatory cytokines.Furthermore,BZLs RNA-20 reduces intracellular levels of cytokines induced by lipoteichoic acid(LTA)and polyinosinic-polycytidylic acid(poly(I:C)).We found that BZL-s RNA-20 rescued the viability of cells infected with avian influenza H5N1,SARS-Co V-2,and several of its variants of concern(VOCs).Acute lung injury induced by LPS and SARS-Co V-2 in mice was significantly ameliorated by the oral medical decoctosome mimic(bencaosome;sphinganine(d22:0)+BZL-s RNA-20).Our findings suggest that BZLs RNA-20 could be a pan-anti-ARDS/ALI drug. | Dandan Zhao Yuhao Qin Jiaqi Liu Kegong Tang Shuaiyao Lu Zirui Liu Yexuan Lin Cong Zhang Fengming Huang Jiahui Chang Chang Li Mingyao Tian Yiming Ma Xiaoyun Li Congzhao Zhou Xiao Li Xiaozhong Peng Ningyi Jin Chengyu Jiang | 2023 | Science China(Life Sciences)2023，66，7： | 1 |
| 7 | An invasive zone in human liver cancer identified by Stereo-seq promotes hepatocyte–tumor cell crosstalk,local immunosuppression and tumor progression显示文摘Dissecting and understanding the cancer ecosystem,especially that around the tumor margins,which have strong implications for tumor cell infiltration and invasion,are essential for exploring the mechanisms of tumor metastasis and developing effective new treatments.Using a novel tumor border scanning and digitization model enabled by nanoscale resolution-SpaTial Enhanced REsolution Omics-sequencing(Stereo-seq),we identified a 500µm-wide zone centered around the tumor border in patients with liver cancer,referred to as“the invasive zone”.We detected strong immunosuppression,metabolic reprogramming,and severely damaged hepatocytes in this zone.We also identified a subpopulation of damaged hepatocytes with increased expression of serum amyloid A1 and A2(referred to collectively as SAAs)located close to the border on the paratumor side.Overexpression of CXCL6 in adjacent malignant cells could induce activation of the JAK-STAT3 pathway in nearby hepatocytes,which subsequently caused SAAs’overexpression in these hepatocytes.Furthermore,overexpression and secretion of SAAs by hepatocytes in the invasive zone could lead to the recruitment of macrophages and M2 polarization,further promoting local immunosuppression,potentially resulting in tumor progression.Clinical association analysis in additional five independent cohorts of patients with primary and secondary liver cancer(n=423)showed that patients with overexpression of SAAs in the invasive zone had a worse prognosis.Further in vivo experiments using mouse liver tumor models in situ confirmed that the knockdown of genes encoding SAAs in hepatocytes decreased macrophage accumulation around the tumor border and delayed tumor growth.The identification and characterization of a novel invasive zone in human cancer patients not only add an important layer of understanding regarding the mechanisms of tumor invasion and metastasis,but may also pave the way for developing novel therapeutic strategies for advanced liver cancer and other solid tumors. | Liang Wu Jiayan Yan Yinqi Bai Feiyu Chen Xuanxuan Zou Jiangshan Xu Ao Huang Liangzhen Hou Yu Zhong Zehua Jing Qichao Yu Xiaorui Zhou Zhifeng Jiang Chunqing Wang Mengnan Cheng Yuan Ji Yingyong Hou Rongkui Luo Qinqin Li Liang Wu Jianwen Cheng Pengxiang Wang Dezhen Guo Waidong Huang Junjie Lei Shang Liu Yizhen Yan Yiling Chen Sha Liao Yuxiang Li Haixiang Sun Na Yao Xiangyu Zhang Shiyu Zhang Xi Chen Yang Yu Yao Li Fengming Liu Zheng Wang Shaolai Zhou Huanming Yang Shuang Yang Xun Xu Longqi Liu Qiang Gao Zhaoyou Tang Xiangdong Wang Jian Wang Jia Fan Shiping Liu Xinrong Yang Ao Chen Jian Zhou | 2023 | Cell Research2023，33，8： | 1 |
| 8 | Design of flexible inorganic thermoelectric devices for decrease of heat loss显示文摘Thermoelectric(TE)devices can realize the conversion of heat energy and electrical power based on Seebeck effect and Peltier effect.Among them,flexible TE devices have received more attention recently due to their better attachment to various heat sources and aimed components with arbitrary shapes.To improve the performance of flexible TE devices for various application scenarios,large efforts have been made to design the leg patterns,the electrical and thermal contact issues,and the substrate and encapsulation materials for the decrease of heat loss.This paper is to review the advancements about the design of flexible inorganic TE devices over the last decade.Firstly,the design of flexible thin-film TE devices based on the direction of temperature gradient,including the patterns of TE legs,the fabrication methods,and the flexible substrate materials is summarized.Secondly,the design of wearable TE devices that contains common architecture of the module,the substrates and encapsulations,the electrical and thermal contact,and some thin-film based wearable devices with curving TE legs is demonstrated.Thirdly,the characterizations of the flexibility of TE devices and the current applications are outlined.Moreover,some views about the future development for TE devices are proposed. | Defang Ding Fengming Sun Fan Xia Zhiyong Tang | 2021 | Nano Research2021，14，7： | 1 |
| 9 | Microstructural influences on the high cycle fatigue life dispersion and damage mechanism in a metastable β titanium alloy显示文摘In this work,the effect of microstructure features on the high-cycle fatigue behavior of Ti-7Mo-3Nb-3Cr-3Al(Ti-7333)alloy is investigated.Fatigue tests were carried out at room temperature in lab air atmosphere using a sinusoidal wave at a frequency of 120 Hz and a stress ratio of 0.1.Results show that the fatigue strength is closely related to the microstructure features,especially theα_(p) percentage.The Ti-7333 alloy with a lowerα_(p) percentage exhibits a higher scatter in fatigue data.The bimodal fatigue behavior and the duality of the S-N curve are reported in the Ti-7333 alloy with relatively lowerα_(p) percentage.Crack initiation region shows the compoundα_(p)/βfacets.Facetedα_(p) particles show crystallographic orientation and morphology dependence characteristics.Crack-initiation was accompanied by faceting process across elongatedα_(p) particles or multiple adjacentα_(p) particles.These particles generally oriented for basal slip result in near basal facets.Fatigue crack can also initiate at elongatedα_(p) particle well oriented for prismatic slip.Theβfacet is in close correspondence to{110}or{112}plane with high Schmid factor.Based on the fracture observation and FIB-CS analysis,three classes of fatigue-critical microstructural configurations are deduced.A phenomenological model for the formation ofα_(p) facet in the bimodal microstructure is proposed.This work provides an insight into the fatigue damage process of theβprecipitate strengthened metastableβtitanium alloys. | Zhihong Wu Hongchao Kou Nana Chen Zhixin Zhang Fengming Qiang Jiangkun Fan Bin Tang Jinshan Li | 2021 | Journal of Materials Science & Technology2021，，11： | 0 |
| 10 | Relating the composition of continental margin surface sediments from the Ross Sea to the Amundsen Sea,West Antarctica,to modern environmental conditions显示文摘Investigating the multiple proxies involving productivity,organic geochemistry,and trace element(TE)enrichment in surface sediments could be used as paleoenvironment archives to gain insights into past and future environmental conditions changes.We present redox-sensitive TEs(Mn,Ni,Cu,U,P,Mo,Co,V,Zn,and Cd),productivity-related proxies(total organic carbon and opal),and total nitrogen and CaCO_(3) contents of bulk surface sediments of this area.The productivity proxies from the shelf and coastal regions of the Ross and the Amundsen seas showed that higher productivity was affiliated with an area of nutrient-rich deep water upwelling.The upwelling of weakly corrosive deep water may be beneficial for preserving CaCO_(3),while highly corrosive dense water,if it forms on the shelf near the coastal region(coastal polynya),could limit the preservation of CaCO_(3) in modern conditions.There were no oxic or anoxic conditions in the study area,as indicated by the enrichment factors of redox-sensitive TEs(Mn,Co,and U).The enrichment factor of Cd,which is redox-sensitive,indicated suboxic redox conditions in sediment environments because of high primary productivity and organic matter preservation/decomposition.The enrichment factors of other redox-sensitive TEs(P,Ni,Cu,V,and Zn)and the correlations between the element/Ti ratio with productivity and nutrient proxies indicated that the organic matter decomposed,and there was massive burial of phytoplankton biomass.There was variation in the enrichment,such that sediments were enriched in P,Mo,and Zn,but depleted in Ni,Cu,and V. | WANG Jiakai LI Tiegang TANG Zheng XIONG Zhifang LIU Yanguang CHEN Zhihua CHANG Fengming | 2022 | Advances in Polar Science2022，33，1： | 0 |
| 11 | Efficacy of bronchoscopic thermal vapor ablation in patients with heterogeneous emphysema and lobar quantification by three-dimensional ventilation/perfusion single-photon emission computed tomography/computed tomography: a prospective pilot study from China显示文摘Chronic obstructive pulmonary disease(COPD)is characterized by emphysema and airflow limitation and is one of the leading causes of morbidityand mortalityworldwide.Endoscopic lung volumereduction(ELVR)is a minimally invasive technique for patients with severe hyperinflation and advanced emphysema.To date,the most investigated form of ELVR isvalve implantation,which is toplacevalves in all the segments of an emphysematous lobe.However,valve replacements do not achieve adequate lung volume reduction in the,presence of interlobar collateral ventilation(CV).l1 in addition,with the heterogeneity existing withinthe treatment lobe,complete lobar treatment from implants may result in excessive reduction of the less diseased segments.Thus,a more targeted approach of the most severe emphysematous parts of the lobe is warranted. | Wenjun Zhu Yuchen Zhang Felix J.F.Herth Dan Liu Hui Zhu Jingyu Shi Chujie Zhang Gongshun Tang Fengming Luo | 2022 | Chinese Medical Journal2022，135，17： | 0 |
| 12 | RUNX1 promotes mitophagy and alleviates pulmonary inflammation during acute lung injury显示文摘Dear Editor,Acute lung injury(ALI)is a significant contributor to the development of acute respiratory distress syndrome(ARDS),which is a severe clinical condition associated with high morbidity and mortality.1 It is increasingly evident that preserving mitochondrial health in alveolar epithelial cells holds great therapeutic potential for ARDS.2 Mitophagy,a cellular process aimed at maintaining mitochondrial health,plays a critical role in this regard.3 Therefore,gaining a comprehensive understanding of the factors that regulate mitophagy in alveolar epithelial cells during ALI could greatly inform the development of future therapeutic approaches for ARDS. | Xiaoju Tang Lichun Zhong Xin Tian Ying Zou Silu Hu Jia Liu Ping Li Min Zhu Fengming Luo Huajing Wan | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员