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| 1 | Pathogenic T-cells and inflammatory monocytes incite inflammatory storms in severe COVID-19 patients显示文摘Pathogenic human coronavirus infections,such as severe acute respiratory syndrome CoV(SARS-CoV)and Middle East respiratory syndrome CoV(MERS-CoV),cause high morbidity and mortality[1,2].Recently,a severe pneumonia-associated respiratory syndrome caused by a new coronavirus(SARS-CoV-2)was reported in December 2019 in the city of Wuhan,Hubei province,China[3-5],which was also named as pneumonia-associated respiratory syndrome(PARS)[6]and can cause coronavirus disease 2019(COVID-19)to seriously endanger human health. | Yonggang Zhou Binqing Fu Xiaohu Zheng Dongsheng Wang Changcheng Zhao Yingjie Qi Rui Sun Zhigang Tian Xiaoling Xu Haiming Wei | 2020 | National Science Review2020，7，6： | 54 |
| 2 | FH 17 cells in human recurrent pregnancy loss and ~re-eclampsia显示文摘 | Binqing Fu | 2014 | Cellular & Molecular Immunology2014，11，6： | 36 |
| 3 | Decidual natural killer cells and the immune microenvironment at the maternal-fetal interface显示文摘During early pregnancy,an orchestrated evolutionary maternal adaption toward tolerance of the semiallogeneic fetus is required to ensure decidualization and early embryo development.Remodeling of the immune system involves natural killer cells(NKs),macrophages,T cells and dendritic cells(DCs) altering the microenvironment in the deciduas.In particular,a unique population of NK cells with a CD56^(bright)CD16^- phenotype in the decidua has been proposed to play a key role in the maternal adaptation to pregnancy.However,there is a tendency for pregnancy immunology to reflect transplantation immunology regarding the assumption that the maternal immune system should be suppressed.This tendency is misleading.We discuss how the immune system is formed in early deciduas and the interactions between maternal NK cells and fetal growth.We propose that the maternal immune response must not be fully suppressed and is even necessary for the local response of uterine NK cells. | Binqing Fu Haiming Wei | 2016 | Science China(Life Sciences)2016，59，12： | 15 |
| 4 | Dynamic contrast-enhanced MRI versus ^(18)F-FDG PET/CT: Which is better in differentiation between malignant and benign solitary pulmonary nodules?显示文摘Objective: To prospectively compare the discriminative capacity of dynamic contrast enhanced-magnetic resonance imaging(DCE-MRI) with that of ^(18)F-fluorodeoxyglucose(^(18)F-FDG) positron emission tomography/computed tomography(PET/CT) in the differentiation of malignant and benign solitary pulmonary nodules(SPNs).Methods: Forty-nine patients with SPNs were included in this prospective study. Thirty-two of the patients had malignant SPNs, while the other 17 had benign SPNs. All these patients underwent DCE-MRI and ^(18)F-FDG PET/CT examinations. The quantitative MRI pharmacokinetic parameters, including the trans-endothelial transfer constant(K^(trans)), redistribution rate constant(K_(ep)), and fractional volume(Ve), were calculated using the Extended-Tofts Linear two-compartment model. The ^(18)F-FDG PET/CT parameter, maximum standardized uptake value(SUV_(max)), was also measured. Spearman's correlations were calculated between the MRI pharmacokinetic parameters and the SUV_(max) of each SPN. These parameters were statistically compared between the malignant and benign nodules. Receiver operating characteristic(ROC) analyses were used to compare the diagnostic capability between the DCE-MRI and ^(18)F-FDG PET/CT indexes.Results: Positive correlations were found between K^(trans) and SUV_(max), and between K_(ep) and SUV_(max)(P<0.05).There were significant differences between the malignant and benign nodules in terms of the K^(trans), K_(ep) and SUV_(max) values(P<0.05). The areas under the ROC curve(AUC) of K^(trans), K_(ep) and SUV_(max) between the malignant and benign nodules were 0.909, 0.838 and 0.759, respectively. The sensitivity and specificity in differentiating malignant from benign SPNs were 90.6% and 82.4% for K^(trans); 87.5% and 76.5% for K_(ep); and 75.0% and 70.6%for SUV_(max), respectively. The sensitivity and specificity of K^(trans) and K_(ep) were higher than those of SUV_(max), but there was no significant difference between them(P>0.05).Conclusions: DCE-MRI can be used to differentiate between benign and malignant SPNs and has the advantage of being radiation free. | Feng Feng Fulin Qiang Aijun Shen Donghui Shi Aiyan Fu Haiming Li Mingzhu Zhang Ganlin Xia Peng Cao | 2018 | Chinese Journal of Cancer Research2018，30，1： | 10 |
| 5 | “Polymer-in-ceramic” based poly(ε-caprolactone)/ceramic composite electrolyte for all-solid-state batteries显示文摘Inspired by the concept of 'polymer-in-ceramic',a composite poly(ε-caprolactone)(PCL)/ceramic containing LiTFSI is prepared and investigated as a solid electrolyte for all-solid-state batteries.The composite with the optimum concentration of 45 wt% LiTFSI and 75 wt% Li1.5Al0.5Ge1.5(PO4)3(LAGP,NASICON-type structure) exhibits a high ionic conductivity(σi=0.17 mS cm-1) at 30℃,a transference number of 0.30,and is stable up to 5.0 V.The composite electrolyte is a flexible and self-standing membrane.Solid-state LiFePO4//Li batteries with this composite electrolyte demonstrate excellent cycling stability with high discharge capacity of 157 mA h g-1,high capacity retention of 96% and coulombic efficiency of 98.5% after 130 cycles at 30℃ and 0.1 C rate.These electrochemical properties are better than other PCL-based allsolid-lithium batteries,and validate the concept of 'polymer-in-ceramic' by avoiding the drawback of lower conductivity in prior 'polymer-in-ceramic' electrolyte at high concentration of the ceramic. | Bohao Zhang Yulong Liu Jia Liu Liqun Sun Lina Cong Fang Fu Alain Mauger Christian M.Julien Haiming Xie Xiumei Pan | 2021 | Journal of Energy Chemistry2021，30，1： | 4 |
| 6 | MDM2 SNP309 contributes to tumor susceptibility:A meta-analysis显示文摘潜在地功能的多型性, SNP309,在 MDM2 的倡导者区域,基因在出版研究看了不确定的结果的癌症风险,而是个人被含有。获得在 MDM2 SNP309 和癌症的风险之间的协会的更精确的估计,我们在与肿瘤和 33,046 控制的不同类型包括了 26,160 个盒子的 59 份出版物执行了 70 单个研究的元分析。概括机会比率(或) 并且相应当适当时, 95% 信心间隔(CI ) 用改正效果和随机效果的模型被估计。总的来说,变体遗传型在不同基因模型为所有癌症类型与显著地增加的癌症风险被联系(GG 对 TT:或, 1.123;95% CI, 1.0561.193;GG/GT 对 TT:或, 1.028;95% CI, 1.0061.050 ) 。在成层的分析,为大多数的研究仍然是的增加的风险癌症,亚洲人口,和医院打字 -- 在不同基因模型的 /population-based 研究,而显著地减少了,风险在前列腺癌症被发现(GG 对 TT:或, 0.606;95% CI, 0.4070.903;GG/GT 对 TT:或, 0.748;95% CI, 0.5790.968 ) 。在结论,元分析的数据建议 MDM2 SNP309 是为癌症风险的潜在的 biomarker。 | Xiaoman Wo Dong Han Haiming Sun Yang Liu Xiangning Meng Jing Bai Feng Chen Yang Yu Yan Jin Songbin Fu | 2011 | Journal of Genetics and Genomics2011，38，8： | 3 |
| 7 | Tocilizumab in patients with moderate or severe COVID-19: a randomized, controlled, open-label, multicenter trial显示文摘Tocilizumab has been reported to attenuate the“cytokine storm”in COVID-19 patients.We attempted to verify the effectiveness and safety of tocilizumab therapy in COVID-19 and identify patients most likely to benefit from this treatment.We conducted a randomized,controlled,open-label multicenter trial among COVID-19 patients.The patients were randomly assigned in a 1:1 ratio to receive either tocilizumab in addition to standard care or standard care alone.The cure rate,changes of oxygen saturation and interference,and inflammation biomarkers were observed.Thirty-three patients were randomized to the tocilizumab group,and 32 patients to the control group.The cure rate in the tocilizumab group was higher than that in the control group,but the difference was not statistically significant(94.12%vs.87.10%,rate difference 95%CI−7.19%–21.23%,P=0.4133).The improvement in hypoxia for the tocilizumab group was higher from day 4 onward and statistically significant from day 12(P=0.0359).In moderate disease patients with bilateral pulmonary lesions,the hypoxia ameliorated earlier after tocilizumab treatment,and less patients(1/12,8.33%)needed an increase of inhaled oxygen concentration compared with the controls(4/6,66.67%;rate difference 95%CI−99.17%to−17.50%,P=0.0217).No severe adverse events occurred.More mild temporary adverse events were recorded in tocilizumab recipients(20/34,58.82%)than the controls(4/31,12.90%).Tocilizumab can improve hypoxia without unacceptable side effect profile and significant influences on the time virus load becomes negative.For patients with bilateral pulmonary lesions and elevated IL-6 levels,tocilizumab could be recommended to improve outcome. | Dongsheng Wang Binqing Fu Zhen Peng Dongliang Yang Mingfeng Han Min Li Yun Yang Tianjun Yang Liangye Sun Wei Li Wei Shi Xin Yao Yan Ma Fei Xu Xiaojing Wang Jun Chen Daqing Xia Yubei Sun Lin Dong Jumei Wang Xiaoyu Zhu Min Zhang Yonggang Zhou Aijun Pan Xiaowen Hu Xiaodong Mei Haiming Wei Xiaoling Xu | 2021 | Frontiers of Medicine2021，15，3： | 2 |
| 8 | Analysis of uterine CD49a^(+) NK cell subsets in menstrual blood reflects endometrial status and association with recurrent spontaneous abortion显示文摘Maternal uterine immune cells,especially natural killer(NK)cells,are important for successful pregnancy,and an abnormal number or function of uterine NK cells is closely correlated with an impaired endometrial environment and miscarriage.However,there are currently no noninvasive testing methods using reliable indicators that accurately predict uterine changes leading to miscarriage.Here,we confirmed that before implantation,menstrual blood(MB)from healthy donors had 70%CD49a^(+)tissue-resident NK(trNK)cells,the majority of which were CD49a^(+)Eomes+NK cells.Importantly,MB from patients with recurrent spontaneous abortion(RSA)had many fewer CD49a^(+)trNK cells than MB from controls.Analysis of uNK cell populations in MB may better predict an abnormal endometrial environment associated with miscarriage than peripheral blood(PB)analysis.Therefore,we suggest using MB-and CD49a-related markers as a promising noninvasive way to evaluate endometrial status. | Xianhong Tong Min Gao Xianghui Du Fangting Lu Limin Wu Haiming Wei Binqing Fu | 2021 | Cellular & Molecular Immunology2021，18，7： | 2 |
| 9 | Pyroptotic macrophages stimulate the SARS-CoV-2-associated cytokine storm显示文摘Coronavirus disease 2019(COVID-19)is an unprecedented pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).As of 22 February 2021,the worldwide pandemic has resulted in more than 110 million cases and 2.4 million deaths.1 Clinical investigation of COVID-19 patients has shown that a systemic cytokine storm can occur,especially in severe cases.2 Treatment of the SARS-CoV-2-associated cytokine storm with tocilizumab3 or anakinra4 has been shown to immediately improve the clinical outcome in most severe and critical COVID-19 patients.These data highlight the systemic cytokine storm as an important exacerbating event in severe COVID-19;however,our understanding of the molecular mechanisms involved in the initiation of the SARS-CoV-2-associated cytokine storm is limited.In the present study,we uncovered a reasonable explanation for cytokine storm initiation through the analysis of 13 autopsy samples from severe COVID-19 patients. | Jinghe Zhang Haibo Wu XiaoHong Yao Dingyu Zhang Yonggang Zhou Binqing Fu Wei Wang Heng Li Zhe Wang Ziming Hu Yong Ren Rui Sun Zhigang Tian Xiuwu Bian Haiming Wei | 2021 | Cellular & Molecular Immunology2021，18，5： | 1 |
| 10 | Exact three-wave solutions for the KP equation显示文摘 | Zhengde Dai Songqing Lin Haiming Fu Xiping Zeng | 2010 | Applied Mathematics and Computation2010，，5： | 1 |
| 11 | Exact chirped solitary-wave solutions for Ginzburg–Landau equation显示文摘 | Haiming Fu Zhengde Dai | 2009 | Communications in Nonlinear Science and Numerical Simulation2009，，6： | 1 |
| 12 | Ultrasonic effect on the octenyl succinate starch synthesis and substitution patterns in starch granules显示文摘 | CHEN Haiming HUANG Qiang FU Xiong | 2014 | Food Hydrocolloids2014，35，： | 1 |
| 13 | Restoration of HBV-specific CD8+T-cell responses by sequential low-dose IL-2 treatment in non-responder patients after IFN-αtherapy显示文摘Patients with chronic hepatitis B(CHB)undergoing interferon(IFN)-α-based therapies often exhibit a poor HBeAg serological response.Thus,there is an unmet need for new therapies aimed at CHB.This study comprised two clinical trials,including 130 CHB patients,who were treatment-naïve;in the first,92 patients were systematically analyzed ex vivo for interleukin-2 receptor(IL-2R)expression and inhibitory molecules expression after receiving Peg-IFN-α-2b therapy.In our second clinical trial,38 non-responder patients,in whom IFN-αtherapy had failed,were treated with or without low-dose IL-2 for 24 weeks.We then examined the hepatitis B virus(HBV)-specific CD8+T-cell response and the clinical outcome,in these patients.Although the majority of the participants undergoing Peg-IFN-α-2b therapy were non-responders,we observed a decrease in CD25 expression on their CD4+T cells,suggesting that IFN-αtherapy may provide a rationale for sequential IL-2 treatment without increasing regulatory T cells(Tregs).Following sequential therapy with IL-2,we demonstrated that the non-responders experienced a decrease in the numbers of Tregs and programmed cell death protein 1(PD-1)expression.In addition,sequential IL-2 administration rescued effective immune function,involving signal transducer and activator of transcription 1(STAT1)activation.Importantly,IL-2 therapy significantly increased the frequency and function of HBV-specific CD8+T cells,which translated into improved clinical outcomes,including HBeAg seroconversion,among the non-responder CHB patients.Our findings suggest that sequential IL-2 therapy shows efficacy in rescuing immune function in non-responder patients with refractory CHB. | Dongyao Wang Binqing Fu Xiaokun Shen Chuang Guo Yanyan Liu Junfei Zhang Rui Sun Ying Ye Jiabin Li Zhigang Tian Haiming Wei | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 1 |
| 14 | Relationship of Filtration Resistance with Geometry Parameters Across Pleated Aerosol Filter 显示文摘 | Fu Haiming Xu Fang Jin Ruifang | 2010 | Journal of Huaqiao University ( Natural Science)2010，31，3： | 1 |
| 15 | Exact chirped solitary-wave solutions for Ginzburg-Landau equation显示文摘 | Fu Haiming Dai Zhengde | 2010 | Commun Nonlinear Sci Numer Simul2010，15，6： | 1 |
| 16 | Double exp-function method and application显示文摘 | Fu Haiming Dai Zhengde | 2009 | Inter J Nonl Sci &- Numer Simul2009，10，7： | 1 |
| 17 | The -22018A allele matches the lactase persistence phenotype in northern Chinese populations显示文摘 | Lidan Xu Haiming Sun Xuelong Zhang Jingwei Wang Donglin Sun Feng Chen Jing Bai Songbin Fu | 2010 | Scandinavian Journal of Gastroenterology2010，，2： | 1 |
| 18 | Relationship of filtration resistance with geometry parameters across pleated aerosol filter显示文摘 | Fu Haiming Xu Fang Jin Ruifang | 2010 | Journal of Huaqiao University: Natural Science2010，31，3： | 1 |
| 19 | Direct estimation of rupture depths of earthquake faults from coseismic surface deformation显示文摘The rupture dimensions of earthquake faults are important parameters for characterizing earthquake ruptures and ground motions. Two key parameters to be determined are the rupture depth and dip angle of earthquake faults. Dislocation theory in an elastic half space indicates that if a seismic rupture directly runs up to the ground surface, there exist zero points of horizontal strain in the surface deformation, which correspond to the rupture depths, except for pure strike-slip faults. In this study, we use numerical simulations to investigate the possibility of inferring rupture depths from zero-strain points for cases of buried faults and heterogeneous media. The results show that the correspondence of zero-strain points to the rupture depths can be influenced by the heterogeneity of the underground media and the stress field. For buried faults, the correspondence relationship is approximately valid when the fault depth is <1 km. In addition, the range of earthquake fault dip angles can be estimated by horizontal displacements on the ground. We also study how to determine the rupture depths of faults from InSAR data after large earthquakes, and successfully apply the method to the 2008 Wenchuan earthquake. The method proposed here, which determines the parameters of fault geometry according to surface deformation, is simple and easy to perform. With independent of aftershocks, it can provide valuable constraints to kinematic inversions. | FU Zhen HU CaiBo ZHANG HaiMing XU HuiHui CAI YongEn | 2014 | Science China Earth Sciences2014，57，8： | 1 |
| 20 | Light from space illuminating the polar silk road显示文摘The rapid decline of Arctic sea ice has been reminding us the significant impacts caused by global warming.However,the other side of the coin is that this opens a window to utilize the Arctic sea routes in the summer seasons,bringing remarkable economic benefits for ocean transportation between Asia and Europe.However,commercial vessels with low ice classes must tackle substantial environmental challenges in the Arctic sea routes,particularly those caused by variable sea ice,even in the melting seasons.Therefore,the science-based support for shipping safety in the Arctic sea routes is being given more prominence.Emerging satellite remote sensing technology plays a critical role in environmental monitoring in the Arctic.This paper reviews state-of-the-art satellite observations on monitoring sea ice and potential applications on supporting shipping activities in the Arctic Ocean.Moreover,we introduced a recently developed system based on satellite observations to support the safe transportation of Chinese cargo vessels in the Arctic northern sea route,demonstrating the efforts by both the science and business communities to promote the development of the polar silk road. | Xiao-Ming Li Yujia Qiu Yacheng Wang Bingqing Huang Haiming Lu Min Chu Han Fu Fengming Hui | 2022 | International Journal of Digital Earth2022，15，1： | 0 |
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