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| 1 | Aging is a risk factor of nonalcoholic fatty liver disease in premenopausal women显示文摘AIM: To clarify the relationship between age, menopause, and nonalcoholic fatty liver disease (NAFLD) in women. METHODS: We conducted a follow-up study on non-alcoholic fatty liver disease by using abdominal ultrasonography, and investigated the relationship of age and menopause with the development of NAFLD in women. We followed 1829 women and 2572 men (response rate, 86%) selected in 2001 to represent the non-institutionalized adult population of Gifu, Japan. Data collected included self-reported medical history, lifestyle factors, and menopausal status. The postmenopausal state was defined as beginning 1 year after the cessation of menses. We diagnosed NAFLD with the aid of abdominal ultrasonography by using diagnostic criteria describedRESULTS: The prevalence of NAFLD in women increases with age, but does not alter with age in men. Furthermore, the prevalence of NAFLD in premenopausal women (6%) was lower than that in men (24%) and in postmenopausal women (15%). The associations of the postmenopausal state and hormone replacement therapy with NAFLD were statistically significant in a univariate logistic regression model. At the follow-up examination, 67 women (5%) were newly diagnosed with NAFLD. The incidence of NAFLD was 3.5% (28/802) in premenopausal women, 7.5% (4/53) in menopausal women, 6.1% (24/392) in postmenopausal women, and 5.3% (11/206) in women receiving hormone replacement therapy. The weight gain in premenopausal women was equal to that in postmenopausal women. Metabolic syndrome and weight gain were independent risk factors for NAFLD in pre-and postmenopausal women, but age was an independent risk factor in premenopausal women only. CONCLUSION: Aging is a risk factor for NAFLD in premenopausal women, independent of weight gain or influence of metabolic syndrome. | Masahide Hamaguchi Takao Kojima Akihiro Ohbora Noriyuki Takeda Michiaki Fukui Takahiro Kato | 2012 | World Journal of Gastroenterology2012，18，3： | 19 |
| 2 | Identification of individuals with non-alcoholic fatty liver disease by the diagnostic criteria for the metabolic syndrome显示文摘AIM:To clarify the efficiency of the criterion of metabolic syndrome to detecting non-alcoholic fatty liver disease(NAFLD).METHODS:Authors performed a cross-sectional study involving participants of a medical health checkup program including abdominal ultrasonography.This study involved 11 714 apparently healthy Japanese men and women,18 to 83 years of age.NAFLD was defined by abdominal ultrasonography without an alcohol intake of more than 20 g/d,known liver disease,or current use of medication.The revised criteria of the National Cholesterol Education Program Adult Treatment PanelⅢ were used to characterize the metabolic syndrome.RESULTS:NAFLD was detected in 32.2%(95%CI:31.0%-33.5%)of men(n=1874 of 5811)and in 8.7%(95%CI:8.0%-9.5%)of women(n=514 of 5903).Among obese people,the prevalence of NAFLD was as high as 67.3%(95%CI:64.8%-69.7%)in men and 45.8%(95%CI:41.7%-50.0%)in women.Although NAFLD was thought of as being the liver phenotype of metabolic syndrome,the prevalence of the metabolic syndrome among subjects with NAFLD was low both in men and women.66.8%of men and 70.4%of women with NAFLD were not diagnosed with the metabolic syndrome.48.2%of men with NAFLD and 49.8%of women with NAFLD weren't overweight[body mass index(BMI)≥25 kg/m2].In the same way,68.6%of men with NAFLD and 37.9%of women with NAFLD weren't satisfied with abdominal classification(≥90 cm for men and≥80 cm for women).Next,authors defined it as positive at screening for NAFLD when participants satisfied at least one criterion of metabolic syndrome.The sensitivity of the definition'at least 1 criterion'was as good as 84.8%in men and 86.6%in women.Separating subjects by BMI,the sensitivity was higher in obese men and women than in non-obese men and women(92.3%vs 76.8%in men,96.1%vs 77.0%in women,respectively).CONCLUSION:Authors could determine NAFLD effectively in epidemiological study by modifying the usage of the criteria for metabolic syndrome. | Masahide Hamaguchi Noriyuki Takeda Takao Kojima Akihiro Ohbora Takahiro Kato Hiroshi Sarui Michiaki Fukui Chisato Nagata Jun Takeda | 2012 | World Journal of Gastroenterology2012，18，13： | 13 |
| 3 | Protective effect of alcohol consumption for fatty liver but not metabolic syndrome显示文摘AIM:To investigate the effect of alcohol on the metabolic syndrome (MS) and fatty liver in Japanese men and women.METHODS:A cross-sectional study was conducted in a medical health checkup program at a general hospital.This study involved 18 571 Japanese men and women,18-88 years of age,with a mean body mass index of 22.6 kg/m 2.A standardized questionnaire was administered.The total amount of alcohol consumed per week was calculated,and categorized into four grades.Fatty liver was examined by ultrasound modified criteria of the revised National Cholesterol Educa-tion Program Adult Treatment Panel Ⅲ and the new International Diabetes Federation.RESULTS:The prevalence of fatty liver decreased in men and women with light to moderate alcohol consumption,whereas the prevalence of MS was not so changed.The prevalence of fatty liver of any grade in men was lower than that in those with no or minimal alcohol consumption.In women with light to moderate alcohol consumption,prevalence of fatty liver was lower than that in women with no or minimal alcohol consumption.By logistic regression analysis,the odds ratio (OR) for MS in women with light alcohol consumption was decreased to < 1.0,but this change was not clear in men.The OR for fatty liver was clearly < 1.0 in men with any level of alcohol consumption and in women with light to moderate consumption.CONCLUSION:Light to moderate alcohol consumption has a favorable effect for fatty liver,but not for MS in Japanese men and women. | Masahide Hamaguchi Takao Kojima Akihiro Ohbora Noriyuki Takeda Michiaki Fukui Takahiro Kato | 2012 | World Journal of Gastroenterology2012，18，2： | 12 |
| 4 | Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance显示文摘 | Sizuo Kajiyama Goji Hasegawa Mai Asano Hiroko Hosoda Michiaki Fukui Naoto Nakamura Jo Kitawaki Saeko Imai Koji Nakano Mitsuhiro Ohta Tetsuo Adachi Hiroshi Obayashi Toshikazu Yoshikawa | 2008 | Nutrition Research2008，，3： | 1 |
| 5 | Effect of glycemic control on periodontitis in type 2 diabetic patients with periodontal disease显示文摘 | Sayaka Katagiri Hiroshi Nitta Toshiyuki Nagasawa Yuichi Izumi Masao Kanazawa Akira Matsuo Hiroshige Chiba Michiaki Fukui Naoto Nakamura Fumishige Oseko Narisato Kanamura Koji Inagaki Toshihide Noguchi Keiko Naruse Tatsuaki Matsubara Shigeru Miyazaki Takas | 2013 | J Diabetes Invest2013，，3： | 1 |
| 6 | Idiopathic sudden hearing loss in patients with type 2 diabetes显示文摘 | Michiaki Fukui Yoshihiro Kitagawa Naoto Nakamura Mayuko Kadono Shin-ichi Mogami Masayoshi Ohnishi Chizuko Hirata Naoko Ichio Katsuya Wada Chiyoko Kishimoto Hirofumi Okada Hirofumi Miyata Toshikazu Yoshikawa | 2003 | Diabetes Research and Clinical Practice2003，，3： | 1 |
| 7 | Serumuric acid is associated with microalbuminuria and subclinicalatherosclerosis in men with type 2 diabetes mellitus 显示文摘 | Fukui Michiaki Tanaka Muhei Shiraishi Emi | 2008 | Metab Clin Exp2008，57，5： | 1 |
| 8 | Formation of Crossline as a Fluorescent Advanced Glycation End Product in Vitro and in Vivo显示文摘 | Hiroshi Obayashi Koji Nakano Hirofumi Shigeta Makiko Yamaguchi Kuniaki Yoshimori Michiaki Fukui Mitsuhiro Fujii Yoshihiro Kitagawa Naoto Nakamura Ko Nakamura Yoshitaka Nakazawa Kazuharu Ienaga Mitsuhiro Ohta Masataka Nishimura Iwao Fukui Motoharu Kondo | 1996 | Biochemical and Biophysical Research Communications1996，，1： | 1 |
| 9 | Helicobacter pylori infection and arterial stiffness in patients with type 2 diabetes mellitus 显示文摘 | Masayoshi Ohnishi Michiaki Fukui | 2008 | Metabolism Clinical and Experimental2008，57，： | 1 |
| 10 | Helicobacter pylori infection and arterial stiffness in patients with type 2 diabetes mellitus显示文摘 | Masayoshi Ohnishi Michiaki Fukui Takeshi Ishikawa Nahoko Ohnishi Noriko Ishigami Keiji Yoshioka Goji Hasegawa Toshikazu Yoshikawa Naoto Nakamura | 2008 | Metabolism2008，，12： | 1 |
| 11 | Angiotensin II receptor blocker inhibits abnormal accumulation of advanced glycation end products and retinal damage in a rat model of type 2 diabetes显示文摘 | Tetsuya Sugiyama Takashi Okuno Masayuki Fukuhara Hidehiro Oku Tsunehiko Ikeda Hiroshi Obayashi Mitsuhiro Ohta Michiaki Fukui Goji Hasegawa Naoto Nakamura | 2007 | Experimental Eye Research2007，，3： | 1 |
| 12 | Association Between Serum Bioavailable Testosterone Concentration and the Ratio of Glycated Albumin to Glycated Hemoglobin in Men With Type 2 Diabetes显示文摘 | Fukui Michiaki Tanaka Muhei Hasegawa Goji Yoshikawa Toshikazu Nakamura Naoto | 2008 | Diabetes Care2008，，3： | 1 |
| 13 | LOX-1 is a novel marker for peripheral artery disease in patients with type 2 diabetes显示文摘 | Michiaki Fukui Muhei Tanaka Takafumi Senmaru Mamoru Nakanishi Jun Mukai Makoto Ohki Mai Asano Masahiro Yamazaki Goji Hasegawa Naoto Nakamura | 2013 | Metabolism2013，，7： | 1 |
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